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31. 发明申请

US20090130766A1 FLUID SAMPLE TRANSPORT DEVICE WITH REDUCED DEAD VOLUME FOR PROCESSING, CONTROLLING AND/OR DETECTING A FLUID SAMPLE 失效
标题翻译：具有减少死亡体积的流体样品运输装置用于处理，控制和/或检测流体样品
公开(公告)号：US20090130766A1
公开(公告)日：2009-05-21
申请号：US12298951
申请日：2007-04-23
申请人： Johannes Wilhelmus Weekamp
发明人： Johannes Wilhelmus Weekamp
IPC分类号： G01N33/48 , B01L3/00 , G01N1/00
CPC分类号： B01L3/50273 , B01L3/502707 , B01L3/502738 , B01L7/52 , B01L2200/143 , B01L2300/0627 , B01L2300/0645 , B01L2300/0816 , B01L2300/1822 , B01L2300/1827 , B01L2400/0478 , B01L2400/0481 , B01L2400/0655 , Y10T436/25 , Y10T436/2575
摘要： The present invention relates to a fluid sample transport device (1) with reduced dead volume for processing, controlling and/or detecting a fluid sample (3), comprising: a substrate (2), wherein the upper surface of said substrate (2) comprises at least one processing, controlling and/or detecting element (19); at least one flexible membrane (4), wherein the flexible membrane (5) is arranged on the upper surface of said substrate (2); at least one plunger (5) and/or actuating element (9) for actuating an up and/or down movement of the flexible membrane (4) to cause a fluid flow and/or to stop a fluid flow; at least one cover plate (6) arranged on the upper outer surface or lower outer surface of the flexible membrane (4), wherein the cover plate (6) comprises at least one through going hole (10) and/or cut-out (10) for receiving a plunger (5) and/or actuating element (9), so that movement of said plunger (5) and/or actuating element (9) causes a pump and/or valve action of the adjacent arranged flexible membrane area to cause a fluid flow between the upper surface of said substrate (2) and the lower surface of said flexible membrane (4); and wherein at least one channel (7) to direct the fluid sample (3) flow on the substrate (2) is temporally formed by the flexible membrane.
摘要翻译：本发明涉及一种流体样品输送装置（1），其具有减少的死体积用于处理，控制和/或检测流体样品（3），包括：基底（2），其中所述基底（2）的上表面，包括至少一个处理，控制和/或检测元件（19）; 至少一个柔性膜（4），其中所述柔性膜（5）布置在所述基底（2）的上表面上; 至少一个柱塞（5）和/或致动元件（9），用于致动柔性膜（4）的向上和/或向下运动以引起流体流动和/或停止流体流动; 至少一个盖板（6），布置在柔性膜（4）的上外表面或下外表面上，其中盖板（6）包括至少一个通孔（10）和/或切口 10），用于接收柱塞（5）和/或致动元件（9），使得所述柱塞（5）和/或致动元件（9）的运动导致相邻布置的柔性膜区域的泵和/或阀动作在所述基板（2）的上表面和所述柔性膜（4）的下表面之间引起流体流动; 并且其中引导流体样品（3）的至少一个通道（7）在衬底（2）上流动，由柔性膜在时间上形成。

32. 发明授权

US09301874B2 Punctal plugs for controlled release of therapeutic agents 有权
标题翻译：用于控制释放治疗剂的针刺塞
公开(公告)号：US09301874B2
公开(公告)日：2016-04-05
申请号：US13409210
申请日：2012-03-01
申请人： Bret A. Coldren , Peter Paul Willem Leonard Van Den Bekerom , Antonius Wilhelmus Maria De Laat , Johannes Wilhelmus Weekamp , Victor Lust , Gerald Yewey
发明人： Bret A. Coldren , Peter Paul Willem Leonard Van Den Bekerom , Antonius Wilhelmus Maria De Laat , Johannes Wilhelmus Weekamp , Victor Lust , Gerald Yewey
IPC分类号： A61F9/00 , A61M31/00 , A61F9/007 , A61M35/00
CPC分类号： A61F9/00772 , A61F2250/0068
摘要： Lacrimal inserts such as punctal plugs may be utilized for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured for controlled, pulsatile release into the eye.
摘要翻译：诸如泪点塞的泪液插入物可用于将药物递送至眼睛。塞子包括尺寸适于穿过泪点并被定位在眼睑的泪小管内的体部。塞子可以包含至少部分地在主体部分内的芯部或储存器，其包括被配置为用于受控地，脉动地释放到眼睛中的治疗剂。

