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21. 发明授权

US07534846B2 Onium-modified polymer and method for manufacturing same 失效
标题翻译：鎓改性聚合物及其制造方法
公开(公告)号：US07534846B2
公开(公告)日：2009-05-19
申请号：US11126657
申请日：2005-05-11
申请人： Xiaorong Wang , Victor J. Foltz , David F. Lawson
发明人： Xiaorong Wang , Victor J. Foltz , David F. Lawson
IPC分类号： C08F26/06
CPC分类号： C08F8/30 , C08G65/329 , C08G65/333 , C08G65/3331 , C08L71/03 , Y02P20/542
摘要： Onium-modified polymers, such as polyethers and alkylimidazolium-modified polymers are provided. The polymers have desirable properties such as moisture absorbing capability, low volatile organic compounds (VOCs) emission, and enhanced electrical conductivity. A method to prepare the polymers is also provided, in which green solvents such as ionic liquids are utilized as both reaction media and reactants.
摘要翻译：提供了鎓改性聚合物，例如聚醚和烷基咪唑改性的聚合物。聚合物具有所需的性能，例如吸湿能力，低挥发性有机化合物（VOC））发射和增强的导电性。还提供了制备聚合物的方法，其中使用绿色溶剂如离子液体作为反应介质和反应物。

22. 发明授权

US07405266B2 Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof 有权
标题翻译：受阻的聚（乙二醇）链烷酸及其衍生物
公开(公告)号：US07405266B2
公开(公告)日：2008-07-29
申请号：US11716202
申请日：2007-03-09
申请人： Michael David Bentley , Xuan Zhao , Xiaoming Shen , Lihong Guo
发明人： Michael David Bentley , Xuan Zhao , Xiaoming Shen , Lihong Guo
IPC分类号： C08F6/14 , C08G65/34 , C08G65/324 , C08G65/329 , C08G65/332
CPC分类号： C08G65/324 , A61K47/60 , C08G65/32 , C08G65/329 , C08G65/332 , C08G65/3322 , C08G65/333
摘要： The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).
摘要翻译：本发明提供一种空间位阻聚合物，其包含具有至少一个与链烷酸或链烷酸衍生物共价结合的末端的水溶性和非肽性聚合物主链，其中与酸或酸衍生物基团的羰基相邻的碳具有其上的烷基或芳基。烷基或芳基的空间效应允许更好地控制聚合物衍生物的水解稳定性。聚合物主链可以是聚（乙二醇）。

23. 发明申请

US20070166808A1 Methods of preparing activated polymers having alpha nitrogen groups 失效
标题翻译：制备具有α氮基团的活性聚合物的方法
公开(公告)号：US20070166808A1
公开(公告)日：2007-07-19
申请号：US11333072
申请日：2006-01-17
申请人： Hong Zhao , Dechun Wu
发明人： Hong Zhao , Dechun Wu
IPC分类号： C12P17/00 , C12N9/64 , C08F20/00
CPC分类号： C08G65/329 , C08G18/797 , C08G65/333
摘要： Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
摘要翻译：公开了制备基本上具有高纯度的含有电子对的部分的非抗原性聚合物的方法。聚合物可用作合成基于胺的聚合物的中间体和用于与亲核试剂缀合的活化聚合物的形成。还公开了共轭物的共轭物和制备和处理方法。得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

