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21. 发明授权

US07897575B2 Treatment and prevention of vascular dementia 有权
标题翻译：治疗和预防血管性痴呆
公开(公告)号：US07897575B2
公开(公告)日：2011-03-01
申请号：US12072914
申请日：2008-02-28
申请人： John M. Hallenbeck , Hideaki Wakita
发明人： John M. Hallenbeck , Hideaki Wakita
IPC分类号： A61K38/17
CPC分类号： A61K9/0043 , A01K2267/0318 , A01K2267/0375 , A61K38/177 , A61K39/0008 , A61K2039/543 , Y10S514/957 , Y10S514/958
摘要： The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to induce bystander immune tolerance in the mammal. Another aspect of the invention relates to compositions useful for treating or preventing vascular dementia.
摘要翻译：本发明涉及用于治疗或预防哺乳动物血管性痴呆的组合物和方法，包括粘膜施用一定量的E-选择蛋白多肽，其足以诱导哺乳动物的旁观者免疫耐受。本发明的另一方面涉及可用于治疗或预防血管性痴呆的组合物。

22. 发明授权

US07892786B2 Methods for expression and purification of immunotoxins 有权
标题翻译：免疫毒素的表达和纯化方法
公开(公告)号：US07892786B2
公开(公告)日：2011-02-22
申请号：US10566886
申请日：2004-08-02
申请人： David M. Neville , Jung-Hee Woo , Yuan-Yi Liu
发明人： David M. Neville , Jung-Hee Woo , Yuan-Yi Liu
IPC分类号： C12N15/09 , C12N15/10 , C12N15/81
CPC分类号： C07K1/18 , A61K47/6829 , A61K47/6849 , C07K16/2809 , C07K2317/622 , C07K2319/00 , C12N1/16
摘要： The present invention relates to a method of expressing an immunotoxin in Pichia pastoris strain mutated to toxin resistance comprising a) growing the Pichia pastoris in a growth medium comprising an enzymatic digest of protein and yeast extract and maintaining a dissolved oxygen concentration at 40% and above; and b) performing methanol induction with a limited methanol feed of 0.5-0.75 ml/min/IO L of initial volume during induction along with a continuous infusion of yeast extract at a temperature below 17.5° C., antifoaming agent supplied up to 0.07%, agitation reduced to 400 RPM, and the induction phase extended out to 163 h.
摘要翻译：本发明涉及一种在对抗毒素抗性进行突变的巴斯德毕赤酵母菌株中表达免疫毒素的方法，包括：a）在含有蛋白质和酵母提取物的酶促消化物的生长培养基中培养巴斯德毕赤酵母，并将溶解氧浓度保持在40％以上 ; 和b）在诱导期间以0.5-0.75ml / min / IOL的初始体积的有限甲醇进料进行甲醇诱导，同时在低于17.5℃的温度下连续输注酵母提取物，消泡剂提供高达0.07％，搅拌降至400RPM，诱导期延长至163小时。

23. 发明授权

US07888043B2 Modified cardiolipin and uses therefor 有权
标题翻译：改良的心磷脂及其用途
公开(公告)号：US07888043B2
公开(公告)日：2011-02-15
申请号：US12094144
申请日：2006-11-17
申请人： Arnold R. Castro , Huiying Wang
发明人： Arnold R. Castro , Huiying Wang
IPC分类号： G01N33/53 , G01N33/573
CPC分类号： G01N33/571 , G01N33/564 , G01N33/92 , G01N2333/20 , G01N2469/20
摘要： Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies in subjects, for example, when used in lateral flow devices. Lateral flow devices are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.
摘要翻译：描述了用于检测抗脂质体抗体的组合物，方法和装置以及疾病的诊断，例如梅毒。特别地，描述了可以与各种附着分子缀合的氧化的心磷脂，例如BSA，KLH，生物素，合成蛋白MAPS，IgY，链霉亲和素或抗生物素蛋白。这种氧化的心磷脂单独或与一个或多个附着分子复合可用于检测受试者中的抗脂质体抗体，例如当用于侧流装置时。描述了允许检测抗脂质体抗体并允许在生物样品中共同检测非延髓和螺旋体抗体的侧流装置。

