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31. 发明申请

US20150248015A1 OPTICAL ASSEMBLY AND LIGHT MICROSCOPE 审中-公开
标题翻译：光学组装和光学显微镜
公开(公告)号：US20150248015A1
公开(公告)日：2015-09-03
申请号：US14436641
申请日：2013-10-09
申请人： CARL ZEISS MICROSCOPY GMBH
发明人： Daniel Schwedt , Tiemo Anhut , Ralf Netz
IPC分类号： G02B27/58 , G02B26/08 , G02F1/11 , G02B21/00 , G02F1/01
CPC分类号： G02B27/58 , G02B21/0032 , G02B21/0092 , G02B26/0816 , G02F1/0115 , G02F1/0147 , G02F1/11
摘要： An optical assembly that is designed for positioning in a beam path of a light microscope having means for providing structured illuminating light in a sample plane of the light microscope, so that structured illuminating light can be generated in different orientations. The optical assembly has an adjustable deflector in order to deflect an incident light bundle onto one of several beam paths in a selectable manner. Beam splitting devices are located in the beam paths in order to split the light bundle of the respective beam paths into partial light bundles, which are spatially separated from each other. Beam guides are provided for each of the partial light bundles, and guide the partial light bundles to a pupil plane. The beam guides are arranged in such a way that the partial light bundles that belong to the same beam path form a light spot pattern in the pupil plane; and that the light spot patterns of different beam paths in the pupil plane are different from each other.
摘要翻译：一种光学组件，其设计用于在具有在光学显微镜的样品平面中提供结构化照明光的装置的光学显微镜的光束路径中定位，从而可以以不同的取向产生结构化的照明光。光学组件具有可调节的偏转器，以便以可选择的方式将入射光束偏转到几个光束路径中的一个。光束分束装置位于光束路径中，以便将各个光束路径的光束分成彼此在空间上分离的部分光束。为每个部分光束提供光束引导件，并将部分光束引导到光瞳平面。光束引导件被布置成使得属于相同光束路径的部分光束在光瞳平面中形成光点图案; 并且瞳孔平面中的不同光束路径的光点图案彼此不同。

32. 发明授权

US11977216B2 Light microscope and method of capturing images with a light microscope 有权
公开(公告)号：US11977216B2
公开(公告)日：2024-05-07
申请号：US17766098
申请日：2020-10-12
申请人： CARL ZEISS MICROSCOPY GMBH
发明人： Daniel Schwedt , Tiemo Anhut
IPC分类号： G02B21/36 , G01J1/32 , G01J1/44
CPC分类号： G02B21/367 , G01J1/32 , G01J1/44 , G01J2001/442
摘要： A light microscope and a method for capturing images with a light microscope includes guiding illumination light to a sample; guiding detection light from the sample to a plurality of photon-counting sensor elements, which each successively capture a plurality of photon counts; forming a plurality of photon count distributions to be analyzed and at least one reference photon count distribution from the photon counts; calculating a similarity between each photon count distribution to be analyzed and the reference photon count distribution; and identifying sensor elements as overdriven as a function of the calculated similarity of the corresponding photon count distribution(s) to be analyzed.

33. 发明授权

US11966036B2 Light microscope and microscopy method 有权
公开(公告)号：US11966036B2
公开(公告)日：2024-04-23
申请号：US17296623
申请日：2019-11-07
申请人： Carl Zeiss Microscopy GmbH
发明人： Tiemo Anhut , Daniel Schwedt
IPC分类号： G02B21/00 , G01N21/64 , G02B21/04
CPC分类号： G02B21/0032 , G01N21/6458 , G02B21/0076 , G02B21/008 , G02B21/04
摘要： A light microscope having a scanner for scanning a sample with illuminating light and a light detector for measuring sample light. A microlens array having a plurality of microlenses is arranged in front of the light detector in the region of a pupil plane. The light detector respectively has a plurality of detector elements behind each microlens and has a complete readout frequency of at least 100 kHz. By means of the detector elements arranged behind the respective microlens, a wavefront datum regarding the sample light is determined. Moreover, a sample point signal is computed from signals of the detector elements. Illuminating light is successively deflected onto different sample points with the scanner and corresponding sample point signals are captured, wherein, for at least some of the different sample points, a corresponding wavefront datum is also determined. The determined wavefront data can be taken into account in a calculation of a sample image from the plurality of sample point signals.

