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31. 发明申请

US20090101498A1 GLUCOSE SENSORS AND METHODS OF MANUFACTURE THEREOF 有权
标题翻译：葡萄糖传感器及其制造方法
公开(公告)号：US20090101498A1
公开(公告)日：2009-04-23
申请号：US12256043
申请日：2008-10-22
申请人： Fotios Papadimitrakopoulos , Santhisagar Vaddiraju
发明人： Fotios Papadimitrakopoulos , Santhisagar Vaddiraju
IPC分类号： C01B13/00 , C12Q1/54
CPC分类号： C12Q1/006 , A61B5/14532 , C01B13/0248 , C01B13/0259 , C01B13/0285 , C12Q1/003
摘要： Disclosed herein is a device that functions as a glucose sensor. The device has a reference electrode; a counter electrode, a working electrode; an electrically conducting membrane; an enzyme layer; a semi-permeable membrane; a first layer of a first hydrogel in operative communication with the working electrode; the first layer of the first hydrogel being operative to store oxygen; wherein the amount of stored oxygen is proportional to the number of freeze-thaw cycles that the hydrogel is subjected to; and a second layer of the second hydrogel. Disclosed too is a method that comprises using periodically biased amperometry towards interrogation of implantable glucose sensors to improve both sensor's sensitivity and linearity while at the same time enable internal calibration against sensor drifts that originate from changes in either electrode activity or membrane permeability as a result of fouling, calcification and/or fibrosis.
摘要翻译：这里公开了用作葡萄糖传感器的装置。该装置具有参考电极; 对电极，工作电极; 导电膜; 酶层; 半透膜; 与工作电极操作性连通的第一水凝胶的第一层; 所述第一水凝胶的第一层用于储存氧气; 其中储存的氧气的量与水凝胶经受的冻融循环次数成比例; 和第二层水凝胶。还公开了一种方法，其包括使用周期性偏置的电流分析法来询问可植入的葡萄糖传感器，以改善传感器的灵敏度和线性度，同时对来自电极活性或膜渗透性的变化的传感器漂移进行内部校准，这是由于作为结垢，钙化和/或纤维化。

32. 发明申请

US20080154101A1 Implantable Biosensor and Methods of Use Thereof 有权
标题翻译：可植入生物传感器及其使用方法
公开(公告)号：US20080154101A1
公开(公告)日：2008-06-26
申请号：US11862866
申请日：2007-09-27
申请人： Faquir Jain , Fotios Papadimitrakopoulos , Diane Burgess , Daniel H. Grantham , Deborah G. Grantham
发明人： Faquir Jain , Fotios Papadimitrakopoulos , Diane Burgess , Daniel H. Grantham , Deborah G. Grantham
IPC分类号： A61B5/00
CPC分类号： A61B5/076 , A61B1/04 , A61B5/0017 , A61B5/0031 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/1495 , A61B5/7264 , A61B5/742 , A61B17/3403 , A61B17/3468 , A61B34/20 , A61B2017/00367 , A61B2034/2057 , A61B2560/0214 , A61B2560/0219 , A61B2560/0475
摘要： Disclosed herein is an analyte sensing device capable of continuously monitoring metabolic levels of a plurality of analytes. The device comprises an external unit, which, for example, could be worn around the wrist like a wristwatch or could be incorporated into a cell phone or PDA device, and an implantable sensor platform that is suitable, for example, for implantation under the skin. The external device and the internal device are in wireless communication. In one embodiment, the external device and the internal device are operationally linked by a feedback system. In one embodiment, the internal device is encapsulated in a biocompatible coating capable of controlling the local tissue environment in order to prevent/minimize inflammation and fibrosis, promote neo-angiogenesis and wound healing and this facilitate device functionality.
摘要翻译：本文公开了能够连续监测多种分析物的代谢水平的分析物感测装置。该装置包括外部单元，其例如可以像手表一样佩戴在手腕周围，或者可以结合到手机或PDA装置中，以及可植入的传感器平台，其适合于例如用于植入皮肤下。外部设备和内部设备进行无线通信。在一个实施例中，外部设备和内部设备通过反馈系统可操作地链接。在一个实施方案中，内部装置被包封在能够控制局部组织环境的生物相容性涂层中，以便防止/最小化炎症和纤维化，促进新血管生成和伤口愈合，并且这便于装置功能。