24. 发明授权

US07887812B2 Live attenuated Leishmania vaccines 有权
标题翻译：活减毒利什曼原虫疫苗
公开(公告)号：US07887812B2
公开(公告)日：2011-02-15
申请号：US11364682
申请日：2006-02-28
申请人： Hira L. Nakhasi , Angamuthu Selvapandiyan , Alain Debrabant , Robert C. Duncan , Poonam Salotra , Gannavaram Sreenivas
发明人： Hira L. Nakhasi , Angamuthu Selvapandiyan , Alain Debrabant , Robert C. Duncan , Poonam Salotra , Gannavaram Sreenivas
IPC分类号： A61K39/02
CPC分类号： A61K39/008 , A61K2039/522 , C12N1/36 , Y02A50/41
摘要： Targeted disruption of the centrin gene leads to attenuation of growth in Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulent Leishmania strain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of Leishmania.
摘要翻译：中心蛋白基因的靶向破坏导致利什曼原虫生长减弱。本发明的优选实施方案提供了可用于制备免疫原性制剂的利什曼原虫的减毒菌株，包括针对由毒性利什曼原虫菌株感染引起的疾病的疫苗以及用于产生免疫学和诊断试剂的工具。其它优选实施方案提供相关的免疫原性组合物，产生免疫应答的方法，用于生产疫苗的方法，以及形成利什曼原虫减毒菌株的方法。

25. 发明授权

US07879810B2 Immunostimulatory nucleic acid molecules 有权
公开(公告)号：US07879810B2
公开(公告)日：2011-02-01
申请号：US10956494
申请日：2004-10-01
申请人： Arthur M. Krieg , Dennis Klinman , Alfred D. Steinberg
发明人： Arthur M. Krieg , Dennis Klinman , Alfred D. Steinberg
IPC分类号： A61K39/38 , A61K39/00 , A61K31/70 , A61K38/16 , A01N43/04
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

26. 发明授权

US07855276B2 Framework residue substituted humanized COL-1 antibodies and their use 有权
标题翻译：框架残基取代人源化COL-1抗体及其用途
公开(公告)号：US07855276B2
公开(公告)日：2010-12-21
申请号：US11813092
申请日：2005-12-30
申请人： Syed Kasmiri , Rafia Mehdi Kashmiri, legal representative , Jeffrey Schlom , Eduardo A. Padlan
发明人： Syed Kasmiri , Jeffrey Schlom , Eduardo A. Padlan
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , A61K39/00 , G01N33/53
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding positions of a homologous human sequence. In several embodiments, methods are disclosed for the use of a humanized COL-1 antibody in the detection or treatment of a CEA-expressing tumor or cell in a subject. Also disclosed is a kit including the humanized COL-1 antibodies described herein.
摘要翻译：本公开提供与亲本抗体相比保留CEA结合亲和力的人源化COL-1单克隆抗体。本文还公开了与亲本抗体相比具有降低的免疫原性的人源化COL-1单克隆抗体。公开的人源化COL-1抗体包括用来自同源人序列的相应位置的残基取代框架残基。在几个实施方案中，公开了使用人源化COL-1抗体检测或治疗受试者中表达CEA的肿瘤或细胞的方法。还公开了包含本文所述的人源化COL-1抗体的试剂盒。

27. 发明授权

US07851194B2 West Nile viruses with mutations in the 3′ terminal stem and loop secondary structure for use as live virus vaccines 有权
标题翻译：具有3'末端茎和环二级结构突变的西尼罗河病毒用作活病毒疫苗
公开(公告)号：US07851194B2
公开(公告)日：2010-12-14
申请号：US11629560
申请日：2005-06-14
申请人： Lewis Markoff , Li Yu
发明人： Lewis Markoff , Li Yu
IPC分类号： C12N7/00 , C12N7/04 , C12N15/86 , A61K39/12 , A61K39/295
CPC分类号： A61K39/12 , A61K2039/5254 , C12N2770/24134 , C12N2770/24162 , Y02A50/394
摘要： The invention provides West Nile (WN) viruses and chimeric WN viruses having one or more mutations in the 3′ terminal stem loop secondary structure (3′SL) that results in decreased neurovirulence, methods of making such WN viruses, and methods for using these WN viruses to prevent or treat WN virus infection.
摘要翻译：本发明提供西尼罗病毒（WN）病毒和在3'末端茎环二级结构（3'SL）中具有一个或多个突变的嵌合WN病毒，其导致神经毒力降低，制备这种WN病毒的方法以及使用这些WN病毒的方法 WN病毒预防或治疗WN病毒感染。

