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31. 发明授权

US07526338B1 Implantable cardiac device for monitoring diastolic heart failure and method of operation and use thereof 有权
标题翻译：用于监测舒张性心力衰竭的可植入心脏装置及其操作和使用方法
公开(公告)号：US07526338B1
公开(公告)日：2009-04-28
申请号：US11136268
申请日：2005-05-23
申请人： Jong Gill , Xiaoyi Min , Gene A. Bornzin
发明人： Jong Gill , Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61N1/365 , A61B5/02
CPC分类号： A61B5/0215 , A61N1/3627 , A61N1/365 , A61N1/36564 , G06F19/3481 , G16H50/50
摘要： An implantable cardiac device is used to measure one or more parameters relating to cardiac activity of a patient's heart, from which diastolic heart failure (“DHF”) may be monitored and/or detected. These parameters are used to calculate ventricular isovolumetric relaxation time or a related time value. Heart conditions possibly having an influence on the ventricular isovolumetric relaxation time, other than heart conditions due to reduced compliance, may be detected and used to prevent an incorrect calculation of the ventricular isovolumetric relaxation time. The parameters may be measured and the relaxation time calculated multiple times over a period of time, which enables monitoring of the progression of change in the relaxation time. The relaxation time and the progression of change therein are indicators of DHF.
摘要翻译：可植入心脏装置用于测量与患者心脏的心脏活动相关的一个或多个参数，可以从该心脏的心脏监测和/或检测舒张性心力衰竭（“DHF”）。这些参数用于计算心室等容弛豫时间或相关时间值。可能检测并用于可能对心室等容舒张时间（由于依从性降低而导致的心脏状况）影响的心脏状况，以防止心室等容性弛豫时间的错误计算。可以测量参数并且在一段时间内多次计算松弛时间，这可以监测松弛时间的变化进展。舒缓时间及其变化的进展情况是DHF的指标。

32. 发明授权

US07450999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07450999B1
公开(公告)日：2008-11-11
申请号：US11053566
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/378
CPC分类号： A61N1/057 , A61B5/02152 , A61B5/02158 , A61B5/6853 , A61B5/6857 , A61B5/6882
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

33. 发明授权

US07435221B1 System and method for detecting abnormal respiration based on intracardiac electrogram signals using a pattern recognition device 有权
标题翻译：使用模式识别装置，基于心内电描记信号检测异常呼吸的系统和方法
公开(公告)号：US07435221B1
公开(公告)日：2008-10-14
申请号：US11558819
申请日：2006-11-10
申请人： Rupinder Bharmi , Philip de Chazal , Gene A. Bornzin , Michael E. Benser
发明人： Rupinder Bharmi , Philip de Chazal , Gene A. Bornzin , Michael E. Benser
IPC分类号： A61B5/08 , A61B5/02 , A61B5/04
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/02405 , A61B5/0472 , A61B5/08 , A61B5/0803 , A61B5/0816 , A61B5/11 , A61B5/145 , A61B5/411 , A61B5/4818 , A61B5/7267 , A61N1/3601 , A61N1/365 , A61N1/37
摘要： Techniques are provided for detecting abnormal respiration within a patient based upon intracardiac electrogram (IEGM) signals or other electrical cardiac signals. Briefly, abnormal respiration is detected using a pattern recognition trained to discriminate normal and abnormal respiration based on morphological parameters and interval-based parameters extracted from the IEGM signals. In addition, techniques are described for distinguishing among different cardiac rhythm types within the patient while using one or more pattern classifiers or other pattern recognition devices.
摘要翻译：提供了用于基于心内电描记图（IEGM）信号或其他电心脏信号来检测患者内异常呼吸的技术。简而言之，使用根据从IEGM信号提取的形态参数和基于间隔的参数来鉴别正常和异常呼吸的训练的模式识别来检测异常呼吸。此外，描述了用于在使用一个或多个模式分类器或其他模式识别装置的同时区分患者内的不同心律类型之类的技术。

