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    • 35. 发明授权
    • Antigenic peptide compound and immunoassay
    • 抗原肽化合物和免疫测定法
    • US5885771A
    • 1999-03-23
    • US617929
    • 1996-04-24
    • Toshiaki Kumazawa
    • Toshiaki Kumazawa
    • C07K14/18C12Q1/70A61K39/29A61K39/295G01N33/569
    • C07K14/005C12N2770/24222Y10S530/806Y10S530/826
    • An HCV antibody contained in a specimen is measured by an immunoassay method by utilizing the specific binding affinity of a hepatitis C virus (HCV) antibody to an antigenic peptide having the amino acid sequence represented by the following formula (1) or (2):Leu-Ser-Gly-Arg-Pro-Ala-Ile-Val-Pro-Asp-Arg-Glu-Val-Leu-Tyr-Gln-Glu-Phe-Asp-Glu . . . (SEQ ID NO: 1)Val-Asn-Gln-Arg-Ala-Val-Val-Ala-Pro-Asp-Lys-Glu-Val-Leu-Tyr-Glu-Ala-Phe-Asp-Glu . . . (SEQ ID NO: 2)According to the above method, it is possible to determine the serotype of the specimen simply and accurately, while suppressing a cross reaction or a non-specific reaction. As a result, it is also possible to preliminarily predict the effect of interferon treatment in an accurate manner, and to simply observe the course of the curing or treatment for hepatitis C.
    • PCT No.PCT / JP94 / 01823 Sec。 371日期:1996年4月24日 102(e)日期1996年4月24日PCT 1994年10月28日PCT公布。 WO95 / 11918 PCT公开号 日期1995年5月4日通过利用丙型肝炎病毒(HCV)抗体对具有下述式(1)表示的氨基酸序列的抗原肽的特异结合亲和力,通过免疫测定法测定样品中含有的HCV抗体, (2):Leu-Ser-Gly-Arg-Pro-Ala-Ile-Val-Pro-Asp-Arg-Glu-Val-Leu-Tyr-Gln-Glu-Phe-Asp-Glu。 。 。 (SEQ ID NO:1)Val-Asn-Gln-Arg-Ala-Val-Val-Ala-Pro-Asp-Lys-Glu-Val-Leu-Tyr-Glu-Ala-Phe-Asp-Glu。 。 。 (SEQ ID NO:2)根据上述方法,可以在抑制交叉反应或非特异性反应的同时,简单且准确地测定试样的血清型。 因此,也可以准确地预测干扰素治疗的效果,并简单地观察丙型肝炎的治愈或治疗过程。
    • 39. 发明授权
    • Shoe outsole assembly
    • 鞋底组装
    • US5822885A
    • 1998-10-20
    • US797109
    • 1997-02-10
    • Marc R. Loverin
    • Marc R. Loverin
    • A43B13/00A43B23/24A43B23/00
    • A43B1/0072A43B13/00A43B23/24A43B3/0078
    • The outsole assembly of a shoe having an upper defining a volume for enclosing a wearer's foot, with the outsole assembly attached generally therebelow, includes an outsole consisting of an outsole body of transparent material defining a water impervious outsole bottom surface disposed for engagement with a walking surface when worn, an outsole upper surface disposed generally in opposition to the volume, and an outsole side surface extending peripherally about the outsole generally between the outsole bottom and upper surfaces. A grid member defines at least one aperture at the outsole upper surface. An article disposed within the aperture is observable through the water impervious outsole bottom surface of the body of transparent material. A method for shoe assembly is also described.
    • 鞋底的外底组件具有限定用于包围穿着者的脚的体积的鞋面,外底组件通常在其下方附接,其包括外底,该外底由透明材料的外底本体组成,限定了防水外底底面,用于与步行 磨损时的表面,通常与体积相对设置的外底上表面,以及大体上在外底底部和上表面之间围绕外底延伸的外底侧表面。 网格构件在外底上表面上限定至少一个孔。 通过透明材料体的防水外底底部表面可观察到设置在孔内的物品。 还描述了鞋组装的方法。