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31. 发明申请

US20110313488A1 AUTOMATIC NEURAL STIMULATION TITRATION SWEEP 有权
标题翻译：自动神经刺激ATION ATION
公开(公告)号：US20110313488A1
公开(公告)日：2011-12-22
申请号：US13155549
申请日：2011-06-08
申请人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
发明人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/36146
摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.
摘要翻译：各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。神经刺激输出电路被配置为递送神经刺激。控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。控制器被配置为与传感器电路通信。存储器具有存储在其中的指令，可由控制器电路操作。说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数刺激并提供理想的安全余量以防止对神经组织的损伤。

32. 发明申请

US20090012444A1 Osmotic Devices and Methods for Diuretic Therapy 有权
标题翻译：渗透治疗的渗透装置和方法
公开(公告)号：US20090012444A1
公开(公告)日：2009-01-08
申请号：US11772397
申请日：2007-07-02
申请人： Allan Charles Shuros , Eric A. Mokelke , Michael John Kane
发明人： Allan Charles Shuros , Eric A. Mokelke , Michael John Kane
IPC分类号： A61M1/34
CPC分类号： A61B17/1219 , A61B17/12031 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61F2250/0003
摘要： Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes an implantable occlusive device including a wall member defining an enclosed volume, the wall member can include a semi-permeable membrane. The device can also include a solution comprising a solvent and a solute disposed within the enclosed volume of the wall member. The semi-permeable membrane can be permeable to the solvent and impermeable to the solute. The enclosed volume can be configured to expand and contract in response to changes in the osmolality of a bodily fluid. The device can include a positioning member configured to maintain the position of the implantable occlusive device relative to a lengthwise axis of a lymphatic vessel. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.
摘要翻译：本发明的实施方案涉及用于调节肾功能的装置和方法等。在一个实施例中，本发明包括可植入闭塞装置，其包括限定封闭容积的壁构件，所述壁构件可包括半透膜。该装置还可以包括溶液和溶质，该溶质设置在壁构件的封闭体积内。半透膜对溶剂是可渗透的，并且对溶质是不可渗透的。封闭体积可以配置为响应于体液渗透压的变化而膨胀和收缩。该装置可以包括定位构件，其被配置为相对于淋巴管的纵向轴线保持可植入闭塞装置的位置。在一个实施方案中，本发明包括调节患者的肾功能的方法，包括在患者体内植入闭塞装置，所述闭塞装置包括半渗透膜，并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩不渗透膜。本文提供了其它方面和实施例。

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