24. 发明申请

US20060235103A1 Photosensitive resin, photosensitive composition and photo-crosslinked structure 有权
标题翻译：光敏树脂，光敏组合物和光交联结构
公开(公告)号：US20060235103A1
公开(公告)日：2006-10-19
申请号：US11393678
申请日：2006-03-31
申请人： Takeshi Ikeya , Toru Shibuya , Kana Miyazaki
发明人： Takeshi Ikeya , Toru Shibuya , Kana Miyazaki
IPC分类号： C08G18/67
CPC分类号： C08G65/333 , G03F7/012
摘要： The invention provides a photosensitive resin which can readily form, through photo-crosslinking, a surface coating which has hydrophilicity and high bioadaptability; a photosensitive composition containing the photosensitive resin; and a photo-crosslinked structure obtained from the photosensitive composition. The photosensitive resin is represented by the following formula (1): (wherein n represents a mean polymerization degree and is 5 or more; R1 and R2, which may be identical to or different from each other, each represent an alkylene group, an arylene group, an oxyalkylene group, or a single bond; each of X and Y represents a photosensitive unit represented by the following formula (2): or either one of X and Y represents a photosensitive unit represented by the above formula (2) and the other represents an amino group; R3 represents a group selected from among the groups represented by the following formula set (3): R4 represents a group selected from among the groups represented by the following formula set (4): at least one of R3 and R4 has at least one azido group; and R5 represents a hydrogen atom, an alkyl group, an acetal-group-containing alkyl group, an aryl group, an aralkyl group, or a substituent containing a base-forming nitrogen atom).
摘要翻译：本发明提供一种光敏树脂，其可以通过光交联容易地形成具有亲水性和高生物适应性的表面涂层; 含有感光性树脂的感光性组合物; 和由感光性组合物得到的光交联结构。感光性树脂由下式（1）表示：（其中n表示平均聚合度，为5以上; R 1和R 2可以是彼此相同或不同，分别表示亚烷基，亚芳基，氧化烯基或单键; X和Y各自表示由下式（2）表示的感光单元：或X Y表示由上述式（2）表示的光敏单元，另一个表示氨基; R 3表示选自下述式（3）表示的基团：R 4 表示选自由下式（4）表示的基团中的基团：R 3和R 4中的至少一个具有至少一个叠氮基; R 5表示氢原子，烷基，含缩醛基的烷基，芳基，芳烷基或取代基con 除去形成碱的氮原子）。

25. 发明申请

US20060182711A1 Conjugates of an EPO moiety and a polymer 有权
标题翻译： EPO部分和聚合物的共轭物
公开(公告)号：US20060182711A1
公开(公告)日：2006-08-17
申请号：US11357936
申请日：2006-02-16
申请人： Mary Bossard , Gayle Stephenson
发明人： Mary Bossard , Gayle Stephenson
IPC分类号： A61K38/18 , C08L89/00
CPC分类号： C08G65/333 , A61K38/00 , A61K47/60 , C07K14/505 , C08G65/329
摘要： Conjugates of an EPO moiety and one or more non-peptidic water-soluble polymers are provided. Typically, the non-peptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of making conjugates, and methods of administering compositions comprising such conjugates to a patient.
摘要翻译：提供EPO部分和一种或多种非肽水溶性聚合物的共轭物。通常，非肽水溶性聚合物是聚（乙二醇）或其衍生物。还提供了包含这种缀合物的组合物，制备缀合物的方法，以及向患者施用包含这种缀合物的组合物的方法。

