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21. 发明授权

US09068170B2 Generation of pluripotent stem cells using recombinant proteins 有权
标题翻译：使用重组蛋白产生多能干细胞
公开(公告)号：US09068170B2
公开(公告)日：2015-06-30
申请号：US12723063
申请日：2010-03-12
申请人： Hongyan Zhou , Sheng Ding
发明人： Hongyan Zhou , Sheng Ding
IPC分类号： C12N5/074 , C12N15/85
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/14 , C12N2501/01 , C12N2501/065 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2506/08 , C12N2506/094 , C12N2506/1307 , C12N2506/28 , C12N2510/00
摘要： The present invention provides for methods, compositions, and kits of producing an induced pluripotent stem cell from a mammalian non-pluripotent cell using exogenous transcription factors.
摘要翻译：本发明提供了使用外源转录因子从哺乳动物非多能细胞产生诱导多能干细胞的方法，组合物和试剂盒。

22. 发明申请

US20130323833A1 REPROGRAMMING CELLS 有权
标题翻译：转录细胞
公开(公告)号：US20130323833A1
公开(公告)日：2013-12-05
申请号：US13896259
申请日：2013-05-16
申请人： The Scripps Research Institute
发明人： Saiyong Zhu , Sheng Ding
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C12N2501/065 , C12N2501/15 , C12N2501/41 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/727 , C12N2501/73 , C12N2506/03 , C12N2506/094 , C12N2506/28
摘要： The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3′-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
摘要翻译：本发明提供用于使用3'-磷酸肌醇依赖性激酶-1（PDK1）激活剂或促进糖酵解代谢的化合物从非多能哺乳动物细胞产生诱导多能干细胞的方法，组合物和试剂盒，以及其他小分子。

23. 发明申请

US20130273536A1 COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS 有权
标题翻译：用于产生诱导性肺癌干细胞的组合化学和遗传方法
公开(公告)号：US20130273536A1
公开(公告)日：2013-10-17
申请号：US13831289
申请日：2013-03-14
申请人： Scripps Research Institute
发明人： Yan Shi , Caroline Desponts , Sheng Ding , Hongyan Zhou , Tongxiang Lin , Wenlin Li , Saiyong Zhu
IPC分类号： C12N5/071 , C12N15/85
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/14 , C12N2501/01 , C12N2501/065 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2506/08 , C12N2506/094 , C12N2506/1307 , C12N2506/28 , C12N2510/00
摘要： The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
摘要翻译：本发明提供了鉴定和使用小分子以诱导哺乳动物细胞中的多能性以及诱导多能性的其它方法。

24. 发明申请

US20130078718A1 CONVERSION OF VASCULAR ENDOTHELIAL CELLS INTO MULTIPOTENT STEM-LIKE CELLS 审中-公开
标题翻译：血管内皮细胞转化为多个干细胞样细胞
公开(公告)号：US20130078718A1
公开(公告)日：2013-03-28
申请号：US13583294
申请日：2011-03-09
申请人： Damian Medici , Bjorn Olsen
发明人： Damian Medici , Bjorn Olsen
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , C07K14/495 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , C12N2506/28
摘要： Disclosed herein is a method of producing multipotent cells, comprising, activating ALK2 of isolated endothelial cells in a serum starved environment, to thereby produce isolated multipotent cells. Activation can be following a threshold period of serum starvation. Activating ALK2 is by contacting the isolated endothelial cells with TGFβ-2 and/or BMP4. The isolated endothelial cells may be human, such as primary vascular, primary microvascular endothelial cells, primary human umbilical vein endothelial cells (HUVEC) or primary human cutaneous microvascular endothelial cells (HCMEC). The activation of ALK2 significantly decreases expression of VE-cadherein of the cells and/or significantly increases expression of one or more of STRO-1, FSP-1, α-SMA, N-cadherin, fibronectin (FN1), Snail (SNAI1), Slug (SNAI2), ZEB-1, SIP-1, LEF-1, Twist, CD10, CD13, CD44, CD73, CD90, CD120A, and CD124. The multipotent cells may further be used to generate other cell types such as osteoblast-like cells, chondrocyte-like cells, adipocyte-like cells, neural-like cells, and myocyte-like cells, by incubating the isolated multipotent cells in the appropriate culture conditions for a period sufficient to induce differentiation. The induced cells express TIE-2.
摘要翻译：本文公开了一种产生多能细胞的方法，包括在血清饥饿的环境中激活分离的内皮细胞的ALK2，从而产生分离的多能细胞。激活可能在血清饥饿的阈值期后。激活ALK2是通过使分离的内皮细胞与TGF和bgr-2和/或BMP4接触。分离的内皮细胞可能是人类，如原发性血管，原发性微血管内皮细胞，原代人脐静脉内皮细胞（HUVEC）或原发性人皮肤微血管内皮细胞（HCMEC）。 ALK2的激活显着降低细胞的VE-钙粘蛋白的表达，和/或显着增加STRO-1，FSP-1，α-SMA，N-钙粘蛋白，纤连蛋白（FN1），蜗牛（SNAI1）的一种或多种的表达。，Slug（SNAI2），ZEB-1，SIP-1，LEF-1，Twist，CD10，CD13，CD44，CD73，CD90，CD120A和CD124。通过将分离的多能细胞孵育到合适的培养物中，多潜能细胞还可用于产生其它细胞类型，例如成骨细胞样细胞，软骨细胞样细胞，脂肪细胞样细胞，神经样细胞和肌细胞样细胞条件足以诱导分化的时间。诱导细胞表达TIE-2。

