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    • 33. 发明申请
    • ACTIVE MATRIX ORGANIC ELECTROLUMINESCENCE DISPLAY AND ITS GRADATION CONTROL METHOD
    • 有源矩阵有机电致发光显示及其等级控制方法
    • US20090002281A1
    • 2009-01-01
    • US12145673
    • 2008-06-25
    • Kaoru OkamotoTadahiko HiraiJun Sumioka
    • Kaoru OkamotoTadahiko HiraiJun Sumioka
    • G09G3/30
    • G09G3/3241G09G3/2014G09G2300/0842G09G2310/0251G09G2310/0262
    • An active matrix organic electroluminescence(EL) display comprises plural selection and data lines mutually crossed, and a pixel circuit connected to the selection and data lines and having switching devices, a storage capacitor and an organic EL device. In a part of a period that the pixel circuit connected to the selection line is being selected, an applied first data signal is held as a voltage at the storage capacitor of the selected pixel circuit. After the selection signal applying, a first current according to the held voltage is supplied to the organic EL device, and this emits light at luminance according to the first current. In another part of the period, a second current according to an applied second data signal is supplied to the organic EL device of the selected pixel circuit, and this emits light at luminance according to the second current.
    • 有源矩阵有机电致发光(EL)显示器包括相互交叉的多个选择和数据线,以及连接到选择和数据线并具有开关器件,存储电容器和有机EL器件的像素电路。 在选择与选择线连接的像素电路的期间的一部分中,施加的第一数据信号作为所选像素电路的存储电容器的电压被保持。 在选择信号施加之后,根据保持电压的第一电流被提供给有机EL器件,并且根据第一电流发光。 在该周期的另一部分中,根据所施加的第二数据信号的第二电流被提供给所选择的像素电路的有机EL器件,并且根据第二电流发光。
    • 35. 发明授权
    • Benzothiazole derivatives
    • 苯并噻唑衍生物
    • US5900426A
    • 1999-05-04
    • US624746
    • 1996-03-27
    • Hiroki MuramotoKiyoshi FukudaTaisuke HasegawaKaoru OkamotoTakayuki Kotani
    • Hiroki MuramotoKiyoshi FukudaTaisuke HasegawaKaoru OkamotoTakayuki Kotani
    • C07D277/64A61K31/415
    • C07D277/64
    • Benzothiazole derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component possess a lipid lowering activity and are useful pharmaceuticals for the treatment of hyperlipemia. The lipid lowering agents are of the formula: ##STR1## wherein R.sub.1 is halogen, trifluoromethyl, acetamido or --OX.sub.1 ; X.sub.1 is hydrogen, alkyl or acyl; R.sub.2 is hydrogen, halogen, alkyl, hydroxyalkyl, trifluoromethyl, nitro, amino which may be substituted with alkyl or acyl, carboxy which may be esterified with alkyl, or --OX.sub.2 ; X.sub.2 is hydrogen, alkyl, acyl, carboxyalkyl which may be esterified with alkyl; n is an integer from 1 to 3 denoting the number of substituents R.sub.2 ; and plural R.sub.2 may be the same or different when n is 2 or 3; with the proviso that R.sub.1 is a group other than halogen when R.sub.2 is hydrogen. The benzothiazole derivatives and their pharmaceutically acceptable salts significantly decrease cholesterol, triglyceride and low-density lipoprotein in blood.
    • 苯并噻唑衍生物,其药学上可接受的盐和含有所述化合物作为有效成分的治疗剂具有降脂活性,并且是用于治疗高脂血症的有用药物。 降脂剂具有下式:其中R1是卤素,三氟甲基,乙酰氨基或-OX1; X1是氢,烷基或酰基; R 2是氢,卤素,烷基,羟基烷基,三氟甲基,硝基,可被烷基或酰基取代的氨基,可以被烷基或-OX 2酯化的羧基; X 2是可以被烷基酯化的氢,烷基,酰基,羧基烷基; n是1至3的整数,表示取代基R2的数目; 当n为2或3时,多个R2可以相同或不同; 条件是当R 2为氢时,R 1为卤素以外的基团。 苯并噻唑衍生物及其药学上可接受的盐显着降低血液中的胆固醇,甘油三酯和低密度脂蛋白。
    • 36. 发明授权
    • Parabanic acid derivatives
    • 对缬氨酸衍生物
    • US5681843A
    • 1997-10-28
    • US575024
    • 1995-12-19
    • Takayuki KotaniKaoru OkamotoYasuhiro Nagaki
    • Takayuki KotaniKaoru OkamotoYasuhiro Nagaki
    • C07D233/90C07D233/96C07D401/06C07D403/06C07D409/06C07D417/06A10K31/415A01N43/50C07D233/02
    • C07D401/06C07D233/96C07D403/06C07D409/06C07D417/06
    • Parabanic acid derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component are useful pharmaceuticals for the treatment of diabetic complications such as diabetic neuropathy, diabetic cataracts and retinopathy, diabetic nephropathy, diabetic dermopathy, and other diabetic microangiopathy. The compounds of the present invention are represented by the following general formula (I): ##STR1## wherein R is hydrogen, lower alkyl or benzyl; X is substituted phenyl, optionally substituted benzothiazolyl, optionally substituted naphthyl, optionally substituted pyridyl, anthraquinonyl, phthalimide, or thienyl; and n is an integer from 1 to 3. The compounds of the present invention exhibit excellent inhibitory action towards aldose reductase with a high enzyme selectivity. Accordingly, they are useful as drugs for the therapy and prevention of various types of diabetic complications without substantially inhibitory aldehyde reductase.
    • 对映异酸衍生物,其药学上可接受的盐和含有所述化合物作为有效成分的治疗剂是用于治疗糖尿病性并发症如糖尿病性神经病变,糖尿病性白内障和视网膜病变,糖尿病性肾病,糖尿病性皮肤病和其它糖尿病性微血管病变的有用药物。 本发明的化合物由以下通式(I)表示:其中R是氢,低级烷基或苄基; X是取代的苯基,任选取代的苯并噻唑基,任选取代的萘基,任选取代的吡啶基,蒽醌基,邻苯二甲酰亚胺或噻吩基; n为1〜3的整数。本发明的化合物对具有高酶选择性的醛糖还原酶表现出优异的抑制作用。 因此,它们可用作治疗和预防各种类型的糖尿病并发症而不具有实质上抑制性醛还原酶的药物。