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31. 发明申请

US20110076344A1 USE OF A CHEMICALLY-STABILIZED CHLORITE SOLUTION FOR INHIBITING AN ANTIGEN-SPECIFIC IMMUNE RESPONSE 审中-公开
标题翻译：使用化学稳定氯化物溶液抑制抗原特异性免疫应答
公开(公告)号：US20110076344A1
公开(公告)日：2011-03-31
申请号：US12894618
申请日：2010-09-30
申请人： Friedrich-W. KUEHNE , Michael McGRATH , Edgar ENGLEMAN
发明人： Friedrich-W. KUEHNE , Michael McGRATH , Edgar ENGLEMAN
IPC分类号： A61K33/20 , A61P21/04 , A61P3/10 , A61P19/02 , A61P1/00 , A61P25/00 , A61P11/06 , A61P11/00 , A61P17/00
CPC分类号： A61K33/40 , Y02A50/401
摘要： Methods of using a stabilized chlorite solution to inhibit antigen-specific immune responses are disclosed. The stabilized chlorite solution, when administered to a mammal in need thereof, can prevent the presentation of antigens by antigen presenting cells. The stabilized chlorite solution therefore is useful in treating, inter alia, auto-immune diseases, treating diseases caused by an inappropriate immune response, treating lymphoproliferative disease and in inhibiting rejection in transplant patients.
摘要翻译：公开了使用稳定的亚氯酸盐溶液来抑制抗原特异性免疫应答的方法。当向有需要的哺乳动物施用时，稳定的亚氯酸盐溶液可以防止抗原呈递细胞呈递抗原。因此，稳定的亚氯酸盐溶液可用于治疗特别是自身免疫疾病，治疗由不适当的免疫应答引起的疾病，治疗淋巴增生性疾病和抑制移植患者的排斥反应。

32. 发明申请

US20060095824A1 Determining circuit behavior 审中-公开
标题翻译：确定电路行为
公开(公告)号：US20060095824A1
公开(公告)日：2006-05-04
申请号：US10979010
申请日：2004-11-01
申请人： Michael McGrath
发明人： Michael McGrath
IPC分类号： G06F11/00 , G06F17/50 , G06G7/62
CPC分类号： G06F17/5022 , G06F11/261
摘要： Systems, methodologies, media, and other embodiments associated with automatically determining circuit behavior are described. One exemplary system embodiment includes a data acquisition logic that is configured to access a netlist that describes a computer circuit. The exemplary system may also include a logical behavior logic that is configured to facilitate determining a predicted logical behavior for the computer circuit based, at least in part, on the netlist. The exemplary system may also include a test vector logic configured to generate a set of test vectors. The test vectors may facilitate analyzing the computer circuit. The test vectors may be based, at least in part, on the predicted logical behavior for the computer circuit.
摘要翻译：描述了与自动确定电路行为相关联的系统，方法，介质和其他实施例。一个示例性系统实施例包括被配置为访问描述计算机电路的网表的数据获取逻辑。该示例性系统还可以包括逻辑行为逻辑，其被配置为至少部分地基于网表来便于确定计算机电路的预测逻辑行为。示例性系统还可以包括被配置为生成一组测试向量的测试向量逻辑。测试向量可以有助于分析计算机电路。测试向量可以至少部分地基于计算机电路的预测逻辑行为。

