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31. 发明申请

US20170008964A1 ANTIBODY DRUG CONJUGATES 审中-公开
标题翻译：抗体药物联合用药
公开(公告)号：US20170008964A1
公开(公告)日：2017-01-12
申请号：US15204210
申请日：2016-07-07
申请人： David Bryant Batt , Seth Alexander Ettenberg , Nicole Haubst , Tiancen HU , David Jenkins , Matthew John Meyer , Konstantin Petropoulos , Engin Toksoz
发明人： David Bryant Batt , Seth Alexander Ettenberg , Nicole Haubst , Tiancen HU , David Jenkins , Matthew John Meyer , Konstantin Petropoulos , Engin Toksoz
IPC分类号： C07K16/28 , A61K31/506 , A61K47/48
CPC分类号： C07K16/2863 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/662 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/565 , C07K2317/732 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
摘要翻译：本发明涉及抗FGFR2抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。

32. 发明授权

US09498532B2 Antibody drug conjugates 有权
标题翻译：抗体药物偶联物
公开(公告)号：US09498532B2
公开(公告)日：2016-11-22
申请号：US14203997
申请日：2014-03-11
申请人： David Bryant Batt , Seth Alexander Ettenberg , Nicole Haubst , Tiancen Hu , David Jenkins , Engin Toksoz , Konstantin Petropoulos , Matthew John Meyer
发明人： David Bryant Batt , Seth Alexander Ettenberg , Nicole Haubst , Tiancen Hu , David Jenkins , Engin Toksoz , Konstantin Petropoulos , Matthew John Meyer
IPC分类号： A61K47/48 , C07K16/28 , A61K45/06 , A61K49/00 , A61K51/10
CPC分类号： C07K16/30 , A61K31/506 , A61K45/06 , A61K47/549 , A61K47/6803 , A61K47/6849 , A61K47/6879 , A61K2039/505 , C07K16/2863 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
摘要翻译：本发明涉及抗FGFR2和FGFR4抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。

33. 发明授权

US09211160B2 Remotely controlled catheter insertion system with automatic control system 有权
标题翻译：遥控导管插入系统具有自动控制系统
公开(公告)号：US09211160B2
公开(公告)日：2015-12-15
申请号：US13432161
申请日：2012-03-28
申请人： Luiz Geraldo Pivotto , David Jenkins
发明人： Luiz Geraldo Pivotto , David Jenkins
IPC分类号： A61B18/00 , A61B19/00 , A61M25/01
CPC分类号： A61B19/2203 , A61B34/30 , A61B34/74 , A61B2034/301 , A61M25/0136
摘要： A system for remotely controlling the positioning within the body of a patient of an elongated medical device optionally having a control handle, comprises a catheter position system and a remote controller configured to control the robotic device. The catheter position system includes a handle controller; a sled member coupled to the handle controller, the sled member being configured to position the medical device within the body of the patient; and a sled base configured to advance the sled member towards the body of a patient, the sled bed being coupled to a sterile barrier effective to maintain sterility inside the sled base. The catheter position system may include a control system configured to issue positioning commands in response to sensor signals received from the catheter. The catheter position system may also include a motor driven rotatable catheter introducer clamp configured to enable rotation of an introducer.
摘要翻译：用于远程控制细长医疗装置的患者体内定位的系统，其可选地具有控制手柄，包括导管位置系统和配置成控制机器人装置的远程控制器。导管位置系统包括手柄控制器; 联接到手柄控制器的滑动构件，所述滑动构件构造成将所述医疗装置定位在所述患者体内; 以及滑动架基座，其构造成使所述滑动构件朝向患者的身体前进，所述滑板床与无菌屏障联接，所述无菌屏障有效地保持所述滑板底座内的无菌性。导管位置系统可以包括配置为响应于从导管接收的传感器信号发出定位命令的控制系统。导管位置系统还可以包括电动机驱动的可旋转的导管引导器夹具，其构造成能够使导引器旋转。

