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31. 发明授权

US08871920B2 Lipid binding nucleic acids 有权
标题翻译：脂质结合核酸
公开(公告)号：US08871920B2
公开(公告)日：2014-10-28
申请号：US13642555
申请日：2011-04-21
申请人： Werner Purschke , Sven Klussmann , Klaus Buchner , Frank Schwobel , Kai Hoehlig
发明人： Werner Purschke , Sven Klussmann , Klaus Buchner , Frank Schwobel , Kai Hoehlig
IPC分类号： C07H21/04 , G01N33/92 , C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , G01N33/92
摘要： The present invention is related to a nucleic acid molecule capable of binding to a lipid.
摘要翻译：本发明涉及能够结合脂质的核酸分子。

32. 发明申请

US20130165501A1 Lipid Binding Nucleic Acids 有权
标题翻译：脂质结合核酸
公开(公告)号：US20130165501A1
公开(公告)日：2013-06-27
申请号：US13642555
申请日：2011-04-21
申请人： Werner Purschke , Sven Klussmann , Klaus Buchner , Frank Schwoebel , Kai Hoehlig
发明人： Werner Purschke , Sven Klussmann , Klaus Buchner , Frank Schwoebel , Kai Hoehlig
IPC分类号： C12N15/115 , G01N33/92
CPC分类号： C12N15/115 , C12N2310/16 , G01N33/92
摘要： The present invention is related to a nucleic acid molecule capable of binding to a lipid.
摘要翻译：本发明涉及能够结合脂质的核酸分子。

33. 发明申请

US20120053234A1 Hepcidin Binding Nucleic Acids 有权
标题翻译： hepcidin结合核酸
公开(公告)号：US20120053234A1
公开(公告)日：2012-03-01
申请号：US13318144
申请日：2010-04-30
申请人： Simone Sell , Frank Morich , Christian Maasch , Sven Klussmann , Nicole Dinse , Klaus Buchner , Frank Schwobel
发明人： Simone Sell , Frank Morich , Christian Maasch , Sven Klussmann , Nicole Dinse , Klaus Buchner , Frank Schwobel
IPC分类号： A61K31/7088 , C07K2/00 , C07K14/00 , A61K38/22 , G01N33/53 , G01N21/55 , A61P29/00 , C08G65/335 , C07H21/00 , C07H21/02
CPC分类号： C12N15/115 , A61K31/00 , C12N2310/16 , C12N2310/351 , C12N2320/30 , C12Q1/6876 , G01N33/5308 , G01N33/74 , G01N2333/575 , G01N2500/04
摘要： The present invention is related to a nucleic acid capable of binding to hepcidin.
摘要翻译：本发明涉及能够结合铁调素的核酸。

34. 发明授权

US08841431B2 Hepcidin binding nucleic acids 有权
标题翻译：肝素结合核酸
公开(公告)号：US08841431B2
公开(公告)日：2014-09-23
申请号：US13318144
申请日：2010-04-30
申请人： Simone Sell , Frank Morich , Christian Maasch , Sven Klussmann , Nicole Dinse , Klaus Buchner , Frank Schwobel
发明人： Simone Sell , Frank Morich , Christian Maasch , Sven Klussmann , Nicole Dinse , Klaus Buchner , Frank Schwobel
IPC分类号： C07H21/04 , A61K31/00
CPC分类号： C12N15/115 , A61K31/00 , C12N2310/16 , C12N2310/351 , C12N2320/30 , C12Q1/6876 , G01N33/5308 , G01N33/74 , G01N2333/575 , G01N2500/04
摘要： The present invention is related to a nucleic acid capable of binding to hepcidin.
摘要翻译：本发明涉及能够结合铁调素的核酸。

