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31. 发明申请

US20140205994A1 Methods, Devices, Kits and Compositions for Detecting Roundworm, Whipworm, and Hookworm 有权
标题翻译：用于检测蛔虫，鞭虫和钩虫的方法，装置，试剂盒和组合物
公开(公告)号：US20140205994A1
公开(公告)日：2014-07-24
申请号：US13788532
申请日：2013-03-07
申请人： IDEXX LABORATORIES, INC. , DIVERGENCE, INC.
发明人： David Allen Elsemore , Jinming Geng , Laurie A. Flynn , Michael Crawford
IPC分类号： G01N33/53
CPC分类号： G01N33/56966 , G01N33/5308 , G01N33/6893 , G01N2333/43526 , G01N2333/4353 , G01N2469/10
摘要： Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.
摘要翻译：本文公开了用于检测样品中一种或多种蠕虫类抗原的存在或不存在的方法，装置，试剂盒和组合物。本发明的方法，装置，试剂盒和组合物可以用于确认来自哺乳动物的粪便样品中蛔虫，鞭虫和/或钩虫的存在或不存在，并且还可以区分一种或多种蠕虫感染。可以确定哺乳动物中蛔虫，鞭虫和/或钩虫的存在或不存在，例如，为了选择治疗哺乳动物和/或为了确定哺乳动物是否已经除去的目的的最佳过程的治疗后的感染已经开始。

32. 发明申请

US20140050757A1 Compositions and Methods for Detection of Antibodies Specific for Anaplasma phagocytophilum (Aph) and Anaplasma platys (Apl) 有权
标题翻译：用于检测针对不对称的吞噬噬菌体（Aph）和Anaplasma platys（Apl）的抗体的组合物和方法
公开(公告)号：US20140050757A1
公开(公告)日：2014-02-20
申请号：US14069489
申请日：2013-11-01
申请人： IDEXX LABORATORIES, INC.
发明人： Jiayou Liu , Eugene Regis Krah, III , Thomas Patrick O'Connor, JR. , Daniel Karl Rieger
IPC分类号： C07K14/29 , G01N33/569
CPC分类号： C07K14/29 , A61K38/00 , A61K39/0233 , A61K47/6835 , A61K2039/575 , A61K2039/6056 , G01N33/56911 , G01N2333/29 , G01N2469/10 , G01N2469/20 , Y02A50/402
摘要： The invention provides methods and compositions for the detection and treatment of Anaplasma phagocytophilum and Anaplasma platys infection.
摘要翻译：本发明提供了用于检测和处理巨噬细胞巨噬细胞噬菌体（Anaplasma phagocytophilum）和阿扁片（Anaplasma platys）感染的方法和组合物。

33. 发明授权

US08609350B2 Anaplasma phagocytophilum (Aph) antigens and antibodies specific for Anaplasma 有权
标题翻译： Anaplasma phagocytophilum（Aph）抗原和针对Anaplasma特异的抗体
公开(公告)号：US08609350B2
公开(公告)日：2013-12-17
申请号：US13448831
申请日：2012-04-17
申请人： Jiayou Liu , Ramaswamy Chandrashekar
发明人： Jiayou Liu , Ramaswamy Chandrashekar
IPC分类号： G01N33/53
CPC分类号： C07K14/29 , G01N33/56911
摘要： The invention provides methods and compositions for the detection and treatment of Anaplasma phagocytophilum and Anaplasma platys infection.
摘要翻译：本发明提供了用于检测和处理巨噬细胞巨噬细胞噬菌体（Anaplasma phagocytophilum）和阿扁片（Anaplasma platys）感染的方法和组合物。

