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31. 发明申请

US20050020605A1 Quinolyl amide derivatives as CCR-5 antagonists 审中-公开
标题翻译：喹啉酰胺衍生物作为CCR-5拮抗剂
公开(公告)号：US20050020605A1
公开(公告)日：2005-01-27
申请号：US10865976
申请日：2004-06-10
申请人： Shou-Fu Lu , Gary Phillips , Bin Ye
发明人： Shou-Fu Lu , Gary Phillips , Bin Ye
IPC分类号： C07D401/14 , C07D409/14 , C07D471/04 , C07 , A61K31/4545 , A61K31/496
CPC分类号： C07D401/14 , C07D409/14 , C07D471/04
摘要： The present invention relates to a series of compounds which are CCR-5 receptor antagonists of the general formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.
摘要翻译：本发明涉及一系列化合物，其是通式I的CCR-5受体拮抗剂或其药学上可接受的盐，其中变量在本文中定义。

32. 发明授权

US6095705A Fluid applicator 失效
标题翻译：流体涂抹器
公开(公告)号：US6095705A
公开(公告)日：2000-08-01
申请号：US166200
申请日：1998-10-05
申请人： Gary Phillips
发明人： Gary Phillips
IPC分类号： B43K23/008 , A46B5/02
CPC分类号： B43K23/008 , B43K5/005 , B43K8/003
摘要： This invention relates to a fluid applicator. More particularly, this invention relates to an ink applicator which contains a specially adapted finger support for supporting a user's fingers during fluid application. Preferably, the fluid applicator comprises an applicating end portion having an opening for filling and dispensing fluid from the fluid applicator; a central portion connected to the applicating end portion; a sealed end portion fused to the central portion; and a finger support extending from the applicating end portion transversely throughout the central portion for supporting a user's fingers during fluid application.
摘要翻译：本发明涉及流体施加器。更具体地，本发明涉及一种油墨施加器，其包含特别适合的手指支撑件，用于在流体施加期间支撑使用者的手指。优选地，流体施加器包括具有用于从流体施加器填充和分配流体的开口的施用端部分; 连接到所述施加端部的中心部分; 与中心部分熔合的密封端部; 以及手指支撑件，其从施加端部横向延伸穿过中心部分，以在流体施加期间支撑使用者的手指。

33. 发明申请

US20110105559A1 Compositions and Methods for Treating, Controlling, Reducing, Ameliorating, or Preventing Allergy 审中-公开
标题翻译：治疗，控制，减少，改善或预防过敏的组合物和方法
公开(公告)号：US20110105559A1
公开(公告)日：2011-05-05
申请号：US12909387
申请日：2010-10-21
申请人： Brian R. Rohrs , Timothy L. Comstock , Zhenze Hu , Gary Phillips
发明人： Brian R. Rohrs , Timothy L. Comstock , Zhenze Hu , Gary Phillips
IPC分类号： A61K31/4709 , A61P31/00 , A61P29/00
CPC分类号： A61K31/00 , A61K31/4725 , A61K45/06 , A61K2300/00
摘要： A composition for treating, controlling, reducing, ameliorating, or preventing allergy comprises a dissociated glucocorticoid receptor agonist (“DIGRA”), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can comprise an anti-allergic medicament and/or an additional anti-inflammatory agent and can be formulated for topical application, injection, or implantation. The anti-allergic medicament can comprise an antihistamine, a mast-cell stabilizer, a leukotriene inhibitor, an immunomodulator, an anti-IgE agent, or a combination thereof.
摘要翻译：用于治疗，控制，减轻，改善或预防过敏的组合物包括解离的糖皮质激素受体激动剂（“DIGRA”），其前药，其药学上可接受的盐或其药学上可接受的酯。组合物可以包含抗过敏药物和/或另外的抗炎剂，并且可以配制用于局部施用，注射或植入。抗过敏药物可以包含抗组胺剂，肥大细胞稳定剂，白三烯抑制剂，免疫调节剂，抗IgE剂或其组合。

