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31. 发明授权

US08809369B2 Tetrahydroquinoline derivatives 有权
标题翻译：四氢喹啉衍生物
公开(公告)号：US08809369B2
公开(公告)日：2014-08-19
申请号：US13353351
申请日：2012-01-19
申请人： Lichun Feng , Mengwei Huang , Yongfu Liu , Guolong Wu , Shixiang Yan , Hongying Yun , Mingwei Zhou
发明人： Lichun Feng , Mengwei Huang , Yongfu Liu , Guolong Wu , Shixiang Yan , Hongying Yun , Mingwei Zhou
IPC分类号： C07D215/48 , C07D401/04 , C07D401/10 , C07D413/10 , C07D471/04 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P3/04 , A61P3/10
CPC分类号： C07D215/48 , C07D401/04 , C07D401/10 , C07D413/10 , C07D471/04
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions including the compounds.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐或酯，其中R1至R8，A1至A3具有本文所述的化合物和包含该化合物的组合物。

32. 发明申请

US20140153608A1 METHOD FOR MEASURING THICKNESS BY PULSED INFRARED THERMAL WAVE TECHNOLOGY 有权
标题翻译：通过脉冲红外热波技术测量厚度的方法
公开(公告)号：US20140153608A1
公开(公告)日：2014-06-05
申请号：US14002022
申请日：2011-06-14
申请人： Zhi Zeng , Xun Wang , Ning Tao , Lichun Feng
发明人： Zhi Zeng , Xun Wang , Ning Tao , Lichun Feng
IPC分类号： G01B21/08 , G01N25/72
CPC分类号： G01B21/085 , G01N25/72
摘要： A method for measuring thickness or defect depth by pulsed infrared thermal wave technology is described. The method includes heating a measured object by pulsed heating devices, and at the same time, obtaining a thermal image sequence on the surface of the measured object by an infrared thermography device, and storing the thermal image sequence in a general-purpose memory. The method also includes multiplying a temperature-time curve at every point of the thermal image sequence by a corresponding time, thereby obtaining a new curve. The method also includes calculating a first-order differential and obtaining a peak time thereof. The method also includes use of one or more formulas to thereby determine the thickness or the defect depth of the measured object.
摘要翻译：描述了通过脉冲红外热波技术测量厚度或缺陷深度的方法。该方法包括通过脉冲加热装置加热测量对象，同时通过红外热成像装置获得被测物体表面上的热图像序列，并将热图像序列存储在通用存储器中。该方法还包括将热图像序列的每个点处的温度 - 时间曲线乘以相应的时间，从而获得新的曲线。该方法还包括计算一阶差分并获得其峰值时间。该方法还包括使用一个或多个公式从而确定被测物体的厚度或缺陷深度。

33. 发明授权

US08592594B2 Tetrahydro-quinoline derivatives 失效
标题翻译：四氢喹啉衍生物
公开(公告)号：US08592594B2
公开(公告)日：2013-11-26
申请号：US13169097
申请日：2011-06-27
申请人： Li Chen , Lichun Feng , Yun He , Mengwei Huang , Yongfu Liu , Hongying Yun , Mingwei Zhou
发明人： Li Chen , Lichun Feng , Yun He , Mengwei Huang , Yongfu Liu , Hongying Yun , Mingwei Zhou
IPC分类号： C07D215/38
CPC分类号： C07D215/48 , C07D401/06 , C07D405/12 , C07D471/04
摘要： A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
摘要翻译：式（I）化合物或其药学上可接受的盐或酯，其中A1至A3和R1至R10具有权利要求1中给出的含义，可用作药物。这些化合物可用于治疗或预防与AMPK调节相关的疾病，例如肥胖症，血脂异常，高血糖症，1型或2型糖尿病和癌症。

34. 发明授权

US08501933B2 Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists 有权
标题翻译：噻唑和恶唑取代的芳基酰胺作为P2X3和P2X2 / 3拮抗剂
公开(公告)号：US08501933B2
公开(公告)日：2013-08-06
申请号：US12843563
申请日：2010-07-26
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
IPC分类号： C07D345/00 , C07D517/00
CPC分类号： A61K31/5377 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/501 , C07D261/08 , C07D263/32 , C07D275/02 , C07D277/30 , C07D277/56 , C07D277/66 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B, and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R1是式A或式B的基团，X，R2，R3，R4，R5，R6，Ra和Rb如本文所定义。还提供了使用该化合物治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的方法和制备本发明化合物的方法。

