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21. 发明授权

US11572348B2 Syntheses of N-heterocyclic carbenes and intermediates therefor 有权
公开(公告)号：US11572348B2
公开(公告)日：2023-02-07
申请号：US16936725
申请日：2020-07-23
申请人： UMICORE AG & CO. KG
发明人： Steven P. Nolan , Sebastien Meiries
IPC分类号： C07D233/58 , C07C209/70 , C07C211/47 , C07C213/00 , C07C211/45 , C07C209/68 , C07C251/16 , C07C249/02 , C07C215/68 , C07F15/00 , C07D295/096 , C07D295/037 , C07D233/60 , C07C211/46 , B01J31/22 , C07C227/04
摘要： A method of preparing a 2,6 disubstituted anilines includes, reacting a 2-amino isophthalic acid diester with sufficient Grignard reagent R2CH2MgX to form the corresponding diol product, dehydrating the diol product to the corresponding dialkene; and hydrogenating the diol product to form the corresponding aniline. The 2,6 disubstituted anilines can be used to produce N-Heterocyclic Carbenes (NHCs). The NHCs can find application in various fields such as organic synthesis, catalysis and macromolecular chemistry. Palladium catalysts containing the NHCs are also described.

22. 发明授权

US10759763B2 Syntheses of N-heterocyclic carbenes and intermediates therefor 有权
公开(公告)号：US10759763B2
公开(公告)日：2020-09-01
申请号：US15852367
申请日：2017-12-22
申请人： UMICORE AG & CO. KG
发明人： Steven P. Nolan , Sebastien Meiries
IPC分类号： C07D233/58 , C07C251/16 , C07C211/46 , C07C215/68 , C07F15/00 , C07D295/096 , C07D295/037 , C07C209/70 , C07C211/47 , C07C213/00 , C07C211/45 , C07D233/60 , C07C209/68 , B01J31/22 , C07C227/04
摘要： A method of preparing a 2,6 disubstituted anilines includes, reacting a 2-amino isophthalic acid diester with sufficient Grignard reagent R2CH2MgX to form the corresponding diol product, dehydrating the diol product to the corresponding dialkene; and hydrogenating the diol product to form the corresponding aniline. The 2,6 disubstituted anilines can be used to produce N-Heterocyclic Carbenes (NHCs). The NHCs can find application in various fields such as organic synthesis, catalysis and macromolecular chemistry. Palladium catalysts containing the NHCs are also described.

23. 发明授权

US5962365A Process for the manufacture of aromatic amines by gas-phase hydrogenation and catalyst useful thereof 失效
标题翻译：通过气相氢化制备芳香胺的方法及其有用的催化剂
公开(公告)号：US5962365A
公开(公告)日：1999-10-05
申请号：US878592
申请日：1997-06-19
申请人： Reinhard Langer , Hans-Josef Buysch , Ursula Pentling
发明人： Reinhard Langer , Hans-Josef Buysch , Ursula Pentling
IPC分类号： B01J21/18 , B01J23/62 , C07B61/00 , C07C209/36 , C07C211/45 , C07C211/46 , C07C211/47 , C07C211/50 , B01J23/00 , B01J23/42 , C07C5/10
CPC分类号： C07C209/36 , B01J23/628
摘要： Aromatic amines are produced by catalytic hydrogenation of nitroaromatic compounds in the gas phase. The catalyst includes palladium and lead on graphite or on a graphite-containing coke support. From 30 to 6000 equivalents of hydrogen for each equivalent of nitro groups are contacted with the catalyst during this process.
摘要翻译：芳族胺通过在气相中的硝基芳族化合物的催化氢化产生。催化剂包括钯和铅在石墨上或含石墨的焦炭载体上。在此过程中，每当量硝基的30至6000当量氢与催化剂接触。

