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21. 发明申请

US20150129034A1 OPTOELECTRONIC DEVICE COMPRISING PEROVSKITES 审中-公开
标题翻译：包含PEROVSKITES的光电器件
公开(公告)号：US20150129034A1
公开(公告)日：2015-05-14
申请号：US14401452
申请日：2013-05-20
申请人： ISIS INNOVATION LIMITED
发明人： Henry Snaith , Michael Lee
IPC分类号： H01L31/0264 , H01G9/20 , H01L51/42
CPC分类号： H01L31/0264 , H01G9/2004 , H01G9/2036 , H01L51/0032 , H01L51/4213 , H01L51/422 , H01L51/4226 , H01L2031/0344 , H01L2251/306 , Y02E10/549 , Y02P70/521
摘要： The invention provides an optoelectronic device comprising a porous material, which porous material comprises a semiconductor comprising a perovskite. The porous material may comprise a porous perovskite. Thus, the porous material may be a perovskite material which is itself porous. Additionally or alternatively, the porous material may comprise a porous dielectric scaffold material, such as alumina, and a coating disposed on a surface thereof, which coating comprises the semiconductor comprising the perovskite. Thus, in some embodiments the porosity arises from the dielectric scaffold rather than from the perovskite itself. The porous material is usually infiltrated by a charge transporting material such as a hole conductor, a liquid electrolyte, or an electron conductor. The invention further provides the use of the porous material as a semiconductor in an optoelectronic device. Further provided is the use of the porous material as a photosensitizing, semiconducting material in an optoelectronic device. The invention additionally provides the use of a layer comprising the porous material as a photoactive layer in an optoelectronic device. Further provided is a photoactive layer for an optoelectronic device, which photoactive layer comprises the porous material.
摘要翻译：本发明提供一种包括多孔材料的光电子器件，该多孔材料包括包含钙钛矿的半导体。多孔材料可以包括多孔钙钛矿。因此，多孔材料可以是本身是多孔的钙钛矿材料。另外或替代地，多孔材料可以包括多孔介电支架材料，例如氧化铝，以及设置在其表面上的涂层，该涂层包括包含钙钛矿的半导体。因此，在一些实施方案中，孔隙率来自电介质支架而不是钙钛矿本身。多孔材料通常由诸如空穴导体，液体电解质或电子导体的电荷输送材料渗透。本发明还提供了多孔材料在光电器件中作为半导体的用途。进一步提供的是使用多孔材料作为光电子器件中的光敏半导体材料。本发明另外提供了包含多孔材料的层作为光电器件中的光活性层的用途。还提供了一种用于光电子器件的光敏层，该光敏层包括多孔材料。

22. 发明申请

US20150103343A1 TUNABLE OPTICAL FILTER 审中-公开
标题翻译：可控光滤波器
公开(公告)号：US20150103343A1
公开(公告)日：2015-04-16
申请号：US14398755
申请日：2013-05-03
申请人： ISIS INNOVATION LIMITED
发明人： Jason Michael Smith , Claire Vallance
IPC分类号： G01J3/12 , G01N21/25 , G01J3/02 , G02B26/00 , G02B5/20
CPC分类号： G01J3/12 , G01J3/0205 , G01J3/26 , G01J3/32 , G01J2003/1213 , G01N21/25 , G01N2201/061 , G01N2201/068 , G02B5/10 , G02B5/201 , G02B26/001
摘要： An apparatus for performing spectroscopy incorporates, between an EM source and a detector, an optical filter comprising a pair of mirrors opposed along the optical axis and shaped to provide an optical cavity with stable resonance and having a cavity length of at most 50 μm and a mode at a wavelength within said band of wavelengths for bandpass filtering EM radiation passing therethrough. The actuator system is arranged to move the mirrors relative to each other along the length of the optical cavity for tuning the wavelength of said mode.
摘要翻译：用于执行光谱的装置包括在EM源和检测器之间的光学滤波器，该滤光器包括沿着光轴相对的一对反射镜并成形为提供具有至多50μm的空腔长度的光学腔，并且具有至多50μm的空腔长度在波长范围内的波长的波长模式，用于带通滤波EM辐射通过。致动器系统被布置成沿着光腔的长度相对于彼此移动镜子，以调谐所述模式的波长。

