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21. 发明公开

US20240157101A1 DELIVERY OF MACROMOLECULES USING MICROINJECTORS 审中-公开
公开(公告)号：US20240157101A1
公开(公告)日：2024-05-16
申请号：US18550371
申请日：2022-03-18
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： David H. Gracias , Florin M. Selaru , Arijit Ghosh
IPC分类号： A61M31/00 , A61K9/00 , A61K47/36
CPC分类号： A61M31/002 , A61K9/0031 , A61K9/0053 , A61K47/36
摘要： The present disclosure provides microscale devices, systems, and methods thereof for the delivery of therapeutic and prophylactic active agents (e.g., macromolecules).

22. 发明公开

US20240149032A1 EXPANDABLE DEVICES FOR DELIVERY OF ACTIVE AGENTS TO TISSUES 审中-公开
公开(公告)号：US20240149032A1
公开(公告)日：2024-05-09
申请号：US18550595
申请日：2022-03-15
申请人： Epitomee Medical Ltd.
发明人： Gil Cohen , Valery Artamonov , Dan Hashimshony
IPC分类号： A61M31/00 , A61K9/00 , A61M37/00
CPC分类号： A61M31/002 , A61K9/0024 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2210/1042
摘要： This disclosure concerns expandable devices, specifically self-deployed devices, for adherence to a tissue, for example intestinal tissue. The disclosure also concerns expandable devices, specifically self-deployed devices for delivery of at least one active agent to, or across, a tissue.

23. 发明授权

US11979028B2 Method of making and using an apparatus for a locomotive micro-implant using active electromagnetic propulsion 有权
公开(公告)号：US11979028B2
公开(公告)日：2024-05-07
申请号：US17486323
申请日：2021-09-27
申请人： The Board of Trustees of The Leland Stanford Junior University
发明人： Daniel M. Pivonka , Anatoly Anatolievich Yakovlev , Ada Shuk Yan Poon , Teresa H. Meng
IPC分类号： A61M25/01 , A61B1/00 , A61B5/07 , A61M31/00 , H02J50/10 , H02J50/23 , H02J50/27 , H02J50/80 , H02J50/90 , H02J7/34
CPC分类号： H02J50/10 , A61B1/00158 , A61B5/07 , A61M25/0116 , A61M25/0127 , A61M31/002 , H02J50/23 , H02J50/27 , H02J50/80 , H02J50/90 , H02J7/345 , H02J2310/23
摘要： Described is a locomotive implant for usage within a predetermined magnetic field. In one embodiment magnetohydrodynamics is used to generate thrust with a plurality of electrodes. In another embodiment, asymmetric drag forces are used to generate thrust.

24. 发明公开

US20240139102A1 ENCAPSULATION OF GASTRIC RESIDENCE SYSTEMS 审中-公开
公开(公告)号：US20240139102A1
公开(公告)日：2024-05-02
申请号：US18470327
申请日：2023-09-19
申请人： Lyndra Therapeutics, Inc.
发明人： Tyler GRANT , Erik Robert Waldemar RYDE , Raymond Patrick KNOX , Megan BISHOFF
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61K9/0065 , A61K9/4833 , A61M31/002
摘要： Compactable gastric residence systems comprising therapeutic agent formulations for sustained gastric release of therapeutic agents are disclosed, as well as methods and systems for encapsulating such gastric residence systems. The methods and systems for encapsulating the gastric residence systems can be automated from receiving a bulk of gastric residence systems, orienting, placing, compacting, securing, and encapsulating the gastric residence systems.

