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31. 发明授权

US10434757B2 Method of manufacturing a drug delivery device body 有权
公开(公告)号：US10434757B2
公开(公告)日：2019-10-08
申请号：US13258164
申请日：2010-03-31
申请人： Michael Harms , Steffen Raab , Uwe Dasbach , Udo Stauder
发明人： Michael Harms , Steffen Raab , Uwe Dasbach , Udo Stauder
IPC分类号： B32B37/12 , A61M5/31
摘要： The invention relates to a method for manufacturing a drug delivery device body comprising the following steps:At first a first part of the drug delivery device body wherein the surface of the first part of the drug delivery device body consists of at least one selected area and at least one non selected area is provided. The selected area of the drug delivery device body is a part of the contact area of the first part and a second part of the drug delivery device body to be fixed to the first part of the drug delivery device body. Subsequently a layer of an adhesive is deposited on the surface of the first part; means for deposition of the adhesive only in the selected area are provided. The first part with the layer of adhesive and the second part are joined so that the layer of the adhesive is only arranged in the contact area of the first and the second part of the drug delivery device body.

32. 发明授权

US10286150B2 Dose button for a drug delivery device and method for manufacturing a dose button 有权
公开(公告)号：US10286150B2
公开(公告)日：2019-05-14
申请号：US13254470
申请日：2010-03-31
申请人： Michael Harms , Steffen Raab , Udo Stauder , Richard James Vincent Avery , Christopher Nigel Langley , James Alexander Senior , James Alexander Davies
发明人： Michael Harms , Steffen Raab , Udo Stauder , Richard James Vincent Avery , Christopher Nigel Langley , James Alexander Senior , James Alexander Davies
IPC分类号： A61M5/20 , A61M5/00 , A61M37/00
摘要： The present invention relates to a drug delivery device (6) comprising a dose button (1). Furthermore it relates to a method for manufacturing a dose button (1) by using a cutting-off process. The aim of the present invention is to minimize the risk of using a drug delivery device (6) containing a wrong drug. By means of tactile features, a drug delivery device (6) is distinguishable from another drug delivery device (6) containing another type of drug. This tactile feature is manufactured by using a dose button (1) out of metal which is milled or lathed.

33. 发明授权

US09775949B2 Cartridge holder, drug delivery device and method for securing a cartridge in a cartridge holder 有权
公开(公告)号：US09775949B2
公开(公告)日：2017-10-03
申请号：US13575353
申请日：2011-01-31
申请人： Steffen Raab , Sandra Arnhold
发明人： Steffen Raab , Sandra Arnhold
IPC分类号： A61M5/00 , A61M5/24 , A61M5/31 , A61M5/34
CPC分类号： A61M5/24 , A61M5/3134 , A61M5/347 , A61M2005/2437 , A61M2005/2488
摘要： A cartridge holder, which has a distal end and a proximal end, comprises a coupling housing portion in which a cartridge can be inserted at least partly. The coupling housing portion is configured to be coupled to a part of a drug delivery device. The cartridge holder further comprises a fixing member which is connected with the coupling housing portion. The fixing member is moveable radially inwardly to a position in which the fixing member is suitable for securing the cartridge against distal displacement of the cartridge.

34. 发明授权

US09492619B2 Assembly for a drug delivery device and drug delivery device 有权
标题翻译：用于药物递送装置和药物递送装置的组装
公开(公告)号：US09492619B2
公开(公告)日：2016-11-15
申请号：US13575352
申请日：2011-02-02
申请人： Steffen Raab
发明人： Steffen Raab
IPC分类号： A61M5/315
CPC分类号： A61M5/31585 , A61M5/31541 , A61M5/31555 , A61M5/31593
摘要： An assembly for a drug delivery device comprises a housing, at least one stop feature and at least one blocking member. For setting a dose of a drug, the stop feature is configured to be rotated in a dose setting direction with respect to the blocking member and with respect to the housing. For delivering the set dose of the drug, the blocking member is configured to be axially displaced with respect to the stop feature away from an axial starting position and towards an axial interaction position. When the blocking member is in the axial starting position, the blocking member is axially offset from the stop feature and, when the blocking member is in the axial interaction position, the blocking member is configured to mechanically cooperate with the stop feature such that rotation of the stop feature in the dose setting direction with respect to the housing is prevented.
摘要翻译：用于药物递送装置的组件包括壳体，至少一个止动部件和至少一个阻塞部件。为了设置药物的剂量，停止特征被配置为相对于阻塞构件和相对于壳体在剂量设定方向上旋转。为了传递药物的设定剂量，阻挡构件被构造成相对于止动件远离轴向起始位置并且朝向轴向相互作用位置轴向移位。当阻挡构件处于轴向起始位置时，阻挡构件从止动构件轴向偏移，并且当阻挡构件处于轴向相互作用位置时，阻挡构件构造成与止动构件机械配合，阻止了相对于壳体的剂量设定方向的停止特征。