33. 发明申请

US20060042995A1 Suspension packages 审中-公开
标题翻译：悬挂包装
公开(公告)号：US20060042995A1
公开(公告)日：2006-03-02
申请号：US10932740
申请日：2004-09-02
申请人： Michael McGrath , Lewis Lofgren
发明人： Michael McGrath , Lewis Lofgren
IPC分类号： B65D85/30
CPC分类号： B65D43/162 , B65D81/075
摘要： Suspension packages are described that include (a) a first holding member; (b) a second holding member, wherein the second holding member is pivotably connected to the first holding member along a living hinge, such that the first and second holding members are configured to pivot between open and closed positions; (c) a first mounting ring detachably connectable to the first holding member, wherein the first mounting ring comprises a first film-mounting surface; (d) a second mounting ring detachably connectable to the second holding member, wherein the second mounting ring comprises a second film-mounting surface; (e) a first suspension film mounted to the first film-mounting surface; and (f) a second suspension film mounted to the second film-mounting. The first suspension film is recessed with respect to an upper peripheral surface of the first holding member, and the second suspension film protrudes beyond an upper peripheral surface of the second holding member.
摘要翻译：描述了悬挂包装，其包括（a）第一保持构件; （b）第二保持构件，其中所述第二保持构件沿着活动铰链可枢转地连接到所述第一保持构件，使得所述第一和第二保持构件构造成在打开和关闭位置之间枢转; （c）可拆卸地连接到第一保持构件的第一安装环，其中第一安装环包括第一膜安装表面; （d）可拆卸地连接到第二保持构件的第二安装环，其中第二安装环包括第二膜安装表面; （e）安装在第一胶片安装表面上的第一悬挂膜; 和（f）安装在第二胶片安装件上的第二悬架膜。第一悬挂膜相对于第一保持构件的上周面凹陷，第二悬挂膜突出超过第二保持构件的上周面。

34. 发明申请

US20060016294A1 Temperature insulated beverage container receptacle and opening apparatus 审中-公开
标题翻译：隔热饮料容器容器和开口装置
公开(公告)号：US20060016294A1
公开(公告)日：2006-01-26
申请号：US11186680
申请日：2005-07-19
申请人： Michael McGrath , Michael Bilotta
发明人： Michael McGrath , Michael Bilotta
IPC分类号： B67B7/44 , F25D3/08
CPC分类号： B65D25/24 , A47G23/0216 , A47G23/03 , B65D81/3876 , B67B7/16 , B67B7/18 , B67B7/403 , B67B7/44
摘要： A beverage container receptacle and opening apparatus having a base adapted to support a beverage container and having one or a plurality of beverage container openers formed into the base. The openers provide a twist off bottle cap remover, a pry-off bottle cap remover, and a pull tab prying device. A sleeve rising from a top surface of the base provides an insulator as well as a component to hold the container to the base during movement.
摘要翻译：一种饮料容器容器和开口装置，其具有适于支撑饮料容器并具有形成在基座中的一个或多个饮料容器开口的底座。开瓶器提供瓶盖拆卸器，撬开瓶盖拆卸器和拉片撬动装置。从基座的顶表面上升的套筒提供绝缘体以及在运动期间将容器保持在基座上的部件。

35. 发明申请

US20050247650A1 Vertical cable manager 有权
标题翻译：垂直电缆管理器
公开(公告)号：US20050247650A1
公开(公告)日：2005-11-10
申请号：US11123369
申请日：2005-05-06
申请人： Mark Vogel , Michael McGrath
发明人： Mark Vogel , Michael McGrath
IPC分类号： H04Q1/06 , H04Q1/14 , A47F7/00
CPC分类号： H04Q1/062 , H04Q1/066 , H04Q1/068 , H04Q1/13 , H04Q2201/02
摘要： A cable manager is disclosed. The cable manager includes a backbone, a plurality of finger sections connected to the backbone to form a vertical cable channel, and a first pair of horizontal rails connected to the top end of the backbone and a second pair of horizontal rails connected to the bottom end of the backbone. The cable manager also includes a first cross brace connected to the first pair of horizontal rails and a second cross brace connected to the second pair of horizontal rails, and a door hingedly connected to the first and second cross braces. Each cross brace includes a mounting surface having a plurality of guide surfaces and an alignment aid protruding from the mounting surface and extending beyond a horizontal axis extending between the guide surfaces. The door includes a pair of latches connected to a hinge pin through a pair of windows, and a spring connected to the hinge pin and the pair of latches.
摘要翻译：电缆管理器被公开。电缆管理器包括主干，连接到主干以形成垂直电缆通道的多个指状部分，以及连接到主干的顶端的第一对水平轨道和连接到主体的第二对水平轨道的骨干。电缆管理器还包括连接到第一对水平轨道的第一横向支架和连接到第二对水平轨道的第二横向支架，以及铰接地连接到第一和第二横向支架的门。每个横支架包括具有多个引导表面的安装表面和从安装表面突出并延伸超过在引导表面之间延伸的水平轴线的对准辅助件。门包括通过一对窗口连接到铰链销的一对闩锁，以及连接到铰链销和一对闩锁的弹簧。