34. 发明申请

US20090242173A1 TEMPERATURE CONTROL SYSTEM 审中-公开
标题翻译：温度控制系统
公开(公告)号：US20090242173A1
公开(公告)日：2009-10-01
申请号：US12410724
申请日：2009-03-25
申请人： Peter MITCHELL , Gary Phillips , Thomas Smeltzer , Samuel C. Williams
发明人： Peter MITCHELL , Gary Phillips , Thomas Smeltzer , Samuel C. Williams
IPC分类号： F28D15/00 , B65D35/22 , F28F7/00
CPC分类号： F28F7/00 , C12M23/14 , C12M41/12 , F28F2255/02
摘要： An improved system and method for controlling the temperature of fluids during a mixing procedure or a chemical, pharmaceutical, or biological process is disclosed. One embodiment of the system comprises: a first collapsible bag including a perimeter and a maximum dimension thereacross measured at full expansion of the first collapsible bag; a first interior surface portion; a second interior surface portion; one or more welds connecting the first and second interior surface portions of the first collapsible bag so as to form a channel between the first and second interior surface portions, an inlet connected to a first portion of the channel; an outlet connected to a second portion of the channel, the channel defining a bulk fluid flow pathway through the first collapsible bag from the inlet to the outlet; and a first temperature-controlling surface in contact with a first exterior surface portion of the first collapsible bag. A heat exchanger in fluid communication with another vessel that can hold or store the heated or cooled fluid is also disclosed.
摘要翻译：公开了一种用于在混合过程或化学，制药或生物过程中控制流体温度的改进的系统和方法。该系统的一个实施例包括：第一可折叠袋，其包括在第一可折叠袋的完全膨胀时测量的周边和最大尺寸; 第一内表面部分; 第二内表面部分; 连接第一可折叠袋的第一和第二内表面部分的一个或多个焊缝，以在第一和第二内表面部分之间形成通道，连接到通道的第一部分的入口; 所述通道连接到所述通道的第二部分，所述通道限定通过所述第一可折叠袋从所述入口到所述出口的主体流体流动路径; 以及与第一可折叠袋的第一外表面部分接触的第一温度控制表面。还公开了一种与可容纳或储存加热或冷却的流体的另一容器流体连通的热交换器。

35. 发明授权

US07590942B2 System, method and computer program product for documenting and managing execution of procedures in a graphical interface environment 有权
标题翻译：用于在图形界面环境中记录和管理程序执行的系统，方法和计算机程序产品
公开(公告)号：US07590942B2
公开(公告)日：2009-09-15
申请号：US10942088
申请日：2004-09-16
申请人： Gary Phillips , Chris Kourliouros , Kevin Morris , Ray Ramsey
发明人： Gary Phillips , Chris Kourliouros , Kevin Morris , Ray Ramsey
IPC分类号： G06F3/048
CPC分类号： G06F8/70 , G06F17/2247 , G06Q10/06316
摘要： A system, method and computer program product for describing a process visually, converting the visual description to an intermediate format, and directing the process.
摘要翻译：一种用于直观地描述过程的系统，方法和计算机程序产品，将视觉描述转换成中间格式，并指导该过程。

36. 发明申请

US20080033008A1 COMPOSITIONS AND METHODS FOR TREATING, CONTROLLING, REDUCING, OR AMELIORATING INFECTIONS AND SEQUELAE THEREOF 审中-公开
标题翻译：用于治疗，控制，减少或增加感染及其序列的组合物和方法
公开(公告)号：US20080033008A1
公开(公告)日：2008-02-07
申请号：US11832265
申请日：2007-08-01
申请人： Keith W. Ward , Zhenze Hu , Gary Phillips , Raili Kerppola
发明人： Keith W. Ward , Zhenze Hu , Gary Phillips , Raili Kerppola
IPC分类号： A61K31/472 , A61K31/4709 , A61P29/00 , A61P31/00
CPC分类号： A61K45/06 , A61K31/4709 , A61K31/4725 , A61K2300/00
摘要： A composition for treating, controlling, reducing, ameliorating, or alleviating infections and their inflammatory sequelae comprises a dissociated glucocorticoid receptor agonist (“DIGRA”) and an anti-infective agent, such as an antibacterial, antiviral, antifungal, antiprotozoal agent, or a combination thereof. The composition can be formulated for topical application, injection, or implantation.
摘要翻译：用于治疗，控制，减少，改善或减轻感染及其炎症后遗症的组合物包括解离的糖皮质激素受体激动剂（“DIGRA”）和抗感染剂，例如抗细菌剂，抗病毒剂，抗真菌剂，抗原虫剂或的组合。该组合物可以配制用于局部施用，注射或植入。

