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31. 发明申请

US20110104275A1 METHODS AND KITS FOR TREATING CLUSTER HEADACHE DISORDERS 有权
标题翻译：用于治疗丛集性头痛的方法和工具
公开(公告)号：US20110104275A1
公开(公告)日：2011-05-05
申请号：US12935737
申请日：2009-09-04
申请人： John H. Halpern , Torsten Harry Johannes Passie
发明人： John H. Halpern , Torsten Harry Johannes Passie
IPC分类号： A61K9/28 , A61K31/437 , A61P25/00
CPC分类号： A61K31/48 , A61K9/4858 , A61K31/4745
摘要： The invention features methods and kits employing bromolysergide in therapies for the treatment of cluster headache disorders.
摘要翻译：本发明的特征在于在治疗簇头痛障症的治疗中使用溴麦角酰多糖的方法和试剂盒。

32. 发明申请

US20090041826A1 Tissue Implant and Process for Its Production 审中-公开
标题翻译：组织植入物及其生产工艺
公开(公告)号：US20090041826A1
公开(公告)日：2009-02-12
申请号：US12083648
申请日：2006-10-13
申请人： Michael Jagodzinski , Carl Haasper , Christian Krettek
发明人： Michael Jagodzinski , Carl Haasper , Christian Krettek
IPC分类号： A61L27/38 , C12M3/00
CPC分类号： A61L27/3843 , A61L27/24 , A61L27/56
摘要： The present invention relates to a process for producing an implant for medical purposes, to the implant obtainable by the process, and to the bioreactor used for the production of the implant. The implants of the invention can be used as implantable prostheses having essentially the functional characteristics of the following tissues: ligaments and tendons, bone and chondrogenic tissues, e.g. intervertebral discs, and combinations of bone tissue with cartilage tissue, e.g. sections of joints having the cartilaginous surface of a joint surface hacked by bone tissue. According to the invention, a porous matrix material is incubated under cell culture conditions with cells while the matrix is exposed to positive pressure on one side and negative pressure on another side for effective colonization of the matrix.
摘要翻译：本发明涉及用于医疗用途的植入物的制造方法，可通过该方法获得的植入物和用于生产植入物的生物反应器。本发明的植入物可以用作具有基本上具有以下组织的功能特征的可植入假体：韧带和腱，骨和软骨形成组织，例如，椎间盘，以及骨组织与软骨组织的组合。关节表面具有被骨组织侵入的关节表面的软骨表面。根据本发明，将多孔基质材料在细胞培养条件下与细胞一起培养，同时将基质暴露于一侧的正压力并在另一侧暴露负压以有效地定植基质。

33. 发明公开

US20240238006A1 MRI-CT-COMPATIBLE REMOTE-CONTROLLED MICROPOSITIONING SYSTEM 审中-公开
公开(公告)号：US20240238006A1
公开(公告)日：2024-07-18
申请号：US18564380
申请日：2022-05-30
申请人： Otto-von-Guericke-Universität Magdeburg , Medizinische Hochschule Hannover
发明人： Ivan VOGT , Robert ODENBACH , Bennet HENSEN , Enrico PANNICKE
IPC分类号： A61B17/34 , A61B17/00 , A61B90/00
CPC分类号： A61B17/3403 , A61B90/39 , A61B2017/00212 , A61B2017/3407 , A61B2017/3409 , A61B2090/3954
摘要： The invention relates to a positioning device for positioning a medical instrument relative to a patient, wherein the positioning device has a patient fastening member which is specified to fasten the positioning device to the patient, and has an instrument holder which is specified to hold the medical instrument, wherein the patient fastening member has a patient holding surface for bearing on the patient.