34. 发明公开

US20240053594A1 Method and Device for Microscopy 审中-公开
公开(公告)号：US20240053594A1
公开(公告)日：2024-02-15
申请号：US18231988
申请日：2023-08-09
申请人： Carl Zeiss Microscopy GmbH
发明人： Joerg Steinert , Tiemo Anhut , Daniel Schwedt , Wiebke Hilbert , Gerd Heisse
IPC分类号： G02B21/00 , G02B21/36
CPC分类号： G02B21/008 , G02B21/361 , G02B21/0032
摘要： Microscopy and a device for microscopy where with a light field arrangement comprising a multi-lens array and a camera having at least one camera sensor, image data sets which each contain at least one partial image of a sample are successively recorded. To increase a number of the image data sets recordable per unit time, a) measurement data only from a first number of pixels less than a total number of pixels of the at least one camera sensor are read out; b) measurement data only from a second number of pixels less than the total number of pixels or the first number of pixels read are processed further; and/or c) for some or all of the total number of pixels or the first number of pixels read, measurement data are processed further with a bit depth which is less than a maximum possible bit depth.

35. 发明授权

US11525989B2 Optical assembly for scanning excitation radiation and/or manipulation radiation in a laser scanning microscope, and laser scanning microscope 有权
公开(公告)号：US11525989B2
公开(公告)日：2022-12-13
申请号：US16641543
申请日：2018-08-23
申请人： Carl Zeiss Microscopy GmbH
发明人： Tiemo Anhut , Matthias Wald , Daniel Schwedt , Tobias Kaufhold , Beate Böhme
IPC分类号： G02B21/00
摘要： The invention relates to an optical assembly for scanning excitation radiation and/or manipulation radiation in a laser scanning microscope. The optical assembly according to the invention is characterized in that in addition to a first and a second focusing device, a third focusing device is provided in order to generate a third pupil plane which is optically conjugated to a first pupil plane, a third beam deflecting device is arranged on the third pupil plane in order to deflect the excitation radiation and/or manipulation radiation, a first beam deflecting means is provided between the second focusing device and the second pupil plane and the second pupil plane and the third focusing device in order to deflect the excitation radiation and/or manipulation radiation coming from the third focusing device while bypassing the second beam deflecting device in the direction of the second focusing device, a fourth focusing device is provided for generating a fourth pupil plane which is optically conjugated to the third pupil plane, and a variable second beam deflecting means is arranged on the fourth pupil plane in order to switch an optical beam path between a first beam path and a second beam path. The invention additionally relates to a laser scanning microscope.

36. 发明申请

US20210165200A1 METHOD AND APPARATUS FOR IMAGING SAMPLES BY MEANS OF MANIPULATED EXCITATION RADIATION 有权
公开(公告)号：US20210165200A1
公开(公告)日：2021-06-03
申请号：US17108288
申请日：2020-12-01
申请人： Carl Zeiss Microscopy GmbH
发明人： Daniel Schwedt , Tiemo Anhut
IPC分类号： G02B21/00 , G01N21/64
摘要： A method and an apparatus for imaging a sample (14). In the method, a first excitation radiation (5) is focused into a volume of the sample (14) and a caused first detection radiation (15) is captured and evaluated in respect of a form of its wavefront. A second excitation radiation (11) is manipulated on the basis of the evaluation results in order to correct the ascertained deviations of the wavefront. A region (20) to be imaged of the sample (14) is scanned by means of the second excitation radiation (11) and a second detection radiation (16) is captured as image data. The second excitation radiation (11) is directed in the form of at least two partial beams (11T) into the sample volume, into a respective spot (22) illuminated by the partial beam (11T) and the second detection radiations (16) respectively caused by the partial beams (11T) are captured separately.