34. 发明授权

US09018858B2 Calibration method for LED lighting systems 有权
标题翻译： LED照明系统的校准方法
公开(公告)号：US09018858B2
公开(公告)日：2015-04-28
申请号：US13035329
申请日：2011-02-25
申请人： Gannon T. Gambeski , David P. Eckel , Seckin K. Secilmis , Andrew B. Walsh , Richard Waring, Jr. , Rand Lee , David Jenkins , Maciej Adam Jakuc , Jeffrey Reeder
发明人： Gannon T. Gambeski , David P. Eckel , Seckin K. Secilmis , Andrew B. Walsh , Richard Waring, Jr. , Rand Lee , David Jenkins , Maciej Adam Jakuc , Jeffrey Reeder
IPC分类号： G05F1/00 , B64D47/02 , H05B37/02 , B64C27/82 , B64D11/00
CPC分类号： H05B33/086 , B64C2027/8236 , B64D47/02 , B64D2011/0038 , B64D2203/00 , H05B33/0869 , H05B37/0254
摘要： A method of operating a lighting fixture comprising a plurality of discrete illumination sources of distinguishably different color coordinates comprises determining target color coordinates and luminous flux at which to operate the lighting fixture, determining input electrical power values for each of the plurality of discrete illumination sources that substantially produce the target color coordinates and luminous flux by referencing a calibration data lookup table having calibration data based on measurements of the plurality of discrete illumination sources, determining a color mixing zone defined by three distinguishably different color coordinates of the plurality of discrete illumination sources within which the target color coordinates lie according to the calibration data, determining luminous flux ratios for each of the plurality of discrete illumination sources having one of the three distinguishably different color coordinates defining the color mixing zone that substantially produces the target color coordinates, and determining input electrical power levels for each of the plurality of discrete illumination sources that generate the determined luminous flux ratios.
摘要翻译：操作包括可分辨地不同颜色坐标的多个离散照明源的照明器具的方法包括确定用于操作照明器具的目标色坐标和光通量，确定多个离散照明源中的每一个的输入电功率值，通过参考具有基于多个离散照明源的测量的校准数据的校准数据查找表，基本上产生目标色坐标和光通量，确定由多个离散照明源中的三个可分辨地不同的颜色坐标限定的混色区域，目标颜色坐标根据校准数据显示，确定多个离散照明源中的每一个的光通量比，其具有限定色混合区域的三个可区别地不同的颜色坐标之一 lly产生目标色坐标，并且确定产生所确定的光通量比的多个离散照明源中的每一个的输入电功率水平。

35. 发明申请

US20140301946A1 ANTIBODY DRUG CONJUGATES 有权
标题翻译：抗体药物联合用药
公开(公告)号：US20140301946A1
公开(公告)日：2014-10-09
申请号：US14203997
申请日：2014-03-11
申请人： David Bryant BATT , Seth Alexander Ettenberg , Nicole Haubst , Tiancen Hu , David Jenkins , Engin Toksoz , Konstantin Petropoulos , Matthew John Meyer
发明人： David Bryant BATT , Seth Alexander Ettenberg , Nicole Haubst , Tiancen Hu , David Jenkins , Engin Toksoz , Konstantin Petropoulos , Matthew John Meyer
IPC分类号： A61K47/48 , A61K49/00 , A61K51/10 , A61K45/06 , C07K16/28
CPC分类号： C07K16/30 , A61K31/506 , A61K45/06 , A61K47/549 , A61K47/6803 , A61K47/6849 , A61K47/6879 , A61K2039/505 , C07K16/2863 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
摘要翻译：本发明涉及抗FGFR2和FGFR4抗体，抗体片段，抗体药物偶联物及其用于治疗癌症的用途。

36. 发明授权

US08663636B2 Method of treating a malignant tumor by administering antibodies directed to DLL4 有权
标题翻译：通过施用针对DLL4的抗体来治疗恶性肿瘤的方法
公开(公告)号：US08663636B2
公开(公告)日：2014-03-04
申请号：US13446637
申请日：2012-04-13
申请人： Ian Foltz , David Jenkins , Vahe Bedian
发明人： Ian Foltz , David Jenkins , Vahe Bedian
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/28 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/475 , C07K16/22 , C07K2317/565 , C07K2317/92
摘要： The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL4 and as diagnostics.
摘要翻译：本发明涉及针对DLL4的靶向结合剂及其用途。更具体地，本发明涉及针对DLL4的完全人单克隆抗体。所描述的靶向结合剂可用于治疗与DLL4的活性和/或过量产生相关的疾病和作为诊断。

37. 发明申请

US20140056912A1 METHODS OF TREATING SQUAMOUS CELL CARCINOMA 审中-公开
标题翻译：治疗慢性淋巴细胞癌的方法
公开(公告)号：US20140056912A1
公开(公告)日：2014-02-27
申请号：US14114418
申请日：2012-04-27
申请人： Seth Alexander Ettenberg , Vivien W. Chan , Michael Patrick Morrissey , David Jenkins
发明人： Seth Alexander Ettenberg , Vivien W. Chan , Michael Patrick Morrissey , David Jenkins
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/3076 , G01N33/57407 , G01N2400/00 , G01N2800/50 , G01N2800/52
摘要： The disclosure relates to methods for treating a sclerostin-expressing cancer, e.g., a squamous cell carcinoma (SCC), e.g., SCC of the upper aerodigestive tract, esophagus, or lung, employing a therapeutically effective amount of at least one sclerostin antagonist, e.g., an anti-sclerostin antibody, such as Antibody 1, 2, 3, 4 or 5.
摘要翻译：本公开涉及使用治疗有效量的至少一种硬皮素拮抗剂来治疗表达硬脂蛋白的癌症例如鳞状细胞癌（SCC），例如上呼吸消化道，食管或肺的SCC的方法，例如，抗硬核蛋白抗体，如抗体1,2,3,4或5。