37. 发明授权

US07220856B2 Substituted quinoline CCR5 receptor antagonists 失效
标题翻译：取代的喹啉CCR5受体拮抗剂
公开(公告)号：US07220856B2
公开(公告)日：2007-05-22
申请号：US10607530
申请日：2003-06-26
申请人： Laura Dunning , Stefan Jaroch , Monica J. Kochanny , Wheeseong Lee , Xiongdong Lian , Meina Liang , Shou-Fu Lu , James Onuffer , Gary Phillips , Guo-Ping Wei , Bin Ye
发明人： Laura Dunning , Stefan Jaroch , Monica J. Kochanny , Wheeseong Lee , Xiongdong Lian , Meina Liang , Shou-Fu Lu , James Onuffer , Gary Phillips , Guo-Ping Wei , Bin Ye
IPC分类号： C07D223/00 , C07D453/02
CPC分类号： C07D401/04 , C07D215/46 , C07D215/48 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/12 , C07D487/04 , C07D487/08 , C07D491/04
摘要： The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b): enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated disorders employing such compounds.
摘要翻译：本发明涉及式（1a）或（1b）的CCR5受体拮抗剂：其对映异构体，非对映异构体，盐和溶剂化物，其中R 1，R 2，R 2 R 3，R 4，R 5和R 7如本文所定义。本发明还包括使用这种化合物的CCR5介导的病症的方法。

38. 发明申请

US20060167044A1 Piperidine derivatives and their use as anti-inflammatory agents 审中-公开
标题翻译：哌啶衍生物及其作为抗炎剂的用途
公开(公告)号：US20060167044A1
公开(公告)日：2006-07-27
申请号：US11305322
申请日：2005-12-19
申请人： Damian Arnaiz , Yuo-Ling Chou , Monica Kochanny , Wheeseong Lee , Shou-Fu Lu , Anne Mengel , Gary Phillips , Guo Wei , Hongyi Yu
发明人： Damian Arnaiz , Yuo-Ling Chou , Monica Kochanny , Wheeseong Lee , Shou-Fu Lu , Anne Mengel , Gary Phillips , Guo Wei , Hongyi Yu
IPC分类号： A61K31/4709 , A61K31/454 , C07D401/02 , C07D409/02
CPC分类号： C07D211/34 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/54 , C07D211/58 , C07D211/62 , C07D211/70 , C07D401/06 , C07D401/12 , C07D409/06 , C07D409/12 , C07D413/12
摘要： Piperidine derivatives of the following formulae I and II: and their pharmaceutically acceptable salts, which are functional antagonists of the CC chemokine receptor CCR1 and are thus useful as anti-inflammatory agents, a pharmaceutical compositions containing said piperidine derivatives or their pharmaceutically acceptable salts, and methods of their use.
摘要翻译：下式I和II的哌啶衍生物及其药学上可接受的盐，其是CC趋化因子受体CCR1的功能性拮抗剂，因此可用作抗炎剂，含有所述哌啶衍生物或其药学上可接受的盐的药物组合物，以及使用方法