37. 发明授权

US10310243B2 Device and method for multispot scanning microscopy 有权
公开(公告)号：US10310243B2
公开(公告)日：2019-06-04
申请号：US15427337
申请日：2017-02-08
申请人： Carl Zeiss Microscopy GmbH
发明人： Tiemo Anhut , Daniel Schwedt , Tobias Kaufhold , Burkhard Roscher , Stefan Wilhelm
IPC分类号： G02B21/00 , G02F1/11
摘要： The invention relates to a device for multispot scanning microscopy, having a multicolor light source for providing at least one illumination light beam, having a splitting device for splitting the illumination light beam into a plurality of illumination sub-beams, having first optical means for providing an illumination optical path for guiding and focusing the individual illumination sub-beams respectively into a light spot on or in a specimen to be examined, having a scan unit for guiding the light spots over the probe, having a detection unit for detecting detection light emitted by the specimen in detection sub-beams after irradiation with the individual illumination sub-beams, having second optical means for providing a detection optical path for guiding the detection sub-beams to the detector unit, having a control and evaluation unit for controlling the scan unit and for evaluating the detection light detected by the detection unit. The device is characterized in that in the illumination optical path for at least two of the illumination sub-beams a controllable beam manipulation means is present for independent setting of a spectral composition of the respective illumination sub-beam, and the control and evaluation unit is designed to control the beam manipulation means. The invention further relates to a method for multispot scanning microscopy.

38. 发明申请

US20170068080A1 Method and Arrangement for Light Sheet Microscopy 审中-公开
标题翻译：轻型显微镜的方法和布置
公开(公告)号：US20170068080A1
公开(公告)日：2017-03-09
申请号：US15120162
申请日：2015-02-19
申请人： Carl-Zeiss Microscopy GmbH
发明人： Tiemo Anhut , Thomas Kalkbrenner , Daniel Schwedt , Jörg SIEBENMORGEN , Helmut Lippert
IPC分类号： G02B21/00 , G02B27/00 , H04N5/372 , H04N3/02
CPC分类号： G02B21/008 , G02B21/0032 , G02B21/0036 , G02B21/006 , G02B21/0076 , G02B21/16 , G02B21/365 , G02B27/0075 , H04N3/02 , H04N5/372
摘要： An arrangement for light sheet microscopy that includes a means for scanning a sample volume with a light sheet, which includes an angle δ≠90° with the optical axis of an objective. The light sheet passes through the entire sample volume in the propagation direction, and the depth of field Sobj of the objective is less than the optical-axis depth T of this sample volume. An optical device, disposed downstream of the objective, increases the depth of field Sobj to a depth of field Seff≧the depth T of this sample volume. The arrangement also includes a means for positioning the sample volume within the region of the depth of field Seff. A spatially resolving optoelectronic area sensor is disposed downstream of the optical device, and hardware and software are provided to generate sample-volume images from the electronic image signals output by the area sensor.
摘要翻译：一种用于光板显微镜的装置，其包括用光板扫描样品体积的装置，该装置包括与物镜的光轴成δ≠90°的角度。光片沿传播方向通过整个样本体积，物镜的景深Sobj小于该样本体积的光轴深度T. 设置在物镜下游的光学装置将场景Sobj的景深增加到该样本体积的深度S eff≥深度T. 该装置还包括用于将样本体积定位在景深Seff的区域内的装置。空间分辨的光电区域传感器设置在光学装置的下游，并且提供硬件和软件以从由区域传感器输出的电子图像信号产生样本体积图像。