25. 发明公开

US20240123204A1 CARDIOVASCULAR DISEASE MEDICATION ADMINISTRATION METHODS 审中-公开
公开(公告)号：US20240123204A1
公开(公告)日：2024-04-18
申请号：US18275659
申请日：2022-02-04
申请人： AORTO MEDICAL LLC
发明人： Youssef EL AZOUZI
IPC分类号： A61M31/00 , A61F2/07 , A61K31/138 , A61K31/216 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/551 , A61K38/06 , A61K45/06
CPC分类号： A61M31/00 , A61F2/07 , A61K31/138 , A61K31/216 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/551 , A61K38/06 , A61K45/06
摘要： Medication administration methods are provided for treating cardiovascular disease. A method may include administering a baseline dosage of the medication to a patient. A flow diverting apparatus may be implanted into a vessel of the patient such that blood pressure to the patient's kidneys is increased. The flow diverting apparatus is structured to partially occlude blood flow through the vessel when implanted thereby increasing upstream blood pressure. Subsequent to implanting the flow diverting apparatus, the medication dosage may be increased above, or decreased below, the baseline dosage. The dosage may be increased if the medication is a beta-blocker, an angiotensin-receptor Mocker, an angiotensin receptor enzyme inhibitor, a chymase inhibitor, a combination of an angiotensin receptor enzyme inhibitor and an angiotensin-receptor blocker, or a combination of an angiotensin receptor blocker and a neprilysin-inhibitor. The dosage may be decreased if the medication is a diuretic.

26. 发明授权

US11944771B1 Personal medical device for administering treatment via mucous membrane 有权
公开(公告)号：US11944771B1
公开(公告)日：2024-04-02
申请号：US17690755
申请日：2022-03-09
申请人： Andrada Bucataru
发明人： Andrada Bucataru
IPC分类号： A61M31/00 , A61L2/00 , A61L2/26 , G06Q10/0832 , G16H10/40 , G16H20/10 , G16H40/63 , A61J1/05 , H02J7/35
CPC分类号： A61M31/00 , A61L2/0047 , A61L2/26 , G06Q10/0832 , G16H10/40 , G16H20/10 , G16H40/63 , A61J1/05 , A61L2202/11 , A61M2209/06 , H02J7/35
摘要： The invention claims a new type of handheld medical device is meant to help the medical community by enabling them to treat patients remotely. This solves the problem of patient suffering or death due to lack of access to a medical professional or long wait times by enabling a patient-centred response to diseases, such as COVID-19. The device is hand-held, with incorporated germicidal UVC lights, an internal application tip and the delivery mechanism focuses on the mucous membrane. The top chamber connects to a removable container which can be used with the prescribed treatment/therapy, vaccine, or viral testing fluid/reagent, as needed. The versatility, non-invasive nature and germicidal properties constitute distinct improvements over other similar medical devices. This device also promotes the development of non-invasive inoculation and drug delivery systems via the mucous membrane.

27. 发明公开

US20240100310A1 DEVICES, ASSEMBLIES, AND METHODS FOR DELIVERING AGENTS 审中-公开
公开(公告)号：US20240100310A1
公开(公告)日：2024-03-28
申请号：US18475343
申请日：2023-09-27
申请人： Boston Scientific Scimed, Inc.
发明人： Andrew PIC , Christopher R. DEUEL , Aaron ROSENTHAL , Ryan EVERS , Collin MURRAY , John B. GOLDEN , Pauline Rosemary LIMBERG , Adam Gregory McDERMOTT
IPC分类号： A61M31/00 , A61M39/22
CPC分类号： A61M31/00 , A61M39/22 , A61M2039/226 , A61M2202/0468
摘要： A valve assembly for a medical device including a container including a first region and a second region, a first fluid inlet fluidly coupled to the first region, a second fluid inlet fluidly coupled to the second region, and a piston assembly disposed within the container. The container is configured to house an agent within the second region, the first fluid inlet is configured to deliver a first portion of pressurized fluid to the first region at a first pressure level, and the second fluid inlet is configured to deliver a second portion of pressurized fluid to the second region at a second pressure level that is less than the first pressure level. The piston assembly includes a valve configured to move from a first position to a second position in response to the piston assembly moving relative to the container.