39. 发明申请

US20050101644A1 Benzylether amine compounds useful as CCR-5 antagonists 审中-公开
标题翻译：用作CCR-5拮抗剂的苄基醚化合物
公开(公告)号：US20050101644A1
公开(公告)日：2005-05-12
申请号：US10984430
申请日：2004-11-08
申请人： David Davey , Wheeseong Lee , Shou-Fu Lu , Gary Phillips , Guo Ping Wei , Bin Ye
发明人： David Davey , Wheeseong Lee , Shou-Fu Lu , Gary Phillips , Guo Ping Wei , Bin Ye
IPC分类号： A61K31/135 , A61K31/165 , A61K31/40 , A61K31/435 , C07C217/58 , C07C235/42 , C07C255/54 , C07C275/28 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/26 , C07D211/38 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/64 , C07D211/66 , C07D213/20 , C07D213/30 , C07D213/40 , C07D213/53 , C07D213/64 , C07D213/82 , C07D213/89 , C07D217/06 , C07D233/54 , C07D233/88 , C07D235/26 , C07D241/08 , C07D295/13 , C07D295/192 , C07D295/215 , C07D295/26 , C07D319/08 , C07D333/34 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/44 , A61K31/137 , A61K31/138 , A61K31/198
CPC分类号： C07D207/16 , C07C217/58 , C07C235/42 , C07C255/54 , C07C275/28 , C07D207/08 , C07D207/12 , C07D207/14 , C07D211/14 , C07D211/26 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/64 , C07D211/66 , C07D213/20 , C07D213/30 , C07D213/40 , C07D213/53 , C07D213/64 , C07D213/82 , C07D213/89 , C07D217/06 , C07D233/54 , C07D233/64 , C07D233/88 , C07D235/26 , C07D241/08 , C07D295/13 , C07D295/192 , C07D295/215 , C07D295/26 , C07D319/08 , C07D333/34 , C07D401/06 , C07D403/12 , C07D405/12 , C07D471/10 , C07D487/08 , C07D491/10
摘要： The present invention relates to compounds which are CCR-5 receptor antagonists of the general formula I: wherein R1, R2, R3, R4, Ra, Rb, Rc, Rd, X, m and n are as defined herein. The invention further comprises pharmaeceutical compositions comprising such compounds, as well as the use of such compounds to treat CCR-5 mediated disorders.
摘要翻译：本发明涉及通式I的CCR-5受体拮抗剂的化合物：其中R 1，R 2，R 3， R 4，R a，R b，R b，R c，R d， X，m和n如本文所定义。本发明还包括含有这些化合物的药物组合物，以及这些化合物用于治疗CCR-5介导的病症的用途。

40. 发明授权

US06339815B1 Microcontroller system having allocation circuitry to selectively allocate and/or hide portions of a program memory address space 失效
标题翻译：具有用于选择性地分配和/或隐藏程序存储器地址空间的部分的分配电路的微控制器系统
公开(公告)号：US06339815B1
公开(公告)日：2002-01-15
申请号：US09134242
申请日：1998-08-14
申请人： Eugene Feng , Gary Phillips
发明人： Eugene Feng , Gary Phillips
IPC分类号： G06F1300
CPC分类号： G06F9/3802 , G06F9/24
摘要： A microcontroller system has a first and a second block of non-volatile programmable memory and includes a program memory space allocation circuitry. In a first mode of operation, the first and second blocks of programmable memory are prevented from being written by commands external to the microcontroller system. In a second mode, however, the first and second blocks of programmable memory are prevented from being written by commands external to the microcontroller system but the second block of programmable memory can be written based upon execution of commands stored in the first block of programmable memory. By having circuitry to so allocate the programmable memories, the security of the programmable memories is enhanced.
摘要翻译：微控制器系统具有非易失性可编程存储器的第一和第二块，并且包括程序存储器空间分配电路。在第一操作模式中，防止第一和第二可编程存储器块被微控制器系统外部的命令写入。然而，在第二模式中，防止第一和第二可编程存储器块被微控制器系统外部的命令写入，但是可以基于存储在可编程存储器的第一块中的命令的执行来写入第二可编程存储器块。通过具有这样分配可编程存储器的电路，增强了可编程存储器的安全性。

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