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    • 31. 发明授权
    • Cyclic adenosine monophosphate 8-substituted derivatives
    • 环磷酸腺苷8-取代衍生物
    • US4048307A
    • 1977-09-13
    • US616356
    • 1975-09-24
    • Takeshi YokotaNobuyuki SuzukiTsuneo SowaYasuharu SasakiYasutaka Ono
    • Takeshi YokotaNobuyuki SuzukiTsuneo SowaYasuharu SasakiYasutaka Ono
    • C07H19/20A61K31/70
    • C07H19/20
    • Novel cyclic adenosine monophosphate derivatives represented by the following general formula: ##STR1## wherein A stands for --S-- or --NH-- and n is an integer of from 2 to 12, ARE SUPERIOR TO KNOWN CYCLIC ADENOSIENE DERIVATIVES IN BIOLOGICAL AND PHARMACOLOGICAL ACTIVITIES, ESPECIALLY PDE-inhibiting activity and membrane permeability. Accordingly, these derivatives are very effective for remedying and controlling diseases caused by disorder of the intracellular cyclic adenosine monophosphate level, such as asthma and scabies. These derivaives can readily be synthesized by reacting an 8-halogeno cyclic adenosine monophosphate of the following general formula ##STR2## wherein X is a halogen atom such as bromine, with an alkali metal salt of a linear alkylmercaptan having 3 to 13 carbon atoms in the alkyl group or a linear alkylamine having 3 to 13 carbon atoms in the alkyl group.
    • 由以下通式表示的新型环状腺苷一磷酸酯衍生物:其中A代表-S-或-NH-,n是2至12的整数,ARE高于生物和药理学活动中已知的循环腺嘌呤衍生物, 特别是PDE抑制活性和膜通透性。 因此,这些衍生物对于补救和控制由细胞内环腺苷酸单磷酸酯水平紊乱引起的疾病,如哮喘和sc疮非常有效。 这些衍生物可以容易地通过使下列通式为“IMAGE”的8-卤代环腺苷单磷酸酯与其中X为卤素原子如溴的碳原子数为3〜13的直链烷基硫醇的碱金属盐反应 烷基或烷基中具有3至13个碳原子的直链烷基胺。
    • 37. 发明申请
    • Project pre-review estimate method
    • 项目预评估估计方法
    • US20050010459A1
    • 2005-01-13
    • US10885036
    • 2004-07-07
    • Kaoru KawabataTakeshi YokotaShigeru Sato
    • Kaoru KawabataTakeshi YokotaShigeru Sato
    • G06Q10/00G06Q10/06G06Q50/00G06F17/60
    • G06Q10/06G06Q10/063G06Q10/0637
    • A project pre-review estimate method capable of estimating influence of alteration in each process of a project on the whole process (project) considering structural alteration and fluctuating values regarding each process and their factors is provided. The project pre-review estimate method is carried out employing a process evaluation procedure which calculates quantitative and structural alteration amounts of the process plan using not only information on constraints (which has been used by conventional techniques) but also scenario information (in which probability of occurrence of a risk (i.e. a factor of alteration to a process) and the content/degree of influence regarding alteration of arbitrary processes caused by the occurrence of the risk are defined in a scenario format) and information for correcting parameters of the scenario by use of qualitative information on the project.
    • 提供了一种考虑到每个过程及其因素的结构变化和波动值的项目预评估估计方法,其能够估计项目每个过程中的变更对整个过程(项目)的影响。 使用过程评估程序进行项目预评估估计方法,该过程评估程序不仅使用关于约束的信息(已经由常规技术使用)来计算过程计划的定量和结构变化量,而且还使用情景信息(其中概率 风险发生的风险(即过程变更的因素)以及由风险发生引起的任意过程变更的影响的内容/程度在场景格式中定义)以及用于通过使用来修正场景参数的信息 关于项目的定性信息。