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31. 发明授权

US09700201B2 Rapid measurement of visual sensitivity 有权
公开(公告)号：US09700201B2
公开(公告)日：2017-07-11
申请号：US14399136
申请日：2013-05-09
申请人： The Schepens Eye Research Institute, Inc. , The Ohio State University
发明人： Peter Bex , Michael Dorr , Luis Lesmes , Zhong-Lin Lu
IPC分类号： A61B3/02 , A61B3/06 , A61B3/00 , A61B3/032
CPC分类号： A61B3/022 , A61B3/0025 , A61B3/032 , A61B3/06
摘要： Data is received characterizing a result of a first visual sensitivity test assessing capacity to detect spatial form across one or more different target sizes, and different contrasts. Using the received data, one or more first parameters defining a first estimated visual sensitivity for a first range of contrasts and a second range of spatial frequencies is determined. One or more second parameters defining a second estimated visual sensitivity for a third range of contrasts and a fourth range of spatial frequencies is determined using the one or more first parameters and a statistical inference by at least presenting a first visual stimulus, receiving a response, and determining a second visual stimulus based at least on the response and at least a rule. The one or more second parameters is provided. Related apparatus, systems, techniques and articles are also described.

32. 发明申请

US20150150444A1 RAPID MEASUREMENT OF VISUAL SENSITIVITY 有权
标题翻译：快速测量视觉灵敏度
公开(公告)号：US20150150444A1
公开(公告)日：2015-06-04
申请号：US14399136
申请日：2013-05-09
申请人： The Schepens Eye Research Institute, Inc. , The Ohio State University
发明人： Peter Bex , Michael Dorr , Luis Lesmes , Zhong-Lin Lu
IPC分类号： A61B3/02 , A61B3/00
CPC分类号： A61B3/022 , A61B3/0025 , A61B3/032 , A61B3/06
摘要： Data is received characterizing a result of a first visual sensitivity test assessing capacity to detect spatial form across one or more different target sizes, and different contrasts. Using the received data, one or more first parameters defining a first estimated visual sensitivity for a first range of contrasts and a second range of spatial frequencies is determined. One or more second parameters defining a second estimated visual sensitivity for a third range of contrasts and a fourth range of spatial frequencies is determined using the one or more first parameters and a statistical inference by at least presenting a first visual stimulus, receiving a response, and determining a second visual stimulus based at least on the response and at least a rule. The one or more second parameters is provided. Related apparatus, systems, techniques and articles are also described.
摘要翻译：接收数据，其表征第一视觉敏感度测试的结果，评估能力以检测跨越一个或多个不同目标大小的空间形式，以及不同的对比度。使用所接收的数据，确定定义第一对比范围的第一估计视觉灵敏度和空间频率的第二范围的一个或多个第一参数。使用所述一个或多个第一参数和统计推断来确定对于第三范围的对比度和第四范围的空间频率定义第二估计视觉灵敏度的一个或多个第二参数，至少呈现第一视觉刺激，接收响应，以及至少基于所述响应和至少一个规则来确定第二视觉刺激。提供一个或多个第二参数。还描述了相关设备，系统，技术和物品。

33. 发明申请

US20140296159A1 Method for Therapeutic Replenishment and Enrichment of Ocular Surface Lubrication 有权
标题翻译：治疗补充和丰富眼表润滑的方法
公开(公告)号：US20140296159A1
公开(公告)日：2014-10-02
申请号：US14272634
申请日：2014-05-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SCHEPENS EYE RESEARCH INSTITUTE
发明人： Benjamin Sullivan , Tannin A. Schmidt , David A. Sullivan
IPC分类号： A61K38/17 , A61K45/06 , A61K31/728
CPC分类号： A61K38/14 , A61K9/0048 , A61K9/0051 , A61K31/568 , A61K31/685 , A61K31/688 , A61K31/715 , A61K31/728 , A61K38/13 , A61K38/17 , A61K38/1709 , A61K38/1841 , A61K45/06 , A61K47/02 , A61K47/24 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface. The pharmaceutical composition of the present invention comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The pharmaceutical composition of the present invention may also comprise one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent, excipient, astringent, vasoconstrictor, emollient, sodium hyaluronate, hyaluronic acid, and surface active phospholipids, in a pharmaceutically acceptable carrier for topical administration.
摘要翻译：本发明提供了一种药物组合物及其使用方法，用于治疗眼部边界不足，与之相关的症状，或与眼表面相关或导致眼部边界缺陷的不期望状况。本发明的药物组合物包含悬浮在眼科可接受的平衡盐溶液中的人PRG4蛋白，润滑剂片段，同系物或同种型。本发明的药物组合物还可以包含一种或多种选自以下的眼科学上可接受的试剂：药学上可接受的药物，所述药剂选自眼科可接受的抑制剂，赋形剂，收敛剂，血管收缩剂，润肤剂，透明质酸钠，透明质酸和表面活性磷脂载体用于局部给药。

34. 发明授权

US11987801B2 Altering tissue tropism of adeno-associated viruses 有权
公开(公告)号：US11987801B2
公开(公告)日：2024-05-21
申请号：US17053412
申请日：2019-05-10
申请人： Massachusetts Eye and Ear Infirmary , The Schepens Eye Research Institute, Inc.
发明人： Luk H. Vandenberghe , Pauline Schmit , Christopher Tipper , Carmen Unzu , Eric Zinn
IPC分类号： C12N15/86 , C07K14/005 , C12N15/10
CPC分类号： C12N15/86 , C07K14/005 , C12N15/102 , C12N2750/14143
摘要： This disclosure provides compositions and methods for altering or changing the tissue tropism, e.g., liver tropism, of adeno-associated viruses (AAV).

