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31. 发明授权

US06808891B2 Modulators of the function of FAS/APO1 receptors 失效
标题翻译： FAS / APO1受体功能调节剂
公开(公告)号：US06808891B2
公开(公告)日：2004-10-26
申请号：US09933814
申请日：2001-08-22
申请人： David Wallach , Mark Boldin , Eugene Varfolomeev , Igor Mett
发明人： David Wallach , Mark Boldin , Eugene Varfolomeev , Igor Mett
IPC分类号： G01N3353
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/715 , C07K16/2866 , C07K2319/00 , C12N9/641 , C12N9/6475
摘要： Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.

32. 发明授权

US06479632B1 Tumor necrosis factor inhibitory protein and its purification 失效
标题翻译：肿瘤坏死因子抑制蛋白及其纯化
公开(公告)号：US06479632B1
公开(公告)日：2002-11-12
申请号：US09414609
申请日：1999-10-08
申请人： David Wallach , Hartmut Engelmann , Dan Aderka , Menachem Rubinstein
发明人： David Wallach , Hartmut Engelmann , Dan Aderka , Menachem Rubinstein
IPC分类号： C07K1400
CPC分类号： C07K14/7151 , A61K38/00 , C07K16/2866
摘要： Tumor Necrosis Factor (TNF) Inhibitory Protein is isolated and substantially purified. It has the ability to inhibit: (a) the binding of TNF to its receptors, and (b) the cytotoxic effect of TNF. TNF Inhibitory Protein and salts, functional derivatives and active fractions thereof can be used to antagonize the deleterious effects of TNF.
摘要翻译：肿瘤坏死因子（TNF）抑制蛋白被分离并基本纯化。它具有抑制（a）TNF与其受体结合的能力，（b）TNF.TNF抑制蛋白及其盐，功能衍生物及其活性成分的细胞毒性作用可用于拮抗TNF的有害作用。

33. 发明授权

US06323755B1 Dynamic bus locking in a cross bar switch 失效
标题翻译：动态总线锁定在交叉开关中
公开(公告)号：US06323755B1
公开(公告)日：2001-11-27
申请号：US09136023
申请日：1998-08-19
申请人： William Robert Lee , David Wallach
发明人： William Robert Lee , David Wallach
IPC分类号： H04M514
CPC分类号： G06F13/4022
摘要： A cross-bar switch which includes a plurality of master bus ports, the master bus ports adapted to receive a plurality of master buses; a plurality of slave bus ports, the slave bus ports adapted to receive a plurality of slave buses; a switching mechanism for selectively coupling the plurality of master bus ports to the plurality of slave bus ports; and a configuration mechanism for locking at least one of the plurality of slave buses in response to a transfer request initiated by a master device attached to one of the plurality of master buses. The cross-bar switch has the capability of selectively locking slave buses during a bus lock transfer. In the preferred embodiment, the configuration mechanism is a Bus Lock Bit on Configuration Registers on the cross-bar switch. The Bus Lock Bit is programmable through the Device Control Register bus, which allows the cross-bar switch to be dynamically programmable and changed by a processor in a larger system. The cross-bar switch minimizes the cycle latency between data transfers. This improves the bandwidth and throughput on the on-chip bus.
摘要翻译：一种横杆开关，其包括多个主总线端口，所述主总线端口适于接收多个主总线; 多个从属总线端口，所述从属总线端口适于接收多个从属总线; 用于选择性地将多个主总线端口耦合到多个从属总线端口的切换机构; 以及用于响应于由附接到所述多个主总线之一的主设备发起的传送请求而锁定所述多个从属总线中的至少一个的配置机构。交叉开关具有在总线锁传输期间选择性地锁定从站总线的能力。在优选实施例中，配置机制是在横杆开关上的配置寄存器上的总线锁定位。总线锁定位可通过器件控制寄存器总线进行编程，允许交叉开关由较大系统中的处理器动态编程和更改。交叉开关最小化数据传输之间的周期延迟。这样可以提高片上总线的带宽和吞吐量。

