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    • 34. 发明授权
    • Method of transmitting of data and configuring a codebook in multi antenna system
    • 在多天线系统中发送数据和配置码本的方法
    • US08582679B2
    • 2013-11-12
    • US12666777
    • 2008-06-24
    • Moon Il LeeBin Chul IhmHyun Soo KoWook Bong LeeJin Hyuk JungJae Wan Kim
    • Moon Il LeeBin Chul IhmHyun Soo KoWook Bong LeeJin Hyuk JungJae Wan Kim
    • H04L1/02
    • H04W52/346
    • Methods of controlling a transmission power and configuring a codebook in a multi-antenna system to solve a transmission power unbalance between antennas are disclosed. The method of transmitting data in a multi-antenna system includes (A) transmitting one or more pilot signals within a first symbol region through a first antenna unit, and (B) transmitting one or more pilot signals within a second symbol region through a second antenna unit, wherein data within the first symbol region is transmitted through the second antenna unit, and data within the second symbol region is transmitted through the first antenna unit. According to the present invention, since a transmission power unbalance between antennas is solved, a transmission power can be uniformly assigned to each antenna and channel estimation can be easily performed. Moreover, a power amplifier having a uniform amplification range can be used and designed.
    • 公开了在多天线系统中控制发送功率和配置码本以解决天线之间的发送功率不平衡的方法。 在多天线系统中发送数据的方法包括:(A)通过第一天线单元在第一符号区域内传输一个或多个导频信号,以及(B)通过第二天线单元在第二符号区域内传输一个或多个导频信号 天线单元,其中通过第二天线单元发送第一符号区域内的数据,并且通过第一天线单元发送第二符号区域内的数据。 根据本发明,由于天线之间的发送功率不平衡被解决,所以可以将发送功率均匀地分配给每个天线,并且可以容易地进行信道估计。 此外,可以使用和设计具有均匀放大范围的功率放大器。
    • 35. 发明申请
    • USE OF HADES AS TUMOR SUPPRESSOR TARGET
    • 用作肿瘤抑制剂目标
    • US20130157959A1
    • 2013-06-20
    • US13641910
    • 2011-04-21
    • Sungkwan AnJin Hyuk JungJae Ho LeeSeunghee Bae
    • Sungkwan AnJin Hyuk JungJae Ho LeeSeunghee Bae
    • A61K38/17
    • A61K38/17A61K38/53C07K16/18
    • The present invention relates to a new use of Hades as a tumor suppressor target, more particularly to a composition for suppressing tumor comprising an expression or action inhibitor of Hades protein having an amino acid sequence of SEQ ID NO: 2 as an effective ingredient. The present inventors have found that the overexpressed Hades protein interacts with p53 to inhibit the exonuclear mechanism of p53 and the knowdown of Hades induces increase in the expression of p53, demonstrating that Hades is a negative regulator to p53. Therefore, it would be understood that the inhibition of Hades overexpressed in tumor cells contributes to tumor-supressive effects of p53. The drug candidates capable of modulating the expression of the Hades protein, inhibiting the actions of the Hades protein or inhibiting interecation between Hades and p53 are considered a promising anticancer drug.
    • 本发明涉及Hades作为肿瘤抑制靶的新用途,更具体地,涉及具有SEQ ID NO:2的氨基酸序列的Hades蛋白的表达或抑制剂作为有效成分的抑制肿瘤的组合物。 本发明人已经发现,过表达的Hades蛋白与p53相互作用以抑制p53的外核机制,并且Hades的知识诱导p53表达增加,表明Hades是p53的负调节因子。 因此,应当理解,在肿瘤细胞中过表达的Hades的抑制有助于p53的肿瘤抑制作用。 能够调节Hades蛋白表达,抑制Hades蛋白的作用或抑制Hades和p53之间的相互作用的候选药物被认为是有希望的抗癌药物。