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21. 发明授权

US4659744A Fluorocarbon anion exchangers and processes for their preparation 失效
标题翻译：氟碳阴离子交换剂及其制备方法
公开(公告)号：US4659744A
公开(公告)日：1987-04-21
申请号：US624029
申请日：1984-06-25
申请人： Kiyohide Matsui , Yoshiyuki Kikuchi , Tamejiro Hiyama , Etsuko Tobita , Kiyosi Kondo , Akira Akimoto , Toru Seita , Hiroyuki Watanabe
发明人： Kiyohide Matsui , Yoshiyuki Kikuchi , Tamejiro Hiyama , Etsuko Tobita , Kiyosi Kondo , Akira Akimoto , Toru Seita , Hiroyuki Watanabe
IPC分类号： C25B13/08 , C08F8/44 , C08J5/22 , B01J41/14 , C08F8/02
CPC分类号： C08J5/2237 , C08F8/44 , C08J2327/12
摘要： A fluorocarbon anion exchanger which is composed of a fluorocarbon polymer comprising a perfluorocarbon main chain and a pendant chain attached to the main chain, characterized in that the pendant chainhas a terminal group represented by the formula: ##STR1##
摘要翻译：一种氟碳阴离子交换剂，其由包含全氟化碳主链和附着于所述主链的侧链的碳氟聚合物组成，其特征在于所述侧链具有由下式表示的端基：（I）

22. 发明授权

US4487717A Process for recovering a dipeptide derivative 失效
标题翻译：回收二肽衍生物的方法
公开(公告)号：US4487717A
公开(公告)日：1984-12-11
申请号：US415912
申请日：1982-09-08
申请人： Kiyotaka Oyama , Shigeaki Irino , Norio Hagi
发明人： Kiyotaka Oyama , Shigeaki Irino , Norio Hagi
IPC分类号： C07K5/072 , C07K5/075 , C07C103/52
CPC分类号： C07K5/0613 , Y10S530/801
摘要： A process for recovering a dipeptide derivative comprises admixing an aqueous mixture of a solid dipeptide ester derivative of the formula ##STR1## wherein R.sub.1 is a lower alkyl group, R.sub.2 is a side chain group of an amino acid, n is 1 or 2, X is a benzyloxycarbonyl group which can have a nuclear substituent and Y is a hydrogen ion or an ammonium derivative ion of the formula ##STR2## wherein R.sub.3 is a side chain group of an amino acid and R.sub.4 is a lower alkyl group with an organic solvent capable of forming a binary phase system with water; said solvent being present in an amount effective to obtain the transfer of said peptide in the form of a solid from the aqueous phase to the organic solvent phase, settling the resulting admixture to form(1) an organic solvent phase containing in a solid state a substantial amount of dipeptide derivative of the formula ##STR3## wherein R.sub.1, R.sub.2, n and X are as defined above and Z is a hydrogen ion or an ammonium derivative ion of the formula ##STR4## wherein R.sub.3 and R.sub.4 are as defined above, and (2) an aqueous phase, separating the organic solvent phase from the aqueous phase, and recovering the dipeptide derivative from the organic solvent phase.
摘要翻译：回收二肽衍生物的方法包括混合式（I）的固体二肽酯衍生物的水性混合物，其中R1是低级烷基，R2是氨基酸的侧链基团，n是1或 2，X是可以具有核取代基的苄氧基羰基，Y是氢离子或式（II）的铵衍生物离子，其中R3是氨基酸的侧链基团，R4是低级烷基与能够与水形成二元相体系的有机溶剂组合; 所述溶剂的存在量有效地获得将固体形式的所述肽从水相转移到有机溶剂相，沉淀所得混合物以形成（1）含有固态的有机溶剂相a （III）的大量二肽衍生物，其中R 1，R 2，n和X如上所定义，Z是下式的氢离子或铵衍生物离子，其中R 3和R 4 如上所定义，和（2）水相，将有机溶剂相与水相分离，并从有机溶剂相中回收二肽衍生物。

