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31. 发明授权

US3701140A Purse theft alarm 失效
标题翻译：操作报警
公开(公告)号：US3701140A
公开(公告)日：1972-10-24
申请号：US3701140D
申请日：1971-03-05
申请人： RICHARD W DIXON
发明人： DIXON RICHARD W
IPC分类号： A45C13/24 , G08B21/02 , G08B21/00
CPC分类号： A45C13/24 , G08B21/0297
摘要： An audible alarm constituting a part of a lady''s purse and so consttucted that a sudden pull or jerking force exerted on the purse handle will cause the alarm to be actuated. The alarm unit is so constructed that it will continue to operate until a part of the unit is dismantled to effect a deactivation of the alarm.
摘要翻译：构成女士钱包的一部分的声音报警器，如此突出地施加在钱包手柄上的拉力或拉力会导致报警器被致动。报警单元的结构使其能够继续运行，直到设备的一部分被拆除以使报警器失效。

32. 发明申请

US20140100359A1 Dual Variable Domain Immunoglobulin and Uses Thereof 审中-公开
公开(公告)号：US20140100359A1
公开(公告)日：2014-04-10
申请号：US14023336
申请日：2013-09-10
申请人： Chengbin WU , Tariq GHAYUR , Richard W. DIXON , Jochen G. SALFELD
发明人： Chengbin WU , Tariq GHAYUR , Richard W. DIXON , Jochen G. SALFELD
IPC分类号： C07K16/28 , C07K16/22 , C07K16/24
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

33. 发明申请

US20110165066A1 INTERLEUKIN-13 BINDING PROTEINS 有权
标题翻译： INTERLEUKIN-13结合蛋白
公开(公告)号：US20110165066A1
公开(公告)日：2011-07-07
申请号：US13043293
申请日：2011-03-08
申请人： Chengbin Wu , Richard W. Dixon , Jonathan P. Belk , Maria A. Argiriadi , Hua Ying , Carolyn A. Cuff , Terry L. Melim , Shankar Kumar , Paul R. Hinton , Yan Chen
发明人： Chengbin Wu , Richard W. Dixon , Jonathan P. Belk , Maria A. Argiriadi , Hua Ying , Carolyn A. Cuff , Terry L. Melim , Shankar Kumar , Paul R. Hinton , Yan Chen
IPC分类号： A61K51/00 , C07K16/24 , A61K39/395 , C12N9/96 , C07H21/00 , A61P43/00 , A61P11/00 , A61P31/00 , A61P29/00 , A61P1/00 , A61P19/00 , A61P37/06 , A61P25/28 , A61P13/12 , A61P9/00 , C12N15/63 , A61P17/02 , C12N5/10 , C12N1/15 , C12N1/11 , C12N1/19 , C12P21/06 , A61K49/00 , A61K38/20
CPC分类号： A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/473 , Y02A50/478 , Y02A50/481
摘要： The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
摘要翻译：本发明包括IL-13结合蛋白。具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。优选的抗体对hIL-13具有高亲和力，并在体外和体内中和hIL-13活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗体部分可用于检测hIL-13和抑制hIL-13活性，例如在患有hIL-13活性有害的病症的人类受试者中。

34. 发明申请

US20110008357A1 ANTIBODIES THAT BIND IL-18 AND METHODS OF INHIBITING IL-18 ACTIVITY 审中-公开
标题翻译：阻断IL-18的抗体和抑制IL-18活性的方法
公开(公告)号：US20110008357A1
公开(公告)日：2011-01-13
申请号：US12786095
申请日：2010-05-24
申请人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
发明人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
IPC分类号： A61K39/395 , C12P21/00 , C12N5/07 , C12N15/63 , C40B30/04 , C07K2/00 , C07K14/00 , C07K16/24 , C07H21/00 , A61P1/16 , A61P19/02 , A61P29/00 , A61P3/10 , A61P37/06 , A61P25/28 , A61P25/16 , A61P9/10 , A61P37/08 , A61P17/06 , A61P13/12 , A61P11/00 , A61P9/00 , A61P15/08 , A61P25/24 , A61P11/06 , A61P5/16 , A61P5/18 , A61P5/50
CPC分类号： C07K16/244 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K39/395 , A61K31/00
摘要： Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译：提供了结合人白细胞介素-18（hIL-18）的抗体，特别是结合人IL-18表位的抗体。抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。优选的抗体对hIL-18具有高亲和力，并在体外和体内中和hIL-18活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。