25. 发明授权

US12097223B2 Mesenchymal stromal cells and uses related thereto 有权
公开(公告)号：US12097223B2
公开(公告)日：2024-09-24
申请号：US17022807
申请日：2020-09-16
申请人： Astellas Institute for Regenerative Medicine
发明人： Erin Anne Kimbrel , Robert P. Lanza , Jianlin Chu , Nicholas Arthur Kouris
IPC分类号： C12N5/0775 , A61F2/14 , A61F9/08 , A61K35/28 , A61K35/30 , A61K35/34 , A61K35/36 , A61K35/39 , A61K35/407 , C12N5/071 , C12N5/0789 , G06F9/54
CPC分类号： A61K35/28 , A61F2/141 , A61F9/08 , A61K35/30 , A61K35/34 , A61K35/36 , A61K35/39 , A61K35/407 , C12N5/0647 , C12N5/0662 , C12N5/0668 , C12N5/0692 , G06F9/542 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/26 , C12N2502/1171 , C12N2506/02 , C12N2506/11 , C12N2506/28 , C12N2533/54 , G06F2218/00 , A61K35/30 , A61K2300/00 , A61K35/34 , A61K2300/00 , A61K35/36 , A61K2300/00 , A61K35/39 , A61K2300/00 , A61K35/407 , A61K2300/00 , A61K35/28 , A61K2300/00
摘要： The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.

26. 发明申请

US20180171303A1 COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS 审中-公开
公开(公告)号：US20180171303A1
公开(公告)日：2018-06-21
申请号：US15892312
申请日：2018-02-08
申请人： The Scripps Research Institute
发明人： Yan Shi , Caroline Desponts , Sheng Ding , Hongyan Zhou , Tongxiang Lin , Wenlin Li , Saiyong Zhu
IPC分类号： C12N5/074 , C12N15/85
CPC分类号： C12N5/0696 , C12N15/85 , C12N2500/14 , C12N2501/01 , C12N2501/065 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/608 , C12N2501/727 , C12N2506/08 , C12N2506/094 , C12N2506/1307 , C12N2506/28 , C12N2510/00
摘要： The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.

27. 发明申请

US20170252374A1 MESENCHYMAL STROMAL CELLS AND USES RELATED THERETO 审中-公开
公开(公告)号：US20170252374A1
公开(公告)日：2017-09-07
申请号：US15467201
申请日：2017-03-23
申请人： Astellas Institute for Regenerative Medicine
发明人： Erin Anne Kimbrel , Robert P. Lanza , Jianlin Chu , Nicholas Arthur Kouris
IPC分类号： A61K35/28 , A61K35/30 , A61K35/34 , A61K35/36 , C12N5/0775 , A61K35/407 , C12N5/077 , C12N5/071 , C12N5/0789 , A61K48/00 , A61K35/39
CPC分类号： A61K35/28 , A61K35/30 , A61K35/34 , A61K35/36 , A61K35/39 , A61K35/407 , C12N5/0647 , C12N5/0668 , C12N5/0692 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/26 , C12N2502/1171 , C12N2506/02 , C12N2506/11 , C12N2506/28 , C12N2533/54 , A61K2300/00
摘要： The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and method sof treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.

28. 发明授权

US09657274B2 Reprogramming cells 有权
公开(公告)号：US09657274B2
公开(公告)日：2017-05-23
申请号：US15069730
申请日：2016-03-14
申请人： The Scripps Research Institute
发明人： Saiyong Zhu , Sheng Ding
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C12N2501/065 , C12N2501/15 , C12N2501/41 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/727 , C12N2501/73 , C12N2506/03 , C12N2506/094 , C12N2506/28
摘要： The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3′-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.

29. 发明申请

US20160257938A1 Reprogramming Cells 有权
标题翻译：重编程细胞
公开(公告)号：US20160257938A1
公开(公告)日：2016-09-08
申请号：US15069730
申请日：2016-03-14
申请人： The Scripps Research Institute
发明人： Saiyong Zhu , Sheng Ding
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C12N2501/065 , C12N2501/15 , C12N2501/41 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/727 , C12N2501/73 , C12N2506/03 , C12N2506/094 , C12N2506/28
摘要： The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3′-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.
摘要翻译：本发明提供用于使用3'-磷酸肌醇依赖性激酶-1（PDK1）激活剂或促进糖酵解代谢的化合物从非多能哺乳动物细胞产生诱导多能干细胞的方法，组合物和试剂盒，以及其他小分子。

30. 发明申请

US20160038543A1 MESENCHYMAL STROMAL CELLS AND USES RELATED THERETO 审中-公开
公开(公告)号：US20160038543A1
公开(公告)日：2016-02-11
申请号：US14504351
申请日：2014-10-01
申请人： Advanced Cell Technology, Inc.
发明人： Erin Anne Kimbrel , Robert P. Lanza , Jianlin Chu , Nicholas Arthur Kouris
IPC分类号： A61K35/28 , C12N5/0775
CPC分类号： A61K35/28 , A61K35/30 , A61K35/34 , A61K35/36 , A61K35/39 , A61K35/407 , C12N5/0647 , C12N5/0668 , C12N5/0692 , C12N2501/115 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/26 , C12N2502/1171 , C12N2506/02 , C12N2506/11 , C12N2506/28 , C12N2533/54 , A61K2300/00
摘要： The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.

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