28. 发明授权

US07847078B2 PDE11A mutations in adrenal disease 有权
标题翻译： PDE11A突变在肾上腺疾病
公开(公告)号：US07847078B2
公开(公告)日：2010-12-07
申请号：US12161866
申请日：2007-01-19
申请人： Constantine A. Stratakis
发明人： Constantine A. Stratakis
IPC分类号： C07H21/04 , C12N5/00 , C12N5/02 , A61K48/00
CPC分类号： G01N33/6893 , G01N2800/04 , G01N2800/048
摘要： The invention provides previously uncharacterized variants of PDE11A that are correlated with a newly discovered form of Cushing Syndrome that presents at a young age. The invention also provides methods useful to research, screen for, treat, or prevent diagnose the disease using the PDE11A variants, as well as other methods relating thereto.
摘要翻译：本发明提供了与新发现的Cushing综合征形式相关的PDE11A的先前未表征的变体，其在年轻时呈现。本发明还提供了可用于研究，筛选，治疗或预防使用PDE11A变体诊断疾病的方法以及与其相关的其它方法。

29. 发明授权

US07842729B2 Anti tubercular drug: compositions and methods 有权
标题翻译：抗结核药物：组合物和方法
公开(公告)号：US07842729B2
公开(公告)日：2010-11-30
申请号：US11145499
申请日：2005-06-03
申请人： Marina Nikolaevna Protopopova , Richard Edward Lee , Richard Allan Slayden , Clifton E. Barry, III , Elena Bogatcheva , Leo Einck
发明人： Marina Nikolaevna Protopopova , Richard Edward Lee , Richard Allan Slayden , Clifton E. Barry, III , Elena Bogatcheva , Leo Einck
IPC分类号： A61K31/132 , A61K31/135 , A61K31/44 , A61K31/445
CPC分类号： C07C323/25 , A61K31/132 , A61K31/133 , A61K31/137 , A61K31/40 , A61K31/445 , C07C211/27 , C07C211/29 , C07C211/34 , C07C211/35 , C07C211/42 , C07C215/14 , C07C215/30 , C07C215/60 , C07C217/08 , C07C217/10 , C07C217/58 , C07C217/60 , C07C217/62 , C07C323/47 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D211/46 , Y02A50/401 , Y02A50/402 , Y02A50/478 , Y02A50/479
摘要： Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
摘要翻译：用于治疗由感染因子，特别是结核病引起的疾病的方法和组合物。特别地，提供了包含用于治疗感染性疾病的取代的乙二胺的方法和组合物。在一个实施方案中，这些方法和组合物用于治疗分枝杆菌感染，包括但不限于结核病。

30. 发明授权

US07838216B1 Human gene related to but distinct from EGF receptor gene 失效
标题翻译：与EGF受体基因相关但不同的人类基因
公开(公告)号：US07838216B1
公开(公告)日：2010-11-23
申请号：US07110791
申请日：1987-10-21
申请人： C. Richter King , Matthias H. Kraus , Stuart A. Aaronson
发明人： C. Richter King , Matthias H. Kraus , Stuart A. Aaronson
IPC分类号： C12Q1/68
CPC分类号： C07K14/71 , A61K38/00 , G01N33/566 , G01N33/57484 , G01N33/68 , G01N2333/82 , Y02A50/473 , Y10S435/805 , Y10S435/81 , Y10S436/813
摘要： The isolation, cloning and characterization of a human gene related to but distinct from EGF receptor gene has been described. Nucleotide sequence of the gene and amino acid sequence of the polypeptide encoded by the gene have been determined. The use of the nucleic acid probes and antibodies having specific binding affinity with said polypeptide for diagnostic and therapeutic purposes have also been described.
摘要翻译：已经描述了与EGF受体基因相关但不同的人基因的分离，克隆和表征。已经确定了由该基因编码的多肽的基因和氨基酸序列的核苷酸序列。已经描述了使用具有与所述多肽的特异性结合亲和力的核酸探针和抗体用于诊断和治疗目的。

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