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21. 发明授权

US06613894B1 Method for producing a pyranosyl nucleic acid conjugate 有权
标题翻译：吡喃糖基核酸缀合物的制备方法
公开(公告)号：US06613894B1
公开(公告)日：2003-09-02
申请号：US09509010
申请日：2000-03-20
申请人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Gerhard Burdinski
发明人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Gerhard Burdinski
IPC分类号： C07H2102
CPC分类号： C07H21/00 , A61K47/549 , A61K49/0013 , C07H19/04 , C07H21/02 , C07H21/04 , G01N33/532 , Y10S977/728 , Y10S977/80 , Y10S977/836 , Y10S977/894 , Y10S977/896 , Y10S977/904 , Y10S977/914 , Y10S977/915 , Y10S977/924 , Y10S977/925
摘要： The invention relates to a process for the preparation of a pyranosyl nucleic acid of the formula (I) or of the formula (II) The process for the preparation of the pyranosyl nucleic acid comprises (a) bonding the nucleoside to a solid support, (b) deprotecting the 3′,4′-protected nucleoside, (c) reacting the reaction product from step (b) with a 3′,4′-protected pyranosyl nuceloside phosphoramidite, repeating steps (b) and (c) one or more times to produce the desired length of nucleic acid, and coupling a biomolecule to the product of step (d). In a further step, the nucleic acid can be released from the solid support. In one embodiment, the biomolecule may be a DNA or RNA, where furanosyl nucleoside phosphoramidites are added to the pyranosyl nucleic acid.
摘要翻译：本发明涉及制备式（I）或式（II）的吡喃糖基核酸的方法。制备吡喃糖基核酸的方法包括（a）将核苷键合到固体支持物上，（ b）使3'，4'-保护的核苷脱保护，（c）使来自步骤（b）的反应产物与3'，4'-保护的吡喃糖基寡核苷酸亚磷酰胺反应，重复步骤（b）和（c）一个或多个次以产生所需长度的核酸，并将生物分子与步骤（d）的产物偶联。在另一步骤中，核酸可以从固体支持物中释放出来。在一个实施方案中，生物分子可以是DNA或RNA，其中将呋喃糖基核苷亚磷酰胺加入到吡喃糖基核酸中。

22. 发明授权

US06569654B2 Electroactive materials for stimulation of biological activity of stem cells 失效
公开(公告)号：US06569654B2
公开(公告)日：2003-05-27
申请号：US09753407
申请日：2001-01-02
申请人： Venkatram Shastri , Ivan Martin , Robert Langer , Nahid Rahman
发明人： Venkatram Shastri , Ivan Martin , Robert Langer , Nahid Rahman
IPC分类号： C12N1300
CPC分类号： A61K41/0052 , C12M35/02 , C12N5/0068 , C12N13/00 , C12N2533/30 , Y10S977/91 , Y10S977/925
摘要： Compositions, methods and systems are provided for the stimulation of biological activities within stem cells by applying electromagnetic stimulation to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. In general the present invention involves attaching or associating the desired cells to or with a surface comprising an electroactive material, and applying electromagnetic radiation directly to the desired area. In preferred embodiments, the stimulation of biological activities within cells results from inducing one or more activities including, but not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division, contraction, and cell signaling. In exemplary embodiments, the electroactive materials used in the present invention are either two-dimensional substrates such as thin films having at least one surface of an electroactive material, or in alternative embodiments, the electroactive materials are three-dimensional substrates comprising a matrix having at least one surface of an electroactive material.

23. 发明授权

US06521442B2 Polynucleotide compositions encoding broad spectrum &dgr;-endotoxins 有权
公开(公告)号：US06521442B2
公开(公告)日：2003-02-18
申请号：US09916956
申请日：2001-07-27
申请人： Thomas Malvar , Amy Jelen Gilmer
发明人： Thomas Malvar , Amy Jelen Gilmer
IPC分类号： C12N120
CPC分类号： C12N15/8286 , C07K14/325 , C07K2319/00 , Y02A40/162 , Y10S435/975 , Y10S977/914 , Y10S977/924 , Y10S977/925
摘要： Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention.

