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31. 发明申请

US20040110733A1 Methods and agents for treating cardiovascular diseases 审中-公开
标题翻译：治疗心血管疾病的方法和药剂
公开(公告)号：US20040110733A1
公开(公告)日：2004-06-10
申请号：US10309562
申请日：2002-12-04
申请人： Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V.
发明人： Jurgen Borlak , Thomas Thum
IPC分类号： A61K031/57
CPC分类号： A61K31/56
摘要： This invention relates to a method and an agent for treating cardiovascular diseases, especially cardiac hypertrophy, wherein said method and agent consist in increasing testosterone concentration in pathological tissues to normal levels or inhibiting and/or eliminating metabolites from testosterone metabolism. The testosterone concentration in pathological tissues can be increased to normal levels by administering at least one substance from the following groups: testosterone; substances with effects similar to those of testosterone; testosterone mimetics; substances that enhance testosterone synthesis; substances that inhibit testosterone metabolism. Metabolites from testosterone metabolism can be inhibited and/or eliminated by administering at least one substance from the following groups: substances that bind to the androgen receptor, causing the receptor levels to be regulated and thus normalized; substances that bind to the androgen receptor, regulating the androgen receptor-mediated gene expression by inhibiting it, as is observed in cardiac hypertrophy. Areas of application are medicine and pharmaceuticals industry.
摘要翻译：本发明涉及用于治疗心血管疾病，特别是心脏肥大的方法和药剂，其中所述方法和试剂包括将病理组织中的睾酮浓度增加至正常水平，或抑制和/或消除睾酮代谢的代谢物。通过施用以下组中的至少一种物质，将病理组织中的睾酮浓度提高至正常水平：睾酮; 具有与睾丸激素相似效果的物质; 睾酮模拟物增强睾酮合成的物质; 抑制睾酮代谢的物质。通过施用来自以下组的至少一种物质可以抑制和/或消除来自睾丸激素代谢的代谢物：与雄激素受体结合的物质，导致受体水平被调节并因此被归一化; 与雄激素受体结合的物质，通过抑制雄激素受体介导的基因表达，如在心脏肥大中观察到的那样。应用领域是医药行业。

32. 发明申请

US20030183491A1 Transport device and method of transporting to-be-processed elements through a high-temperature zone 有权
标题翻译：运输装置和通过高温区输送待处理元件的方法
公开(公告)号：US20030183491A1
公开(公告)日：2003-10-02
申请号：US10109666
申请日：2002-04-01
申请人： Fraunhofer-Gesellschaft Zur Forderung der angewandten Forschung e.V. , Centrotherm, Elektrische Anlagen GmbH & Co.
发明人： Daniel Biro , Reinhard Lenz , Peter Volk , Gernot Wandel
IPC分类号： B65G025/04
CPC分类号： B65G25/02 , B65G25/06 , B65G2201/02 , F27B9/202 , F27B9/243 , H01L21/677
摘要： The present invention relates to a transport device for transporting to-be-processed elements through a high-temperature zone and a corresponding method. The transport device operates according to the walking beam principle, with thin, elongated carrier elements made of a flexible material, which are maintained under tensile stress along the longitudinal axis of the carrier elements, being provided instead of conventional walking beams. The proposed transport device permits low contamination transport of the elements through a high-temperature zone and improved utilization of energy as well as the ability to use a RTP process.
摘要翻译：本发明涉及通过高温区域运送被处理元件的输送装置及相应的方法。运输装置根据步进梁原理操作，其中提供由柔性材料制成的细长的载体元件，其沿承载元件的纵向轴线保持在拉伸应力下，而不是传统的步进梁。所提出的运输装置允许元件通过高温区域的低污染运输和能量的改进利用以及使用RTP工艺的能力。