39. 发明申请

US20160131881A1 LASER SCANNING MICROSCOPE 有权
标题翻译：激光扫描显微镜
公开(公告)号：US20160131881A1
公开(公告)日：2016-05-12
申请号：US14933917
申请日：2015-11-05
申请人： CARL ZEISS MICROSCOPY GMBH
发明人： Beate Boehme , Matthias Wald , Tiemo Anhut , Daniel Schwedt
IPC分类号： G02B21/00 , G02B26/10 , G02B26/08
CPC分类号： G02B21/0048 , G02B21/0032 , G02B21/006 , G02B21/0076 , G02B21/008 , G02B26/0833 , G02B26/101
摘要： A laser scanning microscope for the acquisition of object images according to varied observation criteria. The microscope includes an illumination and detection unit, an illumination and a detection beam, a microscope objective, a scanning device with a scanning optical component and several scanners, with switching mirrors, each mirror with two switching positions, provided in the illumination and detection beams. Each switching position is assigned to one of several different, optically separate beam paths and each beam path defines a separate operating mode. A concave mirror for imaging a first scanner into at least one more scanner and vice versa is arranged in at least one of the beam paths.
摘要翻译：一种用于根据不同观察标准获取物体图像的激光扫描显微镜。显微镜包括照明和检测单元，照明和检测光束，显微镜物镜，具有扫描光学部件的扫描装置和多个扫描器，具有切换镜，每个反射镜具有两个切换位置，设置在照明和检测光束。每个切换位置被分配到几个不同的光学分离的光束路径中的一个，并且每个光束路径限定单独的操作模式。用于将第一扫描仪成像为至少一个更多扫描器的反射镜，反之亦然，布置在至少一个光束路径中。

40. 发明申请

US20150145981A1 Light Scanning Microscope with Spectral Detection 有权
标题翻译：光谱检测显微镜
公开(公告)号：US20150145981A1
公开(公告)日：2015-05-28
申请号：US14383628
申请日：2013-02-28
申请人： Carl Zeiss Microscopy GmbH
发明人： Tiemo Anhut , Daniel Schwedt , Ralf Wolleschensky , Lars-Christian Wittig , Ulrich Preißer
IPC分类号： G02B26/02 , H04N5/232 , G02B21/00
CPC分类号： G02B26/02 , G01N21/6458 , G02B21/0032 , G02B21/0064 , G02B21/0076 , G02B21/008 , G02B2207/113 , H04N5/23296
摘要： A light scanning microscope with an illumination module switchable between an illumination with m number of spots and an illumination with n number of spots, a deflecting unit which moves the m or n spots in a predetermined sample region, and a detector module for confocal and spectrally resolved detection of the sample radiation. The detector module has a confocal diaphragm unit, a splitting unit which is arranged downstream of the confocal diaphragm unit, a detector, and an imaging unit which images the partial beams on the detector in a spatially separated manner. The confocal diaphragm unit is switchable between a confocal diaphragm with exactly m apertures for m-spot illumination and a confocal diaphragm with n apertures for n-spot illumination. The splitting unit has a first beam path for m-spot illumination and a second beam path for n-spot illumination. The splitting unit is switchable between the two beam paths.
摘要翻译：一种光扫描显微镜，其具有可在具有m个点的照明和具有n个点的照明之间切换的照明模块，用于移动预定样本区域中的m个或n个点的偏转单元和用于共焦和光谱的检测器模块分辨检测样品辐射。检测器模块具有共聚焦膜单元，分配单元，其布置在共聚焦膜单元的下游，检测器和成像单元，其以空间分离的方式对检测器上的部分光束进行成像。共聚焦膜单元可在具有精确m个孔径的m光点照射的共聚焦膜和具有n个用于n光点照明的孔的共聚焦膜之间切换。分割单元具有用于m点照明的第一光束路径和用于n光点照明的第二光束路径。分离单元可在两个光束路径之间切换。

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