33. 发明授权

US06797412B1 Full color display structures using pseudomorphic cladded quantum dot nanophosphor thin films 失效
标题翻译：全彩色显示结构使用伪形包层量子点纳米荧光体薄膜
公开(公告)号：US06797412B1
公开(公告)日：2004-09-28
申请号：US09547415
申请日：2000-04-11
申请人： Faquir C. Jain , Fotios Papadimitrakopoulos
发明人： Faquir C. Jain , Fotios Papadimitrakopoulos
IPC分类号： H05B3300
CPC分类号： B82Y30/00 , B82Y20/00 , C09K11/025 , C09K11/0883 , C09K11/64 , C09K11/883 , H01L33/18 , H05B33/14 , Y10S428/917 , Y10S977/952
摘要： This invention discloses novel device structures for fill color flat panel displays utilizing pseudomorphically cladded quantum dot nanocrystals. Different colors are obtained by changing the core size and composition of the quantum dots while maintaining a nearly defect-free lattice at the core-cladding interface. Light emission from the quantum dot core is obtained either by injection or by avalanche electroluminescence. A nanotip emitter device is also presented. These generic devices can be addressed using a variety of conventional display drivers, including active and passive matrix configuration.
摘要翻译：本发明公开了利用假构造的量子点纳米晶体的填充彩色平板显示器的新型器件结构。通过改变核心尺寸和量子点的组成，同时在芯 - 包层界面处保持几乎无缺陷的晶格，可获得不同的颜色。通过注射或雪崩电致发光获得量子点核的发光。还提出了一种纳米尖端发射器件。可以使用各种常规显示驱动器来解决这些通用设备，包括主动和被动矩阵配置。

34. 发明授权

US06497729B1 Implant coating for control of tissue/implant interactions 有权
标题翻译：用于控制组织/植入物相互作用的植入物涂层
公开(公告)号：US06497729B1
公开(公告)日：2002-12-24
申请号：US09443857
申请日：1999-11-19
申请人： Francis Moussy , Donald Kreutzer , Diane Burgess , Jeffrey Koberstein , Fotios Papadimitrakopoulos , Samuel Huang
发明人： Francis Moussy , Donald Kreutzer , Diane Burgess , Jeffrey Koberstein , Fotios Papadimitrakopoulos , Samuel Huang
IPC分类号： A61F202
CPC分类号： A61L27/54 , A61B5/0031 , A61B5/14532 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/00 , C08L89/00 , C08L27/12 , C08L33/14 , C08L39/06
摘要： A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one tissue response modifier covalently attached to the polymer layer or entrapped within the polymer layer in a quantity effective to control the tissue response at the site of implantation. Preferably, the at least one tissue response modifier controls inflammation, fibrosis, and/or neovascularization. Exemplary tissue response modifiers include, but are not limited to, steroidal and non-steroidal anti-inflammatory agents, anti-fibrotic agents, anti-proliferative agents, cytokines, cytokine inhibitors, neutralizing antibodies, adhesive ligands, and combinations thereof. Use of the various combinations of tissue response modifiers with bioactive polymers provides a simple, flexible and effective means to control the implant/tissue interphase, improving implant lifetime and function.
摘要翻译：一种组织/植入界面，包括植入物和生物活性聚合物层，所述生物活性聚合物层邻近所述植入物的外表面的至少一部分，其中所述聚合物层含有共价连接到所述聚合物层或被截留在所述聚合物层内的至少一个组织响应调节剂其数量有效地控制植入部位的组织反应。优选地，所述至少一种组织反应调节剂控制炎症，纤维化和/或新生血管形成。示例性组织应答调节剂包括但不限于甾体和非甾体抗炎剂，抗纤维化剂，抗增殖剂，细胞因子，细胞因子抑制剂，中和抗体，粘合剂配体及其组合。使用组织反应调节剂与生物活性聚合物的各种组合提供了简单，灵活和有效的手段来控制植入物/组织间期，提高植入物寿命和功能。

35. 发明授权

US5700696A Method for preparation of conjugated arylene or heteroarylene vinylene polymer and device including same 失效
标题翻译：共轭亚芳基或亚杂芳基亚乙烯基聚合物的制备方法及其制备方法
公开(公告)号：US5700696A
公开(公告)日：1997-12-23
申请号：US148599
申请日：1993-11-08
申请人： Edwin Arthur Chandross , Mary Ellen Galvin-Donoghue , Fotios Papadimitrakopoulos
发明人： Edwin Arthur Chandross , Mary Ellen Galvin-Donoghue , Fotios Papadimitrakopoulos
IPC分类号： C08F8/00 , C08G61/00 , C08G61/02 , C08G61/12 , C09K11/06 , H01L51/50 , H05B33/10 , H01L51/40
CPC分类号： C08G61/02 , C09K11/06
摘要： A technique is described for the preparation of conjugated arylene and heteroarylene vinylene polymers wherein conversion of the polymer precursor is effected at a temperature ranging from 150.degree.-300.degree. C. in the presence of forming gas. Studies have shown that the presence of the forming gas suppresses the formation of carbonyl groups, so resulting in an enhancement in photoluminescence and electroluminescence efficiency of the polymer.
摘要翻译：描述了用于制备共轭亚芳基和亚杂芳基亚乙烯基聚合物的技术，其中在形成气体存在下，在150-300℃的温度下进行聚合物前体的转化。研究表明，形成气体的存在抑制羰基的形成，从而导致聚合物的光致发光和电致发光效率的提高。

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