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21. 发明申请

US20040172106A1 Apparatus for ablation with a laser beam 审中-公开
标题翻译：用激光束消融的装置
公开(公告)号：US20040172106A1
公开(公告)日：2004-09-02
申请号：US10689095
申请日：2003-10-21
发明人： Satoshi Imaizumi
IPC分类号： A61N001/00
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00872
摘要： An ablation apparatus capable of obtaining intensity distribution in a concave shape at an irradiation surface even when a laser beam goes through a small opening of an aperture to be formed into a small spot. In the apparatus, a laser light source emits the beam which effects ablation to the object, an irradiation optical system directs and irradiates the beam onto an irradiation surface of the object, an aperture in the system has an opening, a convex lens in the system once collects the beam passed through the opening and directs the beam onto the surface at a defocus position, and an aspherical optical element in the system makes intensity distribution of the beam after passing through the opening to be convex, wherein an aspherical shape of the element is curved where a radius of curvature at a local surface is reduced toward a periphery from an optical axis.
摘要翻译：即使在激光束通过形成小斑点的小孔的小开口的情况下，能够获得在照射面处的凹形状的强度分布的消融装置。在该装置中，激光光源发射对物体进行消融的光束，照射光学系统将光束引导并照射到物体的照射表面上，系统中的孔具有开口，系统中的凸透镜一旦收集通过开口的光束并且在散焦位置将光束引导到表面上，并且系统中的非球面光学元件使光束在通过要凸起的开口之后的强度分布，其中元件的非球面形状是弯曲的，其中局部表面处的曲率半径从光轴朝向周边减小。

22. 发明申请

US20040147910A1 Method and apparatus for obtaining irradiation intensity of a laser beam, and apparatus for irradiating the laser beam 失效
标题翻译：用于获得激光束的照射强度的方法和装置，以及用于照射激光束的装置
公开(公告)号：US20040147910A1
公开(公告)日：2004-07-29
申请号：US10626527
申请日：2003-07-25
发明人： Masanao Fujieda
IPC分类号： A61B018/20
CPC分类号： G01J1/4257 , A61B18/20 , A61B2018/00636 , A61F9/00814 , A61F9/00817 , A61F2009/00855 , A61F2009/00872 , B23K26/0096 , B23K26/705
摘要： A method and an apparatus for obtaining irradiation intensity of a laser beam, and a laser beam irradiation apparatus that enable obtaining an irradiation intensity distribution of a laser beam easily, and attaining more accurate ablation. The method for obtaining an irradiation intensity of a laser beam has the steps of inputting an intensity of fluorescence emitted from a fluorescent glass, the fluorescence intensity being obtained when the laser beam is irradiated onto the fluorescent glass which emits the fluorescence by irradiation of the laser beam with an ablation area of a size required for processing an object to be processed, and obtaining an irradiation intensity distribution of the laser beam in the ablation area based on the inputted fluorescence intensity.
摘要翻译：一种用于获得激光束的照射强度的方法和装置，以及能够容易地获得激光束的照射强度分布并获得更精确的消融的激光束照射装置。用于获得激光束的照射强度的方法具有输入从荧光玻璃发出的荧光强度的步骤，当将激光束照射到通过激光照射发出荧光的荧光玻璃上时获得的荧光强度光束，其具有用于处理待处理物体所需的尺寸的消融区域，并且基于输入的荧光强度获得激光束在消融区域中的照射强度分布。

23. 发明授权

US06592574B1 Hydration and topography tissue measurements for laser sculpting 有权
标题翻译：激光雕刻的水合和地形组织测量
公开(公告)号：US06592574B1
公开(公告)日：2003-07-15
申请号：US09626732
申请日：2000-07-27
申请人： John Karl Shimmick , Charles R. Munnerlyn , George Caudle , Terrance N. Clapham
发明人： John Karl Shimmick , Charles R. Munnerlyn , George Caudle , Terrance N. Clapham
IPC分类号： A61B1818
CPC分类号： A61B3/107 , A61F9/00804 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00855 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： Improved systems, devices, and methods measure and/or change the shape of a tissue surface, particularly for use in laser eye surgery. Fluorescence of the tissue may occur at and immediately underlying the tissue surface. The excitation energy can be readily absorbed by the tissue within a small tissue depth, and may be provided from the same source used for photodecomposition of the tissue. Changes in the fluorescence spectrum of a tissue correlate with changes in the tissue's hydration.
摘要翻译：改进的系统，装置和方法测量和/或改变组织表面的形状，特别是用于激光眼睛手术中。组织的荧光可发生在组织表面的正下方。激发能量可以容易地被组织内的组织深度吸收，并且可以由用于组织光分解的相同来源提供。组织荧光光谱的变化与组织水合的变化相关。

