专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20160090569A1 Scheduled Feed 审中-公开
标题翻译：计划饲料
公开(公告)号：US20160090569A1
公开(公告)日：2016-03-31
申请号：US14865222
申请日：2015-09-25
申请人： TERUMO BCT, INC.
发明人： Boah VANG
IPC分类号： C12M1/36 , C12M3/00 , C12N5/0775
CPC分类号： C12M41/48 , C12M21/08 , C12M25/12 , C12M29/16 , C12N5/0663
摘要： Embodiments described herein generally provide for the scheduled feeding of cells in a cell expansion system. A schedule to proactively and automatically increase and/or maintain inlet rates of media to feed cells may be created, in which inlet rates to the intracapillary portion (or extracapillary portion) of a bioreactor may be increased or maintained according to the schedule. Such schedule may be conservative or aggressive or a combination thereof, for example. Multiple schedules may be used. Scheduled media exchanges may also be included. By following a feed schedule, the monitoring of metabolite levels may be optional. Inlet rates may be increased or maintained without manual manipulation. Media usage may also be more predictable. In an embodiment, a custom task(s) may be created to follow a desired feed schedule. In another embodiment, a pre-programmed task(s) may be used for the scheduled feeding of cells.
摘要翻译：本文描述的实施例通常提供细胞扩增系统中的细胞的计划进料。可以产生主动且自动地增加和/或维持进料细胞的培养基入口速率的时间表，其中可以根据时间表增加或维持生物反应器的毛细血管内部分（或毛细血管外部分）的入口速率。例如，这样的时间表可以是保守的或积极的或其组合。可以使用多个时间表。也可以包括计划的媒体交换。通过遵循饲料计划，代谢物水平的监测可能是可选的。进口费率可能会增加或维持，无需手动操作。媒体使用也可能更可预测。在一个实施例中，可以创建自定义任务以遵循期望的馈送计划。在另一个实施例中，预先编程的任务可以用于计划的单元格馈送。

22. 发明申请

US20150079664A1 Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System with Control Conditions 审中-公开
标题翻译：在具有控制条件的中空纤维生物反应器系统中生长和收获细胞的方法和系统
公开(公告)号：US20150079664A1
公开(公告)日：2015-03-19
申请号：US14548617
申请日：2014-11-20
申请人： Terumo BCT, Inc.
发明人： Thomas G. DILORENZO , Edward Allan STANTON, IV , Glen Delbert ANTWILER , Michael E. KINZIE , Brian J. NANKERVIS , Monique GIVENS , Casey V. MEDINA , Jon A. DODD
IPC分类号： C12M1/34 , C12M1/00 , C12M1/36
CPC分类号： C12M41/44 , C12M23/42 , C12M23/44 , C12M25/10 , C12M25/12 , C12M29/16 , C12M29/20 , C12M41/48 , G06F8/38
摘要： Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
摘要翻译：本文描述的实施例一般涉及使用空气除去室作为电池膨胀系统中的工艺的控制的方法和系统。排气室可以安装在流体输送组件上以与系统一起使用。流体被泵送到空气移除室的流体容纳室中，其中流体容纳室中的流体水平可以通过使用一个或多个传感器来监测。传感器能够在空气去除室内的测量位置处检测空气，缺乏流体，流体和/或气体/流体界面，例如空气/流体界面。用于该系统的协议可以包括一个或多个停止条件。在一个实施例中，基于在空气移除室中检测空气，缺乏流体和/或气体/流体界面，自动停止过程。

