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31. 发明授权

US5223295A Process for the elimination of steroid compounds contained in substance of biological origin 失效
标题翻译：消除生物来源物质中所含类固醇化合物的方法
公开(公告)号：US5223295A
公开(公告)日：1993-06-29
申请号：US707959
申请日：1991-05-22
申请人： Jean-Pierre Maffrand , Jean Courregelongue
发明人： Jean-Pierre Maffrand , Jean Courregelongue
IPC分类号： A23C15/14 , A23D9/00 , A23L5/20 , C11B3/00
CPC分类号： C11B3/006 , A23C15/145 , A23D9/00 , A23L5/27
摘要： The present invention relates to a novel process for the elimination of steroid compounds contained in a substance of biological origin by complexing the steroidal compounds by means of a cyclodextrin, in an aqueous medium, under agitation at a temperature between 20.degree. and 80.degree. C. and then separating the complexes so formed.
摘要翻译：本发明涉及通过在水性介质中，在20〜80℃的温度下，通过环糊精与甾类化合物络合来消除生物来源物质中所含类固醇化合物的新方法。然后分离如此形成的复合物。

32. 发明授权

US4977168A Derivatives of the N .alpha.-arylsulphonylaminoacyl-p-amidinophenyl-alaninamides, and their use as medicaments 失效
标题翻译： Nα-芳基磺酰基氨基酰基对脒基苯基 - 丙烯酰胺的衍生物及其作为药物的用途
公开(公告)号：US4977168A
公开(公告)日：1990-12-11
申请号：US6152
申请日：1987-01-23
申请人： Andre Bernat , Denis Delabassee , Daniel Frehel , Jean-Pierre Maffrand , Eric Vallee
发明人： Andre Bernat , Denis Delabassee , Daniel Frehel , Jean-Pierre Maffrand , Eric Vallee
IPC分类号： A61K38/00 , C07C255/30 , C07D295/12 , C07K5/06 , C07K5/062 , C07K5/065
CPC分类号： C07C255/00 , C07K5/06026 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06078 , A61K38/00
摘要： N.alpha.-substituted derivatives of N.alpha.-arylsulphonylaminoacyl p-amidinophenylalaninamides, their preparation, their use as medicaments and intermediates for their synthesis.
摘要翻译： Nα - 芳基磺酰氨基酰基对脒基苯丙氨酰胺的Nα取代衍生物，它们的制备，它们作为药物的用途和用于合成的中间体。

33. 发明授权

US4880573A Process for eliminating cholesterol contained in a fatty substance of animal origin and the fatty substance with reduced cholesterol obtained 失效
标题翻译：用于消除动物来源的脂肪物质中所含的胆固醇和获得的降低的胆固醇的脂肪物质的方法
公开(公告)号：US4880573A
公开(公告)日：1989-11-14
申请号：US73458
申请日：1987-07-15
申请人： Jean Courregelongue , Jean-Pierre Maffrand
发明人： Jean Courregelongue , Jean-Pierre Maffrand
IPC分类号： A23C15/14 , A23L5/20 , C11B3/02
CPC分类号： A23C15/145 , A23L5/27 , C11B3/02
摘要： In a process for eliminating cholesterol from fatty substances of animal origin used in human diet, the liquefied fatty substances is put into contact with a cyclodextrin, this contact is continued under stirring for 30 minutes to 10 hours at a temperature between the fusion temperature of the fatty substance and 80.degree. C. in such a way as to allow the formation of complexes between the cholesterol and the cyclodextrin, after which the complexes are separated by entrainment in water and separation of the aqueous phase.
摘要翻译：在用于消除人类饮食中使用的动物来源的脂肪物质中的胆固醇的过程中，液化脂肪物质与环糊精接触，该接触在搅拌下继续搅拌30分钟至10小时，脂肪物质和80℃，以使得胆固醇和环糊精之间形成络合物，然后通过夹带在水中并分离水相将络合物分离。