34. 发明授权

US5959094A p75 TNF receptor promoters 失效
标题翻译： p75 TNF受体启动子
公开(公告)号：US5959094A
公开(公告)日：1999-09-28
申请号：US737371
申请日：1996-11-12
申请人： David Wallach , Peter Kuhnert , Gotz Ehrhardt , Oliver Kemper
发明人： David Wallach , Peter Kuhnert , Gotz Ehrhardt , Oliver Kemper
IPC分类号： A61K38/00 , C07K14/715 , C12N15/85 , C12N15/11
CPC分类号： C07K14/7151 , C12N15/85 , A61K38/00 , C12N2830/00 , C12N2830/42 , C12N2830/85
摘要： The present invention is an isolated DNA molecule comprising a promoter of the human p75 TNF-R gene having a sequence consisting of a 5' upstream promoter sequence contained within an approximately 2.0 kbp NcoI fragment of a genomic clone of human p75 TNF-R, or an intron promoter sequence located in the first intron between the first and second exons and contained within an approximately 1.9 kbp SmaI fragment of a genomic clone of human p75 TNF-R. A composition comprising the DNA molecule and a carrier is also described.
摘要翻译： PCT No.PCT / US95 / 05853 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT提交1995年5月11日PCT公布。出版物WO95 / 31206 日期：1995年11月23日本发明是一种分离的DNA分子，其包含人p75 TNF-R基因的启动子，其具有由包含在人p75的基因组克隆的约2.0kbp NcoI片段内的5'上游启动子序列 TNF-R或位于第一和第二外显子之间的第一内含子中的内含子启动子序列，并且包含在人p75 TNF-R的基因组克隆的约1.9kbp SmaI片段内。还描述了包含DNA分子和载体的组合物。

35. 发明授权

US5766917A Method for identifying and producing a protease capable of cleaving the TNF receptor 失效
标题翻译：用于鉴定和产生能够切割TNF受体的蛋白酶的方法
公开(公告)号：US5766917A
公开(公告)日：1998-06-16
申请号：US837941
申请日：1997-04-28
申请人： David Wallach , Cord Brakebusch , Eugene Varfolomeev , Michael Batkin
发明人： David Wallach , Cord Brakebusch , Eugene Varfolomeev , Michael Batkin
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K38/55 , A61K39/395 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K14/715 , C07K14/81 , C07K16/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N9/99 , C12N15/57 , C12P21/08 , C12N9/50
CPC分类号： C07K14/7151 , C07K14/71 , C12N9/6421 , A61K38/00 , C07K2319/00
摘要： Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them.
摘要翻译：提供影响细胞结合的p55肿瘤坏死因子受体（p55-TNF-R）脱落的分子及其制备方法。

36. 发明授权

US4302533A Novel assays for interferon 失效
标题翻译：干扰素的新型测定
公开(公告)号：US4302533A
公开(公告)日：1981-11-24
申请号：US139697
申请日：1980-04-11
申请人： Michel Revel , Adi Kimchi , Lester Shulman , David Wallach
发明人： Michel Revel , Adi Kimchi , Lester Shulman , David Wallach
IPC分类号： G01N33/50 , C12Q1/00 , C12Q1/25 , C12Q1/44 , C12Q1/48 , G01N33/68 , C12Q1/02 , C12Q1/68
CPC分类号： G01N33/6866 , C12Q1/25 , C12Q1/44 , C12Q1/48 , G01N2333/555 , Y10S435/811
摘要： The present invention relates to an assay for the quantitative determination of interferon which comprises extracting a cell previously exposed to said interferon with an extractant, and determining in such extract the quantity of an enzyme the content of which in said cell is a function of the quantity of interferon to which said cell had been previously exposed and to a kit for carrying out such assay.
摘要翻译：本发明涉及用于定量测定干扰素的测定法，其包括用提取剂提取先前暴露于所述干扰素的细胞，并在该提取物中测定其内容物在该细胞中的量是量的函数的干扰素，以及用于进行这种测定的试剂盒。

