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31. 发明授权

US5066585A Method of inhibiting fungus using novel antifungal compounds 失效
标题翻译：使用新型抗真菌化合物抑制真菌的方法
公开(公告)号：US5066585A
公开(公告)日：1991-11-19
申请号：US617219
申请日：1990-11-23
申请人： Alan R. Putnam , Saroj K. Mishra , Muraleedharan G. Nair
发明人： Alan R. Putnam , Saroj K. Mishra , Muraleedharan G. Nair
IPC分类号： C12P19/56
CPC分类号： C12R1/29 , C12P19/56
摘要： A new species of Micromonospora, in particular Micromonospora spartanea ATCC 53803, is described. The species produces antifungal compounds spartanamicins A and B. Methods for the production, isolation and characterization of the compounds are described. The compounds contain deoxy-L-fucose, as well as another hexose and an amino sugar.
摘要翻译：描述了一种新的小单孢菌，特别是小孢子虫（Micomonospora spartanea）ATCC 53803。该物种产生抗真菌化合物spartanamicin A和B.描述了化合物的生产，分离和表征的方法。该化合物含有脱氧-L-岩藻糖，以及另一种己糖和氨基糖。

32. 发明授权

US4876277A Antimicrobial/antifungal compositions 失效
标题翻译：抗微生物/抗真菌组合物
公开(公告)号：US4876277A
公开(公告)日：1989-10-24
申请号：US55737
申请日：1987-05-29
申请人： Basil A. Burke , Muraleedharan G. Nair
发明人： Basil A. Burke , Muraleedharan G. Nair
IPC分类号： A01N43/30 , C07D317/64
CPC分类号： A01N43/30 , C07D317/64
摘要： Substituted olefinic (allyl) benzene compounds which exhibit important antimicrobial (antibacterial and antifungal) activity, compositions and methods of delivery against pathovars and pathogens, and methods of synthesis from commonly available reactants. The antifungal composition active ingredient is one or more 4,5-substituted 2,3-alkylidenedioxy-1-olefinic benzenes of the formula: ##STR1## where R.sub.1 and R.sub.2 may be the same or different, and are selected from OH, and C.sub.1 -C.sub.5 alkoxy (--OR) or thioalkyl (--SR) groups. R.sub.3 and R.sub.4 are selected from H and C.sub.1 -C.sub.5 alkyl, alkenyl and alkynyl groups, and R.sub.5 is selected from C.sub.3 -C.sub.7 alkyl, alkenyl and alkynyl groups. The preferred compounds are 4,5-substituted-2,3-methylenedioxy-1-allyl benzenes. Where R.sub.1 =OCH.sub.3, R.sub.2 =OH, R.sub.3 and R.sub.4 =H and R.sub.5 =allyl (2',3' propenyl) the compound may be called nor methyl-pseudo-dillapiole. Where R.sub.1 =R.sub.2 =OCH.sub.3, R.sub.3 and R.sub.4 are again H, and R.sub.5 =allyl, the compound may be called pseudo-dillapiole. Compositions including these compounds exhibit antimicrobial activity against a variety of pathogens and pathovars, e.g., Xanthomonas campestris spp. bacteria, antifungal activity against a variety of fungi and bacteria, and are highly specific, e.g., antifungal activity against wheat powdery mildew, but do not affect seed germination or have herbicidal or insecticial activity. Methods and compositions for delivery of these agents against such pathogens, and methods of chemical synthesis of the compounds are disclosed.
摘要翻译：显示出重要的抗微生物（抗菌和抗真菌）活性，组合物和递送针对病原体和病原体的方法的取代的烯丙基（烯丙基）苯化合物，以及通常可得的反应物的合成方法。抗真菌组合物活性成分是一种或多种下式的4,5-取代的2,3-亚烷基二氧基-1-烯烃苯：其中R 1和R 2可以相同或不同，并且选自OH，和C 1 -C 5烷氧基（-OR）或硫代烷基（-SR）基团。 R3和R4选自H和C1-C5烷基，烯基和炔基，R5选自C3-C7烷基，烯基和炔基。优选的化合物是4,5-取代-2,3-亚甲二氧基-1-烯丙基苯。其中R1 = OCH3，R2 = OH，R3和R4 = H，R5 =烯丙基（2'，3'丙烯基），化合物可称为甲基假鞭毛虫。当R 1 = R 2 = OCH 3时，R 3和R 4再次为H，R 5为烯丙基，该化合物可称为伪鞭毛虫。包括这些化合物的组合物对各种病原体和病原体表现出抗菌活性，例如野油菜黄单胞菌（Xanthomonas campestris spp。）细菌，针对各种真菌和细菌的抗真菌活性，并且是高度特异性的，例如抗小麦白粉病的抗真菌活性，但不影响种子发芽或具有除草或昆虫活性。公开了用于递送这些试剂以抵抗这种病原体的方法和组合物，以及化合物的化学合成方法。