34. 发明授权

US4791102A Derivatives of the N .alpha.-arylsulphonylaminoacyl-p-amidinophenylalaninamides, their preparation process, their use as medicaments and the pharmaceutical compositions containing them 失效
标题翻译： Nα-芳基磺酰基氨基酰基对脒基苯丙氨酰胺的衍生物，其制备方法，它们作为药物的用途以及含有它们的药物组合物
公开(公告)号：US4791102A
公开(公告)日：1988-12-13
申请号：US6421
申请日：1987-01-23
申请人： Andre Bernat , Denis Delebassee , Daniel Frehel , Jean-Pierre Maffrand , Eric Vallee
发明人： Andre Bernat , Denis Delebassee , Daniel Frehel , Jean-Pierre Maffrand , Eric Vallee
IPC分类号： A61K38/00 , C07C311/15 , C07D295/12 , C07K5/06 , C07K5/062 , C07K5/065 , A61K37/02 , C07C143/78 , C07D207/00 , C07D211/06 , C07D241/04 , C07D265/30 , C07D279/10
CPC分类号： C07C255/00 , C07K5/06026 , C07K5/06069 , C07K5/06078 , A61K38/00
摘要： The present invention is concerned with compounds with the formula: ##STR1## in which: R.sub.1 represents a lower alkyl, a lower hydroxy alkyl or a benzyl group, a phenyl group or a 4-hydroxy phenyl group:R.sub.2 and R.sub.3, identical or different, each represents a lower alkyl or hydroxyalkyl, lower alkenyl, or lower alkynyl radical, or together with the nitrogen to which they are attached, they form a saturated heterocycle such as morpholino, thiomorpholino, pyrrolidino unsubstituted or substituted by an alkoxycarbonyl or carboxyl group, piperazino, 4-(lower alkyl)-piperazino, 4-(lower hydroxyalkyl)-piperazino, or piperidino unsubstituted or substituted by a lower alkyl, benzyl, hydroxy, lower hydroxyalkyl, amino, lower aminoalkyl, alkoxycarbonyl or carboxyl group,Ar represents a phenyl, an alpha-naphthyl or a possibly substituted beta-naphthyl group, or a possibly substituted heteroaryl group chosen from pyridyl, quinolinyl, and isoquinolinyl, as well as their stereoisomers and their mixtures and their salts with pharmaceutically acceptable mineral or organic acids.The invention is also concerned with a preparation process for the products with the formula (I), their use as medicaments and the intermediates for their synthesis.
摘要翻译：本发明涉及具有下式的化合物：其中：R1表示低级烷基，低级羟基烷基或苄基，苯基或4-羟基苯基：R2和R3，相同或不同，各自表示低级烷基或羟基烷基，低级烯基或低级炔基，或与它们连接的氮一起形成饱和杂环，例如吗啉代，硫代吗啉代，未取代的或被烷氧基羰基取代的吡咯烷子基或羧基，哌嗪基，4-（低级烷基） - 哌嗪基，4-（低级羟烷基） - 哌嗪基或未被取代的或被低级烷基，苄基，羟基，低级羟烷基，氨基，低级氨基烷基，烷氧基羰基或羧基取代的哌啶子基， Ar表示苯基，α-萘基或可能取代的β-萘基，或可能取代的选自吡啶基，喹啉基和异喹啉基的杂芳基，以及它们的立体异构体及其混合物 s及其与药学上可接受的矿物或有机酸的盐。本发明还涉及具有式（I）的产物的制备方法，它们作为药物的用途及其合成中间体。

35. 发明授权

US4172134A Benzo [B]thienopyridines, process for their preparation and therapeutic compositions containing same 失效
标题翻译：苯并{8 B {9噻吩并吡啶，其制备方法和含有它们的治疗组合物
公开(公告)号：US4172134A
公开(公告)日：1979-10-23
申请号：US908856
申请日：1978-05-23
申请人： Daniel Frehel , Jean-Pierre Maffrand
发明人： Daniel Frehel , Jean-Pierre Maffrand
IPC分类号： A61K31/435 , A61K31/44 , A61P7/02 , A61P25/20 , C07D333/58 , C07D495/04 , C07D521/00
CPC分类号： C07D495/04 , C07D333/58
摘要： This invention relates to compounds having the formula: ##STR1## in which: R.sup.1 represents hydrogen or a lower alkyl group; an aralkyl group optionally substituted on the aromatic nucleus with at least a halogen atom or a hydroxy, nitro, amino, cyano, carboxy, carboxamido, alkoxycarbonyl, lower alkyl, lower alkoxy or trifluoromethyl group; a nicotinyl group; an isonicotinyl group; a picolyl group; a furfuryl group; a 5-methyl-furfuryl group; a 2- or 3-thenyl group; a 5-methyl-2- or 3-thenyl group; or a 5-chloro-2-thenyl group;R.sup.2 represents hydrogen or a lower alkyl radical; andR.sup.3 and R.sup.4 represent each hydrogen, a halogen atom or a hydroxy, lower alkyl or lower alkoxy group,And their addition salts with inorganic or organic acids.Said new compounds have typically a therapeutically useful sedative and blood-platelet aggregation inhibiting activity.
摘要翻译：本发明涉及具有下式的化合物：其中：