23. 发明申请

US20140187826A1 CATALYTIC BIOREACTORS AND METHODS OF USING SAME 有权
标题翻译：催化生物反应器及其使用方法
公开(公告)号：US20140187826A1
公开(公告)日：2014-07-03
申请号：US14199714
申请日：2014-03-06
申请人： Board of Trustees of Michigan State University
发明人： Robert Mark WORDEN , Yangmu Chloe LIU
IPC分类号： C12M1/00 , C12P7/16
CPC分类号： C12M21/12 , C12M23/34 , C12M25/12 , C12P7/16 , Y02E50/10
摘要： Various embodiments provide a bioreactor for producing a bioproduct comprising a housing; and one or more catalytically active zones located in the housing and adapted to keep two incompatible gaseous reactants separated when in a gas phase, wherein each of said catalytically active zone comprises a catalytic component retainer and a catalytic component retained within and/or on the catalytic component retainer. Each of said catalytically active zones may additionally or alternatively comprise a liquid medium located on either side of the catalytic component retainer and the catalytic component may additionally or alternatively be a suspended catalytic component suspended in a liquid medium located on either side of the catalytic component retainer. Methods of using various embodiments of the bioreactor to produce a bioproduct, such as isobutanol, are also provided.
摘要翻译：各种实施方案提供用于生产包含壳体的生物产物的生物反应器; 以及一个或多个催化活性区域，其位于壳体中并且适于在气相中分离两种不相容的气态反应物，其中每个所述催化活性区域包含催化组分保持体和保留在催化剂内和/或催化剂上的催化组分部件保持器。所述催化活性区域中的每一个可以附加地或者可选地包括位于催化部件保持器的任一侧的液体介质，并且催化组分可以另外地或者替代地悬浮在悬浮的催化组分中，所述催化组分悬浮在位于催化组分保持器。还提供了使用生物反应器的各种实施方案来生产生物产物如异丁醇的方法。

24. 发明申请

US20140051167A1 Concentrating Components of Fluid Circulated through a Cell Growth Chamber 有权
标题翻译：通过细胞生长室循环的流体的浓缩组分
公开(公告)号：US20140051167A1
公开(公告)日：2014-02-20
申请号：US13971652
申请日：2013-08-20
申请人： Terumo BCT, Inc.
发明人： Brian J. NANKERVIS , Thomas G. DiLorenzo , Michael E. Kinzie , Mark E. Jones
IPC分类号： C12M1/00
CPC分类号： C12M47/02 , B01D61/14 , B01D61/22 , B01D63/02 , B01D2311/12 , C12M25/12 , C12M29/16
摘要： One or more embodiments are described directed to a method and system for concentrating components of a fluid circulated through a cell growth chamber such as a cell growth chamber. Accordingly, embodiments include methods and systems that utilize a tangential flow filter to concentrate components of a fluid that in embodiments includes expanded cells. In embodiments, a concentrated fluid component and a concentrated cell component are generated by flowing the fluid with expanded cells across a tangential flow filter. The concentrated cell component may be recirculated to the tangential flow filter to reach some desired concentration of cells. The concentrated fluid component may be collected to utilize cellular-produced constituents in the concentrated fluid component.
摘要翻译：对一个或多个实施方案进行描述，涉及用于浓缩循环通过诸如细胞生长室的细胞生长室的流体的组分的方法和系统。因此，实施方案包括使用切向流过滤器来浓缩流体的组分的方法和系统，其在实施方案中包括扩展的细胞。在实施方案中，通过使具有膨胀的细胞的流体流过切向流过滤器来产生浓缩的流体组分和浓缩的细胞组分。浓缩的细胞组分可以再循环到切向流过滤器以达到某些所需浓度的细胞。可以收集浓缩流体组分以利用浓缩流体组分中的细胞产生的成分。

25. 发明授权

US08431401B2 Method of cultivating cell or tissue 有权
标题翻译：培养细胞或组织的方法
公开(公告)号：US08431401B2
公开(公告)日：2013-04-30
申请号：US12307978
申请日：2007-06-22
申请人： Setsuo Watanabe , Shuichi Mizuno
发明人： Setsuo Watanabe , Shuichi Mizuno
IPC分类号： C12N5/00
CPC分类号： C12M35/04 , C12M25/12 , C12M25/14
摘要： A method for cultivating a culture of a cell, tissue, etc. There is provided a method of cultivating a culture including a cell or tissue (cell construct), imparting bending motion to the culture. By virtue of applying bending force to a culture of a cell, tissue, etc. (cell construct) to thereby curve the culture, continuous compression and extension in a direction of thickness from a concave portion toward a convex portion thereof are induced. The physical stimulation and deformation not attained by conventional pressurization, shear and tension, then can be loaded on the culture to thereby realize the culture appropriate for restoration of tissue at a region accompanied by bending.
摘要翻译：培养细胞，组织等培养的方法提供培养包括细胞或组织（细胞构建体）的培养物，赋予培养物弯曲运动的方法。通过对细胞，组织等的培养（细胞构建体）施加弯曲力，从而弯曲培养，诱导从凹部朝向其凸部的厚度方向的连续压缩和延伸。通过常规加压，剪切和张力不能达到的物理刺激和变形，然后可以加载到培养物上，从而实现适合于在伴随弯曲的区域恢复组织的培养。