23. 发明授权

US4278802A Novel .alpha.-thio-alkanoic acid derivatives 失效
标题翻译：新型α-硫代链烷酸衍生物
公开(公告)号：US4278802A
公开(公告)日：1981-07-14
申请号：US156349
申请日：1980-06-04
申请人： Genichi Tsuchihashi , Katsuyuki Ogura , Shuichi Mitamura
发明人： Genichi Tsuchihashi , Katsuyuki Ogura , Shuichi Mitamura
IPC分类号： C07B61/00 , C07C51/377 , C07C57/30 , C07C59/68 , C07C59/84 , C07C65/34 , C07C69/612 , C07C69/734 , C07D209/46 , C07D209/48 , C07D295/155 , C07D317/30 , C07D333/06 , C07D333/22 , C07D333/24 , C07D333/48 , A61K31/38
CPC分类号： C07D209/48 , C07C323/56 , C07C323/58 , C07C323/59 , C07C51/377 , C07C57/30 , C07C59/68 , C07C59/84 , C07D209/46 , C07D295/155 , C07D317/30 , C07D333/22 , C07D333/24 , Y10S514/916
摘要： Novel .alpha.-thio-alkanoic acid derivatives and a process for their preparation. These novel compounds can be easily converted to useful medicines.
摘要翻译：新型α-硫代链烷酸衍生物及其制备方法。这些新化合物可以容易地转化成有用的药物。

24. 发明授权

US4237298A Aromatic acetic acid derivatives having sulfur atom at alpha-position and process for their preparation 失效
标题翻译：在α-位具有硫原子的芳族乙酸衍生物及其制备方法
公开(公告)号：US4237298A
公开(公告)日：1980-12-02
申请号：US966750
申请日：1978-12-05
申请人： Genichi Tsuchihashi , Katsuyuki Ogura
发明人： Genichi Tsuchihashi , Katsuyuki Ogura
IPC分类号： C07C51/377 , C07C315/02 , C07C319/14 , C07C323/07 , C07C323/56 , C07C323/65 , C07C327/10 , C07D209/48 , C07D295/096 , C07D295/155 , C07D307/38 , C07D307/54 , C07D333/22 , C07D333/24 , C07D501/34 , C07C149/40 , C07D295/14 , C07D307/16
CPC分类号： C07D209/48 , C07C315/02 , C07C319/14 , C07C323/07 , C07C323/56 , C07C323/65 , C07C327/10 , C07C51/377 , C07D295/096 , C07D295/155 , C07D307/38 , C07D307/54 , C07D333/22 , C07D333/24
摘要： Aromatic acetic acid derivatives having a sulfur atom at the alpha-position, and a process for their preparation. Useful drugs can be produced from derivatives. erivatives.
摘要翻译：在α-位具有硫原子的芳族乙酸衍生物及其制备方法。有用的药物可以从衍生物生产。恶魔。

25. 发明授权

US4223448A Dehydration and incineration of sample material 失效
标题翻译：脱水和焚烧样品
公开(公告)号：US4223448A
公开(公告)日：1980-09-23
申请号：US840441
申请日：1977-10-07
申请人： Tomo Saito , Yumiko Nishiyama , Kazuo Watanabe , Naotake Morikawa
发明人： Tomo Saito , Yumiko Nishiyama , Kazuo Watanabe , Naotake Morikawa
IPC分类号： B01D1/00 , F26B3/34 , G21F9/06 , F26B3/30
CPC分类号： F26B3/343 , B01D1/00 , G21F9/06
摘要： A sample material to be dehydrated is enclosed in a container transmissive to microwave and air is past through the container under a microwave radiation to preferentially remove the water content of the sample. The dehydrated sample may be incinerated by switching the air supply to an oxygen supply under the microwave radiation.
摘要翻译：要脱水的样品被封装在对微波透射的容器中，空气在微波辐射下通过容器，以优先除去样品的水分。脱水样品可以通过在微波辐射下将空气供应切换到氧气供应来焚烧。