35. 发明授权

US08222416B2 Azaindole glucokinase activators 有权
标题翻译： Azaindole葡糖激酶活化剂
公开(公告)号：US08222416B2
公开(公告)日：2012-07-17
申请号：US12943539
申请日：2010-11-10
申请人： Steven Joseph Berthel , Li Chen , Wendy Lea Corbett , Lichun Feng , Nancy-Ellen Haynes , Robert Francis Kester , Sung-Sau So , Jefferson Wright Tilley
发明人： Steven Joseph Berthel , Li Chen , Wendy Lea Corbett , Lichun Feng , Nancy-Ellen Haynes , Robert Francis Kester , Sung-Sau So , Jefferson Wright Tilley
IPC分类号： C07D471/02 , A61K31/545
CPC分类号： C07D471/04 , C07C2601/04 , C07C2601/06 , C07D401/06 , C07D403/10 , C07D405/06
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译：本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。

36. 发明授权

US08119644B2 Thiadiazole-substituted arylamides as P2X3 and P2X2/3 antagonists 有权
标题翻译：噻二唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
公开(公告)号：US08119644B2
公开(公告)日：2012-02-21
申请号：US12636723
申请日：2009-12-12
申请人： Li Chen , Lichun Feng , Minmin Yang , Michael Patrick Dillon , Yingjie Lai
发明人： Li Chen , Lichun Feng , Minmin Yang , Michael Patrick Dillon , Yingjie Lai
IPC分类号： A61K31/444 , A61K31/497 , A61K31/433 , A61P13/00 , A61P13/10 , A61P25/00 , C07D417/14 , C07D285/06
CPC分类号： C07D417/14 , A61K31/166 , A61K31/433 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , C07D285/06 , C07D417/12
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted thiadiazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R 1为任选取代的噻二唑基，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

37. 发明授权

US08093275B2 Oxazolone and pyrrolidinone-substituted pryidine amides as P2X3 and P2X2/3 antagonists 有权
标题翻译：恶唑酮和吡咯烷酮取代的Pryidine酰胺作为P2X3和P2X2 / 3拮抗剂
公开(公告)号：US08093275B2
公开(公告)日：2012-01-10
申请号：US12820660
申请日：2010-06-22
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Minmin Yang
IPC分类号： A61K31/44
CPC分类号： A61K31/497 , C07D207/27 , C07D233/32 , C07D263/20 , C07D401/14 , C07D403/12 , C07D407/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D473/00
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中X，Y，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

38. 发明申请

US20120004218A1 NOVEL TETRAHYDRO-QUINOLINE DERIVATIVES 失效
标题翻译：新型四氢喹啉衍生物
公开(公告)号：US20120004218A1
公开(公告)日：2012-01-05
申请号：US13169097
申请日：2011-06-27
申请人： Li Chen , Lichun Feng , Yun He , Mengwei Huang , Yongfu Liu , Hongying Yun , Mingwei Zhou
发明人： Li Chen , Lichun Feng , Yun He , Mengwei Huang , Yongfu Liu , Hongying Yun , Mingwei Zhou
IPC分类号： A61K31/541 , C07D215/48 , C07D413/10 , C07D401/10 , C07D471/04 , C07D405/10 , C07D417/14 , A61K31/4747 , A61K31/47 , A61K31/5377 , A61K31/496 , A61K31/4375 , A61P3/04 , A61P3/10 , A61P35/00 , A61P3/06 , C07D221/20
CPC分类号： C07D215/48 , C07D401/06 , C07D405/12 , C07D471/04
摘要： A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
摘要翻译：式（I）化合物或其药学上可接受的盐或酯，其中A1至A3和R1至R10具有权利要求1中给出的含义，可用作药物。这些化合物可用于治疗或预防与AMPK调节相关的疾病，例如肥胖症，血脂异常，高血糖症，1型或2型糖尿病和癌症。

39. 发明授权

US07989637B2 Triazole-substituted arylamides as P2X3 and P2X2/3 antagonists 失效
标题翻译：三唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
公开(公告)号：US07989637B2
公开(公告)日：2011-08-02
申请号：US12317017
申请日：2008-12-17
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
IPC分类号： C07D249/08
CPC分类号： C07D403/12 , C07D249/06 , C07D401/14
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted triazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要翻译：式I化合物或其药学上可接受的盐，其中R 1为任选取代的三唑基，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。

40. 发明授权

US07858654B2 Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists 失效
标题翻译：咪唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
公开(公告)号：US07858654B2
公开(公告)日：2010-12-28
申请号：US12316942
申请日：2008-12-17
申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
发明人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
IPC分类号： A01N43/50
CPC分类号： C07D233/64 , C07D401/14 , C07D403/12
摘要： Compounds of the formula I: wherein R1 is optionally substituted imidazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
摘要翻译：式I化合物：其中R 1是任选取代的咪唑基，R2，R3，R4，R5，R6，R7和R8如本文所定义。还提供了使用该化合物治疗由P2X3和/或P2X2 / 3受体拮抗剂介导的疾病的方法和制备本发明化合物的方法。

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