26. 发明申请

US20060111250A1 (Per) fluoropolyether additives 审中-公开
标题翻译：（Per）氟聚醚添加剂
公开(公告)号：US20060111250A1
公开(公告)日：2006-05-25
申请号：US11267155
申请日：2005-11-07
申请人： Antonio Russo , Claudio Tonelli
发明人： Antonio Russo , Claudio Tonelli
IPC分类号： C10M105/54 , C10M147/04
CPC分类号： C08G65/007 , C08G65/329 , C08G65/333 , C10M147/04 , C10M169/00 , C10M169/041 , C10M169/06 , C10M177/00 , C10M2213/04 , C10M2213/06 , C10M2213/0606 , C10M2213/0623 , C10M2217/06 , C10N2230/06 , C10N2230/08 , C10N2230/10 , C10N2250/10 , C10N2260/09 , C10N2260/10
摘要： Compounds usable as stabilizing additives of perfluoropolyether fluids working at high temperatures, higher than 200° C. and/or in the presence of metals and/or in the presence of Lewis acids, are formed of (per)fluoropolyether chains and of end groups having a heteroaromatic structure, according to the following general formula: T1-CFW1—O—Rf—CFW2-T2 (I) wherein T1, T2, equal to or different from each other, have the following meanings: F, CF3, C2F5, (C2F4)Cl —CH2—B—Y, —CH(CF3)O—Y, wherein: B═O, S: Y is a substituent formed of a ring having a heterocyclic structure having the following formula: wherein: R1, R2, R3, R4, equal to or different from each other are H, linear or branched C1-C8 perfluoroalkyl, NO2, CN, preferably H; with the proviso that at least one of the two end groups T1, T2 is —CH2—B—Y or —CH(CF3)O—Y, wherein B and Y are as above: W1, W2, equal to or different from each other, are —F, —CF3: Rf is a (per)fluoropolyoxyalkylene chain having a number average molecular weight between 500 and 10,000, preferably between 800 and 5,000.
摘要翻译：可用作在高于200℃和/或在金属存在下和/或在路易斯酸存在下工作的全氟聚醚流体稳定添加剂的化合物由（全）氟聚醚链和具有一个杂芳族结构，根据以下通式：<？in-line-formula description =“In-line Formulas”end =“lead”？> T 1 （I）<？in-line-formula description =“在线公式” 其中T 1，...，T 2彼此相同或不同，具有以下含义：F，CF 3， C 2，C 2，C 5，C 2 -C 4 CH 2，其中：BO，S：Y是由具有下式的杂环结构的环形成的取代基：其中：R 1， 1，R 2，R 3，R 3，R 4等于或不同的是H，lin 耳或支链C 1 -C 8全氟烷基，NO 2，CN，优选H; 条件是两个端基T 1，T 2中的至少一个是-CH 2 -BY或-CH（CF 3）其中B和Y如上所述：W 1，W 2，彼此相同或不同，为-F， -CF 3：Rf是数均分子量在500和10,000之间，优选在800和5,000之间的（全）氟聚氧亚烷基链。

27. 发明申请

US20060073113A1 Polyalkylene glycol derivative and modified bio-related substance 有权
标题翻译：聚亚烷基二醇衍生物和改性生物相关物质
公开(公告)号：US20060073113A1
公开(公告)日：2006-04-06
申请号：US11142678
申请日：2005-06-02
申请人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
发明人： Ken-ichiro Nakamoto , Syunsuke Ohashi , Yuji Yamamoto , Kenji Sakanoue , Chika Itoh , Tohru Yasukohchi
IPC分类号： A61K31/765 , C08G59/14
CPC分类号： C08G65/333 , C08G65/2609 , C08G65/329
摘要： A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mu of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
摘要翻译：含有式（1）化合物的聚亚烷基二醇衍生物：其中R是具有1至24个碳原子的烃基，OA 2是具有2至4个碳原子的氧化烯基，所表示的基团在一个分子中，R彼此相同或不同，在一个分子中由OA 2表示的基团彼此相同或不同，m是氧化烯基的平均摩尔数 m表示10〜1000，X表示能够与生物相关物质发生化学反应的官能团，上述聚亚烷基二醇衍生物的多分散性Mw / Mu在凝胶渗透色谱中满足以下关系：＆lt; 公式描述=“在线公式”end =“lead”？> Mw / Mn <= 1.07 <？in-line-formula description =“In-line Formulas”end =“tail”？>其中Mw表示重量平均分子量，Mn表示数均分子量。

28. 发明申请

US20050147583A1 Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) 有权
标题翻译：聚乙二醇的水解降解氨基甲酸酯衍生物
公开(公告)号：US20050147583A1
公开(公告)日：2005-07-07
申请号：US11033547
申请日：2005-01-10
申请人： Michael Bentley , Xuan Zhao
发明人： Michael Bentley , Xuan Zhao
IPC分类号： A61K9/06 , A61K31/77 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61K47/44 , A61K47/48 , A61P5/00 , A61P5/38 , A61P9/00 , A61P25/22 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P43/00 , C08G65/329 , C08L101/16 , A61K38/17 , A61K31/785
CPC分类号： C08G65/33344 , A61K31/765 , A61K47/60 , C08G18/711 , C08G65/329 , C08G65/331 , C08G65/333 , C08G2210/00 , Y10S435/82
摘要： Poly(ethylene glycol) carbamate derivatives useful as water-soluble prodrugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the drug at a controllable rate as the gel degrades.
摘要翻译：公开了可用作水溶性前药的聚（乙二醇）氨基甲酸酯衍生物。这些可降解的聚（乙二醇）氨基甲酸酯衍生物在水凝胶的可控水解降解中也具有潜在的应用。在这种可降解的水凝胶中，药物可以被捕获在凝胶中并随着凝胶降解而被扩散释放，或者它们可以通过可水解的氨基甲酸酯键共价结合。当凝胶降解时，这些氨基甲酸酯键的水解以可控的速率释放药物。