35. 发明授权

US09393368B2 Drive mechanism for a drug delivery device and drug delivery device 有权
标题翻译：用于药物递送装置和药物递送装置的驱动机构
公开(公告)号：US09393368B2
公开(公告)日：2016-07-19
申请号：US13883393
申请日：2011-11-11
申请人： Philippe Nzike , Steffen Raab , Uwe Dasbach , Uwe Boeser , Ulrich Brüggemann
发明人： Philippe Nzike , Steffen Raab , Uwe Dasbach , Uwe Boeser , Ulrich Brüggemann
IPC分类号： A61M5/315
CPC分类号： A61M5/31585 , A61M5/31511 , A61M5/31515 , A61M5/31525 , A61M5/31528 , A61M5/31533 , A61M5/31565 , A61M5/31571 , A61M5/31583
摘要： The drive mechanism comprises a piston rod, a dose member with a thread engaging a corresponding thread of the body to allow a helical movement of the dose member with respect to the body, a drive sleeve rotationally coupled to the dose member, and stop means provided to restrict or inhibit a movement of the drive sleeve in the proximal direction and in the distal direction with respect to the body, the drive sleeve and the piston rod being unidirectionally coupled.
摘要翻译：驱动机构包括活塞杆，剂量构件，其具有接合主体的相应螺纹的螺纹，以允许剂量构件相对于主体的螺旋运动，旋转地联接到剂量构件的驱动套筒和设置的止动装置以限制或抑制驱动套筒相对于主体在近端方向和远侧方向上的移动，驱动套筒和活塞杆单向联接。

36. 发明授权

US09289560B2 Drive assembly for a drug delivery device and drug delivery device 有权
标题翻译：用于药物递送装置和药物递送装置的驱动组件
公开(公告)号：US09289560B2
公开(公告)日：2016-03-22
申请号：US13509601
申请日：2010-12-06
申请人： Steffen Raab , Uwe Dasbach
发明人： Steffen Raab , Uwe Dasbach
IPC分类号： A61M5/315 , A61M5/31
CPC分类号： A61M5/31586 , A61M5/3146 , A61M5/31501 , A61M5/31541 , A61M5/31555 , A61M5/31556 , A61M5/3156 , A61M5/31573 , A61M5/31575 , A61M5/31585 , A61M5/31593
摘要： A drive assembly for a drug delivery device, comprising a housing with a proximal end and a distal end, and a longitudinal axis (A) extending between the proximal end and the distal end, a rotation sleeve being rotatable relative to the housing, and a piston rod being axially moveable relative to the housing. The piston rod is in mechanical cooperation with the rotation sleeve to be rotatable and moveable in the distal direction relative to the housing when the rotation sleeve rotates in a first direction (D1) and to be stationary in axial direction relative to the housing when the rotation sleeve rotates in a second direction (D2) opposite to the first direction (D1).
摘要翻译：一种用于药物输送装置的驱动组件，包括具有近端和远端的壳体，以及在近端和远端之间延伸的纵向轴线（A），旋转套筒可相对于壳体旋转，并且活塞杆相对于壳体可轴向移动。当旋转套筒沿第一方向（D1）旋转时，活塞杆与旋转套筒机械协作以相对于壳体在远端方向上可旋转并且可移动，并且当旋转轴线相对于壳体在轴向方向上静止时套筒沿与第一方向（D1）相反的第二方向（D2）旋转。