24. 发明申请

US20030125718A1 Multiple beam laser sculpting system and method 有权
公开(公告)号：US20030125718A1
公开(公告)日：2003-07-03
申请号：US10327486
申请日：2002-12-19
申请人： VISX, Incorporated
发明人： Audrey Munnerlyn , George Caudle
IPC分类号： A61B018/18
CPC分类号： C12N15/80 , A61F9/00804 , A61F9/00817 , A61F2009/00872 , A61F2009/00897 , C07K14/37 , C12N9/2428
摘要： The invention improves the laser sculpting of a region of a material to a predetermined shape by improving the smoothness and accuracy of surfaces formed by the sculpting technique. The technique includes projecting plurality of partially overlapping beams toward the region. The invention includes blurring an edge of an ablation to smooth an internal portion of the ablation that is separate from the edge. The blurred edge may be formed by the partially overlapping beams. Using a computer controlled laser delivery system, the position and shape of the overlapping beams may be precisely controlled to sculpt the material to a desired shape according to a laser treatment table.

25. 发明申请

US20030120266A1 Ophthalmic apparatus and corneal surgery apparatus 有权
标题翻译：眼科仪器和角膜手术器械
公开(公告)号：US20030120266A1
公开(公告)日：2003-06-26
申请号：US10307356
申请日：2002-12-02
发明人： Masanao Fujieda
IPC分类号： A61B018/20
CPC分类号： A61B3/11 , A61F9/00804 , A61F9/00817 , A61F2009/00846 , A61F2009/00872 , A61F2009/0088
摘要： An ophthalmic apparatus for obtaining differences between the pupil positions in photopia and scotopia accurately, and a corneal surgery apparatus for ablating a cornea of an eye by laser beam irradiation allowing for the differences. The ophthalmic apparatus has devices for inputting a first image of an anterior eye segment in photopia and a second one in scotopia, for obtaining pupil information in the images and differences between the pupil information in photopia and that in scotopia, and for outputting the differences. The corneal surgery apparatus has devices for irradiating the cornea with a laser beam, for aligning an irradiation position with the eye, for inputting differences between the pupil positions in photopia and scotopia, for detecting the photopic pupil position, for obtaining an alignment position of the laser beam based on the pupil position and the positional difference, and for controlling the alignment device based on the alignment position.
摘要翻译：一种准确地获得光瞳瞳孔位置和瞳孔位置之间的差异的眼科装置，以及用于通过允许差异的激光束照射来消除眼睛角膜的角膜手术装置。该眼科装置具有用于输入前视眼部分的第一图像以及第二图像，用于获得图像中的瞳孔信息以及光瞳中的瞳孔信息与瞳孔之间的差异以及用于输出差异的装置。角膜手术装置具有用于用激光束照射角膜的装置，用于使照射位置与眼睛对准，用于输入光皮和瞳孔中的瞳孔位置之间的差异，以检测明瞳瞳位置，以获得对准位置基于瞳孔位置和位置差的激光束，以及用于基于对准位置控制对准装置。

26. 发明授权

US06575962B2 Apparatus for modifying the surface of the eye through large beam laser polishing and method of controlling the apparatus 失效
标题翻译：用于通过大束激光抛光修饰眼睛表面的装置和控制装置的方法
公开(公告)号：US06575962B2
公开(公告)日：2003-06-10
申请号：US09177442
申请日：1998-10-21
申请人： Kristian Hohla
发明人： Kristian Hohla
IPC分类号： A61F907
CPC分类号： A61F9/008 , A61B2017/00061 , A61F9/00804 , A61F9/00806 , A61F9/00817 , A61F2009/00872 , A61F2009/00882
摘要： A apparatus and method for controlling an apparatus for removing tissue from the eye performs various types of corrections using a relatively large beam, but oscillating, or dithering, that being to prevent reinforcing ridges from being formed during the tissue removal process. Further, various types of correction, such as hyperopia and astigmatism correction, are performed using a large beam that is scanned over the area to be ablated using overlapping shots. Further, the epithelium in the area to be treated is removed using an infrared fluorescent dye to dye the epithelium, and then observing the fluorescent patterns from the epithelium area to be removed. Once a certain area is no longer fluorescent after laser shots, smaller shots are then applied, selectively removing the epithelium from the remaining regions. Again, the fluorescence patterns are observed, and the process is repeated until no epithelium remains. At this point, all of the epithelium is removed, and further a map is created of the initial epithelial thickness at each point in the area from which the epithelium was removed.
摘要翻译：用于控制从眼睛去除组织的装置的装置和方法使用相对大的光束进行各种类型的校正，但是振荡或抖动，以防止在组织去除过程期间形成增强脊。此外，使用在使用重叠拍摄的要消融的区域上扫描的大束来执行各种类型的校正，例如远视和散光校正。此外，使用红外荧光染料除去待处理区域中的上皮以染色上皮，然后观察去除上皮区域的荧光图案。一旦激光照射后某一区域不再荧光，则施加较小的照片，从其余区域选择性地去除上皮。再次，观察荧光图案，重复该过程，直到没有上皮残留。此时，除去所有的上皮细胞，并且进一步在去除上皮的区域的每个点处产生初始上皮厚度的图。

