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31. 发明申请

US20110159572A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL 有权
标题翻译：用于生产1,4-丁二醇的微生物
公开(公告)号：US20110159572A1
公开(公告)日：2011-06-30
申请号：US12947790
申请日：2010-11-16
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun
IPC分类号： C12N1/00
CPC分类号： C12P7/18 , B01D3/002 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/12 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/52 , C12N15/70 , C12N15/81 , C12Y101/01157 , C12Y402/01055
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，该途径包含至少一种编码足够数量产生BDO的BDO途径酶的外源核酸。本发明还提供了使用这种微生物生产BDO的方法。

32. 发明申请

US20110003344A1 METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL 审中-公开
公开(公告)号：US20110003344A1
公开(公告)日：2011-01-06
申请号：US12875068
申请日：2010-09-02
申请人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
发明人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
IPC分类号： C12P19/32 , C12N1/00
CPC分类号： C12P7/18 , C12N9/0008 , C12N9/0036 , C12N9/1007 , C12N9/93 , C12N15/70 , C12P19/32 , Y02E50/343
摘要： The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.

33. 发明申请

US20090191593A1 METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL 有权
标题翻译：使用合成气或其他气态碳源和甲醇的方法和有机体
公开(公告)号：US20090191593A1
公开(公告)日：2009-07-30
申请号：US12358217
申请日：2009-01-22
申请人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
发明人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
IPC分类号： C12P19/60 , C12N1/00
CPC分类号： C12P7/18 , C12N9/0008 , C12N9/0036 , C12N9/1007 , C12N9/93 , C12N15/70 , C12P19/32 , Y02E50/343
摘要： The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.
摘要翻译：本发明提供具有乙酰-CoA途径的非天然存在的微生物生物体，以及利用合成气或合成气和甲醇的能力。在一个实施方案中，本发明提供非天然存在的微生物，其包含一种或多种外源蛋白质，赋予微生物将CO，CO 2和/或H 2转化为乙酰辅酶A（乙酰辅酶A），甲基四氢叶酸（甲基 -THF）或其它所需产物，其中微生物缺乏在不存在一种或多种外源蛋白的情况下将CO或CO 2和H 2转化为乙酰辅酶A或甲基-THF的能力。例如，微生物生物体可以含有至少一种编码乙酰辅酶A途径中的酶或蛋白质的外源核酸。微生物生物能够单独或与甲醇组合使用包含CO，CO 2和/或H 2的合成气体，以产生乙酰辅酶A。本发明另外提供了生产乙酰辅酶A的方法，例如通过培养产生乙酰辅酶A的微生物，其中微生物生物体表达至少一种编码乙酰辅酶A途径酶或蛋白质的外源核酸，其量足够在条件下和足够的时间内产生乙酰辅酶A产生乙酰辅酶A。

34. 发明授权

US09321701B2 Microorganisms and methods for the biosynthesis of butadiene 有权
公开(公告)号：US09321701B2
公开(公告)日：2016-04-26
申请号：US13365132
申请日：2012-02-02
申请人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P5/02 , C12N1/20 , C12N1/00 , C07H21/04 , C07C1/24 , C12P7/04
CPC分类号： C12P5/02 , C07C1/24 , C07C2521/04 , C07C2521/12 , C07C2521/16 , C07C2523/10 , C07C2523/28 , C07C2523/31 , C07C2523/745 , C07C2527/167 , C07C2527/173 , C12N15/52 , C12P5/026 , C12P7/04 , Y02E50/343 , C07C11/167
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.

35. 发明授权

US09169486B2 Microorganisms for producing butadiene and methods related thereto 有权
标题翻译：用于生产丁二烯的微生物及其相关方法
公开(公告)号：US09169486B2
公开(公告)日：2015-10-27
申请号：US13527440
申请日：2012-06-19
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N1/20 , C12P5/02 , C12N15/52 , C12P7/04 , C12P7/16
CPC分类号： C12P7/04 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/16
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
摘要翻译：本发明提供具有丁二烯或巴豆醇途径的非天然存在的微生物。本发明另外提供了使用这种生物体来生产丁二烯或巴豆醇的方法。

36. 发明授权

US09133487B2 Microorganisms for producing methacrylic acid and methacrylate esters and methods related thereto 有权
标题翻译：用于生产甲基丙烯酸和甲基丙烯酸酯的微生物及其相关方法
公开(公告)号：US09133487B2
公开(公告)日：2015-09-15
申请号：US13436811
申请日：2012-03-30
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
IPC分类号： C12N1/12 , C12N1/20 , C12P7/40 , C12P19/32 , C12P7/42 , C12P7/62
CPC分类号： C12P7/40 , C12P7/42 , C12P7/62 , C12P19/32
摘要： The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate.
摘要翻译：本发明提供具有甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯途径的非天然存在的微生物生物。微生物生物体含有编码甲基丙烯酸途径中的酶的至少一种外源核酸。本发明另外提供了生产甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的方法。该方法可以包括培养产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的微生物，其中微生物生物体表达至少一种编码甲基丙烯酸途径酶的外源核酸，其量足以产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯在条件下和足够的时间以产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯。