34. 发明公开

US20240165409A1 NEURAL STIMULATION AND SENSING SYSTEM FOR AUDITORY AND NON-AUDITORY ACTIVATION 审中-公开
公开(公告)号：US20240165409A1
公开(公告)日：2024-05-23
申请号：US18469456
申请日：2023-09-18
申请人： BLACKROCK MICROSYSTEMS, INC. , REGENTS OF THE UNIVERSITY OF MINNESOTA , MEDIZINISCHE HOCHSCHULE HANNOVER , INTERNATIONAL NEUROSCIENCE INSTITUTE , MED-EL ELEKTROMEDIZINISCHE GERAATE GESELLSCHAFT m.b.H. , UNIVERSITY OF UTAH , FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
发明人： Moritz Michael Leber , Robert Kyle Franklin, IV , Sandeep Negi , Joseph David Crew , Janet Liu , Vinh Quang Ngo , Hubert Hyoungil Lim , Geoffrey Mohon Ghose , Luke Aaron Johnson , Inderbir Singh Sondh , Abigail Paige Heiller , Meredith Evelyn Adams , Andrew John Oxenham , Thomas Heinrich Robert Lenarz , Karl-Heinz Hiro Dyballa , Waldo Nogueira Vazquez , Amir Samii , Keno H. B. Hübner , Paul Pontiller , Marco Eder , Daniel M. Sieber , Alexander Mayr , Guntram Wyzisk , Elisabeth A. Hansen , Dominik Hammerer , Florian Solzbacher , Loren Wellington Rieth
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/3606 , A61N1/0558
摘要： The present disclosure generally relates to auditory nerve stimulation to create the perception of sound in the brain of a subject such as an animal or human being. In one form, a system includes an implantable electrode array including a plurality of spaced apart micro-needles. The system also includes a first electrical lead electrically coupled to and extending from the implantable electrode array, and an auditory signal device configured to produce one or more electrical signals representative of communications received from an external processor. An interposer is configured to electrically couple the implantable electrode array and the auditory signal device in an arrangement where one or more electrical signals produced by the auditory signal device may be transmitted through the first electrical lead to the implantable electrode array. Various novel stimulation strategies can be employed, such as place modulated stimulation signals.

35. 发明授权

US11975032B2 Medicament for liver regeneration and for treatment of liver failure 有权
公开(公告)号：US11975032B2
公开(公告)日：2024-05-07
申请号：US16213336
申请日：2018-12-07
申请人： HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GmbH , MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Lars Zender , Torsten Wuestefeld
IPC分类号： A61K35/407 , A61K31/00 , A61K31/352 , A61K31/353 , A61K31/416 , A61K31/4709 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K31/713 , A61M1/02 , C07C237/42 , C07D213/75 , C07D231/54 , C07D231/56 , C07D311/30 , C07D311/36 , C07D401/12 , C07D407/12 , C07D473/38 , C07D487/04 , C12M3/00 , C12N5/071 , C12N15/00 , C12N15/113 , A61M1/36 , C12N15/09 , C12N15/10 , C12N15/11 , C12N15/66 , C12P19/34
CPC分类号： A61K35/407 , A61K31/00 , A61K31/352 , A61K31/353 , A61K31/416 , A61K31/4709 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K31/713 , A61M1/02 , C07C237/42 , C07D213/75 , C07D231/54 , C07D231/56 , C07D311/30 , C07D311/36 , C07D401/12 , C07D407/12 , C07D473/38 , C07D487/04 , C12M3/00 , C12N5/067 , C12N15/00 , C12N15/1137 , C12Y207/11024 , A61M1/36 , C12N15/09 , C12N15/102 , C12N15/11 , C12N15/66 , C12N2310/00 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2810/00 , C12P19/34 , C12N2310/14 , C12N2310/531 , C12N15/11 , C12P19/34 , C12N15/09 , C12N15/102 , C12N15/66
摘要： The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.

36. 发明授权

US11952631B2 Diagnostics and therapy for human respiratory syncytial virus 有权
公开(公告)号：US11952631B2
公开(公告)日：2024-04-09
申请号：US16754390
申请日：2018-10-09
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER , TWINCORE ZENTRUM FÜR EXPERIMENTELLE UND KLINISCHE INFEKTIONSFORSCHUNG GMBH , TECHNISCHE UNIVERSITÄT DRESDEN
发明人： Daniel Todt , Sibylle Haid , Martin Wetzke , Gesine Hansen , Chris Lauber , Lars Kaderali , Thomas Pietschmann
IPC分类号： C12N15/11 , A61K31/7105 , A61K48/00 , C12N15/113 , C12Q1/6883
CPC分类号： C12Q1/6883 , A61K31/7105 , A61K48/005 , C12N15/1131 , C12Q2600/118 , C12Q2600/156
摘要： The present invention pertains to a method for the identification of genetic variants that are associated with the severity of an infectious disease. The invention further pertains to a set of genetic factors associated with the severity of Human respiratory syncytial virus (HRSV) infection, for example in human infants. The genetic polymorphisms identified according to the present invention are for use in the diagnostic of infectious diseases and patient stratification in order to avoid or reduce the occurrence of fatal events during infection or to elect the most appropriate therapeutic approach to treat the disease.