33. 发明申请

US20030139621A1 Method for preparing styryl-functionalized silanes 失效
标题翻译：制备苯乙烯基官能化硅烷的方法
公开(公告)号：US20030139621A1
公开(公告)日：2003-07-24
申请号：US10313007
申请日：2002-12-06
申请人： Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung e.V.
发明人： Stephane Jacob , Lothar Frohlich , Konrad Olma , Michael Popall , Frank Kahlenberg
IPC分类号： C07F007/04
CPC分类号： C07F7/1876
摘要： The invention relates to a method for preparing silanes comprising styryl groups, said silanes being represented by the general formula (I): (St) bSiRnullaR4nullanullbwith improved yields through a reaction with magnesium in a solvent mixture comprising from 30:70 to 70:30 (v/v) of diethyl ether and tetrahydrofuran.
摘要翻译：本发明涉及一种制备包含苯乙烯基的硅烷的方法，所述硅烷由通式（I）表示：（St）bSiR'aR4-a-b，通过与含有30： 70至70:30（v / v）乙醚和四氢呋喃。

34. 发明申请

US20020092834A1 Apparatus for coating a substrate with a plasma arc torch 审中-公开
标题翻译：用等离子弧焊炬涂覆基板的设备
公开(公告)号：US20020092834A1
公开(公告)日：2002-07-18
申请号：US10027684
申请日：2001-12-20
申请人： Fraunhofer-Gesellschaft Zur Forderung der angewandten Forschung e.V.
发明人： Steffen Nowotny , Roman Zieris , Tobias Neumann , Gerhard Eckart
IPC分类号： B23K010/00 , B23K026/14
CPC分类号： H05H1/42
摘要： The invention relates to an apparatus for coating a substrate with a plasma arc torch, and with such a plasma arc torch the powdery additive is to be heated, melted open and accelerated towards the surface with plasma gas generated in the plasma arc torch, and with an additional laser beam. In the plasma arc torch, an annular cathode is located or a plurality of individual cathodes are arranged about a longitudinal axis. Gas is supplied into a plasma space which is located between such an annular cathode or the plurality of cathodes, and such an annular anode. With the invention, coating is to be allowed to be formed with a higher speed and deposition rate, respectively, with respect to the conventional solution with the same and increased quality, respectively, and the directional independence for the formation of the coating is to be ensured. This object is substantially solved in that the laser beam is directed upon the surface to be coated through such an annular cathode or between a plurality of cathodes arranged about the longitudinal axis, and through the annular shaped anode coaxially with respect to the longitudinal axis A.
摘要翻译：本发明涉及一种用等离子弧焊炬涂覆基板的设备，并且通过这样的等离子弧焊炬，粉末状添加剂将被加热，熔化开放并且在等离子体电弧炬中产生等离子体气体而朝向表面加速，并且与一个额外的激光束。在等离子弧焊炬中，环形阴极被定位或者围绕纵向轴线布置多个单独的阴极。将气体供给到位于这样的环状阴极或多个阴极之间的等离子体空间中，以及这种环状阳极。通过本发明，可以分别以相同和提高质量的常规溶液分别以更高的速度和沉积速率形成涂层，并且用于形成涂层的方向独立性应为确保。基本上解决了这个目的，即激光束被引导通过这种环形阴极被涂覆的表面，或者围绕纵向轴线布置的多个阴极之间，以及相对于纵向轴线A同轴地穿过环形阳极。

35. 发明申请

US20020063053A1 Method of producing a thin-film system 失效
标题翻译：薄膜系统的制造方法
公开(公告)号：US20020063053A1
公开(公告)日：2002-05-30
申请号：US09962212
申请日：2001-09-26
申请人： Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V.
发明人： Torsten Winkler , Ralf Bluthner , Klaus Goedicke , Michael Junghahnel , Hans Buchberger , Manfred Muller , Arno Hebgen , Hans-Hermann Schneider
IPC分类号： C23C014/34 , B05D005/12 , H05H001/24
CPC分类号： C23C14/35 , C23C16/515
摘要： Production of a thin-film system containing at least one ultra-thin film, preferentially in the film thickness range from 1 to 10 nm, which is separated by plasma-aided chemical or physical vapor-phase deposition using magnetron discharges. The method is characterized in that in the course of deposition of the ultra-thin film the power output is introduced into the plasma in the form of a controlled number of power pulses and that the average power output during the pulse-on time is set higher by a factor of at least 3 than the averaged power output over the entire coating time during deposition of the ultra-thin film.
摘要翻译：制备含有至少一种超薄膜的薄膜系统，优选在1至10nm的膜厚度范围内，其通过使用磁控管放电的等离子体辅助化学或物理气相沉积分离。该方法的特征在于，在沉积超薄膜的过程中，功率输出以受控数量的功率脉冲的形式被引入等离子体，并且将脉冲接通时间期间的平均功率输出设置得更高比在超薄膜沉积期间的整个涂布时间的平均功率输出至少3倍。