35. 发明公开

US20240108608A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CORNEAL ENDOTHELIUM DISORDERS 审中-公开
公开(公告)号：US20240108608A1
公开(公告)日：2024-04-04
申请号：US18267905
申请日：2021-12-22
申请人： The Schepens Eye Research Institute, Inc.
发明人： Ula Jurkunas
IPC分类号： A61K31/4375 , A61K9/00 , A61K31/09 , A61K31/352 , A61K45/00 , A61P27/02
CPC分类号： A61K31/4375 , A61K9/0048 , A61K31/09 , A61K31/352 , A61K45/00 , A61P27/02
摘要： This application discloses methods and pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD).

36. 发明公开

US20240025986A1 THERAPY FOR GLAUCOMA AND OPTIC NEUROPATHY BY TARGETING COLONY STIMULATING FACTORS 审中-公开
公开(公告)号：US20240025986A1
公开(公告)日：2024-01-25
申请号：US18318336
申请日：2023-05-16
申请人： The Schepens Eye Research Institute, Inc.
发明人： Dong Feng Chen , Ji Min , Kin-Sang Cho
IPC分类号： C07K16/24 , A61K9/00 , A61K38/19 , C07K16/28
CPC分类号： C07K16/243 , A61K9/0048 , A61K38/193 , C07K16/2866 , A61K45/06
摘要： The invention provides compositions and methods for treating optic neuropathic disorders.

37. 发明公开

US20230277454A1 NANO-EMULSION OF CBFß-RUNX1 INHIBITOR FOR OCULAR DRUG DELIVER 审中-公开
公开(公告)号：US20230277454A1
公开(公告)日：2023-09-07
申请号：US18163041
申请日：2023-02-01
申请人： The Schepens Eye Research Institute, Inc.
发明人： Leo A. Kim , Joseph F. Arboleda-Velasquez
IPC分类号： A61K9/107 , A61K31/5513 , A61K47/10 , A61K47/14 , A61K47/24
CPC分类号： A61K9/1075 , A61K31/5513 , A61K47/10 , A61K47/14 , A61K47/24 , A61K9/0048
摘要： The invention provides ocular formulations and features a nano-emulsion composition, e.g., a nano-emulsion comprising a CBFβ-RUNX1 inhibitor. The composition comprises a particle with a length of less than 200 nanometers in at least one dimension.

38. 发明公开

US20230242940A1 METHODS OF MAKING AND USING A VACCINE AGAINST CORONAVIRUS 审中-公开
公开(公告)号：US20230242940A1
公开(公告)日：2023-08-03
申请号：US17918878
申请日：2021-04-13
申请人： Massachusetts Eye and Ear Infirmary , The Schepens Eye Research Institute, Inc.
发明人： Luc H. Vandenberghe , Urja Achal Bhatt , Nerea Zabaleta Lasarte , Wenlong Dai
IPC分类号： C12N15/86 , A61K39/215 , A61P31/14
CPC分类号： C12N15/86 , A61K39/215 , A61P31/14 , A61K2039/54 , C12N2750/14143 , C12N2750/14171
摘要： Provided herein are vaccines against coronavirus that utilize adeno-associated virus (AAV) for delivery.

39. 发明授权

US11692029B2 Therapy for glaucoma and optic neuropathy by targeting colony stimulating factors 有权
公开(公告)号：US11692029B2
公开(公告)日：2023-07-04
申请号：US16977783
申请日：2019-03-05
申请人： The Schepens Eye Research Institute, Inc.
发明人： Ji Min , Kin-Sang Cho , Dong Feng Chen
IPC分类号： A61K39/395 , C07K16/24 , A61K9/00 , A61K38/19 , C07K16/28 , A61K45/06
CPC分类号： C07K16/243 , A61K9/0048 , A61K38/193 , C07K16/2866 , A61K39/395 , A61K45/06
摘要： The invention provides compositions and methods for treating optic neuropathic disorders.

40. 发明申请

US20230072025A1 Stimulation of Human Meibomian Gland Function 有权
公开(公告)号：US20230072025A1
公开(公告)日：2023-03-09
申请号：US17902533
申请日：2022-09-02
申请人： The Schepens Eye Research Institute, Inc.
发明人： David A. Sullivan , Juan Ding , Yang Liu , Wendy Kam
IPC分类号： A61K38/30 , A61K31/5685 , A61K31/7052 , A61K38/28 , A61K38/27 , A61K47/36 , A61K31/573 , A61K45/06 , A61K31/568 , A61K9/00 , A61K31/57
摘要： Disclosed herein are systems and methods for stimulating meibomian gland epithelial cell function by administering to the ocular surface or immediate vicinity of an eye of a subject an effective amount of a pharmaceutical composition containing a PLD-inducing compound, such as the cationic amphiphilic drugs (e.g. azithromycin), androgen or an androgen analogue with androgen effectiveness, corticosteroid, progesterone, IGF-1 or an IGF-1 analogue (e.g. insulin), GH, and mixtures thereof. The pharmaceutical compositions are effective to treat a variety of aliments to the eye including meibomian gland dysfunction, evaporative dry eye disease, lipid abnormalities in meibum or the tear film, and autoimmune diseases such as Sjögren's syndrome.

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