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31. 发明授权

US07419985B2 4-Phenyl substituted tetrahydroisoquinolines and therapeutic use thereof 失效
标题翻译： 4-苯基取代的四氢异喹啉及其治疗用途
公开(公告)号：US07419985B2
公开(公告)日：2008-09-02
申请号：US11231398
申请日：2005-09-21
申请人： James P. Beck , Anthony D. Pechulis , Arthur E. Harms
发明人： James P. Beck , Anthony D. Pechulis , Arthur E. Harms
IPC分类号： A61K31/4741 , A61K31/4743 , A61K31/4745
CPC分类号： C07D491/04 , C07D493/04 , C07D495/04
摘要： Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.
摘要翻译：提供化合物，其通过其可用于治疗各种神经和心理障碍（例如ADHD）的选择性神经递质结合。这样的化合物是如本文所述的具有式IA，IB，IIA，IIB，IIIA或IIIC的4-苯基取代的四氢异喹啉。

32. 发明授权

US07244725B2 Acetyl 2-hydroxy-1, 3-diaminoalkanes 失效
标题翻译：乙酰基2-羟基-1,3-二氨基烷烃
公开(公告)号：US07244725B2
公开(公告)日：2007-07-17
申请号：US10658959
申请日：2003-09-10
申请人： Varghese John , Michel Maillard , James P. Beck , Eric T. Baldwin , Robert Hughes , Shon R. Pulley , Ruth TenBrink
发明人： Varghese John , Michel Maillard , James P. Beck , Eric T. Baldwin , Robert Hughes , Shon R. Pulley , Ruth TenBrink
IPC分类号： C07D279/04 , A61K31/54
CPC分类号： C07C233/36 , C07C235/10 , C07C235/74 , C07C271/24 , C07C311/05 , C07C327/30 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D209/14 , C07D213/38 , C07D213/64 , C07D215/233 , C07D215/38 , C07D215/42 , C07D215/46 , C07D217/22 , C07D233/61 , C07D233/64 , C07D237/08 , C07D237/14 , C07D239/26 , C07D239/38 , C07D241/12 , C07D249/08 , C07D261/08 , C07D265/02 , C07D277/28 , C07D295/135 , C07D307/52 , C07D309/14 , C07D311/68 , C07D311/74 , C07D333/20 , C07D333/22 , C07D335/06 , C07D405/04 , C07D407/06 , C07D409/12 , C07D495/04
摘要： Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and RC are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
摘要翻译：公开了下式的化合物：其中变量Z，X，R 15，R 2，R 3和R C， / SUB>。本文公开的化合物是β-分泌酶的抑制剂，因此可用于治疗阿尔茨海默氏病和以哺乳动物中Aβ肽沉积为特征的其它疾病。

33. 发明授权

US07214715B2 Compounds to treat Alzheimer's disease 失效
标题翻译：治疗阿尔茨海默病的化合物
公开(公告)号：US07214715B2
公开(公告)日：2007-05-08
申请号：US09896139
申请日：2001-06-29
申请人： James P. Beck , Lawrence Y. Fang , John N. Freskos , Andrea Gailunas , Roy Hom , Barbara Jagodzinska , Varghese John , Michel Maillard , Shon R. Pulley , Ruth E. TenBrink
发明人： James P. Beck , Lawrence Y. Fang , John N. Freskos , Andrea Gailunas , Roy Hom , Barbara Jagodzinska , Varghese John , Michel Maillard , Shon R. Pulley , Ruth E. TenBrink
IPC分类号： A61K31/166 , C07D233/78
CPC分类号： C07D295/26 , C07C215/28 , C07C233/78 , C07C235/84 , C07C239/20 , C07C243/22 , C07C243/28 , C07C271/16 , C07C271/18 , C07C275/24 , C07C311/03 , C07C311/08 , C07C311/13 , C07C311/16 , C07C311/37 , C07C317/44 , C07C323/60 , C07D211/60 , C07D215/12 , C07D277/04 , C07D295/13 , C07D303/36 , C07D307/52 , C07D307/54 , C07D333/24 , Y02P20/55 , Y02P20/582
摘要： The present invention is substituted amines of formula (X) and of the formula (X′) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译：本发明是用于治疗阿尔茨海默病和其他类似疾病的式（X）和式（X'）的取代胺。