37. 发明授权

US09254364B2 Assembly for a drug delivery device 有权
标题翻译：组装药物输送装置
公开(公告)号：US09254364B2
公开(公告)日：2016-02-09
申请号：US13498226
申请日：2010-09-28
申请人： Steffen Raab , Sandra Arnhold
发明人： Steffen Raab , Sandra Arnhold
IPC分类号： A61M5/00 , A61M5/315
CPC分类号： A61M5/31535 , A61M5/31551 , A61M5/31553 , A61M5/31556 , A61M5/31585
摘要： An assembly for a drug delivery device (1), comprises a housing (2), a dose member (22), a guide track (42) and a spring member (26). The dose member (22) is adapted to be rotated in a dose setting direction with respect to the housing (2) for setting a dose of a drug (5) and to be rotated in a dose delivery direction with respect to the housing (2) for delivering the set dose. The dose member (22) comprises a guide feature (46). The guide track (42) is configured to mechanically cooperate with the guide feature (46). The guide track (42) comprises a first section (43A) and a second section (43B) which are connected to each other via a connection region (55). The first section (43A) defines an angular start position (54) for the guide feature (46) and the second section (43B) defines an axial stop position (56) for the guide feature (46). When the dose member (22) is rotated in the dose setting direction, the guide feature (46) is angularly displaced from the angular start position (54) towards the connection region (55), the spring member (26) is torsionally biased, the biased spring member (26) tending to angularly displace the guide feature (46) towards the angular start position (54). When the guide feature (46) has passed the connection region (55), the guide feature (46) enters the second section (43B) and is axially displaced in a proximal direction with respect to the housing (2) towards the axial stop position (56). In the axial stop position, reduction of the torsional bias is prevented by mechanical cooperation of the guide feature (46) and the second section (43B).
摘要翻译：一种用于药物输送装置（1）的组件，包括壳体（2），剂量构件（22），导轨（42）和弹簧构件（26）。剂量构件（22）适于相对于壳体（2）以剂量设定方向旋转，用于设定药物（5）的剂量并且相对于壳体（2）以剂量递送方向旋转）用于递送设定的剂量。剂量构件（22）包括引导特征（46）。引导轨道（42）构造成与引导特征（46）机械协作。导轨（42）包括通过连接区域（55）彼此连接的第一部分（43A）和第二部分（43B）。第一部分（43A）限定用于引导特征（46）的角度起始位置（54），并且第二部分（43B）限定用于引导特征（46）的轴向停止位置（56）。当剂量构件（22）在剂量设定方向上旋转时，引导构件（46）从角度起始位置（54）朝向连接区域（55）成角度地移位，弹簧构件（26）被扭转偏置，倾斜的弹簧构件（26）倾向于将引导构件（46）朝向角度起始位置（54）成角度地移动。当引导部件46穿过连接区域55时，引导部件46进入第二部分43B并相对于壳体2朝向轴向停止位置沿近端方向轴向移动（56）。在轴向停止位置，通过引导特征（46）和第二部分（43B）的机械协作来防止扭转偏压的减小。

38. 发明授权

US09089652B2 Drive mechanism for a medication delivery device and medication delivery device 有权
标题翻译：药物输送装置和药物输送装置的驱动机构
公开(公告)号：US09089652B2
公开(公告)日：2015-07-28
申请号：US13133884
申请日：2009-12-09
申请人： Philippe Nzike , Steffen Raab , Ulrich Brüggemann , Uwe Dasbach , Uwe Boeser
发明人： Philippe Nzike , Steffen Raab , Ulrich Brüggemann , Uwe Dasbach , Uwe Boeser
IPC分类号： A61M5/00 , A61M5/315 , A61M5/24
CPC分类号： A61M5/31551 , A61M5/24 , A61M5/3148 , A61M5/31511 , A61M5/31515 , A61M5/31528 , A61M5/31535 , A61M5/31536 , A61M5/31541 , A61M5/31543 , A61M5/31555 , A61M5/31556 , A61M5/31558 , A61M5/3156 , A61M5/31561 , A61M5/3157 , A61M5/31575 , A61M5/3158 , A61M5/31581 , A61M5/31585 , A61M5/31593 , A61M2005/2407 , A61M2005/3152 , A61M2205/581 , A61M2205/582 , F16H25/12 , F16H25/20 , F16H31/001 , Y10T74/18568 , Y10T74/18696
摘要： A drive mechanism for a medication delivery device (1) is proposed, the drive mechanism comprising a housing (13, 17, 40) having a proximal end and a distal end, a rotation member (21) which is adapted to be rotated in a first direction with respect to the housing during setting of a dose of a medication and to be rotated in a second direction with respect to the housing during delivery of the dose, the second direction being opposite to the first direction, a piston rod (12) which is adapted to be displaced in a distal direction with respect to the housing for delivering the dose, a drive member (20) which follows rotational movement of the rotation member in the second direction during delivery of the dose, and a stop member (26) which prevents rotational movement of the drive member with respect to the housing in the first direction during setting of the dose, wherein the rotational movement of the drive member in the second direction is converted into movement of the piston rod in the distal direction with respect to the housing. Furthermore, a medication delivery device is provided for.
摘要翻译：提出了一种用于药物输送装置（1）的驱动机构，所述驱动机构包括具有近端和远端的壳体（13,17,40），旋转构件（21），其适于在第一方向相对于壳体在设置药物剂量期间相对于壳体在第二方向上相对于壳体在剂量递送期间旋转，第二方向与第一方向相反，活塞杆（12）其适于相对于用于输送剂量的壳体在远端方向上移位;驱动构件（20），其在所述剂量递送期间沿所述旋转构件沿所述第二方向旋转运动;以及止动构件（26）），其在剂量设定期间防止驱动构件相对于壳体在第一方向上的旋转运动，其中驱动构件在第二方向上的旋转运动转换为活塞杆的运动相对于壳体的远端方向。此外，提供了一种药物输送装置。