29. 发明申请

US20040149164A1 N-alkylaziridine prepolymers as a dental material 有权
公开(公告)号：US20040149164A1
公开(公告)日：2004-08-05
申请号：US10478807
申请日：2003-11-26
发明人： Gunther Eckhardt , Guenther Lechner , Erich Wanek
IPC分类号： B28B007/36
CPC分类号： C08G73/02 , C08G63/914 , C08G64/42 , C08G65/20 , C08G65/333 , C08G65/33306
摘要： The invention relates to a mixture of elongated N-alkylaziridine prepolymers of general formula (I) wherein n represents a whole number between 1 and 50; R1 represents H or C1 to C12 alkyl; X represents a bivalent, saturated or unsaturated, linear, branched, cyclic or polycyclic hydrocarbon radical which can contain between 0 and 5 heteroatoms from the group 0, NR1, S, which contains a total of between 1 and 50, preferably between 2 and 30, and ideally between 2 and 20 C atoms, and which comprises a group selected from nullNR1-(CnullO)nullOnull, nullNR1-(CnullO)nullNR1-, null(CnullO)nullOnull, null(CnullO)nullSnull, which represents that covalent link with the polymer radical Z; Z represents a bivalent prepolymer radical having number-average molar masses of between 1,500 and 45,000 g/mole, from the group comprising polyester, polycarbonate, polyolefins, polysiloxane and polyethers; E represents nullXnull-A-Xnullnull; A represents a double radical, saturated or unsaturated, linear, branched, cyclic or polycyclic hydrocarbon radical which optionally contains aromatic compounds, can contain between 0 and 15 heteroatoms from group 0, NR1, S, and comprises a total of between 0 and 50, preferably between 1 and 30, and ideally between 1 and 20 C atoms; and Xnull represents a double radical, saturated or un-saturated, linear, branched, cyclic or polycyclic radical which optionally contains aromatic compounds, can contain between 0 and 15 heteroatoms from the group 0, NR1, S, and comprises a group selected from nullNR1-(CnullO)nullOnull, nullNR1-(CnullO)nullNR1-, null(CnullO)nullOnull, null(CnullO)nullS, which represents the covalent link with the polymer radical Z; with non-elongated N-alkylaziridine prepolymers of general formula (II) wherein R1, X and Z have the above-mentioned designations. The invention also relates to the production and the use of said mixture in hardenable compositions, especially in dental materials.

30. 发明授权

US06737505B2 Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof 有权
标题翻译：受阻的聚（乙二醇）链烷酸及其衍生物
公开(公告)号：US06737505B2
公开(公告)日：2004-05-18
申请号：US10283890
申请日：2002-10-30
申请人： Michael David Bentley , Xuan Zhao , Xiaoming Shen , Lihong Guo
发明人： Michael David Bentley , Xuan Zhao , Xiaoming Shen , Lihong Guo
IPC分类号： C08G6534
CPC分类号： C08G65/324 , A61K47/60 , C08G65/32 , C08G65/329 , C08G65/332 , C08G65/3322 , C08G65/333
摘要： The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).
摘要翻译：本发明提供一种空间位阻聚合物，其包含具有至少一个与链烷酸或链烷酸衍生物共价结合的末端的水溶性和非肽性聚合物主链，其中与酸或酸衍生物基团的羰基相邻的碳具有其上的烷基或芳基。烷基或芳基的空间效应允许更好地控制聚合物衍生物的水解稳定性。聚合物主链可以是聚（乙二醇）。

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