24. 发明授权

US5811576A Intermediates for anti-microbial quinolone carboxylic acids 失效
标题翻译：抗微生物喹诺酮羧酸的中间体
公开(公告)号：US5811576A
公开(公告)日：1998-09-22
申请号：US922108
申请日：1997-09-03
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P31/04 , C07C25/02 , C07C25/13 , C07C63/04 , C07C63/06 , C07C63/70 , C07C69/716 , C07C69/738 , C07C205/11 , C07C205/12 , C07C211/47 , C07C211/52 , C07C229/30 , C07C229/34 , C07C321/16 , C07C323/29 , C07D207/09 , C07D207/14 , C07D215/22 , C07D241/04 , C07D295/04 , C07D295/16 , C07D319/06 , C07D401/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D498/06 , C07F5/04
CPC分类号： C07D491/04 , C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be substituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5至9元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

25. 发明授权

US4633018A Process for separating isomers of toluenediamine 失效
标题翻译：分离甲苯二胺异构体的方法
公开(公告)号：US4633018A
公开(公告)日：1986-12-30
申请号：US811623
申请日：1985-12-20
申请人： Hermann A. Zinnen
发明人： Hermann A. Zinnen
IPC分类号： C07C209/86 , C07C20060101 , C07C7/12 , C07C67/00 , C07C209/00 , C07C211/27 , C07C211/47 , C07C211/51 , C07C85/26
CPC分类号： C07C209/86
摘要： This invention comprises a process for separating 2,4-toluenediamine from a feed mixture comprising 2,4-toluenediamine and at least one isomer thereof, which process comprises contacting the mixture at adsorption conditions with an adsorbent comprising a Y type zeolite cation-exchanged with a Ni or Ca cation or an X type zeolite cation-exchanged with a cation from the group Na, Ni and K, thereby selectively adsorbing the 2,4-toluenediamine or an L type zeolite cation-exchanged with a K cation, or an X type zeolite cation exchanged with a Ba cation, thereby selectively adsorbing the 2,6-toluenediamine. The remainder of the feed mixture is removed from the adsorbent and the adsorbed toluenediamine isomer is recovered by desorption at desorption conditions with a desorbent material comprising a lower alcohol or an amine.
摘要翻译：本发明包括从包含2,4-甲苯二胺及其至少一种异构体的进料混合物中分离2,4-甲苯二胺的方法，该方法包括使吸附条件下的混合物与包含Y型沸石阳离子交换的Y型沸石与Na，Ni和K族的阳离子进行阳离子交换的Ni或Ca阳离子或X型沸石，从而选择性吸附2,4-甲苯二胺或与K阳离子交换的L型沸石，或X 型沸石阳离子与Ba阳离子交换，从而选择性吸附2,6-甲苯二胺。从吸附剂中除去剩余的进料混合物，通过在解吸条件下用包含低级醇或胺的解吸剂材料解吸来回收吸附的甲苯二胺异构体。

26. 发明授权

US4554380A Process for the manufacture of o-toluidine and/or m-toluidine and/or p-toluidine 失效
标题翻译：邻甲苯胺和/或间甲苯胺和/或对甲苯胺的制备方法
公开(公告)号：US4554380A
公开(公告)日：1985-11-19
申请号：US644866
申请日：1984-08-27
申请人： Hans-Jurgen Arpe , Heinz Litterer
发明人： Hans-Jurgen Arpe , Heinz Litterer
IPC分类号： C07B61/00 , B01J21/00 , B01J29/40 , C07C67/00 , C07C209/00 , C07C209/64 , C07C209/68 , C07C209/86 , C07C211/47 , C07C85/00
CPC分类号： C07C209/68
摘要： The invention provides a process for the manufacture of o-toluidine and/or m-toluidine and/or p-toluidine, which comprises the two following steps (a) and (b):(a) treatment of a toluidine isomer mixture or of the not intended toluidine isomer or of one of the not intended toluidine isomers with an isomerization catalyst selected from the group of synthetic zeolites of the pentasil type,(b) isolation of the intended isomer or one of the intended isomers from the isomer mixture formed in step (a) by selective adsorption to a medium-pore or large-pore zeolite and subsequent desorption, furthermore discharge of the isolated isomer and recycling of the remaining isomer mixture to step (a).
摘要翻译：本发明提供了制备邻甲苯胺和/或间甲苯胺和/或对甲苯胺的方法，其包括以下两个步骤（a）和（b）：（a）处理甲苯胺异构体混合物或不需要的甲苯胺异构体或一种不需要的甲苯胺异构体，其中异构化催化剂选自pentasil类型的合成沸石，（b）从所形成的异构体混合物中分离出所需异构体或其中一种异构体步骤（a）通过选择性吸附到中孔或大孔沸石并随后解吸，此外排出分离的异构体并将剩余的异构体混合物再循环到步骤（a）。

