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31. 发明授权

US08394790B2 Psychotropic agents having glutamate NMDA activity 有权
标题翻译：具有谷氨酸NMDA活性的精神药物
公开(公告)号：US08394790B2
公开(公告)日：2013-03-12
申请号：US12447381
申请日：2007-10-25
申请人： Moshe Portnoy , Irit Gil-Ad , Avraham Weizman
发明人： Moshe Portnoy , Irit Gil-Ad , Avraham Weizman
IPC分类号： A61P25/18 , A61K31/554 , A61K31/55 , C07D495/00 , C07D281/02
CPC分类号： C07D495/04 , A61K31/551 , A61K47/542 , A61K47/55 , C07D403/04
摘要： The invention provides novel compounds and pharmaceutical compositions for the treatment of psychological and/or psychiatric diseases or disorders.
摘要翻译：本发明提供用于治疗心理和/或精神疾病或病症的新型化合物和药物组合物。

32. 发明申请

US20100279990A1 ANTIPROLIFERATIVE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：抗生素化合物，组合物和使用方法
公开(公告)号：US20100279990A1
公开(公告)日：2010-11-04
申请号：US12308299
申请日：2007-06-08
申请人： Irit Gil-Ad , Moshe Portnoy , Avraham Weizman , Liat Lomnitski
发明人： Irit Gil-Ad , Moshe Portnoy , Avraham Weizman , Liat Lomnitski
IPC分类号： A61K31/56 , C07C215/42 , A61K31/137 , A61P35/00 , A61P17/00 , A61P17/06 , A61P35/02 , A61P19/02 , A61P29/00 , C07D405/12 , A61K31/4525
CPC分类号： C07C211/42 , C07C2602/10 , C07D405/12
摘要： The present invention provides a compound of the formula A-L-B (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein A is a psychotropic derivative; L is a linking group comprising two carbon atoms; and B is an alkyl, alkenyl, alkynyl or aralkyl comprising at least one substituent of the formula Q, wherein: the alkyl, alkenyl, alkynyl or aralkyl is optionally substituted with one or more halogens, hydroxyl, cyano, nitro, amino or thiol; and Q is OR6, OC(O)R6, C(O)R6 C(S)R6, CO2R6, C(O)SR6, C(O)NR6R7, C(S)NR6R7, NR6R7, NR6C(O)R7, NR6C(S)R7, NR6C(O)NR7R8, NR6C(S)NR7R8, NR6SO2R7, NR6SO2NR7R8, SR6, SC(O)R6, SC(O)NR6R7, S(O)R6, SO2R6, SO2NR6R7, or NR6SO2R7R8. Also provided is a pharmaceutical composition that includes one or more compounds of the present invention, and methods of therapeutically using and processes for producing such compounds and compositions.
摘要翻译：本发明提供式A-L-B（I）化合物或其药学上可接受的盐，酯或前药，其中A是精神药物衍生物; L是包含两个碳原子的连接基团; 并且B是包含至少一个式Q取代基的烷基，烯基，炔基或芳烷基，其中：烷基，烯基，炔基或芳烷基任选被一个或多个卤素，羟基，氰基，硝基，氨基或硫醇取代; 并且Q是OR 6，OC（O）R 6，C（O）R 6 C（S）R 6，CO 2 R 6，C（O）SR 6，C（O）NR 6 R 7，C（S）NR 6 R 7，NR 6 R 7，NR 6 C（O） NR 6 C（O）NR 6 R 7，NR 6 C（O）NR 7 R 8，NR 6 C（S）NR 7 R 8，NR 6 SO 2 R 7，NR 6 SO 2 NR 7 R 8，SR 6，SC（O）R 6，SC（O）NR 6 R 7，S（O）R 6，SO 2 R 6，SO 2 NR 6 R 7或NR 6 SO 2 R 7 R 8。还提供了包含一种或多种本发明化合物的药物组合物，以及治疗用途的方法和制备这些化合物和组合物的方法。