23. 发明授权

US08980781B2 Catalysts 有权
标题翻译：催化剂
公开(公告)号：US08980781B2
公开(公告)日：2015-03-17
申请号：US13503906
申请日：2010-10-25
申请人： Dermot O'Hare , Paul Ransom , Andrew Ashley
发明人： Dermot O'Hare , Paul Ransom , Andrew Ashley
IPC分类号： C07F17/00 , C08F4/642 , C08F4/6592 , C08F10/02 , C08F110/02 , B01J31/22 , C08F10/00 , C08F4/659
CPC分类号： C08F110/02 , B01J31/2295 , B01J2231/12 , B01J2531/0263 , B01J2531/46 , B01J2531/48 , B01J2531/49 , C07F17/00 , C08F4/65912 , C08F10/00 , Y10S526/943 , C08F2500/03 , C08F4/65927
摘要： The present invention relates to novel metallocene catalysts of formula I, which is defined herein. The present invention also provides processes for making these catalysts and their use in olefin polymerisation reactions.
摘要翻译：本发明涉及式I定义的新型金属茂催化剂，其定义如下。本发明还提供了制备这些催化剂的方法及其在烯烃聚合反应中的应用。

24. 发明申请

US20140179543A1 IDENTIFICATION OF SMALL-MOLECULE CANDIDATE THERAPEUTICS CAPABLE OF INHIBITING OR INTERFERING WITH A TARGET PROTEIN-PROTEIN INTERACTION 审中-公开
标题翻译：鉴定能够抑制或干扰目标蛋白 - 蛋白质相互作用的小分子候选治疗药物
公开(公告)号：US20140179543A1
公开(公告)日：2014-06-26
申请号：US14002532
申请日：2012-02-29
申请人： Terence Rabbitts , Tomoyuki Tanaka
发明人： Terence Rabbitts , Tomoyuki Tanaka
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/6803 , G01N2500/04
摘要： The present invention provides a method of screening method small-molecule candidate therapeutics capable of inhibiting or interfering with intracellular protein-protein interactions, such as cancer associated oncogenic protein interactions and in particular RAS and LMO2 protein-protein interactions. The present invention also provides methods and assays for rationalized drug design based on identifying small molecular weight protein-protein interaction inhibitor molecules that emulate antibody therapeutics products.
摘要翻译：本发明提供了一种能够抑制或干扰细胞内蛋白质 - 蛋白质相互作用（例如癌症相关致癌蛋白相互作用，特别是RAS和LMO2蛋白质 - 蛋白质相互作用）的小分子候选治疗剂筛选方法。本发明还提供了基于鉴定模拟抗体治疗产物的小分子量蛋白质 - 蛋白质相互作用抑制剂分子的合理化药物设计的方法和测定。

25. 发明申请

US20140127258A1 Viral Vector Immunogenic Compositions 审中-公开
标题翻译：病毒载体免疫原性组成
公开(公告)号：US20140127258A1
公开(公告)日：2014-05-08
申请号：US13877002
申请日：2011-09-30
申请人： Simone de Cassan , Alexander Douglas , Simon Draper , Emily Forbes , Anna Goodman , Adrian Hill , Antia Millicic , Arturo Reyes-Sandoval
发明人： Simone de Cassan , Alexander Douglas , Simon Draper , Emily Forbes , Anna Goodman , Adrian Hill , Antia Millicic , Arturo Reyes-Sandoval
IPC分类号： C12N15/86 , A61K39/015
CPC分类号： C12N15/86 , A61K39/00 , A61K39/015 , A61K39/39 , A61K2039/5256 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/55577 , C12N2710/10343 , C12N2710/24143 , C12N2999/002 , Y02A50/412
摘要： There is provided a composition comprising: (a) a modified vaccinia virus ankara (MVA) vector, wherein said MVA vector comprises a nucleic acid sequence encoding an antigen; and (b) an adjuvant comprising a saponin, or an emulsion. There is also provided a composition comprising: (a) an adenovirus vector, wherein said adenovirus vector comprises a nucleic acid sequence encoding an antigen, and wherein the adenovirus is selected from: a group B adenovirus, a group C adenovirus, and a group E adenovirus; and (b) an adjuvant comprising a saponin, or an emulsion; wherein the group B adenovirus is not an adenovirus 35, the group C adenovirus is not Ad5 having an intact E3 gene region, and the group E adenovirus is not an adenovirus C7. Also provided are corresponding uses of the compositions in medicine.
摘要翻译：提供组合物，其包含：（a）修饰的痘苗病毒安卡拉（MVA）载体，其中所述MVA载体包含编码抗原的核酸序列; 和（b）包含皂角苷或乳剂的佐剂。还提供了一种组合物，其包含：（a）腺病毒载体，其中所述腺病毒载体包含编码抗原的核酸序列，其中所述腺病毒选自：B组腺病毒，C组腺病毒和E组腺病毒和（b）包含皂角苷或乳剂的佐剂; 其中B组腺病毒不是腺病毒35，C组腺病毒不是具有完整E3基因区的Ad5，E组腺病毒不是腺病毒C7。还提供了药物中组合物的相应用途。