27. 发明授权

US4480129A Process for separating isomers of toluidine 失效
标题翻译：分离甲苯胺异构体的方法
公开(公告)号：US4480129A
公开(公告)日：1984-10-30
申请号：US537123
申请日：1983-09-29
申请人： James W. Priegnitz , Hermann A. Zinnen
发明人： James W. Priegnitz , Hermann A. Zinnen
IPC分类号： C07C211/47 , C07C67/00 , C07C209/00 , C07C209/86 , C07C85/26
CPC分类号： C07C209/86
摘要： This invention comprises a process for separating p-toluidine from a feed mixture comprising p-toluidine and o- or m-toluidine, which process comprises contacting the mixture at adsorption conditions with an adsorbent comprising an X or Y-type zeolite cation exchanged with a cation in the group Fe, Mn, Co, Ni or Zn, thereby selectively adsorbing the p-toluidine. The remainder of the feed mixture is removed from the adsorbent and the p-toluidine is recovered by desorption at desorption conditions with a desorbent material comprising aniline or an alkyl amine excluding alkyl amines having eight or more carbon atoms per molecule when the adsorbent comprises an X-type zeolite.
摘要翻译：本发明包括从包含对甲苯胺和邻 - 或间甲苯胺的进料混合物中分离对甲苯胺的方法，该方法包括在吸附条件下将混合物与包含与下式交换的X或Y型沸石阳离子的吸附剂接触： Fe，Mn，Co，Ni或Zn组中的阳离子，从而选择性吸附对甲苯胺。进料混合物的其余部分从吸附剂中除去，并且在脱附条件下用解吸附物质回收对甲苯胺，当包含苯胺或烷基胺的解吸剂材料除去每分子具有八个或更多个碳原子的烷基胺时，当吸附剂包含X 型沸石。

28. 发明授权

US4145228A Process for the joint production of aromatic amines and iron oxide pigments 失效
标题翻译：联合生产芳香胺和氧化铁颜料的方法
公开(公告)号：US4145228A
公开(公告)日：1979-03-20
申请号：US852264
申请日：1977-11-17
申请人： Piero D. Croce , Tullio Pellizzon , Peter Schwarz , Luigi Piccolo
发明人： Piero D. Croce , Tullio Pellizzon , Peter Schwarz , Luigi Piccolo
IPC分类号： C01G49/00 , B01J23/00 , B01J27/00 , C07B61/00 , C07C67/00 , C07C209/00 , C07C209/36 , C07C209/42 , C07C211/46 , C07C211/47 , C07C211/49 , C07C211/51 , C07C213/00 , C07C213/02 , C07C215/76 , C07C217/84 , C07C227/00 , C07C227/04 , C07C229/60 , C07C241/00 , C07C245/08 , C07C301/00 , C07C303/22 , C07C309/45 , C07C311/16 , C09C1/00 , C09C1/22 , C09C1/24
CPC分类号： C09C1/24 , C07C209/36 , C01P2004/50 , C01P2006/60
摘要： Aromatic amines and iron oxide pigment are produced by reacting a ferrous salt, a reduceable aromatic nitrogen compound chosen from nitroderivatives with a single nitro-group or with two nitro-groups and azoderivatives, and a basic compound, chosen from hydroxides and carbonates of ammonium, alkali metals and alkaline earth metals, operating at 25.degree.-200.degree. C. in an aqueous medium. The color of the pigment can be varied from yellow to black by increasing the reaction temperature and the molar ratio between ferrous salt and aromatic nitrogen compound.
摘要翻译：芳族胺和氧化铁颜料通过使亚铁盐，选自硝基衍生物的可还原芳族氮化合物与单个硝基或两个硝基和偶氮衍生物反应制得，和碱性化合物，其选自氢氧化物和碳酸铵，碱金属和碱土金属，在水介质中在25℃-200℃下运行。通过提高反应温度和亚铁盐与芳香族氮化合物的摩尔比，颜料的颜色可以从黄变黑。