39. 发明授权

US08968258B2 Resettable drive mechanism for a medication delivery device and medication delivery device 有权
标题翻译：用于药物输送装置和药物输送装置的可重置驱动机构
公开(公告)号：US08968258B2
公开(公告)日：2015-03-03
申请号：US13133933
申请日：2009-12-09
申请人： Philippe Nzike , Steffen Raab , Ulrich Brüggemann , Uwe Dasbach , Uwe Boeser
发明人： Philippe Nzike , Steffen Raab , Ulrich Brüggemann , Uwe Dasbach , Uwe Boeser
IPC分类号： A61M5/315 , A61M5/24
CPC分类号： A61M5/31543 , A61M5/24 , A61M5/31511 , A61M5/31515 , A61M5/31535 , A61M5/31536 , A61M5/31541 , A61M5/31555 , A61M5/31556 , A61M5/31558 , A61M5/3156 , A61M5/31561 , A61M5/3157 , A61M5/31575 , A61M5/3158 , A61M5/31581 , A61M5/31585 , A61M5/31593 , A61M2005/2407 , A61M2005/3152 , A61M2205/581 , A61M2205/582
摘要： A resettable drive mechanism for a medication delivery device comprising a housing and a drive member rotatable in a second direction for delivering a dose. A piston rod driven distally when a drive member rotates in the second direction. A stop member prevents rotation of the drive member in a first direction opposite the second direction, when the stop member engages the drive member. A clutch member is movable between a delivery and reset position. When the clutch member is in the delivery position, the stop member and the drive member engage and the drive member is prevented from rotating in the first direction. When the clutch member is in the reset position, the drive member and the stop member disengage. The drive member is rotatable in the first direction.
摘要翻译：一种用于药物输送装置的可重置驱动机构，包括壳体和可沿第二方向旋转的用于递送剂量的驱动构件。当驱动构件沿第二方向旋转时，活塞杆向远侧驱动。当止动构件接合驱动构件时，止动构件防止驱动构件沿与第二方向相反的第一方向旋转。离合器构件可在输送和复位位置之间移动。当离合器构件处于排出位置时，停止构件和驱动构件接合，并且防止驱动构件沿第一方向旋转。当离合器构件处于复位位置时，驱动构件和止动构件脱开。驱动构件可沿第一方向旋转。

40. 发明授权

US08968257B2 Coded cartridge holder system for a fluid delivery device 有权
标题翻译：用于流体输送装置的编码盒式支架系统
公开(公告)号：US08968257B2
公开(公告)日：2015-03-03
申请号：US13642554
申请日：2011-04-21
申请人： Uwe Dasbach , Steffen Raab , Michael Harms , Udo Stauder , Volker Korger
发明人： Uwe Dasbach , Steffen Raab , Michael Harms , Udo Stauder , Volker Korger
IPC分类号： A61M5/315 , A61M5/50 , A61M5/24
CPC分类号： A61M5/5086 , A61M5/24 , A61M5/31551 , A61M2005/2407 , A61M2005/2433 , A61M2005/2488 , A61M2005/2492 , A61M2205/6045
摘要： A coded cartridge holder system is disclosed for use with a cartridge assembly (20) containing a fluid and a delivery device (10), where the system has keyed connectors (5, 5′, 6, 6′) to prevent accidental attachment of the wrong fluid delivery device (10). The system comprises a coupling (1) attachable to the dose setting portion (12) of the device (10) and keyed to the proximal end of the cartridge holder (14). The cartridge holder (14) may also contain medical coding (27, 28) to correspond to matching coding (27′, 28′) on the distal end of a cartridge assembly (20).
摘要翻译：公开了一种与包含流体和输送装置（10）的盒组件（20）一起使用的编码盒式存储器系统，其中系统具有键控连接器（5,5'，6,6'），以防止意外地附接错误的流体输送装置（10）。该系统包括可连接到装置（10）的剂量设定部分（12）并且键合到药筒保持器（14）的近端的联接器（1）。药筒保持器（14）还可以包含医疗编码（27,28），以对应于药筒组件（20）的远端上的匹配编码（27'，28'）。

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