24. 发明申请

US20020034796A1 Electroactive materials for stimulation of biological activity of stem cells 失效
标题翻译：用于刺激干细胞生物活性的电活性物质
公开(公告)号：US20020034796A1
公开(公告)日：2002-03-21
申请号：US09753407
申请日：2001-01-02
发明人： Venkatram Shastri , Ivan Martin , Robert Langer , Nahid Rahman
IPC分类号： C12N013/00
CPC分类号： A61K41/0052 , C12M35/02 , C12N5/0068 , C12N13/00 , C12N2533/30 , Y10S977/91 , Y10S977/925
摘要： Compositions, methods and systems are provided for the stimulation of biological activities within stem cells by applying electromagnetic stimulation to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. In general the present invention involves attaching or associating the desired cells to or with a surface comprising an electroactive material, and applying electromagnetic radiation directly to the desired area. In preferred embodiments, the stimulation of biological activities within cells results from inducing one or more activities including, but not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division, contraction, and cell signaling. In exemplary embodiments, the electroactive materials used in the present invention are either two-dimensional substrates such as thin films having at least one surface of an electroactive material, or in alternative embodiments, the electroactive materials are three-dimensional substrates comprising a matrix having at least one surface of an electroactive material.
摘要翻译：提供了组合物，方法和系统，用于通过对电活性材料施加电磁刺激来刺激干细胞内的生物活性，其中电磁刺激与电磁材料结合。通常，本发明涉及将期望的细胞附着或连接到包含电活性材料的表面或与包含电活性材料的表面相连，并将电磁辐射直接施加到期望的区域。在优选的实施方案中，刺激细胞内的生物活性是由于诱导一种或多种活性，包括但不限于基因表达，细胞生长，细胞分化，信号转导，膜通透性，细胞分裂，收缩和细胞信号传导。在示例性实施方案中，本发明中使用的电活性材料是二维底物，例如具有至少一种电活性材料表面的薄膜，或者在替代实施方案中，电活性材料是三维基质，其包含基质，电活性材料的至少一个表面。

25. 发明授权

US06281016B1 Broad-spectrum insect resistant transgenic plants 有权
标题翻译：广谱抗虫转基因植物
公开(公告)号：US06281016B1
公开(公告)日：2001-08-28
申请号：US09253331
申请日：1999-02-19
申请人： Thomas Malvar , Amy Jelen Gilmer
发明人： Thomas Malvar , Amy Jelen Gilmer
IPC分类号： C12N504
CPC分类号： C12N15/8286 , C07K14/325 , C07K2319/00 , Y02A40/162 , Y10S435/975 , Y10S977/914 , Y10S977/924 , Y10S977/925
摘要： Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and tansgenic plants expressing the modified endotoxin are also aspects of the invention.
摘要翻译：公开了具有改进的对鞘翅目，二ter和鳞翅目昆虫的杀虫活性的新型合成修饰的苏云金芽孢杆菌嵌合晶体蛋白。还公开了编码这些新肽的核酸片段。公开了制备和使用这些基因和蛋白质的方法以及重组表达和合适宿主细胞转化的方法。转化的宿主细胞和表达修饰的内毒素的变态植物也是本发明的方面。

26. 发明授权

US10485482B2 Carbon nano tube based antennas 有权
公开(公告)号：US10485482B2
公开(公告)日：2019-11-26
申请号：US15116057
申请日：2015-02-04
申请人： Board of Regents, The University of Texas System
发明人： Ray Baughman , Raquel Robles , Mario Romero-Ortega , Aswini Kanneganti , Young-tae Kim , Ryan Landrith
IPC分类号： A61B5/00 , A61B5/04 , B82Y30/00 , A61B5/0478 , A61N1/05 , A61N1/04 , B82Y5/00
CPC分类号： A61B5/685 , A61B5/04001 , A61B5/0478 , A61B5/6847 , A61B5/6849 , A61N1/0456 , A61N1/05 , A61N1/0529 , B82Y30/00 , A61B2562/0285 , A61B2562/125 , B82Y5/00 , Y10S977/742 , Y10S977/753 , Y10S977/925
摘要： A carbon nanotube (CNT) based electrode and method of making the same is disclosed. The CNT based electrode can have a microelectrode made substantially from a substantially inert metal, a first CNT sheet and a second CNT sheet, wherein the first and second CNT sheets are embedded in a collagen film.