36. 发明授权

US4076819A Thieno-pyridine derivatives and therapeutic composition containing same 失效
标题翻译：噻吩并吡啶衍生物和含有它们的治疗组合物
公开(公告)号：US4076819A
公开(公告)日：1978-02-28
申请号：US676796
申请日：1976-04-14
申请人： Jean-Pierre Maffrand
发明人： Jean-Pierre Maffrand
IPC分类号： A61K31/4365 , C07D213/70 , C07D495/04 , A61K31/44 , C07D407/04
CPC分类号： C07D495/04
摘要： This invention relates to thieno-pyridine derivatives having the formula: ##STR1## in which R.sub.1 is hydrogen or alkyl having 1-6 carbon atoms; R.sub.2 is hydrogen or acetyl or lower alkylcarbamoyl and R.sub.3 is methyl, nitrobenzyl, chlorobenzyl, methoxybenzyl, chlorobenzoyl, trimethoxybenzoyl, pyrrolidinoacetyl, p.toluene-sulfonyl, phenylcarbamoyl, phenylthiocarbamoyl, 3-oxo-butyl, lower alkyl-carbamoyloxy, phenethyl, dichloroacetyl, 2-chlorophenoxy-2-methyl-propionyl or chlorophenyl-carbamoyl, and their pharmaceutically acceptable acid addition salts.Said derivatives have useful anti-inflammatory properties and inhibiting effects on blood plate aggregation which make them therapeutically valuable.
摘要翻译：本发明涉及具有下式的噻吩并吡啶衍生物：其中R1是氢或具有1-6个碳原子的烷基; R2是氢或乙酰基或低级烷基氨基甲酰基，R3是甲基，硝基苄基，氯苄基，甲氧基苄基，氯苯甲酰基，三甲氧基苯甲酰基，吡咯烷子基乙酰基，对甲苯磺酰基，苯基氨基甲酰基，苯基硫代氨基甲酰基，3-氧代 - 丁基，低级烷基 - 氨基甲酰氧基，苯乙基，二氯乙酰基， 2-氯苯氧基-2-甲基 - 丙酰基或氯苯基 - 氨基甲酰基及其药学上可接受的酸加成盐。

37. 发明授权

US4065460A 4,5,6,7-Tetrahydro-thieno[3,2-c]-pyridine derivatives and process for their preparation 失效
标题翻译： 4,5,6,7-四氢噻吩并[8 3,2-c {9-吡啶衍生物及其制备方法
公开(公告)号：US4065460A
公开(公告)日：1977-12-27
申请号：US674734
申请日：1976-04-06
申请人： Alain Heymes , Jean-Pierre Maffrand
发明人： Alain Heymes , Jean-Pierre Maffrand
IPC分类号： A61K31/435 , A61P25/04 , A61P29/00 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04
摘要： This invention relates to 4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine derivatives, having the formula: ##STR1## in which R.sub.1 is hydrogen or alkyl having 1-6 carbon atoms; R.sub.2 is hydrogen, an alkyl group having 1-6 carbon atoms or a phenyl or benzyl radical; R.sub.3 represents an alkyl group having 1-6 carbon atoms or a benzyl radical, and their pharmaceutically acceptable acid addition salts.Said derivatives have an anti-inflammatory and antalgic activity.
摘要翻译：本发明涉及具有下式的4,5,6,7-四氢 - 噻吩并[3,2-c] - 吡啶衍生物：其中R 1是氢或具有1-6个碳原子的烷基; R2是氢，具有1-6个碳原子的烷基或苯基或苄基; R3表示具有1-6个碳原子的烷基或苄基，以及它们的药学上可接受的酸加成盐。

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