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31. 发明授权

US5614365A DNA polymerase having modified nucleotide binding site for DNA sequencing 失效
标题翻译：具有修饰的DNA测序核苷酸结合位点的DNA聚合酶
公开(公告)号：US5614365A
公开(公告)日：1997-03-25
申请号：US337615
申请日：1994-11-10
申请人： Stanley Tabor , Charles Richardson
发明人： Stanley Tabor , Charles Richardson
IPC分类号： C12N15/09 , C07H21/04 , C07K14/195 , C12N9/12 , C12N15/54 , C12Q1/68 , C12R1/01 , C12R1/07 , C12R1/19 , C07H21/02 , C12N9/00 , C12P19/34
CPC分类号： C12N9/1252 , C12Q1/686 , C12Q1/6869
摘要： Modified gene encoding a modified DNA polymerase wherein the modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase.
摘要翻译：编码修饰的DNA聚合酶的修饰基因，其中与相应的天然存在的DNA聚合酶相比，修饰的聚合酶结合双脱氧核苷酸比相应的脱氧核苷酸更好的20倍。

32. 发明授权

US10130696B2 Method of conferring a protective immune response to norovirus 有权
公开(公告)号：US10130696B2
公开(公告)日：2018-11-20
申请号：US12678813
申请日：2008-09-18
申请人： Charles Richardson , Thomas S. Vedvick , Thomas R. Foubert , William Tino
发明人： Charles Richardson , Thomas S. Vedvick , Thomas R. Foubert , William Tino
IPC分类号： A61K39/12 , C12N7/00 , A61K39/00
摘要： The present invention relates to vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to methods of conferring protective immunity to Norovirus infections in a human subject.

33. 发明申请

US20070191722A1 SYSTEM AND METHOD FOR HEART MONITORING 审中-公开
标题翻译：用于心脏监测的系统和方法
公开(公告)号：US20070191722A1
公开(公告)日：2007-08-16
申请号：US11738962
申请日：2007-04-23
申请人： Charles Richardson , Michael Smith , Franz Kellar
发明人： Charles Richardson , Michael Smith , Franz Kellar
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/0006 , A61B5/413 , A61N1/3702 , A61N1/37211 , A61N1/37247 , A61N1/37282
摘要： The present invention provides systems and methods for monitoring a heart. According to one embodiment, the system includes an implantable registering unit for registering an electrical signal from the heart. The system includes a local data unit in operable communication with registering unit. The local data unit may be placed in communication with a computer, which may be at a location remote from the local data unit. The computer is adapted to receive the data from the local data unit corresponding to the registered electrical signal and to compare the registered electrical signal to a reference electrical signal to determine whether the heart is functioning properly.
摘要翻译：本发明提供了用于监测心脏的系统和方法。根据一个实施例，该系统包括用于记录来自心脏的电信号的可植入记录单元。该系统包括与注册单元可操作地通信的本地数据单元。本地数据单元可以被放置成与计算机通信，计算机可以位于远离本地数据单元的位置。计算机适于从与注册的电信号对应的本地数据单元接收数据，并将注册的电信号与参考电信号进行比较，以确定心脏是否正常工作。

