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31. 发明授权

US07452524B2 Method for improvement of tolerance for therapeutically effective agents delivered by inhalation 有权
标题翻译：通过吸入改善治疗有效药物耐受性的方法
公开(公告)号：US07452524B2
公开(公告)日：2008-11-18
申请号：US11045234
申请日：2005-01-28
申请人： Thomas Hofmann , Alan Bruce Montgomery , Kevin Stapleton , William R. Baker
发明人： Thomas Hofmann , Alan Bruce Montgomery , Kevin Stapleton , William R. Baker
IPC分类号： A61K9/00 , A61K9/12
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/008
摘要： A method for improvement of tolerance for therapeutically effective agents delivered by inhalation comprising a pretreatment of a patient with a nebulized lidocaine or a lidocaine-like compound administered immediately or up to about thirty minutes before administration of the primary therapeutically effective agent. The pretreatment of the patient with the nebulized lidocaine or a lidocaine-like compound improves airway tolerance and deposition of the agent in the lungs and makes such deposition more safe, efficacious, controllable and predictable. The method of the invention is especially useful for enhancement of deposition of immunosuppressive agents in the lung(s) of transplant patients, improved tolerance of the drugs by reducing cough, and improving pulmonary drug deposition.
摘要翻译：一种用于改善通过吸入递送的治疗有效药物的耐受性的方法，其包括在给予主要治疗有效药剂之前立即施用或至多约30分钟施用雾化的利多卡因或利多卡因样化合物的患者的预处理。患有雾化利多卡因或利多卡因样化合物的患者的预处理改善了气道耐受性并且将药物沉积在肺中，并使得沉积更安全，有效，可控和可预测。本发明的方法对于增强免疫抑制剂在移植患者的肺中的沉积特别有用，通过减少咳嗽改善药物的耐受性并改善肺部药物沉积。

32. 发明授权

US07452523B2 Targeted delivery of lidocaine and other local anesthetics and a method for treatment of cough and tussive attacks 失效
标题翻译：目标输送利多卡因和其他局部麻醉剂，以及治疗咳嗽和咳嗽发作的方法
公开(公告)号：US07452523B2
公开(公告)日：2008-11-18
申请号：US11045226
申请日：2005-01-28
申请人： Thomas Hofmann , Alan Bruce Montgomery , Kevin Stapleton
发明人： Thomas Hofmann , Alan Bruce Montgomery , Kevin Stapleton
IPC分类号： A61K9/00 , A61K9/12
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/008
摘要： An anti-tussive nebulized solution for targeted delivery of lidocaine into conducting and central airways. A method for treatment of cough and tussive attacks or episodes using said lidocaine solution. A nebulized lidocaine solution administered in daily dose from about 10 mg to 80 mg of lidocaine dissolved in a saline and nebulized into an aerosol having a mass median aerodynamic diameter 3 μm to 10 μm and a geometric standard deviation less than 1.7 using an electronic nebulizer.
摘要翻译：一种用于将利多卡因有针对性地输送到导管和中央气道中的抗咳嗽雾化溶液。使用利多卡因溶液治疗咳嗽和咳嗽发作或发作的方法。雾化的利多卡因溶液以约10mg至80mg的溶解在盐水中的利多卡因和使用电子雾化器雾化成质量中值空气动力学直径3mum至10um，几何标准偏差的气溶胶施用。

33. 发明申请

US20080199410A1 Pulmonary surfactant formulations and methods for promoting mucus clearance 有权
标题翻译：肺表面活性剂配方和促进粘液清除的方法
公开(公告)号：US20080199410A1
公开(公告)日：2008-08-21
申请号：US11901866
申请日：2007-09-19
申请人： Mark E. Johnson , Robert Segal , Thomas Hofmann , Robert J. Capetola
发明人： Mark E. Johnson , Robert Segal , Thomas Hofmann , Robert J. Capetola
IPC分类号： A61K9/12 , A61K38/02 , A61K33/14 , A61P11/12
CPC分类号： A61K31/66 , A61K9/0078
摘要： Methods and compositions to enhance mucus clearance and to treat of pulmonary lung disorders such as cystic fibrosis are disclosed. The methods utilize pulmonary surfactants, alone or combined with hyperosmotic agents, administered to patients in an amount effective to enhance mucus clearance. The compositions comprise a pulmonary surfactant combined with an osmotically active agent.
摘要翻译：公开了增强粘液清除和治疗肺部肺病如囊性纤维化的方法和组合物。该方法单独使用肺表面活性剂或与渗透剂组合，以有效增强粘液清除率的量施用于患者。组合物包含与渗透活性剂组合的肺表面活性剂。