34. 发明授权

US08580272B2 Compositions and methods for detection of antibodies specific for Anaplasma phagocytophilum (Aph) and Anaplasma platys (Apl) 有权
公开(公告)号：US08580272B2
公开(公告)日：2013-11-12
申请号：US13668597
申请日：2012-11-05
申请人： IDEXX Laboratories, Inc.
发明人： Jiayou Liu , Eugene Regis Krah, III , Thomas Patrick O'Connor, Jr. , Daniel Karl Rieger
IPC分类号： A61K39/02 , G01N33/569
CPC分类号： C07K14/29 , A61K38/00 , A61K39/0233 , A61K47/6835 , A61K2039/575 , A61K2039/6056 , G01N33/56911 , G01N2333/29 , G01N2469/10 , G01N2469/20 , Y02A50/402
摘要： The invention provides methods and compositions for the detection and treatment of Anaplasma phagocytophilum and Anaplasma platys infection.

35. 发明申请

US20130130285A1 Markers for Renal Disease 审中-公开
标题翻译：肾脏疾病标志物
公开(公告)号：US20130130285A1
公开(公告)日：2013-05-23
申请号：US13700992
申请日：2011-06-03
申请人： Michael Randolph Atkinson , Mahalakshmi Yerramilli , Murthy V.S.N. Yerramilli
发明人： Michael Randolph Atkinson , Mahalakshmi Yerramilli , Murthy V.S.N. Yerramilli
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/6893 , G01N33/5308 , G01N33/92 , G01N2800/347 , G01N2800/60
摘要： This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
摘要翻译：本发明提供用于诊断肾脏疾病的试剂和方法。肌苷代谢物和蛋白质的差异水平：载脂蛋白CI，载脂蛋白C-II，纤维蛋白原α链或纤维蛋白原A-α链，激肽原，Inter-α抑制剂H4（ITIH4），角蛋白I型细胞松质醇10半胱氨酸蛋白酶抑制剂A，半胱氨酸蛋白酶抑制剂B和其他多肽及其片段提供肾脏疾病的生物标志物并在本文中描述。

36. 发明申请

US20130064842A1 Compositions and Methods for Detection of Antibodies Specific for Anaplasma phagocytophilum (Aph) and Anaplasma platys (Apl) 有权
公开(公告)号：US20130064842A1
公开(公告)日：2013-03-14
申请号：US13668597
申请日：2012-11-05
申请人： IDEXX LABORATORIES, INC.
发明人： Jiayou Liu , Eugene Regis Krah, III , Thomas Patrick O'Connor, Jr. , Daniel Karl Rieger
IPC分类号： G01N33/569 , A61P37/04 , C07K17/00 , C07K14/00 , C07K7/08 , A61K39/00
CPC分类号： C07K14/29 , A61K38/00 , A61K39/0233 , A61K47/6835 , A61K2039/575 , A61K2039/6056 , G01N33/56911 , G01N2333/29 , G01N2469/10 , G01N2469/20 , Y02A50/402
摘要： The invention provides methods and compositions for the detection and treatment of Anaplasma phagocytophilum and Anaplasma platys infection.

37. 发明授权

US08367808B2 Methods, devices, kits and compositions for detecting whipworm 有权
标题翻译：用于检测鞭虫的方法，装置，试剂盒和组合物
公开(公告)号：US08367808B2
公开(公告)日：2013-02-05
申请号：US13182585
申请日：2011-07-14
申请人： David Allen Elsemore , Laurie A. Flynn , Michael Crawford
发明人： David Allen Elsemore , Laurie A. Flynn , Michael Crawford
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K14/43536 , C07K16/18 , G01N33/5308 , G01N2333/43526
摘要： Methods, devices, kits and compositions for detecting the presence or absence of whipworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of whipworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, roundworm, and heartworm. Confirmation of the presence or absence of whipworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.
摘要翻译：本文公开了用于检测粪便样品中鞭虫的存在或不存在的方法，装置，试剂盒和组合物。本发明的方法，装置，试剂盒和组合物可用于确认来自哺乳动物的粪便样品中是否存在鞭虫，所述哺乳动物也可能被钩虫，蛔虫和心虫中的一种或多种感染。可以确认哺乳动物中鞭虫的存在或不存在，例如，为了选择治疗哺乳动物的最佳过程和/或为了确定哺乳动物是否已经在治疗后已经除去感染的目的已经启动

