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31. 发明申请

US20120004196A1 Anti-Viral Compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US20120004196A1
公开(公告)日：2012-01-05
申请号：US13100827
申请日：2011-05-04
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号： A61K31/4184 , C07D401/14 , C07D405/14 , C07D413/14 , C07F7/10 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/438 , A61K31/4545 , A61K31/695 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P31/14 , C07D403/14
CPC分类号： A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译：描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

32. 发明申请

US20110003827A1 HIV protease inhibiting compounds 有权
标题翻译： HIV蛋白酶抑制化合物
公开(公告)号：US20110003827A1
公开(公告)日：2011-01-06
申请号：US11009841
申请日：2004-12-10
申请人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
发明人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
IPC分类号： A61K31/501 , C07C317/48 , C07C311/37 , C07D213/46 , C07D307/14 , C07D333/22 , C07D417/12 , C07D409/06 , C07D403/06 , C07D471/04 , A61K31/216 , A61K31/18 , A61K31/4402 , A61K31/341 , A61K31/381 , A61K31/427 , A61K31/4178 , A61K31/4709 , A61K31/437 , A61K31/506 , A61P31/18
CPC分类号： C07D417/12 , C07C311/18 , C07C311/29 , C07C311/41 , C07C311/47 , C07C317/18 , C07D209/14 , C07D213/30 , C07D213/40 , C07D233/36 , C07D233/64 , C07D233/72 , C07D277/24 , C07D277/28 , C07D307/14 , C07D307/20 , C07D307/52 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D409/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D493/04
摘要： A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

33. 发明授权

US5543505A Synthetic compounds which bind to H. pylori, and uses thereof 失效
标题翻译：与幽门螺杆菌结合的合成化合物及其用途
公开(公告)号：US5543505A
公开(公告)日：1996-08-06
申请号：US213053
申请日：1993-03-15
申请人： Samuel J. Danishefsky , John T. Randolph
发明人： Samuel J. Danishefsky , John T. Randolph
IPC分类号： A61K38/00 , C07H3/06 , C07H17/04 , C07K9/00 , C07K14/765 , C07H15/00 , C07H15/06 , C07H17/00 , C07K1/00
CPC分类号： C07K14/765 , C07H17/04 , C07H3/06 , C07K9/00 , A61K38/00
摘要： The present invention provides a compound having the structure: ##STR1## wherein A is selected from the group consisting of (i) an amino acid bearing an .omega.-amino group or an .omega.--(C.dbd.O)-- group, (ii) an amino acid residue of a peptide, which residue bears an .omega.-amino group or an .omega.-(C.dbd.O)-- group, and (iii) an amino acid residue of a protein, which residue bears an .omega.-amino group or an .omega.-(C.dbd.O)-- group; wherein R.sub.1 is H, OH, NH.sub.2 or NHR.sub.4, where R.sub.4 is SO.sub.2 Ph, a linear or branched chain alkyl or acyl group, or an aryl group; wherein M is a saccharide wherein n is an integer from 0 to 18, and where n is greater than 1, each M is independently the same or different; wherein p is either 0 or 1; wherein R.sub.2, R.sub.3, R.sub.5 and R.sub.6 are independently the same or different and are H or OH, with the proviso that R.sub.2 and R.sub.3 are not both OH, and R.sub.5 and R.sub.6 are not both OH; wherein X and Y are independently the same or different and are H.sub.2 or O; and wherein k is an integer greater than or equal to 1, with the proviso that when A is an amino acid bearing an .omega.-amino group or an .omega.-(C.dbd.O)-- group, k is equal to 1.
摘要翻译：本发明提供具有以下结构的化合物：其中A选自（i）具有ω-氨基或ω-（C = O） - 基团的氨基酸，（ii）肽的氨基酸残基，该残基具有ω-氨基或ω-（C = O） - 基团，和（iii）蛋白质的氨基酸残基，该残基具有ω- 氨基或ω-（C = O） - 基团; 其中R 1是H，OH，NH 2或NHR 4，其中R 4是SO 2 Ph，直链或支链烷基或酰基或芳基; 其中M是糖，其中n是0至18的整数，并且其中n大于1，每个M独立地相同或不同; 其中p是0或1; 其中R2，R3，R5和R6独立地相同或不同，为H或OH，条件是R2和R3不同时为OH，R5和R6不同时为OH; 其中X和Y独立地相同或不同，为H 2或O; 并且其中k是大于或等于1的整数，条件是当A是具有ω-氨基或ω-（C = O） - 基团的氨基酸时，k等于1。

34. 发明授权

US09278922B2 Anti-viral compounds 有权
公开(公告)号：US09278922B2
公开(公告)日：2016-03-08
申请号：US12759986
申请日：2010-04-14
申请人： Pamela L. Donner , Lissa T. Nelson , Tammie K. Jinkerson , Ryan G. Keddy , Christopher E. Motter , Mark A. Matulenko , Allan C. Krueger , David A. DeGoey , Sachin V. Patel , John T. Randolph , Warren M. Kati , Charles W. Hutchins , Todd N. Soltwedel
发明人： Pamela L. Donner , Lissa T. Nelson , Tammie K. Jinkerson , Ryan G. Keddy , Christopher E. Motter , Mark A. Matulenko , Allan C. Krueger , David A. DeGoey , Sachin V. Patel , John T. Randolph , Warren M. Kati , Charles W. Hutchins , Todd N. Soltwedel
IPC分类号： A61K38/05 , A61K31/4025 , A61K31/4184 , A61K31/5377 , C07K5/02 , C07K5/062 , A61P31/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D207/16 , A61K31/454 , C07D205/04 , C07D207/22 , C07D209/52 , C07D211/60 , C07D263/06 , C07D277/06 , C07D401/14 , C07D405/14 , C07D417/14 , C07D487/04 , C07K5/065 , C07K5/078 , A61K38/00
CPC分类号： C07D207/16 , A61K31/4025 , A61K31/4184 , A61K31/454 , A61K31/5377 , A61K38/00 , C07D205/04 , C07D207/22 , C07D209/52 , C07D211/60 , C07D263/06 , C07D277/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07K5/06034 , C07K5/06043 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06139
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