34. 发明授权

US07400920B1 Detection of renal failure by cardiac implantable medical device 有权
标题翻译：通过心脏植入式医疗器械检测肾功能衰竭
公开(公告)号：US07400920B1
公开(公告)日：2008-07-15
申请号：US11202553
申请日：2005-08-11
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61B5/04
CPC分类号： A61B5/0468 , A61B5/201
摘要： Morphological features within electrical cardiac signals are tracked and changes in features are monitored to detect renal failure. The morphological feature may be an interval between corresponding polarization events such as the interval between QRS-complexes and peaks of corresponding T-waves (QTmax interval); the interval between QRS-complexes and ends of corresponding T-waves (QTend interval); or the interval between P-waves and corresponding QRS-complexes (PR interval). The feature may also be the elevation of a cardiac signal segment between corresponding polarization events, such as QRS-complexes and corresponding T-waves (ST segment); a duration of a polarization event, such as a QRS-complex (QRS width); or an amplitude of a polarization event, such as a T-wave (T-wave amplitude). The change in the feature may comprise a decrease in QTmax intervals, a decrease in QTend intervals, a deviation in ST segment elevation, an increase in QRS width, an increase in PR interval or a deviation in T-wave amplitude.
摘要翻译：跟踪电心电信号中的形态学特征，监测特征变化以检测肾功能衰竭。形态特征可以是相应的极化事件之间的间隔，例如QRS-复合物之间的间隔和对应的T波的峰值（QTmax间隔）; QRS复合体与相应T波结束之间的间隔（QTend间隔）; 或P波与相应的QRS复合体之间的间隔（PR间隔）。该特征还可以是对应的极化事件之间的心脏信号段的升高，例如QRS复合物和相应的T波（ST段）; 极化事件的持续时间，例如QRS复合（QRS宽度）; 或极化事件的振幅，例如T波（T波振幅）。特征的变化可以包括QTmax间隔的减小，QTend间隔的减小，ST段抬高的偏差，QRS宽度的增加，PR间期的增加或T波幅度的偏差。

35. 发明授权

US07383091B1 Medical electrical lead providing far-field signal attenuation 有权
标题翻译：医用电源提供远场信号衰减
公开(公告)号：US07383091B1
公开(公告)日：2008-06-03
申请号：US10656649
申请日：2003-09-04
申请人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
发明人： Yougandh Chitre , Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573
摘要： A bipolar pacing and sensing lead incorporates a range of active surface areas for each of the anode and cathode electrodes, and a range of inter-electrode spacings between the anode and cathode electrodes which, in combination, provide acceptable near-field signal amplitudes and attenuate the amplitudes of unwanted signals, such as far-field R-waves, far-field P-waves, and T-waves.
摘要翻译：双极起搏和感测引线包括用于阳极和阴极电极中的每一个的一系列活性表面积，以及阳极和阴极电极之间的一系列电极间间隔，其组合提供可接受的近场信号幅度并衰减不想要的信号的幅度，例如远场R波，远场P波和T波。

36. 发明授权

US07340288B1 Trans-septal intra-cardiac lead system 失效
公开(公告)号：US07340288B1
公开(公告)日：2008-03-04
申请号：US11053493
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04
CPC分类号： A61B5/0215 , A61N1/3627 , A61N1/36514 , A61N2001/0585
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

37. 发明授权

US07274965B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07274965B1
公开(公告)日：2007-09-25
申请号：US11053373
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/00
CPC分类号： A61N1/00
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

38. 发明授权

US07260433B1 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
公开(公告)号：US07260433B1
公开(公告)日：2007-08-21
申请号：US10937656
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/00 , A61B5/02 , A61B5/04
CPC分类号： A61N1/3627 , A61N1/0504 , A61N1/3702 , A61N1/37288 , A61N1/3756
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

39. 发明授权

US07225015B1 System and method for detecting cardiac ischemia based on T-waves using an implantable medical device 有权
公开(公告)号：US07225015B1
公开(公告)日：2007-05-29
申请号：US10603398
申请日：2003-06-24
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0468
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

40. 发明授权

US07130686B1 Selection of preventative arrhythmia therapy based on patient specific histogram data 有权
标题翻译：基于患者特异性直方图数据选择预防性心律失常治疗
公开(公告)号：US07130686B1
公开(公告)日：2006-10-31
申请号：US10187501
申请日：2002-07-01
申请人： Paul A. Levine , Gene A. Bornzin , Anne M. Pianca
发明人： Paul A. Levine , Gene A. Bornzin , Anne M. Pianca
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/3624 , A61N1/36514 , A61N1/36521 , A61N1/36557 , A61N1/395
摘要： Methods and systems for providing cardiac therapy are described. In some embodiments, methods and systems are configured to deliver atrial tachyarrhythmia therapy by confirming that a patient is asleep and thereafter administering the therapy. Sleep can be confirmed, in some embodiments, through the use of a histogram that can be calculated using one or more parameters that are monitored by an implantable stimulation device. Parameters can include both physiological and non-physiological parameters. In other embodiments, atrial tachyarrhythmia therapy is delivered by determining desirable times to administer such therapy. Other various systems and methods for administering cardiac therapy are described.
摘要翻译：描述了提供心脏治疗的方法和系统。在一些实施例中，方法和系统被配置为通过确认患者睡着并且之后施用治疗来递送心房快速性心律失常治疗。在一些实施例中，可以通过使用可以使用由可植入刺激装置监测的一个或多个参数来计算的直方图来确认睡眠。参数可以包括生理参数和非生理参数。在其它实施方案中，通过确定施用此类治疗的期望时间来递送心房快速性心律失常治疗。描述了用于施用心脏治疗的其它各种系统和方法。

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