27. 发明授权

US06520958B1 System and methods for imaging corneal profiles 有权
标题翻译：用于成像角膜剖面的系统和方法
公开(公告)号：US06520958B1
公开(公告)日：2003-02-18
申请号：US09565764
申请日：2000-05-05
申请人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
发明人： John K. Shimmick , Stephen J. Hinkson , Charles R. Munnerlyn
IPC分类号： A61B1818
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00872 , A61F2009/00882
摘要： Systems, methods and apparatus for generating images of portions of the patient's eye, such as the anterior surface of the cornea. The methods and apparatus of the present invention are particularly useful for directly imaging the profile of the ablated region of the cornea during or immediately following a laser ablation procedure, such as photorefractive keratometry (PRK), phototherapeutic keratectomy (PTK), laser in-situ keratomileusis (LASIK) or the like. These methods and apparatus allow the surgeon to precisely image the exterior edge of the eye to characterize the profile of ablated corneas and to determine the spatial variance of tissue ablation rates during the surgical procedures. Methods and apparatus are also provided for generating one or more images depicting the profile of the ablated region of the cornea. The profile is registered with a pre-ablation profile to provide feedback regarding the true ablation properties of the eye. This feedback permits the laser system to be programmed with a laser ablation algorithm based on the measured ablation properties of the eye.
摘要翻译：用于产生患者眼睛部分图像的系统，方法和装置，例如角膜的前表面。本发明的方法和装置特别可用于在激光消融过程期间或之后直接成像角膜的消融区域，例如光折射角膜曲率法（PRK），光治疗角膜切除术（PTK），原位激光角膜磨镶术（LASIK）等。这些方法和装置允许外科医生精确地成像眼睛的外部边缘以表征消融的角膜的轮廓并且确定外科手术过程中组织消融速率的空间方差。还提供了用于产生描绘角膜切除区域的轮廓的一个或多个图像的方法和装置。使用预消融轮廓记录轮廓以提供关于眼睛的真实消融性质的反馈。该反馈允许激光系统基于所测量的眼睛的消融性质用激光烧蚀算法进行编程。

28. 发明授权

US06467907B1 Apparatus for determining an amount of corneal ablation and surgical apparatus for a cornea 有权
标题翻译：用于确定角膜消融量和用于角膜的手术装置的装置
公开(公告)号：US06467907B1
公开(公告)日：2002-10-22
申请号：US09744909
申请日：2001-01-31
申请人： Masanao Fujieda , Yokinobu Ban , Masahiro Oyaizu
发明人： Masanao Fujieda , Yokinobu Ban , Masahiro Oyaizu
IPC分类号： A61B310
CPC分类号： A61B3/107 , A61B3/0025 , A61B3/103 , A61F9/00804 , A61F9/00817 , A61F2009/00872
摘要： The purpose of the present invention is to provide an apparatus for determining an amount of corneal ablation, which can calculates an amount of corneal ablation in order to perform an operation for correcting ametropia adequately, based on a corneal shape and/or an eye refractive power. Another object of the present invention is to provide a surgical apparatus for a cornea, by which the surgical operation can be performed efficiently based on the obtained amount of corneal ablation. The apparatus for determining an amount of corneal ablation, based on which surgical operation for correcting ametropia is performed, the apparatus comprises a first input unit (53) for inputting data of a pre-operative corneal shape of a patient's eye; a second input unit (52, 53, 54) for inputting data of a post-operative corneal shape of the eye, to be estimated (to be a target for correcting); an ablation amount calculating unit (54) for calculating data of a corneal ablation amount of the eye, in a manner of calculating data of an ablation amount in a symmetric component and data of an ablation amount in an asymmetric component separately and respectively, based on the data inputted by the first input unit and the second input unit; and an output unit (56, 59a, 59b) for outputting results calculated by the ablation amount calculating unit.
摘要翻译：本发明的目的是提供一种用于确定角膜消融量的装置，其可以基于角膜形状和/或眼睛屈光力来计算角膜消融的量以便适当地执行用于矫正屈光不正的操作。本发明的另一个目的是提供一种用于角膜的手术装置，通过该手术装置可以基于获得的角膜消融量有效地执行外科手术。该装置包括用于输入患者眼睛的手术前角膜形状的数据的第一输入单元（53），用于确定角膜消融量的装置，基于该量进行矫正屈光异常的外科手术。用于输入要估计的眼睛的术后角膜形状的数据（作为要校正的目标）的第二输入单元（52,53,54）; 一种消融量计算单元，用于以下述方式计算眼睛的角膜消融量的数据：以对称分量计算消融量的数据和不对称分量中的消融量的数据，并分别基于由第一输入单元和第二输入单元输入的数据; 以及用于输出由消融量计算单元计算的结果的输出单元（56,59a，59b）。

