专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US06703376B2 Use of uridine triphosphates and related compounds for the prevention and treatment of pneumonia in immobilized patients 失效
标题翻译：使用尿苷三磷酸和相关化合物预防和治疗固定化患者的肺炎
公开(公告)号：US06703376B2
公开(公告)日：2004-03-09
申请号：US09202825
申请日：1998-12-22
申请人： Karla M. Jacobus , H. Jeff Leighton
发明人： Karla M. Jacobus , H. Jeff Leighton
IPC分类号： A61K3152
CPC分类号： A61K31/7076 , A61K31/7072 , Y10S514/849 , Y10S514/851 , Y10S514/853 , Y10S514/855
摘要： A method of promoting drainage of mucous secretions in the congested airways of a bedridden/immobilized patient or an intubated/mechanically-ventilated patient is disclosed. The method comprises administering to the airways of the patient a uridine phosphate such as uridine 5′-triphsophate(UTP) or P1,P4-di(uridine-5′) tetraphosphate, an analog of UTP, or any other analog, in an amount effective to promote drainage of fluid in the congested airways, including sinuses, to create the ciliary beat frequency of cilia on the surface lumina epithelia cells, to increase the secretions of mucous by goblet cells and to promote the clearance of retained secretions by hydrating mucous secretions, by stimulating ciliary beat frequency in the airways and by stimulating surfactant production. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or eye drops or spray), oral form (liquid or pill), aerosol inhalation, powder form, topical, injected, intra-operative installation or suppository form.
摘要翻译：公开了一种促进卧床/固定化患者或插管/机械通气患者的拥挤气道中的粘液分泌物排泄的方法。该方法包括向患者的气道施用尿苷磷酸盐，例如尿苷5'-三磷酸（UTP）或P1，P4-二（尿苷-5'）四磷酸，UTP类似物或任何其它类似物，其量为有效地促进包括鼻窦在内的拥挤气道中的流体排出，以在表面腔上皮细胞上产生纤毛的睫毛拍频，增加杯状细胞粘液的分泌，并通过保湿粘液分泌物促进保留的分泌物的清除通过刺激气道中的睫状肌搏动频率和刺激表面活性剂生成。还公开了药物制剂及其制备方法。给药方法包括任何液体悬浮液（包括滴鼻剂或滴眼剂或喷雾剂），口服剂型（液体或药丸），气雾剂吸入剂，粉末形式，局部用药，注射用药，术中安装或栓剂形式。

22. 发明授权

US06617352B2 Compounds and methods for the inhibition of the expression of VCAM-1 失效
公开(公告)号：US06617352B2
公开(公告)日：2003-09-09
申请号：US10060734
申请日：2002-01-30
申请人： Patricia K. Somers
发明人： Patricia K. Somers
IPC分类号： A01N3710
CPC分类号： A61K31/222 , A61K31/225 , C07C323/20 , C07C323/21 , C07C323/25 , C07C323/56 , C07C323/66 , C07C323/67 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/855
摘要： This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.

23. 发明授权

US6147250A Compounds and methods for the inhibition of the expression of VCAM-1 失效
公开(公告)号：US6147250A
公开(公告)日：2000-11-14
申请号：US79213
申请日：1998-05-14
申请人： Patricia K. Somers
发明人： Patricia K. Somers
IPC分类号： A61P9/00 , A01N37/02 , A61K31/095 , A61K31/10 , A61K31/133 , A61K31/18 , A61K31/19 , A61K31/22 , A61K31/222 , A61K31/225 , A61K31/336 , A61K31/341 , A61K31/41 , A61K31/7034 , A61P9/10 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P21/02 , A61P29/00 , A61P43/00 , C07C323/00 , C07C323/18 , C07C323/20 , C07C323/21 , C07C323/22 , C07C323/25 , C07C323/31 , C07C323/56 , C07C323/62 , C07C323/66 , C07C323/67 , C07D257/04 , C07D303/22 , C07D307/52 , C07D307/68 , C07H15/203 , C07C69/00
CPC分类号： A61K31/222 , A61K31/225 , C07C323/20 , C07C323/21 , C07C323/25 , C07C323/56 , C07C323/66 , C07C323/67 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/855
摘要： This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.

