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31. 发明申请

US20110312961A1 2,5-Disubstituted Morpholine Orexin REceptor Antagonists 有权
标题翻译： 2,5-二取代吗啉Orexin受体拮抗剂
公开(公告)号：US20110312961A1
公开(公告)日：2011-12-22
申请号：US13124884
申请日：2009-10-15
申请人： Christopher D. Cox , Paul J. Coleman , Broc Flores , John D. Schreier
发明人： Christopher D. Cox , Paul J. Coleman , Broc Flores , John D. Schreier
IPC分类号： A61K31/5377 , A61P25/00 , C07D413/14
CPC分类号： A61K31/445 , C07D265/28 , C07D413/10 , C07D413/14
摘要： The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
摘要翻译：本发明涉及结合并调节神经元烟碱乙酰胆碱受体的活性，制备这些化合物的方法，含有这些化合物的药物组合物的化合物，以及使用这些化合物治疗各种各样的病症和疾病的方法，包括与中枢神经系统（CNS）功能障碍相关的那些。

32. 发明申请

US20110195957A1 SUBSTITUTED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：取代的DIAZEPAN OREXIN受体拮抗剂
公开(公告)号：US20110195957A1
公开(公告)日：2011-08-11
申请号：US13089677
申请日：2011-04-19
申请人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
发明人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
IPC分类号： A61K31/551 , C07D413/14 , C07D495/04 , C07D403/14 , C07D491/044 , C07D487/04 , A61P25/00 , A61P25/18 , A61P25/16 , A61P25/08 , A61P29/00 , A61P3/04
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译：本发明涉及作为食欲肽受体的拮抗剂的取代的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

33. 发明授权

US07951797B2 Substituted diazepan orexin receptor antagonists 有权
标题翻译：取代的二氮杂菜素食欲肽受体拮抗剂
公开(公告)号：US07951797B2
公开(公告)日：2011-05-31
申请号：US11998812
申请日：2007-11-30
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox
IPC分类号： A61P25/20 , A61K31/551 , C07D243/08
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译：本发明涉及作为食欲素受体的拮抗剂的取代的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

34. 发明申请

US20100256121A1 SUBSTITUTED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS 有权
标题翻译：取代的DIAZEPAN OREXIN受体拮抗剂
公开(公告)号：US20100256121A1
公开(公告)日：2010-10-07
申请号：US12739304
申请日：2008-10-27
申请人： Jeffrey M. Bergman , Paul J. Coleman , Christopher D. Cox , Anthony J. Roecker
发明人： Jeffrey M. Bergman , Paul J. Coleman , Christopher D. Cox , Anthony J. Roecker
IPC分类号： A61K31/551 , A61P25/20 , A61P3/04 , A61P3/10 , A61P25/24 , A61P25/16 , A61P25/02 , A61P25/18 , C07D403/12
CPC分类号： C07D403/14 , C07D403/04 , C07D413/14 , C07D417/14
摘要： The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which orexin receptors are involved.
摘要翻译：本发明涉及作为食欲素受体的拮抗剂的二氮杂环庚烷化合物，其可用于治疗神经性和精神疾病以及食欲素受体参与的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗其中涉及食欲素受体的疾病中的用途。

35. 发明申请

US20090124603A1 Diazepan Orexin Receptor Antagonists 有权
标题翻译：二氮杂环磷酰胺受体拮抗剂
公开(公告)号：US20090124603A1
公开(公告)日：2009-05-14
申请号：US12225506
申请日：2007-03-27
申请人： Karen M. Brashear , Paul J. Coleman , Christopher D. Cox , Anthony M. Smith , David B. Whitman
发明人： Karen M. Brashear , Paul J. Coleman , Christopher D. Cox , Anthony M. Smith , David B. Whitman
IPC分类号： A61K31/5513 , C07D243/08
CPC分类号： C07D417/04 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14
摘要： The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译：本发明涉及作为食欲肽受体的拮抗剂的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

