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31. 发明授权

US4422337A Method of compensating the interference DC voltages in the electrode circuit in magnetic-conductive flow measurement 失效
标题翻译：在导磁流量测量中补偿电极电路中的干扰直流电压的方法
公开(公告)号：US4422337A
公开(公告)日：1983-12-27
申请号：US304169
申请日：1981-09-21
申请人： Peter Hafner
发明人： Peter Hafner
IPC分类号： G01F1/60
CPC分类号： G01F1/60
摘要： An arrangement for magnetic-inductive flow measurement of an electrically conductive liquid flowing in a conduit includes a magnetic field generator which generates a periodically reversed magnetic field passing through the conduit perpendicularly to the flow direction. In the conduit two electrodes are disposed. The voltage taken from the electrodes is applied to a measuring amplifier. Connected to the output of the measuring amplifier are two sample and hold circuits which are controlled by a control circuit in such a manner that they sample the output voltage of the measuring amplifier for equal induction values of opposite sign of the magnetic field and store the sampling values until the next sampling. A subtraction circuit forms the difference of the stored sampling values. In a control loop between the output and the input of the measuring amplifier there is a storing control circuit which in predetermined compensation time intervals forms a compensation voltage value regulating the output voltage of the measuring amplifier to zero. The compensation method resides in that each compensation time interval lies within the time interval, corresponding to the switched-on magnetic field, in which also the preceding sampling time interval lies.
摘要翻译：用于在导管中流动的导电液体的磁感应流量测量的布置包括磁场发生器，其产生垂直于流动方向穿过导管的周期性反转的磁场。在管道中设置两个电极。从电极取得的电压被施加到测量放大器。连接到测量放大器的输出的是两个采样和保持电路，它们由控制电路控制，使得它们以与磁场相反的相等的感应值相等的方式对测量放大器的输出电压进行采样，并存储采样值直到下一次抽样。减法电路形成存储的采样值的差异。在测量放大器的输出和输入之间的控制回路中存在一个存储控制电路，其在预定的补偿时间间隔内形成将测量放大器的输出电压调节到零的补偿电压值。补偿方法在于，每个补偿时间间隔在对应于接通磁场的时间间隔内，其中也是先前的采样时间间隔。

32. 发明授权

US10478574B2 Nasal administration 有权
公开(公告)号：US10478574B2
公开(公告)日：2019-11-19
申请号：US12161466
申请日：2006-01-19
申请人： Per Gisle Djupesland , Roderick Peter Hafner
发明人： Per Gisle Djupesland , Roderick Peter Hafner
IPC分类号： H01M4/86 , H01M4/90 , A61M15/08 , H01M8/023 , H01M8/124 , H01M8/0247 , H01M8/2425
摘要： A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit (17) for insertion into a nasal airway (1) of a subject and comprising an outlet unit (21) which includes a nozzle (25) for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle: wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.

33. 发明申请

US20150165139A1 INTRANASAL ADMINISTRATION 审中-公开
标题翻译：国际行政管理（INTRANASAL ADMINISTRATION）
公开(公告)号：US20150165139A1
公开(公告)日：2015-06-18
申请号：US14635561
申请日：2015-03-02
申请人： Roderick Peter HAFNER
发明人： Roderick Peter HAFNER
IPC分类号： A61M15/00 , A61M15/08 , A61K38/28 , A61K9/00 , A61K38/22 , A61K38/17
CPC分类号： A61M15/0098 , A61K9/0043 , A61K38/1796 , A61K38/2228 , A61K38/28 , A61M15/0091 , A61M15/08 , A61M2202/064 , A61M2210/0618 , A61M2210/0625
摘要： Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.
摘要翻译：蛋白质如胰岛素和胰岛素类似物，特别是免疫原性蛋白质鼻腔给予受试者鼻腔上后部区域，特别是嗅球区域。

34. 发明授权

US09017689B2 Peptides for vaccine against birch allergy 有权
标题翻译：用于针对桦木过敏的疫苗的肽
公开(公告)号：US09017689B2
公开(公告)日：2015-04-28
申请号：US13578888
申请日：2011-02-15
申请人： Roderick Peter Hafner , Paul Laidler , Mark Larche , Christopher Hugh Reginald Stocker
发明人： Roderick Peter Hafner , Paul Laidler , Guy Layton , Mark Larche
IPC分类号： A61K38/00 , A61K39/00 , A61K39/35 , A61K39/36 , G01N33/00 , G01N33/53
CPC分类号： A61K39/36 , A61K39/35 , A61K2039/53 , A61K2039/577 , G01N33/5023 , G01N33/505 , G01N2500/04
摘要： The present invention relates to compositions comprising peptides for preventing or treating allergy to birch, and in particular to optimal combinations of peptides for preventing or treating said allergy.
摘要翻译：本发明涉及包含用于预防或治疗桦树过敏的肽的组合物，特别涉及用于预防或治疗所述变态反应的肽的最佳组合。

35. 发明授权

US08652485B2 Peptide for vaccine 有权
标题翻译：疫苗肽
公开(公告)号：US08652485B2
公开(公告)日：2014-02-18
申请号：US12673412
申请日：2008-08-15
申请人： Roderick Peter Hafner , Paul Laidler , Mark Larche
发明人： Roderick Peter Hafner , Paul Laidler , Mark Larche
IPC分类号： A61K38/00 , A61K38/04 , A61K39/00 , A61K39/35 , A61K39/36 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： A61K39/0003 , A61K38/00 , A61K39/0002 , A61K39/0005 , A61K39/0008 , A61K39/35 , A61K39/36 , A61K39/39 , C07K7/06 , C07K7/08 , C07K14/415 , C07K14/435 , C07K14/43531 , C07K16/16 , C07K16/18 , C07K2319/00 , G01N33/56977
摘要： The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.
摘要翻译：本发明涉及包含用于预防或治疗对尘螨的过敏的肽的组合物，特别涉及用于预防或治疗所述过敏的肽的最佳组合。

