专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US07057721B2 Wide field method for detecting pathogenic microorganisms 有权
标题翻译：用于检测病原微生物的广域方法
公开(公告)号：US07057721B2
公开(公告)日：2006-06-06
申请号：US10608470
申请日：2003-06-27
申请人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
发明人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0272 , G01J3/10 , G01N21/35 , G01N21/3577 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N2021/6417 , G01N2021/6423 , G01N2021/656 , G01N2201/0221
摘要： Pathogenic microorganisms are detected in a wide field of view and classified by Raman light scattered light from these organisms together with digital pattern recognition of their spectral patterns.
摘要翻译：在广泛的视野中检测致病微生物，并通过来自这些生物的拉曼光散射光以及它们的光谱图案的数字图案识别来分类病原微生物。

32. 发明授权

US08253936B2 Raman characterization of transplant tissue 有权
标题翻译：移植组织的拉曼表征
公开(公告)号：US08253936B2
公开(公告)日：2012-08-28
申请号：US12537513
申请日：2009-08-07
申请人： Jeffrey Cohen , John S Maier , Shona Stewart
发明人： Jeffrey Cohen , John S Maier , Shona Stewart
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0237 , G01J3/0291 , G01J3/0294 , G01J3/44 , G01N2021/656
摘要： A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.
摘要翻译：用于确定样品的疾病状态和临床结果的系统和方法。照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。在一个实施方案中，化学方法是主要成分分析。在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

33. 发明授权

US08078268B2 System and method of chemical imaging using pulsed laser excitation and time-gated detection to determine tissue margins during surgery 有权
标题翻译：使用脉冲激光激发和时间门控检测的化学成像的系统和方法来确定手术期间的组织边缘
公开(公告)号：US08078268B2
公开(公告)日：2011-12-13
申请号：US12565279
申请日：2009-09-23
申请人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J Treado
发明人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J Treado
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , A61B5/4064 , G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/65 , G01N2021/6484 , G01N2201/08
摘要： System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
摘要翻译：使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。

34. 发明申请

US20100081127A1 System and Method of Chemical Imaging Using Pulsed Laser Excitation and Time-Gated Detection to Determine Tissue Margins During Surgery 有权
标题翻译：使用脉冲激光激发和时间门控检测的化学成像系统和方法来确定手术中的组织边缘
公开(公告)号：US20100081127A1
公开(公告)日：2010-04-01
申请号：US12565279
申请日：2009-09-23
申请人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J. Treado
发明人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson , Patrick J. Treado
IPC分类号： C12Q1/70 , C12Q1/06
CPC分类号： A61B5/0075 , A61B5/0071 , A61B5/0084 , A61B5/4064 , G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/65 , G01N2021/6484 , G01N2201/08
摘要： System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
摘要翻译：使用脉冲激光激发和时间门控检测来区分生物样品中组织边缘的系统和方法。用基本单色的脉冲激光照射含有生物组织的区域，从而产生拉曼散射的光子。使用时间门控检测来检测拉曼散射的光子，从而从包含生物体组织的区域的肿瘤部位或非肿瘤部位的特征的照射区域获得拉曼光谱图像。肿瘤部位和非肿瘤部位之间的边界被区分，并且显示拉曼光谱图像中的边界位置。

35. 发明授权

US07596404B2 Method of chemical imaging to determine tissue margins during surgery 有权
标题翻译：化学成像方法来确定手术中的组织边缘
公开(公告)号：US07596404B2
公开(公告)日：2009-09-29
申请号：US11361256
申请日：2006-02-24
申请人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
发明人： John S. Maier , Shona Stewart , Jeffrey Cohen , Matthew Nelson
IPC分类号： A61B6/00
CPC分类号： G01N21/65 , A61B5/0075 , A61B5/0084 , G01N2021/6484 , G01N2021/656 , G01N2201/08
摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.
摘要翻译：在各种医疗过程中区分组织边缘的方法和系统。用基本上单色的光照射含有生物组织的区域。从照射区域获得拉曼光谱数据。在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

36. 发明授权

US07548310B2 Method and apparatus for compact spectrometer for multipoint sampling of an object 有权
标题翻译：用于多物体采样的紧凑型光谱仪的方法和装置
公开(公告)号：US07548310B2
公开(公告)日：2009-06-16
申请号：US11366660
申请日：2006-03-03
申请人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
发明人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
摘要翻译：本公开涉及通过使用便携式或手持式装置对样品进行多点光谱分析来评估样品中一种或多种危险剂的发生的方法和装置。公开了采用拉曼光谱法和其他分光光度法的方法。还公开了适于执行这种多点方法的设备和系统。