26. 发明授权

US4219659A Process for the preparation of thiophene derivatives and thiophene derivatives obtained therethrough 失效
标题翻译：制备噻吩衍生物和噻吩衍生物的方法
公开(公告)号：US4219659A
公开(公告)日：1980-08-26
申请号：US910290
申请日：1978-05-30
申请人： Tamotsu Fujisawa , Kunikazu Sakai , Akira Kurebayashi
发明人： Tamotsu Fujisawa , Kunikazu Sakai , Akira Kurebayashi
IPC分类号： C07D333/16 , C07D333/22 , C07D333/24 , C07D333/28
CPC分类号： C07D333/16 , C07D333/22 , C07D333/24
摘要： An .alpha.-(2-thienyl)propionic acid can easily be prepared in a high yield and high selectivity by reacting a 2-(dihaloacetyl)thiophene which is easily obtainable by acetylation and halogenation of a substituted or unsubstutitued thiophene, with a methylmetal compound and then reacting an alkali metal hydroxide with the reaction product. .alpha.-(2-Thienyl)propionic acids are useful compounds from which, for example, thioprofenic acid can easily be prepared. Thioprofenic acid is known as an anti-inflammatory agent. As reaction intermediates, 1-(2-thienyl)-1-dihalomethylethanols can be obtained. Which are novel and useful compounds.
摘要翻译：通过使易于获得的取代或未取代的噻吩的乙酰化和卤化的2-（二卤代乙酰基）噻吩与甲基金属化合物反应，可以以高产率和高选择性制备α-（2-噻吩基）丙酸，和然后使碱金属氢氧化物与反应产物反应。 α-（2-噻吩基）丙酸是有用的化合物，其中例如可以容易地制备硫代丙烯酸。硫代丙酸被称为抗炎剂。作为反应中间体，可以得到1-（2-噻吩基）-1-二卤代甲基乙醇。哪些是新颖有用的化合物。

27. 发明授权

US4212946A Process for recovering protease 失效
标题翻译：回收蛋白酶的方法
公开(公告)号：US4212946A
公开(公告)日：1980-07-15
申请号：US907203
申请日：1978-05-18
申请人： Yuji Nonaka , Kiyotaka Oyama , Heijiro Satoh
发明人： Yuji Nonaka , Kiyotaka Oyama , Heijiro Satoh
IPC分类号： C12N9/00 , C07K5/06 , C07K5/075 , C12N9/50 , C12P21/02 , C12N9/48 , C07G7/02
CPC分类号： C12N9/50 , C12P21/02 , Y10S435/816
摘要： Protease is recovered by reacting a first amino acid whose amino group is protected with a protective group with a second amino acid whose carboxyl group is protected with a protective group, in an aqueous medium in the presence of a protease to result a peptide synthesis to deposit the addition compound of a dipeptide and said second C-terminal protected amino acid; dissolving said addition compound by adding an organic solvent to a precipitate separated from the reaction mixture and isolating the protease from an organic solvent suspension or dissolving said addition compound by adding a water immiscible organic solvent and separating the organic solvent phase by a liquid-liquid separation.The addition compound can be dissolved in an organic solvent after separating the precipitate from the reaction mixture.The addition compound can be also dissolved by adding a water-immiscible organic solvent to the reaction mixture and the organic solvent phase can be separated from the aqueous phase.
摘要翻译：通过使氨基被保护基团的第一个氨基酸与其羧基被保护基团保护的第二个氨基酸在水性介质中在蛋白酶存在下反应，从而使肽合成沉积，从而回收蛋白酶二肽和所述第二C末端保护的氨基酸的加成化合物; 通过向从反应混合物分离的沉淀物中加入有机溶剂来溶解所述加成化合物，并从有机溶剂悬浮液中分离蛋白酶或通过加入与水不混溶的有机溶剂溶解所述加成化合物并通过液 - 液分离分离有机溶剂相。在从反应混合物中分离出沉淀物后，加成化合物可以溶解在有机溶剂中。加成化合物也可以通过向反应混合物中加入与水不混溶的有机溶剂而溶解，并且有机溶剂相可以与水相分离。

28. 发明授权

US4212945A Process for recovering protease 失效
标题翻译：回收蛋白酶的方法
公开(公告)号：US4212945A
公开(公告)日：1980-07-15
申请号：US907006
申请日：1978-05-18
申请人： Yuji Nonaka , Kiyotaka Oyama , Heijiro Satoh
发明人： Yuji Nonaka , Kiyotaka Oyama , Heijiro Satoh
IPC分类号： C12N9/00 , C07K5/06 , C07K5/075 , C12N9/50 , C12P21/02 , C12N9/48 , C07G7/02
CPC分类号： C12N9/50 , C12P21/02 , Y10S435/816
摘要： Protease is recovered by reacting a first amino acid whose amino group is protected with a protective group with a second amino acid whose carboxyl group is protected with a protective group, in an aqueous medium in the presence of a protease to result a peptide synthesis to deposit the addition compound of a dipeptide and said second C-terminal protected amino acid; dissolving said addition compound into the aqueous medium by adding a polar organic solvent which is miscible with water and separating an insoluble material from the resulting suspension by a solid-liquid separation to isolate the protease.
摘要翻译：通过使氨基被保护基团的第一个氨基酸与其羧基被保护基团保护的第二个氨基酸在水性介质中在蛋白酶存在下反应，从而使肽合成沉积，从而回收蛋白酶二肽和所述第二C末端保护的氨基酸的加成化合物; 通过加入与水混溶的极性有机溶剂将所述加成化合物溶解在水性介质中，并通过固液分离从所得悬浮液中分离出不溶物，分离蛋白酶。