36. 发明申请

US20050159493A1 Methods for modulating macrophage proliferation using polyamine analogs 有权
标题翻译：使用多胺类似物调节巨噬细胞增殖的方法
公开(公告)号：US20050159493A1
公开(公告)日：2005-07-21
申请号：US11022153
申请日：2004-12-22
申请人： Michael McGrath
发明人： Michael McGrath
IPC分类号： A61K31/132 , A61K31/13 , A61K31/131 , A61K31/155 , A61P25/28 , A61P43/00 , G01N33/50 , G01N33/569 , G01N33/68
CPC分类号： G01N33/56972 , A61K31/13 , A61K31/131 , A61K31/155 , G01N33/5055 , G01N33/6896 , G01N2800/2821
摘要： Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.
摘要翻译：提供了在巨噬细胞相关疾病患病或有风险的个体中调节巨噬细胞增殖的方法。该方法采用多胺类似物，或其盐或被保护的衍生物。巨噬细胞增殖已涉及许多严重疾病，包括艾滋病（HIV）相关性痴呆，艾滋病相关性非霍奇金淋巴瘤和阿尔茨海默病。本发明还提供了帮助诊断和监测与巨噬细胞相关的非HIV相关性痴呆，特别是阿尔茨海默病的治疗的方法。本发明还提供了延迟巨噬细胞相关非HIV相关性痴呆（包括阿尔茨海默病）发展的方法，其需要施用调节巨噬细胞增殖的药剂。

37. 发明申请

US20050129784A1 Use of a chemically stabilized chlorite solution for inhibiting an antigen-specific immune response 审中-公开
标题翻译：使用化学稳定的亚氯酸盐溶液来抑制抗原特异性免疫应答
公开(公告)号：US20050129784A1
公开(公告)日：2005-06-16
申请号：US10895941
申请日：2004-07-22
申请人： Friedrich-W. Kuehne , Michael McGrath , Edgar Engleman
发明人： Friedrich-W. Kuehne , Michael McGrath , Edgar Engleman
IPC分类号： A61K33/20 , A61K33/40 , A61P1/00 , A61P1/16 , A61P3/10 , A61P11/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/06 , A61P43/00 , A61K33/14
CPC分类号： A61K33/40 , Y02A50/401
摘要： Methods of using a stabilized chlorite solution to inhibit antigen-specific immune responses are disclosed. The stabilized chlorite solution, when administered to a mammal in need thereof, can prevent the presentation of antigens by antigen presenting cells. The stabilized chlorite solution therefore is useful in treating, inter alia, auto-immune diseases, treating diseases caused by an inappropriate immune response, treating lymphoproliferative disease and in inhibiting rejection in transplant patients.
摘要翻译：公开了使用稳定的亚氯酸盐溶液来抑制抗原特异性免疫应答的方法。当向有需要的哺乳动物施用时，稳定的亚氯酸盐溶液可以防止抗原呈递细胞呈递抗原。因此，稳定的亚氯酸盐溶液可用于治疗特别是自身免疫疾病，治疗由不适当的免疫应答引起的疾病，治疗淋巴增生性疾病和抑制移植患者的排斥反应。