29. 发明授权

US3929889A Synthesis of aromatic amines by reaction of aromatic compounds with ammonia 失效
标题翻译：芳香族化合物与氨的反应合成芳香胺
公开(公告)号：US3929889A
公开(公告)日：1975-12-30
申请号：US42902373
申请日：1973-12-19
申请人： DU PONT
发明人： SQUIRE EDWARD NOONAN
IPC分类号： C07C209/02 , C07C211/47 , C07C211/51 , C07C217/90 , C07C85/18
CPC分类号： C07C209/02 , C07C213/02 , C07C211/51 , C07C217/90
摘要： An improved process for producing an aromatic amine is provided in which an aromatic compound is reacted with ammonia in the presence of a conditioned nickel/nickel oxide cataloreactant at a temperature of from about 150*C. to about 500*C. and at a pressure of from about 10 to about 1000 atmospheres.
摘要翻译：提供了一种制备芳香胺的改进方法，其中芳族化合物与氨在温度为约150℃至约500℃的条件下，在调节的镍/镍氧化物催化反应物存在下，为约10至约1000个大气压。

30. 发明授权

US3868420A Nuclear alkylation of anilins 失效
标题翻译：尼日利亚的核酸碱解
公开(公告)号：US3868420A
公开(公告)日：1975-02-25
申请号：US28035372
申请日：1972-08-14
申请人： SANDOZ LTD
发明人： EVANS FRANK , FREY WALTER , STAEHELI JOERG , TOTH ISTVAN
IPC分类号： C07B61/00 , B01J23/00 , B01J23/24 , B01J23/28 , B01J29/00 , C07C67/00 , C07C209/00 , C07C209/68 , C07C211/47 , C07C39/06
CPC分类号： B01J23/24 , B01J23/28 , C07C209/68
摘要： The present invention provides a process for the production of phenylamines alkylated in the ortho and/or para positions by alkyl groups of 1 to 4 carbon atoms and unsubstituted on the amino group, which comprises reacting a phenylamine having an ortho and/or para position available for alkylation with an alkanol of 1 to 4 carbon atoms in the vapour phase and with heating to a temperature of from 350* to 450*C, using a catalyst selected from aluminium oxide and aluminium oxide/molybdenum oxide mixed catalyst in which the amount of molybdenum oxide is approximately from 0.01 to 20 percent by weight, which catalyst has a minimum surface area 50 m2/g.
摘要翻译：本发明提供了一种在邻位和/或对位上由1-4个碳原子的烷基烷基化并在氨基上未被取代的苯基胺的制备方法，该方法包括使具有邻位和/或对位的苯胺在气相中使用1至4个碳原子的链烷醇进行烷基化，并且使用选自氧化铝和氧化铝/氧化钼混合催化剂的催化剂加热到350-450℃的温度，其中，氧化钼为约0.01〜20重量％，该催化剂的最小表面积为50m 2 / g。

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