26. 发明授权

US08716456B2 Pentalenes 有权
公开(公告)号：US08716456B2
公开(公告)日：2014-05-06
申请号：US12530451
申请日：2008-03-10
申请人： Dermot Michael O'Hare , Andrew Edward Ashley
发明人： Dermot Michael O'Hare , Andrew Edward Ashley
IPC分类号： C07F5/00 , C07F7/00 , C07F13/00 , C07F15/00 , C07C35/00 , C07C13/615
CPC分类号： C07C13/44 , B01J31/2295 , B01J2231/46 , B01J2531/11 , B01J2531/38 , B01J2531/46 , B01J2531/48 , B01J2531/72 , B01J2531/74 , B01J2531/822 , B01J2531/845 , C07C29/143 , C07C45/62 , C07C45/65 , C07C45/676 , C07C49/443 , C07C49/633 , C07C2602/22 , C07F17/02 , C08F4/6192 , C08F4/61927 , C08F4/65925 , C08F10/00 , C08F2410/03 , C08F4/80 , C08F4/76 , C08F4/70 , C08F4/619 , C08F4/54 , C07C35/31
摘要： The present invention relates to per-substituted pentalene compounds, including permethylpentalene and precursors thereof. In particular, the invention provides substituted pentalene compounds and methods of preparing substituted pentalene compounds; complexes of metals with substituted pentalene compounds and methods for their production; and the use of complexes of metals with substituted pentalene compounds in catalysis.
摘要翻译：本发明涉及全取代的柔性烯化合物，包括二甲基蒎烯及其前体。特别地，本发明提供取代的柔性烯化合物和制备取代的柔性烯化合物的方法; 金属与取代的柔性烯化合物的复合物及其制备方法; 以及金属与取代的柔性烯化合物在催化中的配合物的使用。

27. 发明授权

US08706437B2 Calibration of particle detectors 有权
标题翻译：颗粒检测器的校准
公开(公告)号：US08706437B2
公开(公告)日：2014-04-22
申请号：US13123497
申请日：2009-10-12
申请人： Ian Alexander Walmsley , Brian John Smith , Jeffrey Stephen Lundeen , Peter James Mosley , Graciana Puentes , Hendrik Bernd Coldenstrodt-Ronge , Nicholas Lloyd Thomas-Peter , Andrew Philip Worsley
发明人： Ian Alexander Walmsley , Brian John Smith , Jeffrey Stephen Lundeen , Peter James Mosley , Graciana Puentes , Hendrik Bernd Coldenstrodt-Ronge , Nicholas Lloyd Thomas-Peter , Andrew Philip Worsley
IPC分类号： G06F19/00
CPC分类号： G01J11/00
摘要： A method of calibrating an optical detector arrangement (38,42) comprises simultaneously generating a plurality of entangled photon pairs, such that one photon from each pair traverses a first path (36-38-42) and the other photon from each pair traverses a second path (36-40-44). The number of photons received along the first path is calculated using the detector arrangement (38,42), while the number of simultaneously-generated photons received along the second path is calculated using a second detector arrangement (40,44). These photon numbers are used to calculated an estimate of the detection efficiency (50) of the first detector arrangement (38,42).
摘要翻译：校准光学检测器装置（38,42）的方法包括同时产生多个纠缠的光子对，使得每一对的一个光子穿过第一路径（36-38-42），并且来自每一对的另一个光子穿过一个第二路（36-40-44）。使用检测器装置（38,42）计算沿着第一路径接收的光子的数量，而使用第二检测器装置（40,44）计算沿着第二路径接收的同时生成的光子的数量。这些光子数用于计算第一检测器装置（38,42）的检测效率（50）的估计。