35. 发明授权

US07700739B2 IL-12/p40 binding proteins 有权
标题翻译： IL-12 / p40结合蛋白
公开(公告)号：US07700739B2
公开(公告)日：2010-04-20
申请号：US11478096
申请日：2006-06-29
申请人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
发明人： Susan E. Lacy , Emma Fung , Jonathan P. Belk , Richard W. Dixon , Michael Roguska , Paul R. Hinton , Shankar Kumar
IPC分类号： C07K16/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
摘要翻译：本发明包括IL-12p40结合蛋白，特别是结合人白细胞介素-12（hIL-12）和/或人IL-23（hIL-23）的抗体。具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。优选的抗体对hIL-12和/或hIL-23具有高亲和力，并在体外和体内中和h IL-12和/或hIL-23活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性，例如在患有hIL -12和/或hIL-23活性是有害的。

36. 发明授权

US07468371B2 Tricyclic pyrazole kinase inhibitors 有权
标题翻译：三环吡唑激酶抑制剂
公开(公告)号：US07468371B2
公开(公告)日：2008-12-23
申请号：US11089473
申请日：2005-03-24
申请人： Lee D. Arnold , Jürgen Dinges , Richard W. Dixon , Stevan W. Djuric , Anna M. Ericsson , Kimba Fischer , Alan F. Gasiecki , Vijaya J. Gracias , James H. Holms , Makoto Takeshita , Michael R. Michaelides , Melanie A. Muckey , Paul Rafferty , Douglas H. Steinman , Carol K. Wada , Zhiren Xia , Irini Akritopoulou-Zanze , Henry Q. Zhang
发明人： Lee D. Arnold , Jürgen Dinges , Richard W. Dixon , Stevan W. Djuric , Anna M. Ericsson , Kimba Fischer , Alan F. Gasiecki , Vijaya J. Gracias , James H. Holms , Makoto Takeshita , Michael R. Michaelides , Melanie A. Muckey , Paul Rafferty , Douglas H. Steinman , Carol K. Wada , Zhiren Xia , Irini Akritopoulou-Zanze , Henry Q. Zhang
IPC分类号： A61K31/496 , A61K31/415 , C07D231/54 , C07D409/14
CPC分类号： C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
摘要： Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译：本发明的化合物可用于抑制蛋白酪氨酸激酶。还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。

37. 发明申请

US20080249305A1 Novel imidazole based heterocycles 审中-公开
标题翻译：新型咪唑类杂环
公开(公告)号：US20080249305A1
公开(公告)日：2008-10-09
申请号：US12079510
申请日：2008-03-27
申请人： David J. Calderwood , Kristine E. Frank , Patrick Betschmann , Eric C. Breinlinger , Richard W. Dixon
发明人： David J. Calderwood , Kristine E. Frank , Patrick Betschmann , Eric C. Breinlinger , Richard W. Dixon
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention is directed to novel imidazopyrazine compounds useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译：本发明涉及用作激酶抑制剂的新颖的咪唑并嗪化合物，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。

38. 发明授权

US07400979B2 Method of identifying inhibitors of Lck 有权
标题翻译：鉴定Lck抑制剂的方法
公开(公告)号：US07400979B2
公开(公告)日：2008-07-15
申请号：US10212346
申请日：2002-08-05
申请人： David W. Borhani , David Calderwood , Richard W. Dixon , Gavin C. Hirst , Peter Hrnciar , Andreas Loew , Adelaine Leung , Kurt Ritter
发明人： David W. Borhani , David Calderwood , Richard W. Dixon , Gavin C. Hirst , Peter Hrnciar , Andreas Loew , Adelaine Leung , Kurt Ritter
IPC分类号： G06F17/11 , G06F17/50 , G06F19/00
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention relates to polypeptides which comprise the ligand binding domain of Lck, crystalline forms of these polypeptides, and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Lck. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential selective inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain selectively.
摘要翻译：本发明涉及包含Lck的配体结合结构域，这些多肽的结晶形式的多肽，以及这些结晶形式用于确定Lck催化结构域的三维结构的多肽。本发明还涉及在设计和/或鉴定Lck活性的潜在抑制剂的方法中单独或与抑制剂复合的Lck催化结构域的三维结构的用途，例如抑制结合的化合物天然底物到Lck催化结构域。本发明还涉及在设计和/或鉴定Lck活性的潜在选择性抑制剂的方法中单独或与抑制剂复合的Lck催化结构域的三维结构的用途，例如抑制Lck活性结合的化合物选择性地对Lck催化结构域的天然底物。