35. 发明授权

US07629456B2 Modified L-nucleic acid 有权
标题翻译：改良的L-核酸
公开(公告)号：US07629456B2
公开(公告)日：2009-12-08
申请号：US10493569
申请日：2002-10-25
申请人： Christian Lange , Bernd Eschgfäller , Sven Klussmann
发明人： Christian Lange , Bernd Eschgfäller , Sven Klussmann
IPC分类号： C07H21/04 , C07H21/00 , A61K31/70
CPC分类号： C12N15/115 , A61K31/713 , A61K47/60 , C07H21/00 , C12N2310/16 , C12N2310/351 , C12N2310/353 , C12N2320/30
摘要： The present invention relates to a modified L-nucleic acid, comprising a L-nucleic acid part and a non-L-nucleic acid part, whereby the L-nucleic acid part is conjugated to the non-L-nucleic acid part and the conjugation of the L-nucleic acid part with the non-L-nucleic acid past leads to a slowed elimination out of the organism, in comparison with a L-nucleic acid which only comprises the L-nucleic acid part, said L-nucleic acid part being a spiegelmer.
摘要翻译：本发明涉及包含L-核酸部分和非L-核酸部分的修饰的L-核酸，其中所述L-核酸部分与非-L-核酸部分缀合，并且所述缀合与非L-核酸部分的L-核酸部分相比，与仅包含L-核酸部分的L-核酸相比，导致生物体的减缓消除，所述L-核酸部分作为一个刺客

36. 发明申请

US20100081710A1 Modified L-Nucleic Acid 审中-公开
标题翻译：改良的L-核酸
公开(公告)号：US20100081710A1
公开(公告)日：2010-04-01
申请号：US12541142
申请日：2009-08-13
申请人： Christian Lange , Bernd Eschgfaller , Sven Klussmann
发明人： Christian Lange , Bernd Eschgfaller , Sven Klussmann
IPC分类号： A61K31/7088 , C07H21/04
CPC分类号： C12N15/115 , A61K31/713 , A61K47/60 , C07H21/00 , C12N2310/16 , C12N2310/351 , C12N2310/353 , C12N2320/30
摘要： A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.
摘要翻译：描述了含有与非L-核酸部分缀合的L-核酸部分的修饰的L-核酸。缀合物具有延长的保留时间并显示出来自生物体的延迟消除。

37. 发明申请

US20090179480A1 Vehicle Wheel for a Double-Track Vehicle or Cover Therefor 有权
标题翻译：用于双轨车辆或车盖的车轮
公开(公告)号：US20090179480A1
公开(公告)日：2009-07-16
申请号：US11972242
申请日：2008-01-10
申请人： Florian Modlinger , Rainer Demuth , Sven Klussmann
发明人： Florian Modlinger , Rainer Demuth , Sven Klussmann
IPC分类号： B60B19/10 , B60B7/02
CPC分类号： B60B19/10
摘要： The invention relates to a vehicle wheel for a double-track vehicle or an external cover therefor, having passage openings, particularly for a cooling air flow for a wheel brake provided on the interior side of the wheel, in the lateral projection, the passage openings having a width in the radial direction which changes when viewed in the circumferential direction such that, viewed against the rotating direction of the wheel when the vehicle is driving forward, the above-mentioned width decreases, and in that the—viewed in the radial direction—centers of the virtual segments of the passage opening which follow one another against the rotating direction move quasi (virtually) in the direction of the wheel center. As a result, the force as well as the lever arm of the drag is reduced, so that a moment of resistance is obtained which is significantly decreased. The passage openings are preferably bounded by spokes extending essentially in the radial direction.
摘要翻译：本发明涉及一种用于双轨车辆或其外盖的车轮，具有通道开口，特别是用于在侧向突起中设置在车轮内侧的车轮制动器的冷却空气流，通道开口具有沿圆周方向观察时沿径向变化的宽度，使得当车辆向前行驶时，相对于车轮的旋转方向观察，上述宽度减小，并且在径向上观察 - 相对于旋转方向彼此相对的通道开口的虚拟段的中心在轮中心的方向上准确地（虚拟地）移动。结果，阻力的力和杠杆臂减小，从而获得显着降低的电阻力矩。通道开口优选地由基本上沿径向方向延伸的辐条限定。

38. 发明申请

US20060003326A1 Modified l-nucleic acid 有权
标题翻译：修饰的1-核酸
公开(公告)号：US20060003326A1
公开(公告)日：2006-01-05
申请号：US10493569
申请日：2002-10-25
申请人： Christian Lange , Bernd Eschgfaller , Sven Klussmann
发明人： Christian Lange , Bernd Eschgfaller , Sven Klussmann
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12N15/115 , A61K31/713 , A61K47/60 , C07H21/00 , C12N2310/16 , C12N2310/351 , C12N2310/353 , C12N2320/30
摘要： The present invention relates to a modified L-nucleic acid, comprising a L-nucleic acid part and a non-L-nucleic acid part, whereby the L-nucleic acid part is conjugated to the non-L-nucleic acid part and the conjugation of the L-nucleic acid part with the non-L-nucleic acid past leads to a slowed elimination out of the organism, in comparison with a L-nucleic acid which only comprises the L-nucleic acid part, said L-nucleic acid part being a spiegelmer.
摘要翻译：本发明涉及包含L-核酸部分和非L-核酸部分的修饰的L-核酸，其中所述L-核酸部分与非-L-核酸部分缀合，并且所述缀合与非L-核酸部分的L-核酸部分相比，与仅包含L-核酸部分的L-核酸相比，导致生物体的减缓消除，所述L-核酸部分作为一个刺客