28. 发明授权

US08691586B2 Formation of bilayers of amphipathic molecules 有权
标题翻译：形成双相分子双分子
公开(公告)号：US08691586B2
公开(公告)日：2014-04-08
申请号：US13607337
申请日：2012-09-07
申请人： John Hagen Pryce Bayley , Matthew Holden , Andrew John Heron , David Needham
发明人： John Hagen Pryce Bayley , Matthew Holden , Andrew John Heron , David Needham
IPC分类号： G01N33/68
CPC分类号： G01N33/6872 , G01N33/5432 , G01N2333/31 , Y10T436/12
摘要： A method of forming bilayers of amphipathic molecules uses droplets of aqueous solution in a hydrophobic medium such as oil. A layer of amphipathic molecules such as a lipid is formed around the surfaces of the droplets. This may be achieved by providing the lipid in the oil and leaving the droplets for a time sufficient to form the layer. The droplets are brought into contact with one another so that a bilayer of the amphipathic molecules is formed as an interface between the contacting droplets. The bilayers may be used for a wide range of studies. The technique has numerous advantages including providing a long lifetime for the bilayers, allowing study of small volumes and allowing the construction of chains and networks of droplets with bilayers in between to study complex systems.
摘要翻译：形成两亲分子双层的方法使用疏水介质如油中的水溶液滴。在液滴的表面周围形成一层两亲性分子，例如脂质。这可以通过在油中提供脂质并将液滴留下足以形成该层的时间来实现。使液滴彼此接触，使得两亲分子的双层形成为接触液滴之间的界面。双层可用于广泛的研究。该技术具有许多优点，包括为双层提供长寿命，允许研究小体积，并允许在双层之间建立链条和液滴网络以研究复杂系统。

29. 发明申请

US20140087399A1 ASSAY METHOD FOR PEPTIDE SPECIFIC T-CELLS 有权
标题翻译：肽特异性T细胞的测定方法
公开(公告)号：US20140087399A1
公开(公告)日：2014-03-27
申请号：US14090221
申请日：2013-11-26
申请人： ISIS INNOVATION LIMITED
发明人： AJIT LALVANI , ROGER HAMILTON BROOKES
IPC分类号： G01N33/569
CPC分类号： G01N33/56972 , A61K39/00 , C07K14/35 , G01N33/543 , G01N33/56905 , G01N33/56983 , G01N33/56988 , G01N33/56994 , G01N33/6863 , G01N33/6866 , G01N33/6878 , Y02A50/412
摘要： A method of assaying for peptide-specific T-cells comprises adding peptide to a fluid sample of fresh peripheral blood mononuclear cells, and detecting a cytokine such as interferon-y produced by T-cells that have been pre-sensitised to the peptide. The assay method is quick and cheap and is expected to be useful for the study of various disease states including Hepatitis B, Hepatitis C, tuberculosis, malaria, HIV and influenza.
摘要翻译：测定肽特异性T细胞的方法包括向新鲜外周血单核细胞的流体样品中加入肽，并检测已经对肽预致敏的T细胞产生的细胞因子如干扰素-γ。测定方法快速便宜，预计可用于研究各种疾病状态，包括乙型肝炎，丙型肝炎，结核病，疟疾，艾滋病毒和流行性感冒。

30. 发明授权

US08617821B2 Assay method for peptide specific T-cells 有权
公开(公告)号：US08617821B2
公开(公告)日：2013-12-31
申请号：US12510594
申请日：2009-07-28
申请人： Ajit Lalvani , Roger Hamilton Brookes
发明人： Ajit Lalvani , Roger Hamilton Brookes
IPC分类号： G01N33/532 , A61K39/04
CPC分类号： G01N33/56972 , A61K39/00 , C07K14/35 , G01N33/543 , G01N33/56905 , G01N33/56983 , G01N33/56988 , G01N33/56994 , G01N33/6863 , G01N33/6866 , G01N33/6878 , Y02A50/412
摘要： A method of assaying for peptide-specific T-cells comprises adding peptide to a fluid sample of fresh peripheral blood mononuclear cells, and detecting a cytokine such as interferon-γ produced by T-cells that have been pre-sensitized to the peptide. The assay method is quick and cheap and is expected to be useful for the study of various disease states including Hepatitis B, Hepatitis C, tuberculosis, malaria, HIV and influenza.

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