33. 发明授权

US07772195B2 Methods and compositions for the treatment of obesity, insulin related diseases and hypercholesterolemia 有权
标题翻译：用于治疗肥胖症，胰岛素相关疾病和高胆固醇血症的方法和组合物
公开(公告)号：US07772195B2
公开(公告)日：2010-08-10
申请号：US11072151
申请日：2005-03-04
申请人： Muraleedharan G. Nair , Bolleddula Jayaprakasam , Lawrence K. Olson , Robert E. Schutzki
发明人： Muraleedharan G. Nair , Bolleddula Jayaprakasam , Lawrence K. Olson , Robert E. Schutzki
IPC分类号： A61K31/7048 , A61K31/57 , A61K31/353
CPC分类号： A61K31/353 , A61K31/57 , A61K31/7048
摘要： A method for the treatment of obesity, diabetes, high cholesterol and related diseases including hyperglycemia, lipid disorders, hyperglyceridemia, dyslipidemia and atherosclerosis in mammals using anthocyanins, anthocyanidins, ursolic acid and/or betulinic acid is described. Compositions adapted for these treatments are also described.
摘要翻译：描述了使用花青素，花青素，熊果酸和/或桦木酸的哺乳动物中治疗肥胖症，糖尿病，高胆固醇和相关疾病的方法，包括高血糖症，脂质紊乱，高甘油三酯血症，血脂异常和动脉粥样硬化。还描述了适于这些处理的组合物。

34. 发明授权

US07658937B2 Anthraquinones and process for the preparation and method of use thereof 失效
标题翻译：蒽醌及其制备方法及其使用方法
公开(公告)号：US07658937B2
公开(公告)日：2010-02-09
申请号：US11074227
申请日：2005-03-07
申请人： Muraleedharan G. Nair , Mugunthu R. Dhananjeyan , Michael A. Kron , Youli P. Milev
发明人： Muraleedharan G. Nair , Mugunthu R. Dhananjeyan , Michael A. Kron , Youli P. Milev
IPC分类号： A01N25/00 , A01N37/02 , A01N37/06 , A61K31/22 , A61K31/225
CPC分类号： C07C50/34 , C07C46/00
摘要： A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with at least two hydroxyl groups. Remaining hydroxy groups were converted to methoxy groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also, a method of treating or preventing malaria, filariasis schistosomiasis and other parasitic diseases using anthraquinones.
摘要翻译：描述了制备羟基取代的蒽醌的方法。该方法将邻苯二甲酸酐（取代或未取代的）与至少两个羟基取代的苯环部分结合。剩余的羟基在一些蒽醌中转化为甲氧基。该化合物特别可用于治疗寄生虫病。另外，使用蒽醌治疗或预防疟疾，丝虫病血吸虫病和其他寄生虫病的方法。

35. 发明授权

US07264833B2 Cyclooxygenase-2 inhibitory withanolide compositions and method 失效
标题翻译：环氧合酶-2抑制性脱脂素组合物及方法
公开(公告)号：US07264833B2
公开(公告)日：2007-09-04
申请号：US11406869
申请日：2006-04-19
申请人： Muraleedharan G. Nair , Bolleddula Jayaprakasam
发明人： Muraleedharan G. Nair , Bolleddula Jayaprakasam
IPC分类号： A01N65/00
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
摘要翻译：描述了环加氧酶-2酶抑制卵磷脂。特别地，来自隐翅藻的化合物是去甲腺苷酸的优选来源，尽管它们可以来自其它植物来源。 COX-2抑制对COX-1具有选择性。

36. 发明授权

US07141253B2 Cyclooxygenase-2 inhibitory withanolide compositions and method 失效
公开(公告)号：US07141253B2
公开(公告)日：2006-11-28
申请号：US10887036
申请日：2004-07-08
申请人： Muraleedharan G. Nair , Bolleddula Jayaprakasam
发明人： Muraleedharan G. Nair , Bolleddula Jayaprakasam
IPC分类号： A01N65/00
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.