36. 发明申请

US20090118200A1 Proline bis-amide orexin receptor antagonists 审中-公开
标题翻译：脯氨酸双酰胺食欲素受体拮抗剂
公开(公告)号：US20090118200A1
公开(公告)日：2009-05-07
申请号：US11920596
申请日：2006-05-22
申请人： Jeffrey M. Bergman , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Craig Lindsley , Swati Pal Mercer , Anthony J. Roecker , David B. Whitman
发明人： Jeffrey M. Bergman , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Craig Lindsley , Swati Pal Mercer , Anthony J. Roecker , David B. Whitman
IPC分类号： A61K38/05 , C07D403/12 , C07D401/14 , C07D413/14 , A61K31/4184 , A61P25/00
CPC分类号： C07D403/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译：本发明涉及作为食欲素受体的拮抗剂的脯氨酸双酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

37. 发明申请

US20080207693A1 Mitotic Kinesin Inhibitors 审中-公开
公开(公告)号：US20080207693A1
公开(公告)日：2008-08-28
申请号：US11886282
申请日：2006-03-10
申请人： Paul J. Coleman , Christopher D. Cox , George D. Hartman
发明人： Paul J. Coleman , Christopher D. Cox , George D. Hartman
IPC分类号： A61K31/454 , C07D263/52 , C07D295/00 , A61P35/00 , A61K31/424
CPC分类号： C07D401/12 , C07D207/20
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

38. 发明申请

US20080182843A1 Mitotic Kinesin Inhibitors 失效
标题翻译：有丝分裂驱动蛋白抑制剂
公开(公告)号：US20080182843A1
公开(公告)日：2008-07-31
申请号：US11883507
申请日：2006-02-06
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Lou Anne Neilson , David B. Whitman
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Lou Anne Neilson , David B. Whitman
IPC分类号： A61K31/4162 , C07D405/04 , A61K31/5377 , A61P35/00 , C07D413/14
CPC分类号： C07D491/052
摘要： The present invention relates to tricyclic pyrazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译：本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的三环吡唑。本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

39. 发明申请

US20080132490A1 Substituted diazepan orexin receptor antagonists 有权
标题翻译：取代的二氮杂菜素食欲肽受体拮抗剂
公开(公告)号：US20080132490A1
公开(公告)日：2008-06-05
申请号：US11998812
申请日：2007-11-30
申请人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
发明人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
IPC分类号： A61K31/551 , A61P43/00 , C07D243/06
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译：本发明涉及作为食欲素受体的拮抗剂的取代的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

40. 发明授权

US06284941B1 Bandage having a scar treatment pad for scar management and scar repair 失效
标题翻译：绷带具有疤痕治疗垫，用于瘢痕管理和疤痕修复
公开(公告)号：US06284941B1
公开(公告)日：2001-09-04
申请号：US09309631
申请日：1999-05-11
申请人： Craig M. Cox , Christopher D. Cox , Perry A. Isenberg
发明人： Craig M. Cox , Christopher D. Cox , Perry A. Isenberg
IPC分类号： A61F1300
CPC分类号： A61K9/7084 , A61F13/0226 , A61F13/023 , A61F13/0253 , A61F2013/0037 , A61L15/26 , C08L83/04
摘要： A bandage for the treatment of dermal scars, keloids, wounds or abrasions by contacting the skin of the user. The bandage includes a flexible member having a first side and a second side and further having an adhesive located on the first side. A scar treatment pad such as a layer of silicone elastomer is attached by the adhesive to the first side of the flexible member. The bandage is used by placing the first side of the flexible member in contact with the skin of the user such that the layer of silicone elastomer substantially contacts a scarred area of the skin. The adhesive removably attaches the first side of the flexible member substantially in contact with an unscarred area of the skin of the user. The layer of silicone elastomer attached to the first side of the flexible member improves the cosmetic and functional aspects of the scarred area of the skin of the user.
摘要翻译：用于通过接触使用者的皮肤来治疗皮肤瘢痕，瘢痕疙瘩，伤口或擦伤的绷带。绷带包括具有第一侧和第二侧的柔性构件，并且还具有位于第一侧上的粘合剂。通过粘合剂将诸如硅酮弹性体层的疤痕治疗垫附接到柔性构件的第一侧。通过将柔性构件的第一侧与使用者的皮肤接触使得绷带被使用，使得硅氧烷弹性体层基本上接触皮肤的疤痕区域。粘合剂可移除地将柔性构件的第一侧与使用者的皮肤的不起眼的区域基本上接触。附着在柔性构件的第一侧上的硅氧烷弹性体层改善了使用者皮肤的疤痕区域的化妆品和功能方面。

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