37. 发明授权

US08304384B2 Caspase-8 and inflammation, infection and wound healing 失效
标题翻译：胱天蛋白酶-8和炎症，感染和伤口愈合
公开(公告)号：US08304384B2
公开(公告)日：2012-11-06
申请号：US12306929
申请日：2007-06-27
申请人： David Wallach , Rinat Abramovitch , Eitan Galun , Tehila Ben Moshe , Hila Barash
发明人： David Wallach , Rinat Abramovitch , Eitan Galun , Tehila Ben Moshe , Hila Barash
IPC分类号： A61K38/16 , A61P31/04 , C07K14/435
CPC分类号： A61K38/4873 , A61K38/55 , C12N15/113 , C12N15/1135 , C12N2310/11 , C12Y304/22061 , Y02A50/409 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to the regulatory role of caspase-8 in infection by intracellular pathogen, inflammation and wound healing.
摘要翻译：本发明涉及胱天蛋白酶-8在细胞内病原体感染，炎症和伤口愈合中的调节作用。

38. 发明申请

US20110293593A1 SIVA 2 STABILIZATION 审中-公开
标题翻译： SIVA 2稳定
公开(公告)号：US20110293593A1
公开(公告)日：2011-12-01
申请号：US12866532
申请日：2009-02-11
申请人： David Wallach , Parameswaran Ramakrishnan , Andrei Kovalenko
发明人： David Wallach , Parameswaran Ramakrishnan , Andrei Kovalenko
IPC分类号： A61K38/45 , C12P21/00 , C12N5/10 , C12N1/19 , A61P29/00 , C07K1/107 , C07K19/00 , G01N33/566 , C12Q1/48 , A61P35/00 , C07K14/47 , A61K38/17
CPC分类号： C12N9/93 , A61K38/00
摘要： The present invention relates to modulation of SIVA2 stability by N-acetylglucosamine, phosphorylation of ubiquitination in treatment or prevention of diseases, disorders or conditions.
摘要翻译：本发明涉及通过N-乙酰氨基葡萄糖调节SIVA2稳定性，在治疗中泛素化的磷酸化或预防疾病，病症或病症。

39. 发明申请

US20100204091A1 SIVA Ubiquitination and/or Degradation-Related Activity and Modulators Thereof 有权
标题翻译： SIVA泛素化和/或降解相关活性和调节剂
公开(公告)号：US20100204091A1
公开(公告)日：2010-08-12
申请号：US12160627
申请日：2007-01-11
申请人： David Wallach , Parameswaran Ramakrishnan , Wang Wangxia , Andrei Kovalenko
发明人： David Wallach , Parameswaran Ramakrishnan , Wang Wangxia , Andrei Kovalenko
IPC分类号： A61K38/16 , G01N33/53 , C07K14/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , A61K48/00 , A61P35/00
CPC分类号： C12Q1/25 , G01N2333/9015 , G01N2500/02 , G01N2800/24
摘要： The present invention relates to the ubiquitination and/or degradation-related activity of a SIVA polypeptide and to agents capable of modulating said activity.
摘要翻译：本发明涉及SIVA多肽和能够调节所述活性的试剂的泛素化和/或降解相关活性。

40. 发明申请

US20090297515A1 Use of Caspase-8 Inhibitors for Modulating Hematopoiesis 审中-公开
标题翻译：使用半胱天冬酶-8抑制剂调节血细胞生成
公开(公告)号：US20090297515A1
公开(公告)日：2009-12-03
申请号：US12472039
申请日：2009-05-26
申请人： David Wallach , Eugene Varfolomeev , Yael Pewzner-Jung , Tae-Bong Kang , Tehila B. Moshe
发明人： David Wallach , Eugene Varfolomeev , Yael Pewzner-Jung , Tae-Bong Kang , Tehila B. Moshe
IPC分类号： A61K39/395 , A61K38/43 , A61K48/00 , A61K38/48
CPC分类号： C12N15/1137 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , A01K2267/0381 , A61K38/4873 , A61K48/00 , C12N9/6472 , C12N15/8509 , C12N2310/11 , C12N2310/14 , C12N2800/30 , C12N2830/00 , C12N2830/85 , C12Y304/22061
摘要： A method of inhibiting hematopoiesis in a subject is provided. The method is effected by downregulating an expression or activity of caspase-8 in the subject thereby inhibiting hematopoiesis therein.
摘要翻译：提供了抑制受试者造血的方法。该方法通过下调受试者中半胱天冬酶-8的表达或活性，从而抑制其中的造血作用。

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