33. 发明申请

US20130100685A1 LED LIGHTING ASSEMBLY WITH MOUNTING ELEMENT FOR OPTICS 审中-公开
标题翻译： LED照明组件与光学安装元件
公开(公告)号：US20130100685A1
公开(公告)日：2013-04-25
申请号：US13809598
申请日：2011-07-12
申请人： Johannes Wilhelmus Weekamp , Rob Bosma , Norbertus Antonius Maria Sweegers
发明人： Johannes Wilhelmus Weekamp , Rob Bosma , Norbertus Antonius Maria Sweegers
IPC分类号： F21V17/16
CPC分类号： F21V17/16 , F21S41/143 , F21S41/39 , F21S43/14 , F21S43/37 , F21V17/005 , F21Y2115/10 , Y10T29/49895
摘要： A lighting assembly, a mounting element and a manufacturing method are described. The lighting assembly includes an LED assembly 20 comprising an LED lighting element 14 provided on a carrier part 12. In order to mount an optical element 50 for forming an emission beam from light emitted from the LED lighting elements 14 a mounting element 30 is provided. The optical element 50 is mounted on the LED assembly 20 by this mounting element 30, which includes mount structure 32, clamps 44 for fixing the optical element 50, a positioning element 34 for positioning on the LED assembly 30 and an alignment part 40. The alignment part 40 comprises a flexible portion 36 and a first fixing part 46. The mount structure 32 comprises a second fixing part 48 movable relative to the first fixing part 46, which is arranged next to the first fixing part 46. The positioning element 34 is positioned on the LED assembly 20. A predetermined alignment may be achieved by fixing the first fixing part 46 to the second fixing part 48.
摘要翻译：描述照明组件，安装元件和制造方法。照明组件包括LED组件20，其包括设置在载体部分12上的LED照明元件14.为了安装用于从LED照明元件14发射的光形成发射光束的光学元件50，提供安装元件30。光学元件50通过该安装元件30安装在LED组件20上，安装元件30包括安装结构32，用于固定光学元件50的夹具44，用于定位在LED组件30上的定位元件34和对准部分40。对准部分40包括柔性部分36和第一固定部分46.安装结构32包括可相对于邻近第一固定部分46设置的第一固定部分46可移动的第二固定部分48.定位元件34是定位在LED组件20上。可以通过将第一固定部分46固定到第二固定部分48来实现预定的对准。

34. 发明申请

US20120136351A1 CATHETER FOR OPEN-LOOP IRRIGATED ABLATION OF TISSUE 有权
标题翻译：用于组织开放循环灌注的导管
公开(公告)号：US20120136351A1
公开(公告)日：2012-05-31
申请号：US13388998
申请日：2010-08-26
申请人： Johannes Wilhelmus Weekamp , Jan Frederik Suijver , Waltherus Cornelis Jozef Bierhoff , Szabolcs Deladi , Godefridus Antonius Harks
发明人： Johannes Wilhelmus Weekamp , Jan Frederik Suijver , Waltherus Cornelis Jozef Bierhoff , Szabolcs Deladi , Godefridus Antonius Harks
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B8/12 , A61B8/445 , A61B18/1815 , A61B18/20 , A61B2017/003 , A61B2018/00029 , A61B2018/00351 , A61B2018/00357 , A61B2018/1472 , A61B2018/1497 , A61B2090/3782 , A61B2090/3784 , A61N7/022 , A61N2007/0078
摘要： The present invention relates to a catheter (20) adapted for open-loop irrigated ablation, such as RF ablation, of a tissue (40). Said catheter has a distal tip (22) with an ablation entity (15) adapted for performing ablation of the tissue, an irrigation hole (21) and an ultrasound transducer (5) adapted for transmitting and/or receiving ultrasonic waves. The ultrasound transducer is disposed behind or in the irrigation hole of the catheter, so as to allow an irrigation fluid to flow out of the irrigation hole, and so as to allow transmitting and/or receiving the ultrasonic waves through the irrigation hole. The invention also relates to an imaging system and to a corresponding method for operating a catheter.
摘要翻译：本发明涉及适用于组织（40）的开环灌洗消融（例如RF消融）的导管（20）。所述导管具有远侧末端（22），其具有适于进行组织消融的消融实体（15），适于发射和/或接收超声波的冲洗孔（21）和超声换能器（5）。超声波换能器设置在导管的后面或其中的冲洗孔中，以便使冲洗流体从冲洗孔流出，并且允许通过冲洗孔传输和/或接收超声波。本发明还涉及一种用于操作导管的成像系统和相应的方法。