34. 发明申请

US20050234360A1 Systems, methods and computer program products for heart monitoring 有权
标题翻译：用于心脏监测的系统，方法和计算机程序产品
公开(公告)号：US20050234360A1
公开(公告)日：2005-10-20
申请号：US11072463
申请日：2005-03-07
申请人： Charles Richardson
发明人： Charles Richardson
IPC分类号： A61B5/00 , A61B5/0402 , A61B5/0452 , A61N1/37 , A61N1/372
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/413 , A61B5/726 , A61N1/3702 , A61N1/37211 , A61N1/37247
摘要： The present invention provides systems, methods and computer program products for monitoring a heart. According to one embodiment, the system includes an implantable registering unit. The registering unit comprises a first controller structured to register an electrical signal from the heart. The system includes a second controller in operable communication with the first controller. The second controller comprises a data repository structured to receive data corresponding to the registered electrical signal and being structured to store the data. The data repository stores data corresponding to a baseline electrical signal of the heart. The second controller is structured to receive the data from the first controller corresponding to the registered electrical signal and to compare the registered electrical signal to the baseline electrical signal to determine whether the heart is functioning properly.
摘要翻译：本发明提供了用于监测心脏的系统，方法和计算机程序产品。根据一个实施例，系统包括可植入的登记单元。注册单元包括被配置为从心脏登记电信号的第一控制器。该系统包括与第一控制器可操作地通信的第二控制器。第二控制器包括数据仓库，其被构造为接收对应于所注册的电信号的数据，并被构造为存储数据。数据存储库存储对应于心脏的基线电信号的数据。第二控制器被构造成从对应于注册的电信号的第一控制器接收数据，并将注册的电信号与基线电信号进行比较，以确定心脏是否正常工作。

35. 发明申请

US20120156243A1 NOROVIRUS VACCINE FORMULATIONS 有权
公开(公告)号：US20120156243A1
公开(公告)日：2012-06-21
申请号：US12816495
申请日：2010-06-16
申请人： Charles RICHARDSON , Thomas S. Vedvick , Thomas R. Foubert , William T. Tino
发明人： Charles RICHARDSON , Thomas S. Vedvick , Thomas R. Foubert , William T. Tino
IPC分类号： A61K39/125 , A61P31/14
CPC分类号： A61K39/12 , A61K39/125 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/55572 , A61K2039/70 , C07K16/10 , C12N7/00 , C12N2770/16023 , C12N2770/16034
摘要： The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.

36. 发明申请

US20110260013A1 BAG MASTER SYSTEM 审中-公开
标题翻译：袋主系统
公开(公告)号：US20110260013A1
公开(公告)日：2011-10-27
申请号：US13092125
申请日：2011-04-21
申请人： Charles Richardson
发明人： Charles Richardson
IPC分类号： B65B67/04 , B23P19/04
CPC分类号： B65B67/04 , B65B67/12 , Y10T29/49815 , Y10T29/49826
摘要： A debris collection device comprising: a graduated columnar member having, a first open end located in a top rim, a second open end located in a bottom rim, an inner surface, and an outer surface. First open end and second open end of the graduated columnar member oppose each other to form a through-hole between the top rim and the bottom rim defined by the inner surface having an inner volume of the graduated columnar member (creating a funnel profile.) The outer surface may comprise a flat portion such that the debris collection device can be laid in a debris collection orientation on a ground surface (parallel to) suitable to convey refuse from the ground surface into the top rim, though the graduated columnar member, and into a flexible bag removably-coupled to the bag holding periphery of the bottom rim to storably-contain said refuse for transport to another location.
摘要翻译：一种碎片收集装置，包括：分级柱状构件，其具有位于顶部边缘中的第一开口端，位于底部边缘中的第二开口端，内表面和外表面。刻度柱状构件的第一开口端和第二开口端彼此相对以在由具有分级柱状构件的内部容积的内表面限定的顶部边缘和底部边缘之间形成通孔（产生漏斗形状）。外表面可以包括平坦部分，使得碎屑收集装置可以在地面（平行于）适于将垃圾从地面传送到顶部边缘的地面（平行于）通过分级柱状构件放置在碎片收集方向上，以及成为可移除地联接到底部边缘的袋保持周边的柔性袋，以可存储地容纳所述垃圾以运送到另一位置。