38. 发明申请

US20130006566A1 Automated Calibration Method and System for a Diagnostic Analyzer 有权
标题翻译：诊断分析仪的自动校准方法和系统
公开(公告)号：US20130006566A1
公开(公告)日：2013-01-03
申请号：US13548769
申请日：2012-07-13
申请人： Jeremy Hammond , Dominic Pelletier , Jason Aguiar
发明人： Jeremy Hammond , Dominic Pelletier , Jason Aguiar
IPC分类号： G06F19/00
CPC分类号： G01N35/00693 , G01N2035/00702
摘要： An automated method for calibrating in real time a diagnostic analyzer includes the steps of receiving diagnostic results of patient samples calculated by the analyzer using pre-set parameters of the analyzer, and calculating the centroid of the analyzer's diagnostic results. The centroid of the analyzer's diagnostic results is subtracted from a centroid of diagnostic results of a field population of comparable analyzers to obtain a bias in the centroid of the analyzer's diagnostic results. The bias is compared to predetermined limits Should the bias fall outside the predetermined limits, an optimization factor is derived and applied to the analyzer's diagnostic results to obtain optimized results from the analyzer without changing the pre-set parameters of the analyzer.
摘要翻译：用于实时校准诊断分析仪的自动化方法包括以下步骤：使用分析仪的预设参数来接收由分析仪计算的患者样品的诊断结果，以及计算分析仪诊断结果的质心。分析仪诊断结果的重心从相当分析仪的现场人群的诊断结果的重心中减去，以获得分析仪诊断结果的质心偏差。将偏压与预定限度进行比较如果偏差超出预定极限，则推导出优化因子并将其应用于分析仪的诊断结果，以从分析仪获得优化结果，而无需更改分析仪的预设参数。

39. 发明授权

US08293253B2 Compositions for controlled delivery of pharmaceutically active compounds 有权
标题翻译：用于药物活性化合物的控制递送的组合物
公开(公告)号：US08293253B2
公开(公告)日：2012-10-23
申请号：US11259027
申请日：2005-10-27
申请人： Yerramilli V. S. N. Murthy
发明人： Yerramilli V. S. N. Murthy
IPC分类号： A61K9/00 , A01N37/12
CPC分类号： A61K31/198 , A61K31/7056 , A61K31/7076 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal by injection. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.
摘要翻译：本发明涉及提供药物活性化合物的持续释放的药物组合物和通过将该药物组合物通过注射施用于动物来治疗或预防动物病症的方法。当通过注射将药物组合物施用于动物时，它们形成随时间释放药物活性化合物的药物贮库。药物组合物也可以口服给药。

40. 发明申请

US20120121479A1 Proboscis For Use With A Diagnostic Instrument 有权
标题翻译：用于诊断仪器的长鼻镜
公开(公告)号：US20120121479A1
公开(公告)日：2012-05-17
申请号：US13295614
申请日：2011-11-14
申请人： Michael Andrew Brookmire
发明人： Michael Andrew Brookmire
IPC分类号： B01L3/00
CPC分类号： G01N35/10 , G01N2035/00277 , G01N2035/103
摘要： A proboscis for use with a diagnostic instrument includes an elongated main body having a proximal end and an opposite distal end, and a lumen extending between the proximal and distal ends. The distal end includes an orifice which is in fluid communication with the lumen. A fluid splash guard is affixed to the main body at the distal end, and provides protection for the orifice and lumen from being clogged with a sample fluid.
摘要翻译：用于诊断仪器的长鼻子包括具有近端和相对远端的细长主体和在近端和远端之间延伸的内腔。远端包括与管腔流体连通的孔口。流体防溅罩在远端固定在主体上，并为孔和内腔提供保护以免被样品流体堵塞。

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