38. 发明授权

US06703202B2 Evaluating and predicting clinical outcomes by gene expression analysis 失效
标题翻译：通过基因表达分析评估和预测临床结果
公开(公告)号：US06703202B2
公开(公告)日：2004-03-09
申请号：US09725499
申请日：2000-11-30
申请人： Michael McGrath , Stefan Meuer , Friedrich-Wilhelm Kuehne
发明人： Michael McGrath , Stefan Meuer , Friedrich-Wilhelm Kuehne
IPC分类号： C12Q168
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6883 , C12Q1/707 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： Methods of determining clinical outcomes in patients suffering from a pathological condition or syndrome are provided. Levels of intracellular gene expression re measured from a clinical sample provided by the patient, and the levels are compared to reference levels. Deviations from reference levels are predictive of clinical outcomes, for example, disease progression or response to therapeutic intervention.
摘要翻译：提供了确定病理状况或综合征患者临床结局的方法。从患者提供的临床样品中测量细胞内基因表达水平，并将该水平与参考水平进行比较。与参考水平的偏差是预测临床结果，例如疾病进展或对治疗干预的反应。

39. 发明申请

US20130060710A1 System, Method and Apparatus for Managing and Conducting Property Inspections 审中-公开
标题翻译：管理和进行财产检查的制度，方法和装置
公开(公告)号：US20130060710A1
公开(公告)日：2013-03-07
申请号：US13462540
申请日：2012-05-02
申请人： Matthew Preuss , Jerry Hosack , Najah Manni , John Musinski , Michael McGrath
发明人： Matthew Preuss , Jerry Hosack , Najah Manni , John Musinski , Michael McGrath
IPC分类号： G06Q50/16
CPC分类号： G06Q50/163 , G06Q10/10 , G06Q50/16
摘要： A system for managing property inspections may include a base computer and a memory unit coupled to the base computer. The memory unit may have stored therein a plurality of property inspection requests and a number of property inspector records, with each of the plurality of property inspection requests including at least one attribute of a corresponding property to be inspected and with each of the number of property inspector records including data associated with a corresponding property inspector, and instructions that are executable by the base computer to assign the property inspection requests to the property inspectors based on matches between the at least one attribute of the plurality of property inspection requests and at least one of the data associated with the number of property inspection records. The property inspectors may access their assignments of property inspections through a web portal.
摘要翻译：用于管理属性检查的系统可以包括基本计算机和耦合到基本计算机的存储器单元。存储单元可以在其中存储多个属性检查请求和多个属性检查器记录，其中多个属性检查请求中的每个属性检查请求包括要检查的对应属性的至少一个属性以及每个属性数量检查员记录，包括与相应的属性检查器相关联的数据，以及可由基本计算机执行的指令，以基于多个属性检查请求中的至少一个属性与至少一个属性检查请求之间的匹配来向属性检查者分配属性检查请求与物业检验记录数量相关联的数据。财产检查员可以通过门户访问其财产检查任务。

40. 发明申请

US20120219970A1 METHODS FOR MODULATING MACROPHAGE PROLIFERATION IN OCULAR DISEASE USING POLYAMINE ANALOGS 审中-公开
标题翻译：使用聚氨酯类似物调节眼部疾病的大鼠增生的方法
公开(公告)号：US20120219970A1
公开(公告)日：2012-08-30
申请号：US13470072
申请日：2012-05-11
申请人： Michael McGrath
发明人： Michael McGrath
IPC分类号： G01N33/566 , C12Q1/06
CPC分类号： A61K31/13 , A61K31/131 , A61K31/155 , G01N33/6896 , G01N2333/523 , G01N2800/164
摘要： Methods for modulating macrophage proliferation in an individual afflicted with or at risk for an ocular disease such as ARMD are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including ARMD. The invention also provides methods for aiding diagnosis and monitoring therapy of an ocular disease such as ARMD.
摘要翻译：提供了在患有或具有眼部疾病如ARMD的风险的个体中调节巨噬细胞增殖的方法。该方法采用多胺类似物，或其盐或被保护的衍生物。巨噬细胞增殖已涉及许多严重的疾病，包括ARMD。本发明还提供了用于帮助诊断和监测眼部疾病如ARMD的治疗的方法。

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