34. 发明授权

US07328216B2 System and method for personalized search, information filtering, and for generating recommendations utilizing statistical latent class models 有权
标题翻译：用于个性化搜索，信息过滤以及使用统计潜在类模型生成建议的系统和方法
公开(公告)号：US07328216B2
公开(公告)日：2008-02-05
申请号：US10639024
申请日：2003-08-11
申请人： Thomas Hofmann , Jan Christian Puzicha
发明人： Thomas Hofmann , Jan Christian Puzicha
IPC分类号： G06F17/30
CPC分类号： G06F17/30699 , Y10S707/99934 , Y10S707/99936 , Y10S707/99942
摘要： The system implements a novel method for personalized filtering of information and automated generation of user-specific recommendations. The system uses a statistical latent class model, also known as Probabilistic Latent Semantic Analysis, to integrate data including textual and other content descriptions of items to be searched, user profiles, demographic information, query logs of previous searches, and explicit user ratings of items. The system learns one or more statistical models based on available data. The learning may be reiterated once additional data is available. The statistical model, once learned, is utilized in various ways: to make predictions about item relevance and user preferences on un-rated items, to generate recommendation lists of items, to generate personalized search result lists, to disambiguate a users query, to refine a search, to compute similarities between items or users, and for data mining purposes such as identifying user communities.
摘要翻译：该系统实现了一种用于个性化过滤信息和自动生成用户特定建议的新方法。系统使用统计潜在类别模型（也称为概率潜在语义分析）来整合包括要搜索的项目的文本和其他内容描述的数据，用户简档，人口统计信息，先前搜索的查询日志以及项目的显式用户评级。系统基于可用数据学习一个或多个统计模型。一旦有其他数据可以重新学习。已经学习的统计模型以各种方式被利用：对未评级项目进行项目相关性和用户偏好的预测，以产生项目的推荐列表，生成个性化搜索结果列表，消除用户查询的歧义，以改进搜索，计算项目或用户之间的相似性，以及数据挖掘目的，如识别用户社区。

35. 发明申请

US20070280311A1 Device and method to create a low divergence, high power laser beam for material processing applications 有权
标题翻译：用于材料处理应用的低发散高功率激光束的设备和方法
公开(公告)号：US20070280311A1
公开(公告)日：2007-12-06
申请号：US11805596
申请日：2007-05-23
申请人： Thomas Hofmann
发明人： Thomas Hofmann
IPC分类号： H01S3/10
CPC分类号： B23K26/03 , B23K26/034 , B23K26/0622 , B23K26/0665 , B23K26/0738 , B23K26/0853 , B23K26/40 , B23K2101/34 , B23K2101/40 , B23K2103/50 , C30B13/24 , C30B29/06
摘要： A thin beam laser crystallization apparatus for selectively melting a film deposited on a substrate is disclosed having a laser source producing a pulsed laser output beam, the source having an oscillator comprising a convex reflector and a piano output coupler; and an optical arrangement focusing the beam in a first axis and spatially expanding the beam in a second axis to produce a line beam for interaction with the film.
摘要翻译：公开了一种用于选择性地熔化沉积在基板上的薄膜的薄射束激光结晶装置，其具有产生脉冲激光输出光束的激光源，该源具有包括凸反射器和钢琴输出耦合器的振荡器; 以及光学布置，将光束聚焦在第一轴线上，并且在第二轴线上空间地扩展光束以产生用于与胶片相互作用的线束。