26. 发明授权

US08399245B2 Rotation system for cell growth chamber of a cell expansion system and method of use therefor 有权
标题翻译：细胞扩张系统细胞生长室旋转系统及其使用方法
公开(公告)号：US08399245B2
公开(公告)日：2013-03-19
申请号：US12703041
申请日：2010-02-09
申请人： Paul M. Leuthaeuser , Jon A. Dodd , Thomas G. DiLorenzo
发明人： Paul M. Leuthaeuser , Jon A. Dodd , Thomas G. DiLorenzo
IPC分类号： C12M1/10 , C12M1/00 , C12M3/00
CPC分类号： C12M23/50 , B01F11/00 , B01F11/0005 , C12M23/42 , C12M23/48 , C12M25/10 , C12M25/12 , C12M27/10 , C12M27/14 , C12M27/16 , C12N5/0068
摘要： A system and method for rotating a cell growth chamber of a cell expansion system includes a rotatable member for engaging a chamber coupling attached to the cell growth chamber. The rotatable member includes an independently operable mechanism for engaging a rotatable fitting associated with the chamber coupling. In at least one embodiment, the chamber coupling is selectively rotatable by turning the rotatable member, thereby rotating the cell growth chamber around a first axis. The cell growth chamber is also selectively rotatable around a second axis by turning the rotatable fitting associated with the chamber coupling. Other novel aspects include a way of attaching the cell growth chamber to the shaft assembly, and a new tube routing clip.
摘要翻译：用于旋转电池膨胀系统的电池生长室的系统和方法包括用于接合附接到电池生长室的室耦合的可旋转构件。可旋转构件包括用于接合与腔室联接器相关联的可旋转配件的可独立操作的机构。在至少一个实施例中，通过转动可旋转构件来选择性地旋转室联接器，从而使细胞生长室围绕第一轴线旋转。通过转动与腔室联接件相关联的可旋转配件，细胞生长室也可以围绕第二轴线选择性地旋转。其他新颖的方面包括将细胞生长室附接到轴组件的方式和新的管路径夹。

27. 发明授权

US08309347B2 Cell expansion system and methods of use 有权
标题翻译：细胞扩增系统及使用方法
公开(公告)号：US08309347B2
公开(公告)日：2012-11-13
申请号：US12042798
申请日：2008-03-05
申请人： Glen Delbert Antwiler
发明人： Glen Delbert Antwiler
IPC分类号： C12M3/00 , C12M1/00 , C12M1/12 , C12N5/02
CPC分类号： C12N5/0663 , C12M25/10 , C12M25/12 , C12M29/10 , C12M29/16 , C12M41/00 , C12N2521/00
摘要： Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.
摘要翻译：提供电池膨胀系统和使用方法。细胞扩增系统通常包括中空纤维细胞生长室，以及分别与中空纤维内部和中空纤维外部相关联的第一和第二循环回路（毛细管内毛细管环和毛细血管外循环）。还提供了可拆卸的流动电路和膨胀电池的方法。

28. 发明申请

US20120089930A1 Customizable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System 有权
标题翻译：可定制的中空纤维生物反应器系统中生长和收获细胞的方法和系统
公开(公告)号：US20120089930A1
公开(公告)日：2012-04-12
申请号：US13269351
申请日：2011-10-07
申请人： Edward Allan STANTON, IV , Glen Delbert ANTWILER , Patrick J. HOWLEY , Michael E. KINZIE , Jon A. DODD , Casey V. Medina
发明人： Edward Allan STANTON, IV , Glen Delbert ANTWILER , Patrick J. HOWLEY , Michael E. KINZIE , Jon A. DODD , Casey V. Medina
IPC分类号： G06F3/048
CPC分类号： C12M41/44 , C12M23/42 , C12M23/44 , C12M25/10 , C12M25/12 , C12M29/16 , C12M29/20 , C12M41/48 , G06F8/38
摘要： Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
摘要翻译：本文描述的实施例通常涉及用于定制用于细胞扩增系统的协议的方法和系统。通过用户界面，用户可以创建用于加载，增长和/或收获单元的自定义任务。自定义任务可以包括一个或多个步骤，其中用户可以根据需要添加或省略步骤。可以为与自定义任务相关联的设置输入数据，其中实施例提供在每次执行自定义任务时输入这样的数据。在另一个实施例中，可以配置自定义任务的设置，其中可以在选择自定义任务时存储和检索这样的设置。自定义任务的定制和配置可以使用单元扩展系统的图视图进行，其中过程设置与图形用户界面元素相关联。

