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21. 发明申请

US20160287684A1 THERAPIES, VACCINES, AND PREDICTIVE METHODS FOR BEE COLONY COLLAPSE SYNDROME 审中-公开
标题翻译： BEE COLONY COLLAPSE SYNDROME的治疗方法，疫苗和预测方法
公开(公告)号：US20160287684A1
公开(公告)日：2016-10-06
申请号：US15038389
申请日：2014-11-21
申请人： Samuel BOGOCH , Elenore S. BOGOCH , Anne-Elenore Bogoch BORSANYI , Samuel Winston BOGOCH
发明人： Samuel BOGOCH , Elenore S. BOGOCH , Anne-Elenore Bogoch BORSANYI , Samuel Winston BOGOCH
IPC分类号： A61K39/00 , C07K14/37 , G01N33/68 , C07K16/18 , C12N9/14 , C07K14/435 , C07K16/14
CPC分类号： A61K39/0003 , A61K38/00 , A61K39/0002 , A61K2039/552 , C07K14/37 , C07K14/43531 , C07K14/43572 , C07K16/14 , C07K16/18 , C07K2317/34 , C12N9/14 , C12Y306/01003 , G01N33/6818
摘要： The present invention provides therapies, vaccines, and predictive methods for Colony Collapse Disorder in bees and provides compounds for diagnosing, preventing, and treating Colony Collapse Disorder, A first non-limiting aspect of the present invention provides an isolated or synthesized peptide of up to 100 amino acid residues comprising at least one peptide sequence that is at least 70%, 80%, 90%, or 95% homologous with at least one Replikin peptide sequence identified in a CCD factor in honeybees or in any honeybee including but not limited to at least one Replikin sequence identified in at least one isolate of Varroa destructor, Nosema species, Deformed wing virus, Israeli acute paralysis virus, Kashmir bee virus. Sac brood virus, or in honeybees, including, but not limited to Apis mellifera and Apis cerana, or any Replikin sequence in the ATPase or complementary sex-determination (csd) gene of a honeybee.
摘要翻译：本发明提供了蜜蜂中的集落塌陷障碍的治疗，疫苗和预测方法，并提供了用于诊断，预防和治疗集落塌陷障碍的化合物。本发明的第一非限制性方面提供了一种分离或合成的多肽 100个氨基酸残基，其包含至少一个至少70个，80％，90％或95％同源于至少一个在蜜蜂中的CCD因子中鉴定的Replikin肽序列的肽序列，或包含但不限于至少一种在至少一种Varroa析构物，Nosema种，变形翼病毒，以色列急性麻痹病毒，克什米尔蜂病毒分离物中鉴定的Replikin序列。包括但不限于Apis mellifera和Apis cerana，或蜜蜂的ATPase或互补性别决定（csd）基因中的任何Replikin序列。

22. 发明授权

US09289472B2 Use of HSP70 as a regulator of enzymatic activity 有权
标题翻译：使用HSP70作为酶活性的调节剂
公开(公告)号：US09289472B2
公开(公告)日：2016-03-22
申请号：US13969944
申请日：2013-08-19
申请人： Orphazyme Aps
发明人： Thomas Kirkegaard Jensen , Marja H. Jaattela
IPC分类号： A61K38/47 , A61K31/445 , A61K45/06 , A61K31/56 , A61K31/4545 , A61K38/16 , A61K38/43 , A61K38/46 , A61K38/17
CPC分类号： A61K31/4545 , A61K31/445 , A61K31/56 , A61K33/30 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/43 , A61K38/46 , A61K38/47 , A61K45/06 , C12Y306/01003
摘要： The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP.
摘要翻译：本发明涉及调节酶的酶活性的方法，其中所述酶与BMP相互作用，所述方法包括施用或诱导Hsp70或其功能片段或变体的步骤，其形式适于允许BMP之间的相互作用和Hsp70，或其功能片段或变体，从而调节与BMP相互作用的酶的酶活性。

