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    • 32. 发明授权
    • Complex-forming proteins
    • 复合物形成蛋白
    • US06495346B1
    • 2002-12-17
    • US09481593
    • 2000-01-12
    • Valerie JeromeHans-Harald SedlacekRolf Müller
    • Valerie JeromeHans-Harald SedlacekRolf Müller
    • C12N1562
    • C07K7/08A61K38/00C07K14/82C07K2319/00C07K2319/09C07K2319/50C07K2319/71C07K2319/73C07K2319/81C12N15/1055C12N15/62
    • The invention relates to a complex of specifically complex-forming proteins which are not naturally occurring, comprising the following components: a) at least one ligand specific for a target structure, b) at least one protein comprising a mutated dimerization domain, the mutated dimerization domain having been derived by mutation of a naturally occurring dimerization domain, it being possible for this mutated dimerization domain to interact specifically with component c) and the component b) being connected covalently to the component a), c) at least one protein comprising a mutated dimerization domain, the mutated dimerization domain having been derived by mutation of a naturally occurring dimerization domain, it being possible for this mutated dimerization domain to interact specifically with component b) and the component c) is linked covalently to the component d), and d) at least one effector. In addition, the invention relates to the use and preparation of these complexes, and to nucleic acid constructs coding for the proteins mentioned and use thereof.
    • 本发明涉及不是天然存在的特异性复合物形成蛋白质的复合物,其包含以下组分:a)至少一种对靶结构特异的配体,b)至少一种包含突变二聚化结构域的蛋白质,所述突变的二聚化 已经通过天然存在的二聚化结构域的突变产生的结构域,该突变的二聚化结构域可能与组分c)特异性相互作用,并且组分b)与组分a)共价连接,c)至少一种蛋白质,其包含 突变的二聚化结构域,突变的二聚化结构域是通过天然存在的二聚化结构域的突变产生的,该突变的二聚化结构域可能与组分b)特异性相互作用,并且组分c)与组分d)共价连接, d)至少一个效应器。 此外,本发明涉及这些复合物的使用和制备,以及编码所述蛋白质的核酸构建体及其用途。
    • 37. 发明申请
    • Encapsulation system
    • 封装系统
    • US20060222766A1
    • 2006-10-05
    • US10553402
    • 2004-04-16
    • Rolf MüllerFederico Innerebner
    • Rolf MüllerFederico Innerebner
    • B01J13/02
    • B01J13/06A01N25/26A01N25/28A23P10/30A61K9/5036A61K47/36B01J13/02
    • An encapsulating systems of particles consisting of a matrix or an envelope and a phase enclosed therein. The envelope can be obtained from very low-viscous, highly concentrated solutions and melted masses having a variable crystalline part and a variable network density. The encapsulation system is suitable for the encapsualation of moderately to low viscous liquids, especially hydrophobic active ingredients such as fragrances, aromatics and pharmaceutical active ingredients. The system enables the range of method parameters to be significantly increased compared to previous encapsulation systems improves the stability of the envelopes of the encapsulation systems, and enables the release characteristics to be influenced in a targeted manner.
    • 由矩阵或封套组成的颗粒的封装系统和封闭在其中的相。 包膜可以从非常低粘度,高度浓缩的溶液和具有可变结晶部分和可变网络密度的熔融物质获得。 该封装系统适用于中等至低粘度液体的密封,特别是疏水活性成分如香料,芳香剂和药物活性成分。 与以前的封装系统相比,该系统能够显着提高方法参数的范围,从而提高了封装系统的封套的稳定性,并且使得释放特性能够以有针对性的方式受到影响。
    • 39. 发明授权
    • Method for the hydroformylation of olefins comprising 2 to 8 carbons atoms
    • 包含2至8个碳原子的烯烃加氢甲酰化的方法
    • US06822122B2
    • 2004-11-23
    • US10311371
    • 2002-12-16
    • Wolfgang RichterRoland KrokoszinskiRolf MüllerMichael McAtee
    • Wolfgang RichterRoland KrokoszinskiRolf MüllerMichael McAtee
    • C07C4529
    • C07C45/50C07C47/02
    • Disclosed is a method for the hydroformylation of olefins comprising 2 to 8 atoms, whereby a) an inflow containing olefins and a gas mixture containing hydrogen and carbon monoxide are fed into a reaction zone and reacted in the presence of a hydroformylation catalyst, b) the reaction product which is released from the raw hydroformylation product is redirected into the reaction zone during the extraction of a gaseous recovery flow. The inventive method is characterised in that c) the recovery flow is brought into intimate contact with a wash liquid in order to eliminate the unreacted olefins contained therein, the wash liquid being a vented hydroformylation product, and the olefin-charged wash liquid and the raw hydroformylation product are redirected for regeneration. Said inventive method enables unreacted olefins to be reclaimed to a large extent from the recovery flow.
    • 公开了包含2至8个原子的烯烃加氢甲酰化的方法,其中a)含有烯烃和含有氢气和一氧化碳的气体混合物的流入物被加入到反应区中并在加氢甲酰化催化剂存在下反应,b) 在原料加氢甲酰化产物中释放的反应产物在萃取气体回收流程期间被重定向到反应区。 本发明的方法的特征在于:c)使回收流与洗涤液体紧密接触,以便除去其中所含的未反应的烯烃,洗涤液体是排出的加氢甲酰化产物,以及带烯烃的洗涤液体和原料 重新定向加氢甲酰化产物用于再生。 所述本发明的方法使未反应的烯烃在很大程度上从回收流程中回收。