36. 发明申请

US20020023503A1 Method of monitoring and controlling a screwing process 有权
标题翻译：监控和控制螺丝拧紧过程的方法
公开(公告)号：US20020023503A1
公开(公告)日：2002-02-28
申请号：US09940437
申请日：2001-08-29
申请人： Fraunhofer Gesellschaft zur Forderung der angewandten Forschung e.V.
发明人： Eckhardt Schneider , Rudiger Herzer
IPC分类号： F16B031/02
CPC分类号： G01N29/4436 , B25B23/14 , B25B23/1425 , G01N29/07 , G01N29/227 , G01N2291/02827 , G01N2291/02854 , G01N2291/044 , G01N2291/101 , G01N2291/2626 , G01N2291/269 , G01N2291/2691
摘要： The present invention relates to a method for monitoring and, if need be, controlling a screwing process in the creation of a screw connection using a screw, in which ultrasonic pulses are repeatedly coupled into the screw starting from the head of the screw using a pulse-echo method before and during the tightening process and the time it takes the ultrasonic pulses to traverse the length of the screw (propagation time) is measured. Before starting the tightening process, a dependency of the propagation time of the ultrasonic pulse on the predetermined tension of the screw is calculated from the material-specific characteristic values of the screw utilizing the measured propagation time through the load-free screw. Comparison of a change in propagation time dependent on a screw parameter with a calculated change in propagation time dependent on the predetermined tension of the screw permits drawing conclusions about the control of the screwing process. Thus, in particular, significant deviations indicate poor adherence to the specifications or thread damage, whereas minor deviations can be utilized to control the screwing process.
摘要翻译：本发明涉及一种用于监测的方法，并且如果需要的话，在使用螺钉的螺杆连接的创建中控制螺丝拧紧过程，其中使用脉冲将超声波脉冲从螺杆的头部重新连接到螺钉中在紧固过程之前和期间以及超声波脉冲穿过螺杆长度所需的时间（传播时间）进行测量。在开始紧固过程之前，利用所测量的通过无负载螺杆的传播时间，从螺杆的材料特性值计算超声波脉冲的传播时间对螺杆的预定张力的依赖性。根据螺杆参数的传播时间的变化与根据螺杆的预定张力的计算的传播时间的变化的比较允许得出关于螺旋过程的控制的结论。因此，特别地，显着的偏差表示对规格或螺纹损伤的粘附性差，而可以利用较小的偏差来控制螺纹拧紧过程。

37. 发明申请

US20010027927A1 Method and device for the detection of not easily volatized substances 有权
标题翻译：用于检测不易挥发物质的方法和装置
公开(公告)号：US20010027927A1
公开(公告)日：2001-10-11
申请号：US09824704
申请日：2001-04-04
申请人： Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V.
发明人： Michael Krausa , Klaus Schorb , Stefan Krebs , Frank Becker
IPC分类号： G01N027/26
CPC分类号： G01N33/0057 , G01N27/4045
摘要： A method for the detection of not easily volatized substances in particular of nitrotoluene, trinitrotoluene, dinitrotoluene, or derivatives of nitrotoluene as well as chemical warfare substances such as Clark, Lewisite, Lost, Sarin, Soman, Tabun or the like in soil, liquid and gases, wherein an electrode configuration, comprising at least a working electrode and an opposing electrode, is brought into contact with a substance under examination via an electrolyte and a voltage is applied to the working electrode whose value is increased and decreased at least once with substantially equal beginning and end values within a predetermined time period, wherein the current strength is determined during this at least one measurement cycle in dependence on the applied voltage, is distinguished in that a plurality of measurement cycles are scanned, and differences of current values of sequential measurement cycles are determined and, in the event of the occurrence of a cathode current maximum, the associated voltage value is determined, held constant and the current strength extracted. A device is thereby utilized with which the electrolyte is in the form of a thin layer applied to the end of the sensor element coming in contact with the substance under investigation, the sensor element comprising at least a working and an opposing electrode.
摘要翻译：在土壤，液体中检测不易挥发的物质，特别是硝基甲苯，三硝基甲苯，硝基甲苯或硝基甲苯的衍生物以及诸如Clark，Lewisite，Lost，Sarin，Soman，Tabun等的化学物质的挥发物质的方法。气体，其中至少包括工作电极和相对电极的电极配置通过电解质与被检查物质接触，并且将电压施加到工作电极上，该电极的值基本上增加至少减少一次在预定时间段内具有相同的起始值和结束值，其中根据所施加的电压在该至少一个测量周期期间确定电流强度，其特征在于扫描多个测量周期，以及顺序的当前值的差异确定测量周期，并且在发生阴极电流最大的情况下，确定相关电压值，保持恒定，并提取电流强度。因此利用这样一种装置，其中电解质呈薄膜形式，施加到与所研究的物质接触的传感器元件的端部，传感器元件至少包括工作电极和相对电极。