34. 发明授权

US07084152B2 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof 失效
标题翻译： 4-苯基取代的四氢异喹啉的治疗用途
公开(公告)号：US07084152B2
公开(公告)日：2006-08-01
申请号：US09902845
申请日：2001-07-11
申请人： James P. Beck , Anthony D. Pechulis , Arthur E. Harms
发明人： James P. Beck , Anthony D. Pechulis , Arthur E. Harms
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D491/04 , C07D493/04 , C07D495/04
摘要： Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.
摘要翻译：提供化合物，其通过其可用于治疗各种神经和心理障碍（例如ADHD）的选择性神经递质结合。这样的化合物是如本文所述的具有式IA，IB，IIA，IIB，IIIA或IIIC的4-苯基取代的四氢异喹啉。

35. 发明授权

US06969709B2 Macrocycles useful in the treatment of Alzheimer's disease 失效
标题翻译：可用于治疗阿尔茨海默病的大环
公开(公告)号：US06969709B2
公开(公告)日：2005-11-29
申请号：US10171182
申请日：2002-06-12
申请人： Shon R. Pulley , James P. Beck , Ruth E. TenBrink
发明人： Shon R. Pulley , James P. Beck , Ruth E. TenBrink
IPC分类号： A61K31/395 , A61K31/4427 , A61P25/28 , C07D273/02 , C07D413/12
CPC分类号： C07D413/12 , C07D273/02
摘要： The present invention are macrocycles of the formula (IX): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
摘要翻译：本发明是式（Ⅸ）的大环化合物：用于治疗阿尔茨海默病和其它类似疾病。这些化合物包括β-分泌酶的抑制剂，其可用于治疗阿尔茨海默病和以哺乳动物中Aβ肽沉积为特征的其它疾病。本发明的化合物可用于降低Aβ肽形成的药物组合物和治疗方法。

36. 发明授权

US4616512A Torquemeter 失效
公开(公告)号：US4616512A
公开(公告)日：1986-10-14
申请号：US674165
申请日：1984-11-23
申请人： Sydney Himmelstein , Richard S. Tveter , James P. Beck
发明人： Sydney Himmelstein , Richard S. Tveter , James P. Beck
IPC分类号： G01L3/10
CPC分类号： G01L3/102 , G01L3/105 , Y10S73/02
摘要： A nonintrusive, or noncontact, shaft torquemeter for use in measuring torque transmission through a rotatable shaft. The torquemeter includes an annular torque-sensing coil structure having an annular excitation coil and a pickup coil magnetically coupled to the excitation coil through an improved magnetostrictive coupling structure carried by the shaft. In the illustrated embodiment, the magnetostrictive coupling portion is provided on a tube coaxially fixed at its ends to the shaft. The invention comprehends the provision of structure for preventing a continuous annular conductive path through the coupling portion or tube. Other structure for improving torque measuring accuracy may be provided, including the use of an outer magnetic stator core, and the provision of annular corrugations in the tube for preventing transmission of nontorque forces, such as bending forces, to the coupling portion. In one embodiment, the coupling portion is defined by a portion of the mounting tube, and in another embodiment, the coupling portion is defined by a layer of magnetostrictive material on the tube.
摘要翻译：用于测量通过可旋转轴的扭矩传递的非侵入式或非接触式轴扭矩计。扭矩计包括环形扭矩感测线圈结构，其具有环形激励线圈和通过由轴承载的改进的磁致伸缩耦合结构与励磁线圈磁耦合的拾取线圈。在所示实施例中，磁致伸缩耦合部分设置在同轴固定在其端部上的管上。本发明包括提供用于防止通过联接部分或管的连续环形导电路径的结构。可以提供用于提高扭矩测量精度的其它结构，包括使用外部磁性定子芯，以及在管中提供环形波纹，以防止诸如弯曲力的非扭矩力传递到联接部分。在一个实施例中，联接部分由安装管的一部分限定，并且在另一个实施例中，联接部分由管上的一层磁致伸缩材料限定。

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