36. 发明授权

US08546405B2 Anti-viral compounds 有权
公开(公告)号：US08546405B2
公开(公告)日：2013-10-01
申请号：US12644432
申请日：2009-12-22
申请人： David A. DeGoey , Pamela L. Donner , Warren M. Kati , Charles W. Hutchins , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Preethi Krishnan , Neeta C. Mistry , Tami J. Pilot-Matias , Sachin V. Patel , Xiaoyan Li , Todd N. Soltwedel , Lissa T. Nelson
发明人： David A. DeGoey , Pamela L. Donner , Warren M. Kati , Charles W. Hutchins , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Preethi Krishnan , Neeta C. Mistry , Tami J. Pilot-Matias , Sachin V. Patel , Xiaoyan Li , Todd N. Soltwedel , Lissa T. Nelson
IPC分类号： A01N43/54 , A01N43/90 , A01N43/42 , A61K31/519 , A61K31/44 , C07D239/42 , C07D405/00 , C07D401/04 , C07D471/00 , C07D487/00 , C07D409/00 , C07D411/00
CPC分类号： C07D471/04 , C07D239/48
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

37. 发明授权

US08193227B2 HIV protease inhibiting compounds 有权
标题翻译： HIV蛋白酶抑制化合物
公开(公告)号：US08193227B2
公开(公告)日：2012-06-05
申请号：US11009841
申请日：2004-12-10
申请人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
发明人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
IPC分类号： A61K31/415 , C07D233/00
CPC分类号： C07D417/12 , C07C311/18 , C07C311/29 , C07C311/41 , C07C311/47 , C07C317/18 , C07D209/14 , C07D213/30 , C07D213/40 , C07D233/36 , C07D233/64 , C07D233/72 , C07D277/24 , C07D277/28 , C07D307/14 , C07D307/20 , C07D307/52 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D409/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D493/04
摘要： A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

38. 发明授权

US08178548B2 Anti-infective agents and uses thereof 有权
公开(公告)号：US08178548B2
公开(公告)日：2012-05-15
申请号：US12212315
申请日：2008-09-17
申请人： Pamela L. Donner , John T. Randolph , Allan C. Krueger , David A. Betebenner , Douglas K. Hutchinson , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , John K. Pratt , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , John E. Hengeveld , Rodger F. Henry , Xiaochun Lou , Geoff G. Z. Zhang
发明人： Pamela L. Donner , John T. Randolph , Allan C. Krueger , David A. Betebenner , Douglas K. Hutchinson , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , John K. Pratt , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , John E. Hengeveld , Rodger F. Henry , Xiaochun Lou , Geoff G. Z. Zhang
IPC分类号： A61K31/505 , C07D239/02 , C07D401/00
CPC分类号： C07D239/22 , A61K31/513 , C07D239/54 , C07D239/553 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

39. 发明申请

US20110207699A1 Anti-Viral Compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US20110207699A1
公开(公告)日：2011-08-25
申请号：US12964027
申请日：2010-12-09
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Clarence J. Maring , Michael D. Tufano , David A. Betebenner , Todd W. Rockway , Dachun Liu , John K. Pratt , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Clarence J. Maring , Michael D. Tufano , David A. Betebenner , Todd W. Rockway , Dachun Liu , John K. Pratt , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号： A61K31/695 , C07D401/14 , A61K31/454 , C07F5/02 , A61K31/69 , C07D401/10 , C07D403/14 , A61K31/4178 , A61K31/496 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/397 , C07F7/10 , A61P31/18
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译：描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

40. 发明申请

US20110137633A1 ANTI-VIRAL COMPOUNDS AND METHODS OF IDENTIFYING THE SAME 审中-公开
标题翻译：抗病毒化合物及其鉴定方法
公开(公告)号：US20110137633A1
公开(公告)日：2011-06-09
申请号：US12959941
申请日：2010-12-03
申请人： CHARLES W. HUTCHINS , DAVID A. DEGOEY , WARREN M. KATI , ALLAN C. KRUEGER , JOHN T. RANDOLPH , ROLF WAGNER , PAMELA L. DONNER
发明人： CHARLES W. HUTCHINS , DAVID A. DEGOEY , WARREN M. KATI , ALLAN C. KRUEGER , JOHN T. RANDOLPH , ROLF WAGNER , PAMELA L. DONNER
IPC分类号： G06G7/48 , C07D403/12 , C07D403/14 , C07D409/14 , C07D401/14
CPC分类号： C07D401/14 , C07D207/16 , C07D403/14 , C07D409/14 , C07D471/04 , C07D519/00
摘要： Methods of identifying NS5A inhibitors are provided. Novel binding sites are identified on NS5A dimers, and these binding sites can be used to design and/or identify new NS5A inhibitors.
摘要翻译：提供鉴定NS5A抑制剂的方法。在NS5A二聚体上鉴定新的结合位点，并且这些结合位点可用于设计和/或鉴定新的NS5A抑制剂。

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