24. 发明授权

US6025334A Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof 失效
标题翻译：具有抗溶解，抗炎，抗血管生成和抗肿瘤活性的鲨鱼软骨提取物; 制造方法，使用方法及其组合物
公开(公告)号：US6025334A
公开(公告)日：2000-02-15
申请号：US550003
申请日：1995-10-30
申请人： Eric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus
发明人： Eric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus
IPC分类号： A61K38/00 , A23J1/00 , A61K20060101 , A61K8/96 , A61K8/98 , A61K9/19 , A61K33/06 , A61K33/14 , A61K33/26 , A61K33/30 , A61K35/32 , A61K35/60 , A61P1/04 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/06 , A61P17/10 , A61P17/14 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/06 , B01D15/08 , B01D61/14 , C07K1/00
CPC分类号： A61K8/987 , A61K35/60 , A61Q17/00 , A61Q19/00 , A61Q19/08 , A61K2800/75 , Y10S514/828 , Y10S514/855 , Y10S514/859 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, direct anti-tumor proliferating, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a homogenate of cartilage in an aqueous solution, this homogenate being centrifuged and further fractionated to obtain a total extract having molecules of a molecular weight comprised between 0 to 500 KDa. The composition of the liquid extract has then been investigated by different ways. Further fractionation of this extract led to the preliminary characterization of some of its active components. Due to the multiplicity of biological activities of the total liquid extract, it can be used for treating numerous diseases or conditions such as those having components selected from the group consisting of tumor proliferation, angiogenesis, inflammation and collagenolysis. This extract has no offensive effect on normal body functions. Therefore, this shark cartilage extract has a very promising therapeutic value. The process for the obtention of cartilage extracts is simple and efficient. The unexpectedly valuable products obtained by this process are therefore an indication of a new and non-obvious process.
摘要翻译：本发明涉及软骨提取物及其制造方法。已经通过改进的方法获得具有抗血管生成，直接抗肿瘤增殖，抗炎和抗胶原活化的鲨鱼软骨提取物。该方法包括以下步骤：在水溶液中获得软骨匀浆，将该匀浆离心分离并进一步分级，得到分子量为0-500KDa的分子的总提取物。然后通过不同的方式研究了液体提取物的组成。该提取物的进一步分级导致其一些活性组分的初步表征。由于总液体提取物的生物活性的多样性，其可用于治疗多种疾病或病症，例如具有选自肿瘤增殖，血管发生，炎症和胶原溶解的组分的疾病或病症。该提取物对正常身体功能无异味。因此，这种鲨鱼软骨提取物具有非常有希望的治疗价值。获取软骨提取物的过程简单有效。因此，通过这一过程获得的意想不到的有价值的产品是新的和非显而易见的过程的指示。

25. 发明授权

US5698537A Method of lowering the viscosity of mucus 失效
标题翻译：降低粘液粘度的方法
公开(公告)号：US5698537A
公开(公告)日：1997-12-16
申请号：US666631
申请日：1996-06-18
申请人： Thaddeus P. Pruss
发明人： Thaddeus P. Pruss
IPC分类号： A61K31/685
CPC分类号： A61K31/685 , Y10S514/826 , Y10S514/851 , Y10S514/855
摘要： The use of phospholipids of the following formula to reduce the viscosity of mucus in a patient is described: ##STR1## wherein one of X, Y, or Z represent: ##STR2## in which each R represents hydrogen or methyl, and each of the other two of X, Y, or Z represents --CO--R.sup.1 in which R.sup.1 represents linear or branched C.sub.11-21 alkyl or C.sub.11-21 alkenyl, unsubstituted or substituted with one or more substituents selected from the group consisting of halo, C.sub.1-6 linear or branched alkoxy or cyano.
摘要翻译：描述了使用下式的磷脂来降低患者中粘液的粘度，其描述如下：其中X，Y或Z之一表示：其中每个R代表氢或甲基， X，Y或Z中的另外两个表示-CO-R 1，其中R 1表示直链或支链C 11-21烷基或C 11-21链烯基，未取代或被一个或多个选自卤素，C 1-6 直链或支链烷氧基或氰基。