37. 发明授权

US07471387B1 System and method for the electrostatic detection and identification of threat agents 有权
标题翻译：用于静电检测和识别威胁剂的系统和方法
公开(公告)号：US07471387B1
公开(公告)日：2008-12-30
申请号：US11351278
申请日：2006-02-09
申请人： Patrick J. Treado , Charles W. Gardner, Jr. , John S. Maier , David Keller
发明人： Patrick J. Treado , Charles W. Gardner, Jr. , John S. Maier , David Keller
IPC分类号： G01N21/00 , G01N21/65
CPC分类号： G01J3/44 , G01N21/65
摘要： A system and method for detecting aerosol threats comprising electrostatic collection and deposition of a threat agent onto a substrate. The threat agent deposited on the substrate is illuminated with a plurality of photons to thereby produce Raman scattered photons. The Raman scattered photons are analyzed in order to identify the threat agent.
摘要翻译：一种用于检测气溶胶威胁的系统和方法，包括将威胁剂静电收集和沉积到基底上。沉积在基板上的威胁剂被多个光子照射，由此产生拉曼散射的光子。分析拉曼散射光子以识别威胁剂。

38. 发明授权

US07465911B2 Apparatus and method for chemical imaging of a biological sample with at least two spectral images of the sample obtained simultaneously 有权
标题翻译：具有同时获得的样品的至少两个光谱图像的生物样品的化学成像的装置和方法
公开(公告)号：US07465911B2
公开(公告)日：2008-12-16
申请号：US11907613
申请日：2007-10-15
申请人： David Tuschel , John S. Maier
发明人： David Tuschel , John S. Maier
IPC分类号： H01L27/00
CPC分类号： G01N21/6428 , G01J3/10 , G01J3/2823 , G01J3/4406 , G01N21/31 , G01N21/65 , G01N2021/6419 , G01N2021/6421 , G01N2021/6423
摘要： In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.
摘要翻译：在一个实施方案中，本公开涉及一种用于确定染色样品的照明参数的方法，所述方法可包括提供染色样品并获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。

39. 发明授权

US07440096B2 Method and apparatus for compact spectrometer for fiber array spectral translator 有权
标题翻译：用于光纤阵列光谱转换器的紧凑型光谱仪的方法和装置
公开(公告)号：US07440096B2
公开(公告)日：2008-10-21
申请号：US11366531
申请日：2006-03-03
申请人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
发明人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
摘要： The disclosure relates to a portable system having a fiber array spectral translator (“FAST”) for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

40. 发明授权

US07403273B2 System and method for the deposition, detection and identification of threat agents using a phase mask 有权
标题翻译：使用相位掩模沉积，检测和识别威胁剂的系统和方法
公开(公告)号：US07403273B2
公开(公告)日：2008-07-22
申请号：US11351333
申请日：2006-02-09
申请人： Patrick J. Treado , Charles W. Gardner, Jr. , John S. Maier
发明人： Patrick J. Treado , Charles W. Gardner, Jr. , John S. Maier
IPC分类号： G01N21/00 , G01N21/65 , G01J3/44
CPC分类号： G01J3/44 , G01N21/65
摘要： A system method for depositing a sample of a threat agent is deposited onto a substrate. The threat agent is illuminated via an illumination source along an optical path with a plurality of photons to thereby produce photons transmitted, reflected, emitted or Raman scattered by the threat agent. An optical system collects elastic scatter photons produced by the threat agent and at least one of photons transmitted, reflected, emitted or Raman scattered by the threat agent, wherein said illumination source is located along an optical path, and said substrate is located along a plane wherein the optical path is at an angle other than 90° with respect to the substrate plane. The depth of field of the optical system is extended by passing at least one of the following through a phase mask: elastic scattered photons, and photons transmitted, reflected, emitted or Raman scattered by the threat agent.
摘要翻译：将用于沉积威胁剂的样品的系统方法沉积在基底上。通过沿着具有多个光子的光路的照明源照射威胁剂，从而产生由威胁剂散射的透射，反射，发射或拉曼的光子。光学系统收集由威胁剂产生的弹性散射光子和由威胁剂散射的发射，反射，发射或拉曼的光子中的至少一种，其中所述照明源沿着光路定位，并且所述衬底沿着平面其中所述光路相对于所述基板平面成90°以外的角度。通过使以下各项中的至少一个通过相位掩模：弹性散射光子和由威胁剂散发的透射，反射，发射或拉曼的光子来延长光学系统的景深。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式