39. 发明授权

US06415475B1 Handle for adjustable hitch head assembly 失效
标题翻译：手柄用于可调式挂钩头组件
公开(公告)号：US06415475B1
公开(公告)日：2002-07-09
申请号：US09794552
申请日：2001-02-27
申请人： Richard W. Dixon
发明人： Richard W. Dixon
IPC分类号： A45C1322
CPC分类号： B60D1/14 , B60D1/00 , B60D1/07 , B60D1/46 , B60D2001/006 , Y10T16/44 , Y10T16/469 , Y10T16/4707 , Y10T16/498 , Y10T16/509
摘要： A hitch handle for engaging and facilitating carrying of a hitch head assembly of the type which includes a substantially vertically extending adjustable hitch bar having one or more circular openings. The handle has an L-shaped portion, the elongated leg of which forms a hand grasp for the user and the shortened leg of which extends in a direction to in use bear against a part of the hitch bar. The front leg of the U member is secured to the elongated leg of the L-shaped portion, the U member being in a plane transverse to the plane of the L-shaped portion. The second leg of the U-shaped member is removably receivable in an opening in the substantially vertical hitch bar. Upon the second leg of the U being so received, an upward force supplied by the user at the hand grasp rotates the L around the axis defined by the second leg of the U to bring the shorter leg to bear against the hitch head assembly, thereby frictionally locking the handle against further rotation and enabling balanced lifting of the hitch head assembly by the user.
摘要翻译：用于接合和便于携带这种类型的搭接头组件的搭接手柄，其包括具有一个或多个圆形开口的基本上垂直延伸的可调节牵引杆。手柄具有L形部分，其细长的腿为使用者形成手抓握，并且其缩短的腿沿着使用中的方向延伸到搭接杆的一部分上。 U构件的前腿固定到L形部分的细长腿部，U构件处于横向于L形部分的平面的平面中。 U形构件的第二腿可移除地容纳在基本垂直的搭接杆的开口中。在U的第二腿被如此容纳的情况下，用户在握手时提供的向上的力使L围绕由U的第二腿限定的轴线旋转，以使较短的腿抵靠搭接头组件，从而摩擦地锁定手柄以防止进一步旋转，并且能够使用者平衡地提起搭接头组件。

40. 发明授权

US5547247A Passenger tray table with ingress/egress position 失效
标题翻译：客舱托盘，带入口/出口位置
公开(公告)号：US5547247A
公开(公告)日：1996-08-20
申请号：US291182
申请日：1994-08-16
申请人： Richard W. Dixon
发明人： Richard W. Dixon
IPC分类号： A47C7/70 , A47B39/00
CPC分类号： A47C7/70
摘要： A stowable seat tray table for use with a seat, such as a passenger seat, having a tray table stowage compartment on one side of the seat. The tray table includes a tray table having a long side and a perpendicular short side with the table connected to a seat for permitting the table to be moved into and out of the stowage compartment. The table pivots and translates. The pivot movement and the translating movement permit the table to be moved when out of the stowage compartment between a use position wherein the long side of the table extends across the seat from one side to an opposing side for use by the occupant and an ingress/egress position wherein the table is pivoted about a vertical axis and laterally translated towards the stowage compartment to provide sufficient room for the passenger to ingress or to egress from the seat.
摘要翻译：用于与座椅（例如乘客座椅）一起使用的可收起的座椅托盘台，在座椅的一侧具有托盘台存放隔间。托盘台包括具有长边和垂直短边的托盘台，桌子连接到座位，用于允许工作台移入和移出装载室。桌子枢轴转动。枢轴运动和平移运动允许工作台在从载物间隔开的位置之间移动，在使用位置之间，其中桌子的长边从座椅的一侧延伸穿过座椅从一侧到相对侧，以供乘客使用，并且进入/ 出口位置，其中工作台围绕垂直轴线枢转并横向朝向装载隔间移动，为乘客进入或从座椅排出提供足够的空间。

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