37. 发明授权

US11812740B2 Method for genetically modifying a vascularised tissue 有权
公开(公告)号：US11812740B2
公开(公告)日：2023-11-14
申请号：US16615085
申请日：2018-05-23
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Rainer Blasczyk , Constanca Ferreira De Figueiredo
IPC分类号： A01N1/02 , A61L27/36 , C12N15/85
CPC分类号： A01N1/0226 , A01N1/0284 , A61L27/3625 , A61L27/3687 , C12N15/85
摘要： The invention provides an ex-vivo method, i.e. an in vitro method, for genetically modifying cells of a vascularised tissue, which can be anorgan, during normothermic or subnormothermic perfusion without damaging the tissue or its cells due to oxygen undersupply. The method enables keeping the vascularised tissue at normothermic or subnormothermic conditions over a sufficient period of time to genetically modify the cells e.g. with viral vectors.

38. 发明申请

US20220348920A1 LNCRNAS FOR THERAPY AND DIAGNOSIS OF CARDIAC HYPERTROPHY 有权
公开(公告)号：US20220348920A1
公开(公告)日：2022-11-03
申请号：US17811995
申请日：2022-07-12
申请人： Medizinische Hochschule Hannover
发明人： Thomas THUM , Kumarswamy REGALLA , Janika VIERECK
IPC分类号： C12N15/113 , A61K48/00 , A61P9/00 , C12Q1/6883
摘要： The present invention relates to a pharmaceutical composition comprising (i) a compound promoting the expression and/or the activity of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 12, 8 to 11 and 13; and/or (ii) a compound inhibiting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 1 to 7, 27 and 28. The present invention also relates to a compound (i) promoting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 12, 8 to 11 and 13; and/or (ii) inhibiting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 1 to 7, 27 and 28 for use in treating or preventing cardiac hypertrophy.

39. 发明授权

US11333660B2 Analytical process for predicting the therapeutic effect of BH3 mimetics 有权
公开(公告)号：US11333660B2
公开(公告)日：2022-05-17
申请号：US16500307
申请日：2018-04-03
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER
发明人： Michaela Scherr , Matthias Eder
IPC分类号： C12Q1/00 , G01N33/50
摘要： The present invention relates to an analytical in vitro process for predicting the therapeutic effectiveness of at least one pharmaceutical compound in the treatment of leukemia and/or lymphoma, the process analysing the transmembrane potential of mitochondria in cells isolated from a patient by quantification of fluorescence emitted from a dye indicating induction of apoptosis.

40. 发明申请

US20220133796A1 FUSION PROTEIN FOR USE IN THE TREATMENT OF HVG DISEASE 有权
公开(公告)号：US20220133796A1
公开(公告)日：2022-05-05
申请号：US17494610
申请日：2021-10-05
申请人： Medizinische Hochschule Hannover , Technische Universität Braunschweig
发明人： Elmar Jäckel , Fatih Noyan , Michael Hust
IPC分类号： A61K35/17 , A61P37/06 , C07K14/725 , C07K16/28 , C07K19/00 , C12N15/85
摘要： A fusion protein for use in the treatment of HvG disease in a patient having received a transplant, for use in suppressing the host's immune response directed against the transplant. The fusion protein is adapted for use in suppressing the immune rejection of a transplant which contains or expresses HLA-A*02 or SLA-01*0401 in a recipient patient who is negative for HLA-A*02 or SLA-01*0401, i.e. the patient prior to transplantation does not express HLA-A*02 or SLA-01*0401. The fusion protein is a chimeric antigen receptor (CAR), which upon expression in regulatory T-cells (Treg) causes a specific suppressor activity of the regulatory T-cells in the presence of HLA-A*02 or SLA-01*0401.

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