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31. 发明申请

US20210149175A1 OPTICAL IMAGING DEVICE FOR A MICROSCOPE 有权
公开(公告)号：US20210149175A1
公开(公告)日：2021-05-20
申请号：US17082320
申请日：2020-10-28
申请人： Leica Microsystems CMS GmbH
发明人： Kai RITSCHEL , Marco BINGEL , Patric PELZER
IPC分类号： G02B21/36 , G06T7/37 , G06T7/80 , G06K9/20
摘要： An optical imaging device for a microscope comprises a first optical system configured to form a first optical image corresponding to a first region of a sample in accordance with a first imaging mode, a second optical system configured to form a second optical image corresponding to a second region of said sample, wherein said first and second regions spatially coincide in a target region of said sample and said first and second imaging modes are different from each other, a memory storing first distortion correction data suitable for correcting a first optical distortion caused by said first optical system in said first optical image, second distortion correction data suitable for correcting a second optical distortion caused by said second optical system in said second optical image, and transformation data suitable for correcting positional misalignment between said first and second optical images, and a processor which is configured to process first image data representing said first optical image based on said first distortion correction data for generating first distortion corrected image data, to process second image data representing said second optical image based on said second distortion correction data for generating second distortion corrected image data; and to combine said first and second distortion corrected image data based on said transformation data for generating combined image data representing a combined image which corresponds to said target region of said object.

32. 发明申请

US20210063714A1 OPTICAL DEVICE, OPTICAL MODULE AND MICROSCOPE FOR SCANNING LARGE SAMPLES 有权
公开(公告)号：US20210063714A1
公开(公告)日：2021-03-04
申请号：US16977820
申请日：2019-02-20
申请人： Leica Microsystems CMS GmbH
发明人： Florian FAHRBACH , Werner KNEBEL , Peter POTT , Wernher FOUQUET
IPC分类号： G02B21/00 , G02B21/33 , G02B21/24 , G01N21/64 , G01N21/47
摘要： An optical device for illuminating a sample located in a sample volume with illumination light and for detecting scattered and/or fluorescent light from the sample includes an optical illumination assembly, an optical detection assembly and at least one attachment element. The optical illumination assembly is configured to transmit the illumination light along an illumination path into the sample volume. The optical detection assembly is configured to collect and relay the scattered and/or fluorescent light from the sample volume along a detection path. At least portions of the illumination path and/or of the detection path extend in the at least one attachment element.

33. 发明授权

US10824116B2 Method for forming a digital value from a clock signal and from a data signal 有权
公开(公告)号：US10824116B2
公开(公告)日：2020-11-03
申请号：US16498393
申请日：2018-04-04
申请人： Leica Microsystems CMS GmbH
发明人： Bernd Widzgowski
IPC分类号： G04F10/00 , G16H10/40 , G02B21/00 , H04L7/033
摘要： A method forms a digital value from a clock signal and a digital data signal. The method includes sampling the clock signal in order to obtain a clock signal digital value sequence and sampling the digital data signal in order to obtain a data signal digital value sequence. Sampling points are ascertained from the clock signal digital value sequence, at which data signal digital values are extracted from the data signal digital value sequence. The digital value is formed from the data signal digital values.

34. 发明授权

US10823951B2 Method for imaging in a microscope with oblique illumination 有权
公开(公告)号：US10823951B2
公开(公告)日：2020-11-03
申请号：US16326937
申请日：2017-08-17
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Benjamin Deissler , Albrecht Weiss , Alexander Weiss
IPC分类号： H04N9/47 , G02B21/36 , G06T5/20 , G02B21/08
摘要： A method for imaging in a microscope with oblique illumination includes illuminating an object by an illumination beam path that is obliquely incident on an object plane of the microscope. A microscopic image of the object and a corresponding digital image signal are produced. The digital image signal is processed by digital image processing using a convolution kernel to increase contrast. An increased-contrast digital image is produced from the processed digital image signal.

35. 发明申请

US20200341256A1 METHOD AND DEVICE FOR ADJUSTING THE FOCUS OR DETERMINING THE REFRACTIVE INDEX OF A SAMPLE MEDIUM, NON-VOLATILE COMPUTER-READABLE STORAGE MEDIUM AND MICROSCOPE 审中-公开
公开(公告)号：US20200341256A1
公开(公告)日：2020-10-29
申请号：US16955813
申请日：2018-12-21
申请人： Leica Microsystems CMS GmbH
发明人： Florian Fahrbach
IPC分类号： G02B21/24 , G02B21/00 , G01N21/41
摘要： A method for adjusting a focus of an optical system includes focusing measurement light in a sample space using an optical arrangement. The measurement light is transmitted on a sample side of the optical arrangement through at least one optical medium. The measurement light reflected by a reflector and transmitted through a further optical arrangement is detected using a detector arrangement. A working distance between the optical arrangement and the reflector is ascertained based on the measurement light detected by the detector, wherein a focus of the measurement light lies on the reflector for the working distance.