23. 发明申请

US20150259703A1 METHOD FOR PREPARING SPECIFIC CELLS OF HUMAN-DERIVED CELLS 有权
标题翻译：用于制备人源细胞特异性细胞的方法
公开(公告)号：US20150259703A1
公开(公告)日：2015-09-17
申请号：US14434284
申请日：2013-02-05
申请人： TRDIGM & CO., LTD.
发明人： Katsutomo Hamada
IPC分类号： C12N15/85 , C12N9/14 , G01N33/50 , C12N9/12
CPC分类号： C12N15/85 , C12N9/1276 , C12N9/14 , C12N15/11 , C12N2330/10 , C12N2503/02 , C12N2510/00 , C12N2510/04 , C12N2800/90 , C12Y207/07049 , C12Y306/01003 , G01N33/5011
摘要： A method for preparing neoplastically transformed cells from human-derived cells, including the step of introducing human telomerase catalytic subunit (hTERT) gene, SV40 small T antigen (SV40ST) gene, and an oligonucleotide derived from Alu7 sequence into the human-derived cells. A method for introducing a gene for neoplastically transforming human-derived cells, including incorporating human telomerase catalytic subunit (hTERT) gene, SV40 small T antigen (SV40ST) gene, and an oligonucleotide derived from Alu7 sequence into the same or different vectors, and introducing the genes into human-derived cells therewith. The methods of the present invention can be utilized upon induction of neoplastic transformation to various human normal cells in order to elucidate mechanisms for onset of cancer, so that the method can be effectively utilized in the search of a new drug discovery target molecule.
摘要翻译：包括将人端粒酶催化亚基（hTERT）基因，SV40小T抗原（SV40ST）基因导入人源性细胞的衍生细胞的方法，以及衍生自Alu7序列的寡核苷酸引入人源细胞的步骤。引入人源性细胞的新型基因导入方法，包括将人端粒酶催化亚基（hTERT）基因，SV40小T抗原（SV40ST）基因以及衍生自Alu7序列的寡核苷酸引入相同或不同的载体中，并引入将基因转化成人源细胞。本发明的方法可以在诱导对各种人正常细胞的肿瘤转化时使用，以阐明癌症发病的机制，从而可以有效地利用该方法来寻找新的药物发现靶分子。

24. 发明申请

US20150004151A1 USE OF HSP70 AS A REGULATOR OF ENZYMATIC ACTIVITY 审中-公开
标题翻译：使用HSP70作为酶活性的调节剂
公开(公告)号：US20150004151A1
公开(公告)日：2015-01-01
申请号：US14330235
申请日：2014-07-14
申请人： Orphazyme Aps
发明人： Thomas Kirkegaard Jensen , Marja H. Jaattela
IPC分类号： A61K38/46 , A61K45/06
CPC分类号： A61K31/4545 , A61K31/445 , A61K31/56 , A61K33/30 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/43 , A61K38/46 , A61K38/47 , A61K45/06 , C12Y306/01003
摘要： The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP.
摘要翻译：本发明涉及调节酶的酶活性的方法，其中所述酶与BMP相互作用，所述方法包括施用或诱导Hsp70或其功能片段或变体的步骤，其形式适于允许BMP之间的相互作用和Hsp70，或其功能片段或变体，从而调节与BMP相互作用的酶的酶活性。

25. 发明授权

US08540985B2 Use of Hsp70 as a regulator of enzymatic activity 有权
标题翻译：使用Hsp70作为酶活性的调节剂
公开(公告)号：US08540985B2
公开(公告)日：2013-09-24
申请号：US13001316
申请日：2009-06-26
申请人： Thomas Kirkegaard Jensen , Marja Helena Jaattela
发明人： Thomas Kirkegaard Jensen , Marja Helena Jaattela
IPC分类号： A61K31/60 , A61K31/337 , A61K31/282 , A61K31/405 , A61K31/4545 , A61K31/685
CPC分类号： A61K31/4545 , A61K31/445 , A61K31/56 , A61K33/30 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/43 , A61K38/46 , A61K38/47 , A61K45/06 , C12Y306/01003
摘要： The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP.
摘要翻译：本发明涉及调节酶的酶活性的方法，其中所述酶与BMP相互作用，所述方法包括施用或诱导Hsp70或其功能片段或变体的步骤，其形式适于允许BMP之间的相互作用和Hsp70，或其功能片段或变体，从而调节与BMP相互作用的酶的酶活性。