27. 发明申请

US20180003665A1 NANOSTRUCTURED MICROELECTRODES AND BIOSENSING DEVICES INCORPORATING THE SAME 审中-公开
公开(公告)号：US20180003665A1
公开(公告)日：2018-01-04
申请号：US15703120
申请日：2017-09-13
申请人： The Governing Council of the University of Toronto
发明人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
IPC分类号： G01N27/327 , G01N27/30 , G01N33/543
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925
摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

28. 发明申请

US20160310261A1 ARTIFICIAL ELECTRONIC SKIN 有权
标题翻译：人造电子皮肤
公开(公告)号：US20160310261A1
公开(公告)日：2016-10-27
申请号：US14935395
申请日：2015-11-07
申请人： International Business Machines Corporation
发明人： Bahman Hekmatshoartabari , Ghavam G. Shahidi , Davood Shahrjerdi
IPC分类号： A61F2/10 , H01L21/3213 , H01L27/12 , H01L23/498 , H01L21/683
CPC分类号： A61F2/105 , A61F2/50 , A61F2/5044 , A61F2/70 , A61F2/76 , A61F2002/5001 , A61F2002/5007 , A61F2002/5061 , A61F2002/6827 , A61F2002/7635 , B82Y15/00 , G01L5/228 , H01L21/32133 , H01L23/4985 , H01L27/124 , H01L27/1255 , H01L27/1259 , H01L29/0676 , H01L29/16 , Y10S977/762 , Y10S977/925 , Y10T29/49103
摘要： High resolution active matrix nanowire circuits enable a flexible platform for artificial electronic skin having pressure sensing capability. Comb-like interdigitated nanostructures extending vertically from a pair of opposing, flexible assemblies facilitate pressure sensing via changes in resistance caused by varying the extent of contact among the interdigitated nanostructures. Electrically isolated arrays of vertically extending, electrically conductive nanowires or nanofins are formed from a doped, electrically conductive layer, each of the arrays being electrically connected to a transistor in an array of transistors. The nanowires or nanofins are interdigitated with further electrically conductive nanowires or nanofins mounted to a flexible handle.
摘要翻译：高分辨率有源矩阵纳米线电路能够实现具有压力感测能力的人造电子皮肤的灵活平台。从一对相对的柔性组件垂直延伸的梳状叉指状纳米结构通过改变交错的纳米结构之间的接触程度而引起的电阻变化促进压力感测。垂直延伸的导电纳米线或纳米线的电隔离阵列由掺杂的导电层形成，每个阵列电连接到晶体管阵列中的晶体管。纳米线或纳米线与安装到柔性手柄的另外的导电纳米线或纳米线交错。

29. 发明授权

US08888969B2 Nanostructured microelectrodes and biosensing devices incorporating the same 有权
标题翻译：纳米结构微电极和包含其的生物传感装置
公开(公告)号：US08888969B2
公开(公告)日：2014-11-18
申请号：US13061465
申请日：2009-09-01
申请人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
发明人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
IPC分类号： C25B11/02 , G01N27/30 , G01N33/543
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925
摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.
摘要翻译：本文公开了纳米结构微电极和结合其的生物感测装置。

30. 发明申请

US20110066219A1 CONDUCTING POLYMER NANOWIRE BRAIN-MACHINE INTERFACE SYSTEMS AND METHODS 有权
标题翻译：导电聚合物纳米级机器接口系统和方法
公开(公告)号：US20110066219A1
公开(公告)日：2011-03-17
申请号：US12892659
申请日：2010-09-28
申请人： Rodolfo R. Llinas , Ian W. Hunter , Bryan P. Ruddy
发明人： Rodolfo R. Llinas , Ian W. Hunter , Bryan P. Ruddy
IPC分类号： A61N1/05
CPC分类号： A61B5/04001 , A61B5/4041 , B82Y10/00 , Y10S977/762 , Y10S977/925
摘要： The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.
摘要翻译：本发明涉及导电聚合物纳米线及其在脑 - 机界面中的用途，其是安全，坚固和微创的。根据本发明的第一方面，公开了一种包含导电聚合物纳米线的基于血管的脑机界面。

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