38. 发明授权

US11982840B2 Laser-based splicing of glass fibers onto optical components 有权
公开(公告)号：US11982840B2
公开(公告)日：2024-05-14
申请号：US17365485
申请日：2021-07-01
申请人： Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V.
发明人： Steffen Bohme , Thomas Schreiber , Simone Fabian
IPC分类号： G02B6/255 , G02B6/32
CPC分类号： G02B6/255 , G02B6/2551 , G02B6/32
摘要： The invention relates to a method for laser-based splicing of a glass fiber (1) onto an optical component (3), comprising the following steps:

arranging both surfaces to be spliced substantially parallel to each other and at a predefined distance from each other; and
aiming a laser beam (4) at the optical component (3).

In order to specify an improved method in which the properties of the joining partners are maintained to the greatest extent during splicing, which exhibits high reproducibility and in particular is suitable for splicing joining partners of different cross-sections, the invention proposes that the angle of incidence of the laser beam (4) on the surface of the optical component be between 15° and 45°.

39. 发明公开

US20240062131A1 Data Driven Multi-Criteria Optimization of Chemical Formulations 审中-公开
公开(公告)号：US20240062131A1
公开(公告)日：2024-02-22
申请号：US18268986
申请日：2021-12-17
申请人： BASF SE , Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V.
发明人： David Hajnal , Stefan Lehner , Julia Reske , Michael Bortz , Karl-Heinz Kuefer , Philipp Suess
IPC分类号： G06Q10/0633 , G06Q10/0639 , G06Q50/04
CPC分类号： G06Q10/0633 , G06Q10/06395 , G06Q50/04
摘要： The present invention relates generally to the field of chemical formulations in a chemical production facility, and more particularly to providing assistance for producing a chemical formulation in a chemical production facility. In detail, the present invention relates to a computer-implemented method for providing assistance for optimizing chemical formulations, comprising: (a) receiving input data, preferably via an input unit, of at least one set of experimental data comprising formulation data and/or process data, key physicochemical properties of the formulation and a target product profile, TPP, comprising a minimum product requirement, (b) performing multicriterial optimization based on a computational model based on experimental data via a processing unit and (c) providing optimization signal, preferably via an output unit, wherein the optimization signal is configured to control and/or monitor, preferably via a control unit, the production process of the chemical formulation

40. 发明授权

US11885299B2 Method and testing device for testing rotor blades 有权
公开(公告)号：US11885299B2
公开(公告)日：2024-01-30
申请号：US17288623
申请日：2019-10-24
申请人： Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V.
发明人： Moritz Batge , Malo Rosemeier , Bernd Haller , Kwangtae Ha , Willi Wroblewski , Florian Sayer
IPC分类号： F03D13/30 , G01M5/00 , F03D17/00
CPC分类号： F03D13/30 , G01M5/0058
摘要： A method for testing a rotor blade of a wind turbine may include predefining a setpoint bending moment distribution. At least two active load-introducing means may be provided which each engage on a load frame. A first of the at least two active load-introducing means may be configured for introducing load in a pivot direction of the rotor blade and a second of the at least two active load-introducing means may be configured for introducing load in an impact direction of the rotor blade. Also provided is at least one passive load-introducing means. A cyclic introduction of load is effected by the at least two active load-introducing means, where a load introduction frequency of the first active load-introducing means and a load introduction frequency of the second active load-introducing means are selected such that the ratio thereof is rational. A testing device for carrying out the method is also provided.

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