26. 发明授权

US5618925A Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof 失效
标题翻译：鲨鱼软骨提取物具有抗血管生成活性和对肿瘤消退的作用; 制作方法
公开(公告)号：US5618925A
公开(公告)日：1997-04-08
申请号：US384555
申请日：1995-02-03
申请人： Eric Dupont , Paul Brazeau , Christi Juneau
发明人： Eric Dupont , Paul Brazeau , Christi Juneau
IPC分类号： A61K38/00 , A23J1/00 , A61K20060101 , A61K33/06 , A61K33/14 , A61K33/26 , A61K33/30 , A61K35/32 , A61K35/60 , A61P17/00 , A61P17/06 , A61P17/10 , A61P35/00 , C07K1/00
CPC分类号： A61K35/60 , Y10S514/828 , Y10S514/855 , Y10S514/859 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： The present invention relates to shark cartilage extracts and to a method of producing the same, these extracts having anti-angiogenic properties (reduction of the area of blood vessels observed in vivo on experimentally induced tumors), tumor regressive activity in vivo as well as demonstrating a direct inhibitory effect on tumor cell lines. This process does not involve any denaturing solvent or product and does not involve the use of any enzymes. It consists of obtaining a blend of whole cartilage in an aqueous solution of neutral pH, preferably pure water, this blend being centrifuged and the pellet and supernatant kept for further processing. The pellet is lyophylized and tested for anti-tumor and anti-angiogenic activities in vivo and in vitro, with or without supernatant. The supernatant has been shown to have anti-angiogenic and tumor regressive activities in vivo. The composition of the supernatant has then been investigated by different ways. Fractionation of this supernatant led to the characterization of some of its active components. The fractions were tested for their direct in vitro activity on cancer cell lines. Therefore, it is assumed that the non-fractionated supernatant has such an in vitro activity. Lyophilization substantially destroys the activity of these liquid fractions while no such abolition is observed in the solid extract.
摘要翻译：本发明涉及鲨鱼软骨提取物及其制备方法，这些提取物具有抗血管生成特性（减少实验诱导的肿瘤体内观察到的血管面积），体内的肿瘤回归活性以及展示对肿瘤细胞系的直接抑制作用。该方法不涉及任何变性溶剂或产物，并且不涉及使用任何酶。它包括在中性pH水溶液（优选纯水）中获得整个软骨的混合物，将该混合物离心，并将沉淀和上清液保持进一步处理。将沉淀物冻干，并在体内和体外测试具有或不含上清液的抗肿瘤和抗血管生成活性。已经显示上清液在体内具有抗血管生成和肿瘤回归活性。然后通过不同的方式研究上清液的组成。分离这种上清液导致其一些活性组分的表征。测试这些级分在癌细胞系上的直接体外活性。因此，假定非分级上清液具有这样的体外活性。冻干基本上破坏了这些液体部分的活性，而在固体提取物中没有观察到这样的消除。

27. 发明授权

US5560913A Pharmaceutical compositions 失效
标题翻译：药物组合物
公开(公告)号：US5560913A
公开(公告)日：1996-10-01
申请号：US379407
申请日：1995-01-27
申请人： Philip L. Kupper
发明人： Philip L. Kupper
IPC分类号： A61K9/00 , A61K36/45 , A61K36/736 , A61K36/752 , A61K36/886 , A61K47/36 , A61K47/46 , A61K35/78 , A61K31/19 , A61K31/44
CPC分类号： A61K9/0095 , A61K47/36 , A61K47/46 , Y10S514/819 , Y10S514/82 , Y10S514/825 , Y10S514/849 , Y10S514/853 , Y10S514/855 , Y10S514/858 , Y10S514/859 , Y10S514/861 , Y10S514/893 , Y10S514/895
摘要： The present invention relates to orally ingestible, pharmaceutical compositions containing at least one pharmaceutical active and a taste masking component.
摘要翻译：本发明涉及含有至少一种药物活性和味道掩蔽组分的口服可摄取的药物组合物。