36. 发明授权

US08590530B2 Nasal delivery devices 有权
标题翻译：鼻输送装置
公开(公告)号：US08590530B2
公开(公告)日：2013-11-26
申请号：US13471146
申请日：2012-05-14
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M11/00
CPC分类号： A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要： A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.
摘要翻译：一种用于将物质递送到受试者鼻腔的鼻输送装置和方法，所述输送装置包括：容器接收单元，其包括用于接收含物质的容器的容器室，所述容器容纳物容纳要输送到鼻腔的物质所述物体，所述容器室包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与容器室的出口流体连通的鼻梁; 接口单元，其包括与容器室的入口流体连通的接口，并且被吸入物体通过其吸入，从而将物质夹带在容器中并将其传送通过喷嘴; 以及用于减轻呼出气中的湿气对来自容器的物质夹带的影响的减湿装置。

37. 发明申请

US20130098362A1 Nasal Delivery Devices 有权
标题翻译：鼻输送装置
公开(公告)号：US20130098362A1
公开(公告)日：2013-04-25
申请号：US13471146
申请日：2012-05-14
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M15/08 , A61M15/00
CPC分类号： A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要： A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.
摘要翻译：一种用于将物质递送到受试者鼻腔的鼻输送装置和方法，所述输送装置包括：容器接收单元，其包括用于接收含物质的容器的容器室，所述容器容纳物容纳要输送到鼻腔的物质所述物体，所述容器室包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与容器室的出口流体连通的鼻梁; 接口单元，其包括与容器室的入口流体连通的接口，并且被吸入物体通过其吸入，从而将物质夹带在容器中并将其传送通过喷嘴; 以及用于减轻呼出气中的湿气对来自容器的物质夹带的影响的减湿装置。

38. 发明申请

US20120014978A1 COMPOSITIONS WITH REDUCED DIMER FORMATION 有权
标题翻译：具有减少二维形成的组合物
公开(公告)号：US20120014978A1
公开(公告)日：2012-01-19
申请号：US13131505
申请日：2009-11-27
申请人： Roderick Peter Hafner , Paul Laidler
发明人： Roderick Peter Hafner , Paul Laidler
IPC分类号： A61K39/35 , A61P37/08 , A61P37/02 , A61K39/00
CPC分类号： A61K39/35 , A61K9/08 , A61K9/19 , A61K39/0008 , A61K47/10 , A61K47/20 , A61K47/26
摘要： The present invention relates to the use of a non-reducing carbohydrate or carbohydrate derivative and at least one agent which inhibits dimer formation in a freeze-dried composition comprising at least one peptide that contains a free cysteine residue, to provide a freeze-dried composition with improved long-term storage stability.
摘要翻译：本发明涉及非还原性碳水化合物或碳水化合物衍生物和至少一种抑制二聚物形成的试剂在包含至少一种含有游离半胱氨酸残基的肽的冷冻干燥组合物中的用途，以提供冷冻干燥组合物具有改善的长期储存稳定性。

39. 发明申请

US20110053827A1 INTRANASAL ADMINISTRATION 审中-公开
标题翻译：国际行政管理（INTRANASAL ADMINISTRATION）
公开(公告)号：US20110053827A1
公开(公告)日：2011-03-03
申请号：US12303667
申请日：2007-06-08
申请人： Roderick Peter Hafner
发明人： Roderick Peter Hafner
IPC分类号： A61K38/02 , C07K14/00 , A61P3/10 , A61P3/04 , A61P25/28 , A61M31/00
CPC分类号： A61M15/0098 , A61K9/0043 , A61K38/1796 , A61K38/2228 , A61K38/28 , A61M15/0091 , A61M15/08 , A61M2202/064 , A61M2210/0618 , A61M2210/0625
摘要： Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.
摘要翻译：蛋白质如胰岛素和胰岛素类似物，特别是免疫原性蛋白质鼻腔给予受试者鼻腔上后部区域，特别是嗅球区域。

40. 发明申请

US20100260805A1 PEPTIDE FOR VACCINE 有权
标题翻译：疫苗用肽
公开(公告)号：US20100260805A1
公开(公告)日：2010-10-14
申请号：US12673412
申请日：2008-08-15
申请人： Roderick Peter Hafner , Paul Laidler , Mark Larche
发明人： Roderick Peter Hafner , Paul Laidler , Mark Larche
IPC分类号： A61K39/35 , A61P37/08 , C12N15/00 , C12Q1/02
CPC分类号： A61K39/0003 , A61K38/00 , A61K39/0002 , A61K39/0005 , A61K39/0008 , A61K39/35 , A61K39/36 , A61K39/39 , C07K7/06 , C07K7/08 , C07K14/415 , C07K14/435 , C07K14/43531 , C07K16/16 , C07K16/18 , C07K2319/00 , G01N33/56977
摘要： The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.
摘要翻译：本发明涉及包含用于预防或治疗对尘螨的过敏的肽的组合物，特别涉及用于预防或治疗所述变态反应的肽的最佳组合。

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