38. 发明申请

US20070244375A1 Method for Screening and Treating Patients at Risk of Medical Disorders 审中-公开
标题翻译：筛查和治疗患有医疗障碍风险的患者的方法
公开(公告)号：US20070244375A1
公开(公告)日：2007-10-18
申请号：US11670071
申请日：2007-02-01
申请人： David Jenkins , Roland Maude-Griffin
发明人： David Jenkins , Roland Maude-Griffin
IPC分类号： A61B1/00
CPC分类号： A61N1/36085 , A61N1/36007
摘要： Method for screening patients to predict which patients at risk of a medical disorder, such as morbid obesity, gastrointestinal problems, or gastroesophageal problems, will be responders, and conversely, which patients will not, to achieve a favorable outcome from therapy for that disorder. This method supports an intervention strategy for patients having weight or gastrointestinal problems that will cut health costs. It enables patients and care-givers alike to more efficiently use their time, efforts and resources by enabling an early selection of an appropriate treatment modality for a given patient. Its application also extends to other implantable medical devices and therapies using them.
摘要翻译：用于筛选患者以预测哪些患有医疗障碍风险的患者（例如病态肥胖，胃肠道问题或胃食管问题）的方法将是应答者，相反地，哪些患者不会从该疾病的治疗中获得有利的结果。该方法支持患有体重或胃肠道问题的患者的干预策略，这将降低健康成本。它使患者和护理人员能够通过早期选择给定患者的适当治疗方式来更有效地利用其时间，努力和资源。其应用还扩展到使用它们的其他可植入医疗设备和疗法。

39. 发明申请

US20070178214A1 CARBONATED PROTEIN DRINK AND METHOD OF MAKING 有权
标题翻译：碳酸蛋白饮料和制备方法
公开(公告)号：US20070178214A1
公开(公告)日：2007-08-02
申请号：US11685641
申请日：2007-03-13
申请人： Shawn Sherwood , David Jenkins
发明人： Shawn Sherwood , David Jenkins
IPC分类号： A23C21/00
CPC分类号： A23L2/66 , A23L2/54 , A23V2002/00 , A23V2250/032 , A23V2250/044 , A23V2200/204 , A23V2250/046 , A23V2200/15 , A23V2250/11 , A23V2250/54252 , A23V2250/0644 , A23V2250/242 , A23V2250/264
摘要： An improved carbonated protein beverage/drink composition which provides a relatively bill protein content, ranging from about 2% by weight to about 15% by weight, while simultaneously employing a carbonation concentration between about 0.1 volumes of carbonation (per volume of liquid drink solution or liquid drink suspension) to about 4 volumes of carbonation. Preferably the protein is whey protein. The carbonated protein beverage has been heat treated to inactivate microbes in the presence of the carbonation which is used to provide taste and mouth feel for the drink. Typically, the treatment for microbe inactivation is carried out in the individual package used for storage and handling of the carbonated protein drink.
摘要翻译：一种改进的碳酸化蛋白质饮料组合物，其提供相对高的蛋白质含量，范围为约2重量％至约15重量％，同时使用碳酸化浓度为约0.1体积％的碳酸化（每体积液体饮料溶液或液体饮料悬浮液）至约4体积的碳酸化。蛋白质优选为乳清蛋白。碳酸化蛋白质饮料已经被热处理以在碳酸化存在下灭活微生物，其用于提供饮料的口味和口感。通常，用于微生物灭活的处理在用于储存和处理碳酸化蛋白质饮料的单个包装中进行。

40. 发明申请

US20070167793A1 Method and system for enhancing spectral doppler presentation 审中-公开
标题翻译：增强光谱多普勒显示的方法和系统
公开(公告)号：US20070167793A1
公开(公告)日：2007-07-19
申请号：US11302391
申请日：2005-12-14
申请人： Praveen Dala-Krishna , David Jenkins , Charles Byrd
发明人： Praveen Dala-Krishna , David Jenkins , Charles Byrd
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/06 , A61B8/12 , A61B8/461 , A61B8/466 , A61B8/488
摘要： A method and system for enhancing Doppler spectrum displays is described. Two or more colors are utilized to represent the power scale in the spectral Doppler display. Doppler signals from stronger reflectors of ultrasound, such as cardiac muscle or vessel walls, can then be assigned a different color than Doppler signals from weaker reflectors, such as blood, allowing for better understanding and interpretation of the Doppler spectra.
摘要翻译：描述了一种用于增强多普勒频谱显示的方法和系统。利用两种或更多种颜色来表示频谱多普勒显示中的功率尺度。然后，来自较强的超声反射器（例如心肌或血管壁）的多普勒信号可以被分配与来自较弱反射器（例如血液）的多普勒信号不同的颜色，从而更好地理解和解释多普勒光谱。

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