35. 发明申请

US20110229619A1 DOMESTIC BEVERAGE DISPENSING DEVICE HAVING COOLING MEANS 审中-公开
标题翻译：具有冷却方式的家用饮料分配装置
公开(公告)号：US20110229619A1
公开(公告)日：2011-09-22
申请号：US13131049
申请日：2009-11-30
申请人： Peter Carel Krom , Karel Johannes Adrianus Van Den Aker , Christoph Dobrusskin , Johannes Wilhelmus Weekamp
发明人： Peter Carel Krom , Karel Johannes Adrianus Van Den Aker , Christoph Dobrusskin , Johannes Wilhelmus Weekamp
IPC分类号： C12G3/00 , B67D7/80
CPC分类号： B67D1/0857 , B67D1/04 , B67D1/0869
摘要： A domestic beverage dispensing device comprising conduit means (3) for supplying the beverage (2) from a keg (1) to a tap (5) and a cooling member (12). The cooling member (12) has a passage (13) surrounded by heat conductive material. A disposable tube (17) of deformable material forms at least a part of said conduit means (3) and extends through said passage (13). The deformability of the material of the disposable 5 tube (17) is such that the outer surface of the wall of the tube (17) abuts against the inner surface of said passage (13) when the beverage is pressurized.
摘要翻译：一种家用饮料分配装置，包括用于将饮料（2）从小桶（1）供应到水龙头（5）和冷却构件（12）的导管装置（3）。冷却构件（12）具有被导热材料包围的通道（13）。可变形材料的一次性管（17）形成所述导管装置（3）的至少一部分并延伸通过所述通道（13）。一次性管5的材料的可变形性使得当饮料被加压时，管17的壁的外表面与所述通道（13）的内表面抵接。

36. 发明授权

US08011082B2 Method of manufacturing a package carrier 有权
标题翻译：制造包装载体的方法
公开(公告)号：US08011082B2
公开(公告)日：2011-09-06
申请号：US12092835
申请日：2006-10-26
申请人： Johannes Wilhelmus Weekamp , Antonius Constant Johanna Cornelis Van Den Ackerveken , Will J. H. Ansems
发明人： Johannes Wilhelmus Weekamp , Antonius Constant Johanna Cornelis Van Den Ackerveken , Will J. H. Ansems
IPC分类号： G01R31/28
CPC分类号： H05K7/00 , B01L3/502707 , B01L2200/12 , B01L2300/0627 , B01L2300/0645 , B01L2300/0816 , B01L2300/0838 , H01L2224/85385 , H05K1/0284 , H05K1/182 , H05K3/0014 , H05K3/20 , H05K13/046 , H05K2201/09118 , H05K2201/10151 , Y10T29/49002 , Y10T29/49004 , Y10T29/49124 , Y10T29/49147 , Y10T29/49169 , Y10T29/4981
摘要： A package carrier enclosing at least one microelectronic element has a pattern of electrically conductive connection pads for electric connection of the package to another device. The package carrier is manufactured by providing a sacrificial carrier; applying an electrically conductive pattern to one side of the carrier; bending the carrier to create a shape having an elevated portion and recessed portions; forming a body member on the carrier at the side where the electrically conductive pattern is present; removing the sacrificial carrier; and placing a microelectronic element in a recess created in the body member at the position where the elevated portion of the carrier has been, and connecting the microelectronic element to the electrically conductive pattern. Furthermore, a hole in the package provides access to a sensitive surface of the microelectronic element.
摘要翻译：封装至少一个微电子元件的封装载体具有用于将封装电连接到另一器件的导电连接焊盘的图案。通过提供牺牲载体来制造包装载体; 将导电图案施加到所述载体的一侧; 弯曲载体以形成具有升高部分和凹陷部分的形状; 在存在导电图案的一侧在载体上形成体部件; 去除牺牲载体; 以及将微电子元件放置在在载体的升高部分已经存在的位置处在本体构件中形成的凹部中，并将微电子元件连接到导电图案。此外，封装中的孔提供对微电子元件的敏感表面的访问。