36. 发明申请

US20070280308A1 High power excimer laser with a pulse stretcher 有权
标题翻译：具有脉冲担架的大功率准分子激光器
公开(公告)号：US20070280308A1
公开(公告)日：2007-12-06
申请号：US11805583
申请日：2007-05-23
申请人： Alexander Ershov , James Ferrell , Thomas Hofmann , Daniel Reiley , Chris Remen
发明人： Alexander Ershov , James Ferrell , Thomas Hofmann , Daniel Reiley , Chris Remen
IPC分类号： H01S3/22
CPC分类号： H01S3/225 , H01S3/0057 , H01S3/03 , H01S3/034
摘要： An apparatus and method is disclosed which may comprise a high power excimer or molecular fluorine gas discharge laser DUV light source system which may comprise: a pulse stretcher which may comprise: an optical delay path mirror, an optical delay path mirror gas purging assembly which may comprise: a purging gas supply system directing purging gas across a face of the optical delay line mirror. The optical delay path mirror may comprise a plurality of optical delay path mirrors; the purging gas supply system may direct purging gas across a face of each of the plurality of optical delay line mirrors. The purging gas supply system may comprise: a purging gas supply line; a purging gas distributing and directing mechanism which may direct purging gas across the face of the respective optical delay path mirror.
摘要翻译：公开了一种装置和方法，其可以包括高功率准分子或分子氟气体放电激光DUV光源系统，其可以包括：脉冲展宽器，其可以包括：光学延迟路径反射镜，光学延迟路径镜气体清洗组件，其可以包括：吹扫气体供应系统，其引导净化气体穿过光学延迟线反射镜的表面。光学延迟路径镜可以包括多个光学延迟路径镜; 净化气体供应系统可以引导净化气体穿过多个光学延迟线反射镜中的每一个的表面。净化气体供应系统可以包括：净化气体供应管线; 吹扫气体分配和引导机构，其可以将吹扫气体引导通过相应的光学延迟路径反射镜的表面。

37. 发明授权

US07128944B2 Method for making thermally tempered glass comprising a non-abrasive, porous, SiO2 antireflection layer 有权
标题翻译：包括非研磨性多孔SiO 2抗反射层的热钢化玻璃的方法
公开(公告)号：US07128944B2
公开(公告)日：2006-10-31
申请号：US10399439
申请日：2001-10-17
申请人： Hans-Joachim Becker , Armin Dauwalter , Andreas Gombert , Walther Glaubitt , Thomas Hofmann , Monika Kursawe
发明人： Hans-Joachim Becker , Armin Dauwalter , Andreas Gombert , Walther Glaubitt , Thomas Hofmann , Monika Kursawe
IPC分类号： B05D5/06
CPC分类号： C03C17/25 , C03C1/008 , C03C17/006 , C03C17/007 , C03C2217/213 , C03C2217/425 , C03C2218/113
摘要： The invention relates to thermally tempered safety glass comprising an non-abrasive and porous SiO2 layer which is stable during sintering and has a refractive index of between 1.25 and 1.40. The inventive safety glass can be obtained by coating standard soda-lime glass with an aqueous coating solution having a pH value of between 3 and 8 and containing between 0.5 and 5.0 wt. % of [SiOx(OH)y]n particles (0
摘要翻译：本发明涉及一种热回火安全玻璃，其包括非烧结和多孔的SiO 2层，其在烧结期间是稳定的并且折射率在1.25至1.40之间。本发明的安全玻璃可以通过用pH值在3和8之间并含有0.5至5.0重量％的含水涂层溶液涂覆标准钠钙玻璃来获得。％的颗粒（0

38. 发明申请

US20060204629A1 Pyridinium-betain compounds and their use 审中-公开
标题翻译：吡啶鎓 - 甜菜碱化合物及其用途
公开(公告)号：US20060204629A1
公开(公告)日：2006-09-14
申请号：US10548416
申请日：2003-03-10
申请人： Imre Blank , Martin Grigorov , Thomas Hofmann
发明人： Imre Blank , Martin Grigorov , Thomas Hofmann
IPC分类号： A23L1/226
CPC分类号： C07H13/00 , A23L27/2056 , C07F9/65586
摘要： The present invention concerns Pyridinium-Betain compounds of the following general formula (A) R1 is H R2 is a chemical group formed by a sugar pentose or hexose ring, substituted at C5 or C6, respectively, with an acid residue taken from the group—phosphoryl, sulfonyl, or carboxyl, and R2 is connected to the pyridaine ring either at C1 or C2 positions R3 is taken from the group consisting of OH, including the ionised form O−, R4 is an aliphatic chain (CH2)n, where n is the chain length in the range from n=0 to n=4, R5 is taken from the group consisting of residues—hydroxy, methoxy, ethoxy, methyl, ethyl, furfurylthio and derivatives, and wherein the counter-ion is taken from the group consisting of sodium, potassium, ammonium, calcium, chloride, carbonate, sulphate, phosphate, and the like.
摘要翻译：本发明涉及以下通式（A）的吡啶鎓 - 甜菜碱化合物。R 1是由糖戊糖或己糖环形成的化学基团，其由 C5或C6，其中残基取自基团 - 磷酰基，磺酰基或羧基，R 2和R 2在C1或C2位置R 3连接到吡啶酮环上， / SUB>取自由OH组成的组，包括电离形式，其中R 4是脂族链（CH 2 2 N）其中n是在n = 0至n = 4的范围内的链长，R 5取自残基羟基，甲氧基，乙氧基甲基，乙基，糠基硫代和衍生物，其中抗衡离子取自钠，钾，铵，钙，氯化物，碳酸盐，硫酸盐，磷酸盐等。