28. 发明公开

US20240099890A1 FOAM EARPLUG WITH TRANSDERMAL MATERIAL 审中-公开
公开(公告)号：US20240099890A1
公开(公告)日：2024-03-28
申请号：US18520400
申请日：2023-11-27
申请人： Moldex-Metric, Inc.
发明人： Mark Magidson , James Hornstein , Fred Ryan
IPC分类号： A61F11/08 , A61M31/00
CPC分类号： A61F11/08 , A61M31/002 , A61L31/16
摘要： A foam earplug for reception at least partially within the ear canal and including a body portion formed of resilient foam plastic material having a multiple open cell structure and having a size and shape for at least partial reception within the ear canal. A transdermal material having a particular beneficial action, and with an outer layer of the foam earplug infused with the transdermal material so that the benefits of the transdermal material is in transdermal contact with the ear canal. One example is a humectant material and, specifically, a moisturizer/lubricating material, for providing an increase to the lubrication and moisturizing in the car canal. A second example is where the beneficial action is provided by systemic distribution such as a sleep aid, i.e., Melatonin, so that when the earplugs are worn during sleep, the earplugs will provide a sleep aid to the wearer.

29. 发明授权

US11939440B2 Alcohol soluble protein gas-liquid interface self-assembled porous membrane and preparation method thereof 有权
公开(公告)号：US11939440B2
公开(公告)日：2024-03-26
申请号：US18029103
申请日：2022-08-31
申请人： SOUTH CHINA AGRICULTURAL UNIVERSITY
发明人： Jie Xiao , Wuhui Lu , Jiyang Cai
IPC分类号： C08J5/22 , B01D67/00 , C08J5/18 , C08J9/28 , A61M31/00 , B01D69/00
CPC分类号： C08J5/18 , C08J9/28 , A61M31/002 , B01D67/0002 , B01D69/00 , C08J5/2212 , C08J2389/00
摘要： An alcohol soluble protein gas-liquid interface self-assembled porous membrane and a preparation method thereof are provided. The alcohol soluble protein gas-liquid interface self-assembled porous membrane is prepared from an alcohol soluble protein membrane storage solution by an anti-solvent method. The porous interface membrane is rapidly prepared by an alcohol soluble protein interface self-assembled one-step method and can be rapidly formed within 4 seconds, which greatly improves the preparation efficiency of the alcohol soluble protein membrane. The structure (size, pore diameter, micro porosity) of the alcohol soluble protein interface self-assembled porous membrane is precisely regulated and controlled by regulating and controlling process parameters, and a new preparation solution of an alcohol soluble protein base membrane, which is more efficient and has a modifiable structure compared with an alcohol soluble protein membrane prepared by a traditional solvent evaporation method, is developed.

30. 发明公开

US20240082496A1 A NOZZLE FOR A SYRINGE, A THUMB TAB FOR A SYRINGE, AND AN OSTEOTOME 审中-公开
公开(公告)号：US20240082496A1
公开(公告)日：2024-03-14
申请号：US18263496
申请日：2022-01-31
申请人： NATURALSKN LIMITED
发明人： Callum GRAHAM
IPC分类号： A61M5/30 , A61M5/31 , A61M31/00
CPC分类号： A61M5/3007 , A61M5/31 , A61M31/002 , A61M2202/0007 , A61M2202/0415 , A61M2205/02 , A61M2205/19 , A61M2210/0625
摘要： Aspects of the present invention relate to a nozzle for a syringe for injecting blood plasma into a sinus cavity within a patients mouth. The nozzle comprises a body having a passage extending through the body along a longitudinal axis of the nozzle. The passage extends from a proximal end to a distal end of the body and an inlet to the passage is located at the proximal end of nozzle for receiving blood plasma from the syringe. An outlet from the passage is positioned at the distal end of the nozzle for distributing blood plasma in the sinus cavity. The outlet comprises an outlet aperture located on a distal tip of the nozzle and at least one exit gate extending from the passage through the distal end of the body. Aspects of the present invention relate to a thumb tab for plunging a plunger of a syringe, the thumb tab comprising a base portion for attachment to the plunger and a resiliently deformable spring element extending from the base portion. The spring element is moveable from a relaxed position to a compressed position in response to a user pressing on the spring element to depress the plunger within the syringe, in use. Aspects of the present invention relate to an osteotome, the osteotome comprising: a body having a longitudinal axis; the body having a distal end, and the body comprising a distal shoulder extending around an external surface of the body; the distal end of the body extending distally from the distal shoulder, and wherein the distal end of the body tapers in a distal direction from the distal shoulder towards a distal tip along the longitudinal axis.

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