37. 发明授权

US07955558B2 Device for testing a fluid 有权
标题翻译：用于测试流体的装置
公开(公告)号：US07955558B2
公开(公告)日：2011-06-07
申请号：US12092840
申请日：2006-10-30
申请人： Johannes Wilhelmus Weekamp , Menno Willem Jose Prins , Albert Hendrik Jan Immink
发明人： Johannes Wilhelmus Weekamp , Menno Willem Jose Prins , Albert Hendrik Jan Immink
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , G01N27/00 , G01N31/22 , G01N33/52 , B01L3/00
CPC分类号： B01L3/5029 , A61B10/0051 , A61B2010/0009 , B01L3/502715 , B01L2200/027 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , B01L2400/065
摘要： A device for testing a fluid including an elongated carrier; two foam members for absorbing the fluid, which are arranged at an end of the carrier; a positioning member having a sleeve which is slidably arranged on the carrier; and a diagnostic device, which is arranged in the positioning member having a sensor die adapted to detecting at least one property of the fluid and means for supplying the fluid to a sensor surface of the sensor die. After the fluid has been supplied to the foam members, the positioning member is moved towards the end of the carrier where the foam members are located. When the diagnostic device comes into contact with one of the foam members, the fluid is squeezed from the foam member and supplied to the sensor surface of the sensor die through the fluid supplying means of the diagnostic device.
摘要翻译：一种用于测试包括细长载体的流体的装置; 用于吸收流体的两个泡沫构件，其布置在载体的端部; 定位构件，其具有可滑动地布置在所述载体上的套筒; 以及诊断装置，其布置在所述定位构件中，所述诊断装置具有适于检测所述流体的至少一个性质的传感器管芯和用于将所述流体供应到所述传感器管芯的传感器表面的装置。在将流体供应到泡沫构件之后，定位构件朝向泡沫构件所在的载体的端部移动。当诊断装置与其中一个泡沫构件接触时，流体被从泡沫构件挤压并通过诊断装置的流体供给装置供应到传感器模头的传感器表面。

38. 发明授权

US07918702B2 Large area LED array and method for its manufacture 失效
标题翻译：大面积LED阵列及其制造方法
公开(公告)号：US07918702B2
公开(公告)日：2011-04-05
申请号：US12298062
申请日：2007-04-11
申请人： Johannes Wilhelmus Weekamp
发明人： Johannes Wilhelmus Weekamp
IPC分类号： H01J9/00
CPC分类号： F21K9/90 , F21S4/28 , F21Y2115/10 , H01L33/62 , H01L2224/48091 , H01L2224/48465 , H01L2924/00011 , H01L2924/01047 , H01L2924/00014 , H01L2924/00 , H01L2924/01033
摘要： A method for manufacturing a large area LED array, comprising providing two stacks (21) of electrodes (26), each electrode arranged in a meander pattern (4) on a substrate (3), at least two U-turns (7) on one side of the meander each being connected to a LED mounting surface (8) to form a row (9) of mounting surfaces, arranging the stacks so that rows and columns of mounting surfaces intersect each other at a plurality of intersection points (24), and mounting LEDs (22) at these intersection points. The substrate material is then removed, and the stacks are stretched in two directions thereby separating said intersection points (24) from each other. According to the invention, the LEDs can be mounted to the LED mounting surfaces when these are still located close to each other, preferably adjacent to each other enabling a simple and cost efficient mounting process. Further, the size of the substrates on which the conducting layer is formed can be limited. This further increases the cost effectiveness of the process.
摘要翻译：一种用于制造大面积LED阵列的方法，包括提供电极（26）的两个堆叠（21），每个电极以基板（3）上的曲折图案（4）布置，至少两个U形匝（7）每个弯管的一侧连接到LED安装表面（8）以形成安装表面的一排（9），布置堆叠，使得安装表面的行和列在多个交点（24）处彼此相交，并且在这些交点处安装LED（22）。然后去除衬底材料，并且将堆叠沿两个方向拉伸，从而将所述交点（24）彼此分离。根据本发明，LED可以安装在LED安装表面上，当它们仍然彼此靠近时，优选彼此相邻，从而能够实现简单且成本有效的安装过程。此外，可以限制形成导电层的基板的尺寸。这进一步提高了流程的成本效益。