29. 发明申请

US20020055735A1 Apparatrus and method for performing presbyopia corrective surgery 失效
标题翻译： Apparatrus和执行老花眼矫正手术的方法
公开(公告)号：US20020055735A1
公开(公告)日：2002-05-09
申请号：US09944102
申请日：2001-09-04
发明人： Luis Antonio Ruiz
IPC分类号： A61N005/06
CPC分类号： A61F9/013 , A61F9/00808 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00872 , A61F2009/00895
摘要： A process and system for addressing presbyopia of an eye is disclosed and features the resecting of an eye to expose a corneal stroma and system and method for determining an eye sculpturing center point found in a nasal-superior region of the eye. Sculpturing through use of an ablation laser is then carried out relative to the determined eye sculpturing centerpoint which sculpturing includes leaving a central optic zone unable relative to the presbyopic corrective process. Following sculpturing the resected portion of the eye is returned to cover over the sculptured region. The sculpturing profile is also formed with ablation control to define an advantageous (e.g., aspherical) ablation profile in the stroma.
摘要翻译：公开了一种用于解决眼睛老视眼的过程和系统，其特征在于切除眼睛以暴露角膜基质以及用于确定在眼睛的鼻上部区域中发现的眼睛雕刻中心点的系统和方法。然后通过使用消融激光进行雕刻，相对于确定的眼睛雕塑中心点进行雕刻，其中雕刻包括离开不能相对于老花眼矫正过程的中心视觉区域。雕刻后，眼睛的切除部分被覆盖在雕塑区域上。雕刻轮廓也形成有消融控制以限定基质中有利（例如，非球面）消融轮廓。

30. 发明申请

US20020049511A1 Laser method for shaping of optical lenses 失效
标题翻译：光学透镜成形激光方法
公开(公告)号：US20020049511A1
公开(公告)日：2002-04-25
申请号：US09925067
申请日：2001-08-07
发明人： Jay J. Brandinger , Brian D. Hoffman , Edward T. Polkowski
IPC分类号： B23K026/38 , B23K026/40
CPC分类号： B23K26/067 , A61F9/00804 , A61F9/00817 , A61F2009/00846 , A61F2009/00872 , B23K26/032 , B23K26/0608 , B23K26/066 , B23K26/705
摘要： A method for making accurate and precise customized corrections to the surface of an optical lens is described. An electronic correction contour is generated from a measured refractive correction for a patient, and transferred to the surface of the lens by ablation etching with one or more laser pulses. After each of the laser pulses, the refractive properties of the lens are measured and compared to the electronic contour correction derived from a patient's refractive correction. The ablation etching is terminated in localized areas where the refractive properties match the electronic correction contour. End point detection includes monitoring refractive qualities of the lens during the recontouring process, modifying the pattern through changes in the laser pulses.
摘要翻译：描述了对光学透镜的表面进行精确和精确的定制校正的方法。从对患者的测量的屈光矫正产生电子校正轮廓，并且通过用一个或多个激光脉冲进行烧蚀蚀刻将其转移到透镜的表面。在每个激光脉冲之后，测量透镜的折射特性并将其与从患者的屈光矫正导出的电子轮廓校正进行比较。消融蚀刻在折射特性与电子校正轮廓匹配的局部区域中终止。终点检测包括在重构过程中监测透镜的折射质量，通过激光脉冲的变化修改图案。

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