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32. 发明申请

US20140288030A1 COMPOSITIONS FOR IMPROVING CELL VIABILITY AND METHODS OF USE THEREOF 有权
标题翻译：用于改善细胞毒性的组合物及其使用方法
公开(公告)号：US20140288030A1
公开(公告)日：2014-09-25
申请号：US14140083
申请日：2013-12-24
申请人： Amylyx Pharmaceuticals Inc.
发明人： Joshua Cohen , Justin Klee
IPC分类号： A61K31/575 , A61K31/192
CPC分类号： A61K31/575 , A61K31/192 , A61K2300/00
摘要： This invention relates to methods and compositions for use improving cell viability, particularly neural cell viability, and more particularly to methods and compositions for use improving cell viability by reducing reactive oxygen metabolite-mediated oxidative damage in a cell, regulating redox homeostasis in a cell, or reducing mitochondrial dysfunction in a cell. The invention further relates to the administration of the bile acid tauroursodeoxycholic acid (TUDCA) in combination with phenylbutyric Acid (PBA) to improve cell viability, and treat at least one symptom associated with, prevent the time of onset of, or slow the development of a disease related to oxidative stress.
摘要翻译：本发明涉及用于改善细胞活力，特别是神经细胞活力的方法和组合物，更具体地涉及用于通过减少细胞中的活性氧代谢物介导的氧化损伤来改善细胞活力的方法和组合物，调节细胞中的氧化还原体内平衡，或减少细胞中的线粒体功能障碍。本发明进一步涉及将胆汁酸牛磺熊脱氧胆酸（TUDCA）与苯丁酸（PBA）联用以提高细胞存活力，并且治疗至少一种与之相关的症状，预防发病时间或发展迟缓与氧化应激相关的疾病。

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