39. 发明申请

US20100233824A1 MICROFLUIDIC METHODS AND SYSTEMS FOR USE IN DETECTING ANALYTES 审中-公开
标题翻译：用于检测分析的微流感方法和系统
公开(公告)号：US20100233824A1
公开(公告)日：2010-09-16
申请号：US12669213
申请日：2008-07-11
申请人： Godefridus Johannes Verhoeckx , Henkrik Sibolt Van Damme , Jeroen Hans Nieuwenhuis , Sergei Shulepov , Johannes Wilhelmus Weekamp , Mara Johanna Jacoba Sijbers , Harold Johannes Antonius Brans , Femke Karina De Theije , Albert Hendrik Jan Immink
发明人： Godefridus Johannes Verhoeckx , Henkrik Sibolt Van Damme , Jeroen Hans Nieuwenhuis , Sergei Shulepov , Johannes Wilhelmus Weekamp , Mara Johanna Jacoba Sijbers , Harold Johannes Antonius Brans , Femke Karina De Theije , Albert Hendrik Jan Immink
IPC分类号： G01N33/53 , G01N33/00 , B23P17/04
CPC分类号： B01L3/502715 , B01L2200/12 , B01L2200/16 , B01L2300/0627 , B01L2300/0636 , B01L2300/161 , B01L2400/0406 , B01L2400/0487 , Y10T29/49826
摘要： A microfluidic reactor arrangement (100) for use in detecting an analyte in a fluid sample (106) is described. The reactor arrangement is provided with a reagent providing means such that the reagent can be introduced after assembly of the reactor arrangement. The latter can be performed by introducing the reagent in the form of a solution or a dispersion and fixing it on a holding means (118) by removal of the liquid, i.e. by drying, the holding means comprising the reagent in a solid version in the detector chamber. Prior to the introduction of the reagent, components of the reactor arrangement already present, such as the sample inlet can be hydrophilised by a wetting hydrophilising technique. The invention relates to a manufacturing technique as well as to the resulting product. The invention furthermore relates to functionalizing of the reactor arrangement with a particular reagent for particular applications. The latter can be performed well after fabrication and assembly of the major reactor arrangement components.
摘要翻译：描述了用于检测流体样品（106）中的分析物的微流体反应器装置（100）。反应器装置设置有试剂提供装置，使得可以在组装反应器装置之后引入试剂。后者可以通过将试剂以溶液或分散体的形式引入并通过除去液体将其固定在保持装置（118）上来进行，即通过干燥包含试剂的固定装置以固体形式在检测器室。在引入试剂之前，已经存在的反应器装置的组分（例如样品入口）可以通过润湿亲水化技术亲水化。本发明涉及制造技术以及所得到的产品。本发明还涉及用于特定应用的具有特定试剂的反应器装置的功能化。后者可以在主要反应器布置部件的制造和组装之后很好地进行。

40. 发明申请

US20100132797A1 MICROFLUIDIC SYSTEM BASED ON ACTUATOR ELEMENTS 审中-公开
标题翻译：基于执行器元件的微流体系统
公开(公告)号：US20100132797A1
公开(公告)日：2010-06-03
申请号：US12530792
申请日：2008-03-12
申请人： Menno Willem Jose Prins , Johannes Wilhelmus Weekamp , Jacob Marinus Jan Den Toonder
发明人： Menno Willem Jose Prins , Johannes Wilhelmus Weekamp , Jacob Marinus Jan Den Toonder
IPC分类号： F15C3/08 , H01H47/00 , B01L3/00 , G05D7/06 , F15C5/00 , F15C7/00
CPC分类号： F04B19/006 , B01F13/0059 , B01F13/0091 , B01L3/502707 , B01L3/502746 , B01L2400/043 , B01L2400/0638 , F04D33/00 , Y10T29/494 , Y10T29/49826 , Y10T137/0318 , Y10T137/2191 , Y10T137/2202 , Y10T137/2213
摘要： The present invention provides a microfluidic system comprising at least one microchannel (18) having an inner wall (17). The microfluidic system comprises attached to the inner wall (17) of the at least one microchannel (18) a plurality of ciliary N actuator elements (10a-d) and at least one floating current wire (14a-d) present in the at least one microchannel (18) for applying a magnetic field to the plurality of ciliary actuator elements (10a-d) for changing their shape and/or orientation. The present invention also provides a method for the manufacturing of such microfluidic systems and to a method for controlling a fluid flow through a microchannel (18) of such a microfluidic system.
摘要翻译：本发明提供一种包括至少一个具有内壁（17）的微通道（18）的微流体系统。所述微流体系统包括附接到所述至少一个微通道（18）的内壁（17）上的多个睫毛N致动器元件（10a-d）和至少一个浮动电流线（14a-d）一个微通道（18），用于向多个纤毛致动器元件（10a-d）施加磁场，用于改变其形状和/或取向。本发明还提供了一种用于制造这种微流体系统的方法以及用于控制通过这种微流体系统的微通道（18）的流体流动的方法。

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