39. 发明申请

US20060112128A1 Methods, apparatus, and program products for performing incremental probabilitstic latent semantic analysis 失效
标题翻译：用于执行增量概率潜在语义分析的方法，设备和程序产品
公开(公告)号：US20060112128A1
公开(公告)日：2006-05-25
申请号：US10996873
申请日：2004-11-23
申请人： Thorsten Brants , Ioannis Tsochantaridis , Thomas Hofmann , Francine Chen
发明人： Thorsten Brants , Ioannis Tsochantaridis , Thomas Hofmann , Francine Chen
IPC分类号： G06F17/30
CPC分类号： G06F17/2785 , G06F17/2715 , Y10S707/99935 , Y10S707/99943
摘要： One aspect of the invention is that of efficiently and incrementally adding new terms to an already trained probabilistic latent semantic analysis (PLSA) model.
摘要翻译：本发明的一个方面是对已经训练过的概率潜在语义分析（PLSA）模型进行有效和递增地添加新术语。

40. 发明授权

US06798812B2 Two chamber F2 laser system with F2 pressure based line selection 失效
标题翻译：双室F2激光系统采用F2压力线选择
公开(公告)号：US06798812B2
公开(公告)日：2004-09-28
申请号：US10243102
申请日：2002-09-13
申请人： German E. Rylov , Thomas Hofmann , Richard L. Sandstrom
发明人： German E. Rylov , Thomas Hofmann , Richard L. Sandstrom
IPC分类号： H01S3223
CPC分类号： H01S3/225 , H01S3/03 , H01S3/036 , H01S3/09702 , H01S3/1055 , H01S3/2258 , H01S3/2308
摘要： The present invention provides an injection seeded modular gas discharge laser system capable of producing high quality pulsed laser beams at pulse rates of about 4,000 Hz or greater and at pulse energies of about 5 to 10 mJ or greater for integrated outputs of about 20 to 40 Watts or greater. Two separate discharge chambers are provided, one of which is a part of a master oscillator producing a very narrow band seed beam which is amplified in the second discharge chamber. The parameters chamber can be controlled separately permitting optimization of wavelength parameters in the master oscillator and optimization of pulse energy parameters in the amplifying chamber. A preferred embodiment is a F2 laser system configured as a MOPA and specifically designed for use as a light source for integrated circuit lithography. In this preferred embodiment, both of the chambers and the laser optics are mounted on a vertical optical table within a laser enclosure. In the preferred MOPA embodiment, each chamber comprises a single tangential fan providing sufficient gas flow to permit operation at pulse rates of 4000 Hz or greater by clearing debris from the discharge region in less time than the approximately 0.25 milliseconds between pulses. The master oscillator is operated with a fluorine partial pressure and total gas pressure within specified ranges in order to reduce the intensity of the weak line to less than 0.01% of the strong line. Therefore, the need for line selection optical equipment is avoided.
摘要翻译：本发明提供一种注射接种的模块化气体放电激光系统，其能够以约4,000Hz或更大的脉冲速率产生高质量的脉冲激光束，并且在约20至40瓦特的集成输出的脉冲能量为约5至10mJ或更大的脉冲能量或更大。提供两个单独的放电室，其中之一是主振荡器的一部分，其产生在第二放电室中放大的非常窄的带状晶体束。可以分别控制参数室，允许在主振荡器中优化波长参数并优化放大室中的脉冲能量参数。优选实施例是被配置为MOPA并被专门设计用作集成电路光刻的光源的F2激光系统。在该优选实施例中，腔室和激光光学器件都安装在激光外壳内的垂直光学平台上。在优选的MOPA实施例中，每个腔室包括单个切向风扇，其通过在比脉冲之间的大约0.25毫秒更短的时间内清除来自放电区域的碎屑来提供足够的气流以允许以4000Hz或更高的脉冲速率操作。主振荡器以氟分压和总气体压力在指定范围内运行，以将弱线的强度降低到强线的0.01％以下。因此，避免了线路选择光学设备的需要。

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