36. 发明申请

US20200319659A1 DEVICE AND METHOD FOR FEEDING AN IMMERSION MEDIUM 审中-公开
公开(公告)号：US20200319659A1
公开(公告)日：2020-10-08
申请号：US16835449
申请日：2020-03-31
申请人： Leica Microsystems CMS GmbH
发明人： Alexander WEISS , Sebastian HITZLER , Christian SCHUMANN
IPC分类号： G05D9/12 , G02B21/33
摘要： A feed device for an immersion medium for use with an objective enabling a specimen to be imaged microscopically includes a cap fitted releasably or fixedly to the objective and delimiting a receptacle space for the immersion medium. The cap has an exit opening aligned with an optical element of the objective facing the specimen. The immersion medium held in the receptacle space is feedable through the exit opening to a target space situated between the optical element of the objective and the specimen. A sensor is integrated in the cap and has an electrode structure configured to detect an amount of the immersion medium fed through the exit opening to the target space. The electrode structure at least partly encloses the exit opening and has a spatial detection region extending away from the exit opening in a radial direction.

37. 发明授权

US10698192B2 Method and microscopy system for scanning a sample 有权
公开(公告)号：US10698192B2
公开(公告)日：2020-06-30
申请号：US16352875
申请日：2019-03-14
申请人： LEICA MICROSYSTEMS CMS GMBH , EMBL European Molecular Biology Laboratory
发明人： Frank Sieckmann , Urban Liebel
IPC分类号： G02B21/00 , G01N15/14 , G02B21/36 , G06K9/00 , G06F19/00 , G16H40/67
摘要： A microscopy system provides for scanning a sample by a microscope, which is at least in part electrically or electronically controllable and in which a plurality of images or digital images are generatable in a scanning operation at different times and/or different locations of the sample. The microscopy system includes a control computer configured to control the microscope, as well as further computers that are integratable into the microscopy system such that an adaptation of the microscopy system is possible dynamically and/or during the scanning operation using at least one of the further computers.

38. 发明申请

US20200041961A1 METHOD FOR FORMING A DIGITAL VALUE FROM A CLOCK SIGNAL AND FROM A DATA SIGNAL 审中-公开
公开(公告)号：US20200041961A1
公开(公告)日：2020-02-06
申请号：US16498393
申请日：2018-04-04
申请人： Leica Microsystems CMS GmbH
发明人： Bernd Widzgowski
IPC分类号： G04F10/00 , H04L7/033 , G02B21/00 , G16H10/40
摘要： A method forms a digital value from a clock signal and a digital data signal. The method includes sampling the clock signal in order to obtain a clock signal digital value sequence and sampling the digital data signal in order to obtain a data signal digital value sequence. Sampling points are ascertained from the clock signal digital value sequence, at which data signal digital values are extracted from the data signal digital value sequence. The digital value is formed from the data signal digital values.

39. 发明申请

US20200004002A1 LIGHT SHEET MICROSCOPE AND MICROSCOPIC METHOD USING A LIGHT SHEET MICROSCOPE 审中-公开
公开(公告)号：US20200004002A1
公开(公告)日：2020-01-02
申请号：US16305395
申请日：2017-06-02
申请人： Leica Microsystems CMS GmbH
发明人： Sebastian Tille , Florian Fahrbach
IPC分类号： G02B21/00 , G02B21/18 , G02B21/36
摘要： A light sheet microscope includes a specimen-side objective having an illumination device configured to provide a first illumination beam which is focused for forming a first light sheet for illuminating a specimen from a first direction, the first light sheet being inclined obliquely in relation to an optical axis of the objective and being guided through the objective. A detector is configured to detect light passing through the objective. The illumination device is further configured to provide at least one second illumination beam which is focused for forming at least one second light sheet for illuminating the specimen from at least one second direction that differs from the first direction, the at least one second light sheet being inclined obliquely in relation to the optical axis of the objective and being guided through the objective.

40. 发明申请

US20190391375A1 ILLUMINATION ARRANGEMENT AND METHOD FOR ILLUMINATION IN A MICROSCOPE AND MICROSCOPE 审中-公开
公开(公告)号：US20190391375A1
公开(公告)日：2019-12-26
申请号：US16462242
申请日：2017-11-10
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： Florian FAHRBACH
IPC分类号： G02B21/00
摘要： An illumination arrangement for a microscope includes an illumination input configured to inject an illumination beam bundle and an illumination output configured to output at least two partial beam bundles generated from the illumination beam bundle. At least one diffractive optical element is configured to split the illumination beam bundle into the at least two partial beam bundles that propagate along partial beam paths, and is configured to effect a relative change in respective propagation directions of the at least two partial beam bundles with respect to one another, such that the at least two partial beam bundles output by the illumination arrangement are non-collinear with respect to one another at the illumination output.

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