28. 发明授权

US5213803A Antiviral composition and method 失效
标题翻译：抗病毒组成及方法
公开(公告)号：US5213803A
公开(公告)日：1993-05-25
申请号：US840321
申请日：1992-02-24
申请人： Jerry J. Pollock , John J. Docherty
发明人： Jerry J. Pollock , John J. Docherty
IPC分类号： A61K8/19 , A61K8/23 , A61K8/44 , A61K8/46 , A61K9/68 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/23 , A61K8/44 , A61K8/463 , Y10S514/855 , Y10S514/934 , Y10S514/966 , Y10S514/967
摘要： A method utilizing compositions for topical application which are adapted for the prevention and treatment of viral infections such as Herpes, AIDS and other envelope virus infections are disclosed. The compositions of the present invention produce a synergistic anti-viral effect when used in combination. The formulation contains a humectant such as sorbitol, glycerol, or other comparable compound in the range of 20-80% w/v final concentration, which facilitates structural and/or functional three dimensional disruption or disorientation of the viral envelope. The activation of the destruction of the envelope and subsequent death of the envelope virus is then achieved using combination of inorganic monovalent anions, nonionic detergents and anionic detergents. These monovalent anions can include sodium bicarbonate, sodium thiocyanate, sodium fluoride and sodium chloride at about 0.5 to 5% w/v final concentration; nonionic detergents such as Tween 20 at concentrations of about 0.1% to 3% v/v, ethanol up to about 15% v/v, and other antimicrobial agents such as chlorhexidine or comparable basic substances at concentrations from about 0.01 to 0.2% v/v. The formulation may also include anionic surfactants, flavor and water added to 100%.
摘要翻译：公开了一种利用适于局部应用的组合物的方法，其适用于预防和治疗病毒感染如疱疹，AIDS和其它包膜病毒感染。当组合使用时，本发明的组合物产生协同的抗病毒作用。制剂含有湿润剂，例如山梨糖醇，甘油或20-80％w / v终浓度范围内的其他类似化合物，这有助于病毒包膜的结构和/或功能性三维破坏或迷失方向。然后使用无机一价阴离子，非离子洗涤剂和阴离子洗涤剂的组合来实现封套破坏的活化和随后的包膜病毒死亡。这些单价阴离子可以包含碳酸氢钠，硫氰酸钠，氟化钠和氯化钠，最终浓度为约0.5至5％w / v; 浓度为约0.1％至3％v / v，最高达约15％v / v的乙醇的非离子洗涤剂，以及浓度为约0.01至0.2％v / v的其他抗微生物剂如氯己定或类似的碱性物质， v。制剂还可以包括阴离子表面活性剂，风味剂和水加到100％中。

29. 发明授权

US5047428A Expectorant comprising hydroxyalkylcysteine derivative 失效
标题翻译：祛痰剂包含羟基烷基半胱氨酸衍生物
公开(公告)号：US5047428A
公开(公告)日：1991-09-10
申请号：US365368
申请日：1989-06-13
申请人： Yoshikuni Itoh , Hiroyuki Mizuno , Chikako Kiyohara , Susumu Sato , Tatsuhiko Katori
发明人： Yoshikuni Itoh , Hiroyuki Mizuno , Chikako Kiyohara , Susumu Sato , Tatsuhiko Katori
IPC分类号： A61K31/195 , A61K31/198 , A61P11/10 , C07C323/58
CPC分类号： A61K31/195 , Y10S514/855
摘要： An expectorant comprising a hydroxyalkylcysteine derivative of the following formula (I) is disclosed. ##STR1## wherein n represents an integer of 1 to 4. The expectorant is stabile, has little side effects and toxicity, and exhibits an excellent expectorant effect.

30. 发明授权

US4812449A In situ active compound assembly 失效
标题翻译：原位活性化合物组装
公开(公告)号：US4812449A
公开(公告)日：1989-03-14
申请号：US108833
申请日：1987-10-14
申请人： Darryl C. Rideout
发明人： Darryl C. Rideout
IPC分类号： A01N61/00 , A61K31/655 , A61K31/33 , A61K31/13 , A61K31/175 , A61K31/35
CPC分类号： B82Y5/00 , A01N61/00 , A61K31/655 , A61K47/48069 , A61K47/481 , B82Y30/00 , Y10S514/855 , Y10S514/895 , Y10S514/908
摘要： Differences in microenvironments associated with various cells and other conditions in this environment are used to advantage in effecting the in situ construction of biologically active agents at target locations in preference to surroundings which are desired to be unaffected.
摘要翻译：与这种环境中的各种细胞和其他条件相关的微环境的差异被用于优先考虑优先于期望不受影响的环境的目标位置的生物活性剂的原位构建。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式