29. 发明申请

US20120028275A1 BIOMIMETIC MEMBRANE FOR CELL EXPANSION 审中-公开
标题翻译：用于细胞扩增的生物膜
公开(公告)号：US20120028275A1
公开(公告)日：2012-02-02
申请号：US13186609
申请日：2011-07-20
申请人： Verena Kieferle , Markus Neubauer
发明人： Verena Kieferle , Markus Neubauer
IPC分类号： G01N33/53 , C12M1/00 , C12N5/0775 , C12M3/00 , C12N5/071 , C12Q1/06
CPC分类号： C12N5/0068 , C12M25/10 , C12M25/12 , C12N5/0663 , C12N2533/30 , C12N2533/52 , C12N2533/70
摘要： The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to modification of the membrane surface with a combination of at least one extracellular matrix protein, at least one extracellular matrix (proteo-) glycan, and at least one heparin-binding growth factor. The invention further relates to a method for preparing said modified or coated membrane which can be used for the cultivation of cells, in particular adherent cells, and to methods of using such membrane for the cultivation of cells, in particular adherent cells.
摘要翻译：本发明涉及一种可用于培养粘附或悬浮细胞，特别是贴壁细胞的膜，其中所述膜允许由于膜表面的修饰而使细胞的粘附和增殖，所述膜表面与至少一种细胞外基质蛋白质，至少一种细胞外基质（蛋白质 - ）聚糖，以及至少一种肝素结合生长因子。本发明进一步涉及可用于培养细胞，特别是贴壁细胞的所述修饰或包被的膜的制备方法，以及使用这种膜来培养细胞，特别是贴壁细胞的方法。

30. 发明申请

US20110159584A1 METHOD OF LOADING AND DISTRIBUTING CELLS IN A BIOREACTOR OF A CELL EXPANSION SYSTEM 有权
标题翻译：在细胞扩增系统的生物反应器中加载和分布细胞的方法
公开(公告)号：US20110159584A1
公开(公告)日：2011-06-30
申请号：US12968483
申请日：2010-12-15
申请人： David M. GIBBONS , Brian J. NANKERVIS
发明人： David M. GIBBONS , Brian J. NANKERVIS
IPC分类号： C12N5/071
CPC分类号： C12M29/16 , C12M23/42 , C12M23/50 , C12M25/10 , C12M25/12 , C12M27/14
摘要： A method of distributing a plurality of cells in a bioreactor of a cell expansion system includes manipulating an orientation of the bioreactor such that a net impulse due to gravity acting on the plurality cells in the bioreactor is reduced. One method includes (a) rotating the bioreactor at an angular velocity ω about an axis of rotation and through an angular displacement θ, the bioreactor rotating from a first orientation to a second orientation; (b) holding the bioreactor still at the second orientation for a first period of time t1, wherein t1 substantially equals 2/ω; (c) rotating the bioreactor at the angular velocity ω about the axis of rotation and through the angular displacement θ; and (d) holding the bioreactor still for a second period of time t2, wherein t2 substantially equals t1.
摘要翻译：在细胞扩增系统的生物反应器中分配多个细胞的方法包括操纵生物反应器的取向，使得由于重力作用在生物反应器中的多个细胞上的净冲击减少。一种方法包括：（a）以围绕旋转轴线的角速度ω旋转生物反应器并通过角度位移旋转生物反应器;生物反应器从第一取向旋转到第二取向; （b）将所述生物反应器保持在所述第二方向上第一时间段t1，其中t1基本上等于2 /ω; （c）以关于旋转轴线和角位移的角速度ω旋转生物反应器; 和（d）将生物反应器保持第二时间段t2，其中t2基本上等于t1。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式