37. 发明授权

US07132403B2 Antihelminthic anthraquinones and method of use thereof 失效
标题翻译：抗真菌蒽醌及其使用方法
公开(公告)号：US07132403B2
公开(公告)日：2006-11-07
申请号：US10761071
申请日：2004-01-20
申请人： Robert H. Cichewicz , Muraleedharan G. Nair , James H. McKerrow
发明人： Robert H. Cichewicz , Muraleedharan G. Nair , James H. McKerrow
IPC分类号： A61K31/70 , A61K31/675 , C07H15/00 , C07C50/18
CPC分类号： A61K31/70 , A61K31/21 , C07C50/38 , Y02A50/423
摘要： Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
摘要翻译：描述了蒽醌类化合物，其具有抗耳毒性，特别是可用于抑制血吸虫病的组合物。体外或体内。优选的蒽醌具有下式：其中R 1，R 2，R 3和R 4各自为氢，羟基，卤素，烷基，取代的烷基，烯烃，取代的烯烃，炔烃，芳基，取代的芳基，环状，取代的环状，酸基，碳水化合物或其组合，R是含有1至12个碳的基团，例如甲基，烷基，取代的烷基，醛，羟基，羟甲基，酸基，碳水化合物或其组合，卤素是I，F，Br或Cl。

38. 发明授权

US07000348B2 Method and composition for tree root colonization 有权
标题翻译：树根定植的方法和组成
公开(公告)号：US07000348B2
公开(公告)日：2006-02-21
申请号：US10751874
申请日：2004-01-06
申请人： Michael P. Amaranthus , Muraleedharan G. Nair , Taylor C. Reid
发明人： Michael P. Amaranthus , Muraleedharan G. Nair , Taylor C. Reid
IPC分类号： A01G1/04 , A01H1/00 , C12N1/14
CPC分类号： A01G7/06 , A01G18/10
摘要： A method and compositions for increasing ectomycorrhizal colonization of the roots of trees using an alkali metal formononetinate, formononetin or mixtures thereof is described. The method enhances the growth of healthy and impaired trees.
摘要翻译：描述了一种用于增加使用碱金属扁桃酸盐，洋茅素或其混合物来增加树根的外生菌根定殖的方法和组合物。该方法增强了健康和受损树木的生长。

39. 发明授权

US06838443B2 Antihelminthic anthraquinones and method of use thereof 失效
标题翻译：抗真菌蒽醌及其使用方法
公开(公告)号：US06838443B2
公开(公告)日：2005-01-04
申请号：US10723672
申请日：2003-11-26
申请人： Robert H. Cichewicz , Muraleedharan G. Nair , James H. McKerrow
发明人： Robert H. Cichewicz , Muraleedharan G. Nair , James H. McKerrow
IPC分类号： C07H15/244 , A61K31/122 , A61K31/21 , A61K31/70 , A61K31/704 , A61P33/10 , A61P33/12 , C07C50/34 , C07C50/38 , C07C66/02 , C07C69/157 , A01N43/04 , A61K31/545 , A61K31/52
CPC分类号： A61K31/70 , A61K31/21 , C07C50/38 , Y02A50/423
摘要： Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
摘要翻译：描述了蒽醌类化合物，其具有抗耳毒性，特别是可用于抑制血吸虫病的组合物。体外或体内。优选的蒽醌具有下式：其中R 1，R 2，R 3和R 4各自为氢，羟基，卤素，烷基，取代的烷基，烯烃，取代的烯烃，炔，芳基，取代的芳基，环状，取代的环状，酸基，碳水化合物或其组合，R是含有1至12个碳的基团，例如甲基，烷基，取代的烷基，醛，羟基，羟甲基，酸基，碳水化合物或其组合，卤素是I，F，Br或Cl 。

40. 发明授权

US06623743B1 Method for the use of cherry isolates providing antioxidant phytoceutical or nutraceutical benefits 失效
标题翻译：使用提供抗氧化植物营养或营养保健益处的樱桃分离株的方法
公开(公告)号：US06623743B1
公开(公告)日：2003-09-23
申请号：US09662747
申请日：2000-09-15
申请人： Muraleedharan G. Nair , Haibo Wang , Gale M. Strasburg , Alden M. Booren , James I. Gray
发明人： Muraleedharan G. Nair , Haibo Wang , Gale M. Strasburg , Alden M. Booren , James I. Gray
IPC分类号： A61K900
CPC分类号： A61K36/736 , A23L33/105 , A23L33/11
摘要： A method for providing nutraceutical or phytoceutical benefits to a mammal, particularly a human, using cherry derivatives is described. A method for inhibiting oxidation in a living biological material is also described. A composition of anthocyanins, bioflavonoids, phenolics or mixtures thereof from cherries is used in the methods.
摘要翻译：描述了使用樱桃衍生物向哺乳动物，特别是人提供营养药物或植物学益处的方法。还描述了抑制活体生物材料中的氧化的方法。方法中使用花青素，生物类黄酮，酚类或其来自樱桃的混合物的组合物。

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