39. 发明申请

US20090295197A1 Apparatus and Method For Reducing Undesirable Air Flow in a Passenger Compartment of a Vehicle 审中-公开
标题翻译：一种用于减少车辆乘客舱中不良气流的装置和方法
公开(公告)号：US20090295197A1
公开(公告)日：2009-12-03
申请号：US12087886
申请日：2007-01-31
申请人： Jeff Zabel , Florian Drasch , Sven Klussmann , Michael Charwat , Thomas Meiwald , Daniel Paulus , Atsushi Suzuki , Benno Wurm , Joshua Arvizu , Mark Bianco , Brian Biggott , Martin Bodi
发明人： Jeff Zabel , Florian Drasch , Sven Klussmann , Michael Charwat , Thomas Meiwald , Daniel Paulus , Atsushi Suzuki , Benno Wurm , Joshua Arvizu , Mark Bianco , Brian Biggott , Martin Bodi
IPC分类号： B60K37/00
CPC分类号： B60H1/00407 , B60H1/24
摘要： A method and apparatus for reducing undesirable air flow in a passenger compartment of a forward moving vehicle taps into an external air stream source to provide a counteractive air flow supply. The counteractive air flow supply is used to introduce at least one generally forward to rearward directed counteractive flow of air into the passenger compartment at a generally laterally central portion of the vehicle in an amount and at a velocity sufficient to counteract at least a portion of a rearward to forward flow of air in the passenger compartment to provide a forward to rearward directed flow of air through a generally laterally central portion of the passenger compartment at a head level of at least one front seat passenger.
摘要翻译：用于减少前进运动车辆的乘客舱中的不期望的气流的方法和装置分接到外部空气流源中以提供反作用气流供应。反作用气流供应用于在车辆的大致横向中心部分处以足以抵消至少一部分的空气的量和速度将至少一个大致向前的向后定向的反向空气流引入乘客舱内向后以使乘客舱中的空气流动，以在至少一个前排乘客的头部水平处提供向前的向后指向的空气流通过乘客舱的大致侧向的中心部分。

40. 发明申请

US20050208487A1 Immobilized nuckeic acids and uses thereof 审中-公开
标题翻译：固定的尼古丁酸及其用途
公开(公告)号：US20050208487A1
公开(公告)日：2005-09-22
申请号：US10296506
申请日：2001-05-25
申请人： Jens Burmeister , Petra Burgstaller , Sven Klussmann , Thomas Klein , Christian Frauendorf
发明人： Jens Burmeister , Petra Burgstaller , Sven Klussmann , Thomas Klein , Christian Frauendorf
IPC分类号： B01D15/38 , B01J20/289 , B01J20/32 , C12N15/115 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/115 , B01D15/3804 , B01J20/289 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3274 , C12N2310/351
摘要： One aspect of the present invention relates to an immobilized nucleic acid comprising a nucleic acid and a matrix where the nucleic acid is a Spiegelmer and the Spiegelmer is functionally active. Another aspect of the invention concerns an immobilized nucleic acid comprising a nucleic acid and a matrix where the nucleic acid is coupled to the matrix at least via its 3′ end and the nucleic acid is a functional nucleic acid. Finally a further aspect of the invention concerns the use of such immobilized nucleic acids as affinity ligands for example in chromatography and in apheresis.
摘要翻译：本发明的一个方面涉及包含核酸和基质的固定化核酸，其中核酸是Spiegelmer，而Spiegelmer是功能活性的。本发明的另一方面涉及包含核酸和基质的固定核酸，其中核酸至少通过其3'末端偶联至基质，核酸是功能性核酸。最后，本发明的另一方面涉及这种固定化核酸如亲和配体在色谱法和分离术中的应用。

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