26. 发明申请

US20110256101A1 SERCA2 THERAPEUTIC COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： SERCA2治疗组合物及其使用方法
公开(公告)号：US20110256101A1
公开(公告)日：2011-10-20
申请号：US13086829
申请日：2011-04-14
申请人： Roger J. Hajjar , Yoshiaki Kawase , Dennis Ladage , Krisztina Zsebo
发明人： Roger J. Hajjar , Yoshiaki Kawase , Dennis Ladage , Krisztina Zsebo
IPC分类号： A61K35/76 , A61P11/00
CPC分类号： A61K38/46 , A61K48/00 , C12N7/00 , C12N9/14 , C12N15/86 , C12N2750/14143 , C12N2799/025 , C12N2799/04 , C12Y306/01003
摘要： The present invention provides methods for treating pulmonary hypertension in a subject by delivering a therapeutic adeno-associated virus (AAV)-SERCA2 composition to a subject in need thereof.
摘要翻译：本发明提供了通过将治疗性腺相关病毒（AAV）-SERCA2组合物递送至有需要的受试者来治疗受试者的肺动脉高压的方法。

27. 发明授权

US09932590B2 Control of Varroa mite infestation 有权
公开(公告)号：US09932590B2
公开(公告)日：2018-04-03
申请号：US14902505
申请日：2014-07-02
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN , THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS
发明人： Alan Stuart Bowman , Ewan McInnes Campbell , Giles Elliott Budge
IPC分类号： C12N15/113 , A01N57/10 , A23K20/153 , A23K50/90 , A01N57/16
CPC分类号： C12N15/1137 , A01N57/16 , A23K20/153 , A23K50/90 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/51 , C12N2320/30 , C12N2320/31 , C12Y104/03004 , C12Y204/01016 , C12Y205/01018 , C12Y207/0104 , C12Y301/01007 , C12Y306/01003 , C12Y306/03014
摘要： Nucleic acid agents for reducing or removing infestations of the Varroa destructor mite are described. Compositions comprising the nucleic acid agents and methods for controlling mite infestations using the nucleic acid agents and compositions are also disclosed.

28. 发明授权

US09884058B2 Use of Hsp70 as a regulator of enzymatic activity 有权
公开(公告)号：US09884058B2
公开(公告)日：2018-02-06
申请号：US15048483
申请日：2016-02-19
申请人： Orphazyme ApS
发明人： Thomas Kirkegaard Jensen , Marja H. Jaattela
IPC分类号： A61K45/06 , A61K31/445 , A61K31/4545 , A61K38/16 , A61K38/17 , A61K38/43 , A61K38/46 , A61K38/47 , A61K31/56
CPC分类号： A61K31/4545 , A61K31/445 , A61K31/56 , A61K33/30 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/43 , A61K38/46 , A61K38/47 , A61K45/06 , C12Y306/01003
摘要： The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP.

29. 发明申请

US20170360840A1 EXTRACELLULAR VESICLES WITH ENHANCED POTENCY 审中-公开
公开(公告)号：US20170360840A1
公开(公告)日：2017-12-21
申请号：US15625961
申请日：2017-06-16
申请人： United Therapeutics Corporation
发明人： Sarah HOGAN , Roger Marquez ILAGAN , Maria Pia RODRIGUEZ , Carolina MEDRANO , John CHEADLE
IPC分类号： A61K35/28 , C12N15/113 , A61K38/46 , C12N9/12 , C12N5/0775 , C12N9/14 , A61K38/45
CPC分类号： A61K35/28 , A61K38/45 , A61K38/46 , C12N5/0662 , C12N9/1205 , C12N9/14 , C12N15/113 , C12N2310/141 , C12Y207/0104 , C12Y306/01003
摘要： Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.

30. 发明申请

US20160263096A1 USE OF HSP70 AS A REGULATOR OF ENZYMATIC ACTIVITY 有权
公开(公告)号：US20160263096A1
公开(公告)日：2016-09-15
申请号：US15048483
申请日：2016-02-19
申请人： Orphazyme ApS
发明人： Thomas Kirkegaard Jensen , Marja H. Jaattela
IPC分类号： A61K31/4545 , A61K38/17 , A61K38/46
CPC分类号： A61K31/4545 , A61K31/445 , A61K31/56 , A61K33/30 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/43 , A61K38/46 , A61K38/47 , A61K45/06 , C12Y306/01003
摘要： The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP.

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