37. 发明授权

US08940509B2 Microorganisms and methods for the production of caprolactone 有权
标题翻译：微生物和生产己内酯的方法
公开(公告)号：US08940509B2
公开(公告)日：2015-01-27
申请号：US13668117
申请日：2012-11-02
申请人： Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya , Mark J. Burk
发明人： Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya , Mark J. Burk
IPC分类号： C07D313/04 , C12N15/63 , C12P17/02 , C12N5/00 , C08G18/42 , C12P17/08
CPC分类号： C12P17/08 , C07D313/04 , C08G18/4277 , C08G63/08 , C12N5/0018 , C12N15/52 , C12N15/63 , C12N15/70 , C12P17/02
摘要： The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.
摘要翻译：本发明提供了非天然存在的含有己内酯途径的微生物，其具有至少一种编码丁二烯途径酶的外源核酸，其表达量足以产生己内酯。本发明另外提供了使用这种微生物生物体来制备己内酯的方法，该方法是在条件和足够的时间内培养含本文所述的己内酯途径的非天然存在的微生物生物产生己内酯。

38. 发明授权

US08900837B2 Microorganisms for the production of 2-hydroxyisobutyric acid 有权
标题翻译：用于生产2-羟基异丁酸的微生物
公开(公告)号：US08900837B2
公开(公告)日：2014-12-02
申请号：US13531377
申请日：2012-06-22
申请人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
发明人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P7/40 , C12P7/52 , C12P7/42 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12P7/42 , C12N9/0008 , C12N9/1096 , C12N9/88 , C12N9/90 , C12P7/40 , C12Y102/01 , C12Y206/01022 , C12Y403/01 , C12Y504/99002
摘要： The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.
摘要翻译：本发明提供了具有2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径的非天然存在的微生物生物。微生物生物体含有编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径中的酶的至少一种外源核酸。本发明还提供了2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸的制备方法。该方法可以包括培养足够量的表达至少一种编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径酶的外源核酸的2-羟基异丁酸，3-羟基异丁酸或产生甲基丙烯酸的微生物，并培养在条件下和足够的时间内产生2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸。

39. 发明授权

US08865439B2 Microorganisms for the production of methacrylic acid 有权
标题翻译：用于生产甲基丙烯酸的微生物
公开(公告)号：US08865439B2
公开(公告)日：2014-10-21
申请号：US13545880
申请日：2012-07-10
申请人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
发明人： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
IPC分类号： C12P7/40 , C12P7/52 , C12P7/42 , C12N9/00 , C12N1/20 , C07H21/04
CPC分类号： C12P7/42 , C12N9/0008 , C12N9/1096 , C12N9/88 , C12N9/90 , C12P7/40 , C12Y102/01 , C12Y206/01022 , C12Y403/01 , C12Y504/99002
摘要： The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.
摘要翻译：本发明提供了具有2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径的非天然存在的微生物生物。微生物生物体含有编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径中的酶的至少一种外源核酸。本发明还提供了2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸的制备方法。该方法可以包括培养足够量的表达至少一种编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径酶的外源核酸的2-羟基异丁酸，3-羟基异丁酸或产生甲基丙烯酸的微生物，并培养在条件下和足够的时间内产生2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸。

40. 发明授权

US08691553B2 Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol 有权
标题翻译：利用合成气或其他气态碳源和甲醇的方法和生物
公开(公告)号：US08691553B2
公开(公告)日：2014-04-08
申请号：US12863978
申请日：2009-01-22
申请人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
发明人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
IPC分类号： C12N1/20 , C12N9/00 , C12N1/00 , C12P7/42 , C12P7/20 , C07H21/04
CPC分类号： C12P7/18 , C12N9/0008 , C12N9/0036 , C12N9/1007 , C12N9/93 , C12N15/70 , C12P19/32 , Y02E50/343
摘要： The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.
摘要翻译：本发明提供具有乙酰-CoA途径的非天然存在的微生物生物体，以及利用合成气或合成气和甲醇的能力。在一个实施方案中，本发明提供非天然存在的微生物，其包含一种或多种外源蛋白质，赋予微生物将CO，CO 2和/或H 2转化为乙酰辅酶A（乙酰辅酶A），甲基四氢叶酸（甲基 -THF）或其它所需产物，其中微生物缺乏在不存在一种或多种外源蛋白的情况下将CO或CO 2和H 2转化为乙酰辅酶A或甲基-THF的能力。例如，微生物生物体可以含有至少一种编码乙酰辅酶A途径中的酶或蛋白质的外源核酸。微生物生物能够单独或与甲醇组合使用包含CO，CO 2和/或H 2的合成气体，以产生乙酰辅酶A。本发明另外提供了生产乙酰辅酶A的方法，例如通过培养产生乙酰辅酶A的微生物，其中微生物生物体表达至少一种编码乙酰辅酶A途径酶或蛋白质的外源核酸，其量足够在条件下和足够的时间内产生乙酰辅酶A产生乙酰辅酶A。

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