33. 发明申请

US20100130549A1 PSYCHOTROPIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：心理化合物，组合物和使用方法
公开(公告)号：US20100130549A1
公开(公告)日：2010-05-27
申请号：US12522637
申请日：2008-01-10
申请人： Irit Gil-Ad , Moshe Portnoy , Avraham Weizman , Liat Lomnitski
发明人： Irit Gil-Ad , Moshe Portnoy , Avraham Weizman , Liat Lomnitski
IPC分类号： A61K31/4525 , A61K31/135 , A61P25/00 , A61P35/00
CPC分类号： A61K31/135 , A61K31/14 , A61K31/4525
摘要： The present invention provides a method for treating or preventing a disease or disorder treatable by the inhibition of serotonin reuptake in a patient, and/or norepinephrine reuptake and/or dopamine reuptake in a patient, the method comprising administering to the patient a neurotransmitter reuptake inhibiting-effective amount of at least one compound of the formula A-L-B (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein A is a psychotropic derivative; L is a linking group comprising two carbon atoms; and B is an alkyl, alkenyl, alkynyl or aralkyl comprising at least one substituent of the formula Q, wherein: the alkyl, alkenyl, alkynyl or aralkyl is optionally substituted with one or more halogean halogens, hydroxyl, cyano, nitro, amino or thiol; and Q is OR6, OC(O)R6, C(O)R6, C(S)R6, CO2R6, C(O)SR6, C(O)NR6R7, C(S)NR6R7, NR6R7, NR6C(O)R7, NR6C(S)R7, NR6C(O)NR7R8, NR6C(S)NR7R8, NR6SO2R7, NR6SO2NR7R8, SR6, SC(O)R6, SC(O)NR6R7, S(O)R6, SO2R6, SO2NR6R7, or NR6SO2NR7R8.
摘要翻译：本发明提供了一种治疗或预防通过抑制患者血清素再摄取和/或去甲肾上腺素再摄取和/或患者多巴胺再摄取而可治疗的疾病或病症的方法，所述方法包括向患者施用神经递质再摄取抑制 - 有效量的至少一种式ALB（I）化合物或其药学上可接受的盐，酯或前药，其中A是精神药物衍生物; L是包含两个碳原子的连接基团; 并且B是包含至少一个式Q取代基的烷基，烯基，炔基或芳烷基，其中：烷基，链烯基，炔基或芳烷基任选被一个或多个卤代卤素，羟基，氰基，硝基，氨基或硫醇取代 ; （O）R 6，C（O）R 6，C（O）SR 6，C（O）NR 6 R 7，C（S）NR 6 R 7，NR 6 R 7，NR 6 C（O）R 7 ，NR6C（S）R7，NR6C（O）NR7R8，NR6C（S）NR7R8，NR6SO2R7，NR6SO2NR7R8，SR6，SC（O）R6，SC（O）NR6R7，S（O）R6，SO2R6，SO2NR6R7或NR6SO2NR7R8。

34. 发明申请

US20080318931A1 Treatment of Disorders and Diseases of the Colon 审中-公开
标题翻译：治疗疾病和结肠疾病
公开(公告)号：US20080318931A1
公开(公告)日：2008-12-25
申请号：US11631641
申请日：2005-07-06
申请人： Moshe Arkin , Irit Gil-Ad , Avraham Weizman , Liat Lomnitski , Eilon Asculai , Amira Zeevi
发明人： Moshe Arkin , Irit Gil-Ad , Avraham Weizman , Liat Lomnitski , Eilon Asculai , Amira Zeevi
IPC分类号： A61K31/55 , A61K31/137 , A61K31/135 , A61K31/343 , A61P1/06 , A61K31/138 , A61K31/4525 , A61K31/381
CPC分类号： A61K31/343 , A61K31/135 , A61K31/15 , A61K31/192 , A61K31/335 , A61K31/381 , A61K31/4525 , A61K31/55 , Y02A50/491
摘要： A method and a composition for the treatment of an Inflammatory Bowel Disease (IBD) or intestine polyposes is described. The method includes the local administration to the colon of a therapeutically effective amount of at least one Selective Serotonin Reuptake Inhibitor (SSRI) or at least one tricyclic antidepressant (TCA).
摘要翻译：描述了用于治疗炎性肠病（IBD）或肠息肉的方法和组合物。该方法包括向结肠局部施用治疗有效量的至少一种选择性5-羟色胺再摄取抑制剂（SSRI）或至少一种三环抗抑郁药（TCA）。

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