37. 发明授权

US07955603B2 Norovirus vaccine formulations 有权
标题翻译：诺如病毒疫苗制剂
公开(公告)号：US07955603B2
公开(公告)日：2011-06-07
申请号：US12093921
申请日：2007-09-28
申请人： Charles Richardson , Thomas S. Vedvick , Thomas R. Foubert , William T. Tino
发明人： Charles Richardson , Thomas S. Vedvick , Thomas R. Foubert , William T. Tino
IPC分类号： A61K35/00 , C12Q1/70
CPC分类号： A61K39/12 , A61K39/125 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/55572 , A61K2039/70 , C07K16/10 , C12N7/00 , C12N2770/16023 , C12N2770/16034
摘要： The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to a process for the production of both monovalent and multivalent VLPs, the VLPs comprising capsid proteins from one or more Norovirus genogroups.
摘要翻译：本发明涉及包含诺如病毒抗原和佐剂的抗原性和疫苗组合物，特别是单价VLP和多价VLP的混合物的混合物，以及用于生产单价和多价VLP的方法，VLP包含来自一种或多种VLP的衣壳蛋白更多的诺如病毒基因组。

38. 发明授权

US06617166B2 Measurement of accelerated whole blood clotting time 失效
公开(公告)号：US06617166B2
公开(公告)日：2003-09-09
申请号：US09907280
申请日：2001-07-17
申请人： Charles Richardson White Gray
发明人： Charles Richardson White Gray
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N2333/78
摘要： Disclosed is The method of in vitro testing of the state of the blood coagulation system. The Accelerated Whole Blood Clotting Time (A. W. B. C. T.) reflects the degree of over or under activity of the coagulation system of the blood.

39. 发明授权

US5881490A Fishing rig 失效
标题翻译：钓鱼架
公开(公告)号：US5881490A
公开(公告)日：1999-03-16
申请号：US989244
申请日：1997-12-12
申请人： Charles Richardson
发明人： Charles Richardson
IPC分类号： A01K83/06 , A01K91/04
CPC分类号： A01K83/06 , A01K91/04
摘要： A leader wire made from a more flexible 7.times.19 stainless steel cable rather than the standard 7.times.7 cable leader wire includes a loop at one end and a swivel at the other. A first hook is attached to the loop at the end of the leader. Intermediate the two ends is a second hook which is movable along the length of the leader. A length of thin copper wire is twisted around the leader at a position between the second hook and the swivel and is movable therealong. The copper wire can be held in place, however, by a small sleeve that passes over the same. The wire is utilized to hold the mouth of the bait fish closed and to hold the bait fish in place by wrapping the wire around the same.
摘要翻译：由更灵活的7x19不锈钢电缆制成的导线，而不是标准的7x7电缆引线，其一端包括一个环，另一端有一个回转。第一个钩子连接到领导者末端的循环。中间的两端是第二个钩子，它可以沿着引导件的长度移动。在第二个钩子和旋转件之间的一个位置上，细长的铜线长度围绕引导件扭转，并且可以沿其移动。然而，铜线可以保持在适当的位置，而通过一个穿过它的小套管。电线用于将诱饵鱼的口闭合并通过将线缠绕在一起将饵鱼保持在适当的位置。

40. 发明授权

US5685371A Hydrocarbon-assisted thermal recovery method 失效
标题翻译：烃辅助热回收方法
公开(公告)号：US5685371A
公开(公告)日：1997-11-11
申请号：US411367
申请日：1995-06-15
申请人： William Charles Richardson , Donald Stephen Mims , Kevin David Kimber , Arthur Ruch Deemer
发明人： William Charles Richardson , Donald Stephen Mims , Kevin David Kimber , Arthur Ruch Deemer
IPC分类号： C09K8/592 , E21B43/22
CPC分类号： C09K8/592
摘要： A method of enhancing recovery of viscous petroleum is provided. A hydrocarbons mixture comprising hydrocarbons having a selected range of boiling points, all higher than that of water, is injected at relatively low concentrations along with steam. The range and distribution of hydrocarbon boiling points in the mixture to be injected may be selected by experiment or calculations.
摘要翻译：提供了一种提高粘性石油回收率的方法。具有选定的沸点范围的烃的烃混合物全部高于水的烃混合物与蒸汽一起以相对低的浓度注入。可以通过实验或计算来选择要注入的混合物中烃沸点的范围和分布。

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