29. 发明授权

US4169199A Precursors for prostaglandin analogue and process for preparing the same 失效
标题翻译：前列腺素类似物的前体及其制备方法
公开(公告)号：US4169199A
公开(公告)日：1979-09-25
申请号：US862328
申请日：1977-12-20
申请人： Kiyosi Kondo , Daiei Tunemoto , Yuriko Takahatake
发明人： Kiyosi Kondo , Daiei Tunemoto , Yuriko Takahatake
IPC分类号： C07C405/00 , C07D309/10
CPC分类号： C07C405/0033
摘要： Bicyclolactone compounds represented by the formula (I) ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms, R.sup.2 represents a substituted or unsubstituted alkyl group having 1 to 8 carbon atoms and R.sup.3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms;.gamma.-lactone sulfide or sulfoxide compounds represented by the formula (II) ##STR2## wherein R.sup.2 and R.sup.3 are as defined above, R.sup.4 represents a hydrogen atom or a --COOR.sup.1 group wherein R.sup.1 is as defined above, R.sup.5 represents a hydrogen atom or a --CH.sub.2 --Y--(CH.sub.2).sub.n --COOR.sup.6 group wherein Y represents a --CH.sub.2 CH.sub.2 -- group or a --CH.dbd.CH-- group, R.sup.6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and n is an integer of 0 to 6, R.sup.7 represents an alkyl group having 1 to 4 carbon atoms or an aryl group and m is 0 or 1, useful as precursors for prostaglandin analogues; and process for preparing the same.
摘要翻译：由式（I）表示的双环内酯化合物其中R 1表示具有1至4个碳原子的烷基，R 2表示取代或未取代的碳原子数1〜8的烷基，R 3表示氢原子或具有1至4个碳原子的烷基; （II）表示的γ-LACTON硫化物或硫化物化合物其中R 2和R 3如上所定义，R 4表示氢原子或-COOR 1基团，其中R 1如上所定义，R 5表示氢原子或-CH 2 -Y-（CH 2）n -COOR 6基团，其中Y表示-CH 2 CH 2 - 基或-CH = CH-基，R 6表示氢原子或具有1至4个碳原子的烷基，n为 0〜6的整数，R7表示碳原子数为1〜4的烷基或芳基，m为0或1，可用作前列腺素类似物的前体; 及其制备方法。

30. 发明授权

US4144248A Aromatic acetic acid derivatives having sulfur atom at alpha-position and process for their preparation 失效
标题翻译：在α-位具有硫原子的芳族乙酸衍生物及其制备方法
公开(公告)号：US4144248A
公开(公告)日：1979-03-13
申请号：US773114
申请日：1977-02-28
申请人： Genichi Tsuchihashi , Katsuyuki Ogura
发明人： Genichi Tsuchihashi , Katsuyuki Ogura
IPC分类号： C07C51/377 , C07C315/02 , C07C319/14 , C07C323/07 , C07C323/56 , C07C323/65 , C07C327/10 , C07D209/48 , C07D295/096 , C07D295/155 , C07D307/38 , C07D307/54 , C07D333/22 , C07D333/24 , C07D501/34 , A01N9/00 , C07D307/12 , C07D307/16
CPC分类号： C07D209/48 , C07C315/02 , C07C319/14 , C07C323/07 , C07C323/56 , C07C323/65 , C07C327/10 , C07C51/377 , C07D295/096 , C07D295/155 , C07D307/38 , C07D307/54 , C07D333/22 , C07D333/24
摘要： Aromatic acetic acid derivatives having a sulfur atom at the alpha-position, and a process for their preparation. Useful drugs can be produced from these derivatives.
摘要翻译：在α-位具有硫原子的芳族乙酸衍生物及其制备方法。有用的药物可以从这些衍生物生产。

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