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21. 发明申请

US20060074108A1 Matrix metalloprotease (MMP) inhibitors and their application in cosmetic and pharmaceutical composition 审中-公开
标题翻译：基质金属蛋白酶（MMP）抑制剂及其在化妆品和药物组合物中的应用
公开(公告)号：US20060074108A1
公开(公告)日：2006-04-06
申请号：US10711775
申请日：2004-10-04
申请人： Shyam Gupta
发明人： Shyam Gupta
IPC分类号： A61K31/444 , A61K31/4184 , A61K31/4172 , A61K31/401 , A61K31/15 , A61K31/12
CPC分类号： A61K31/12 , A61K31/15 , A61K31/401 , A61K31/4172 , A61K31/4184 , A61K31/444
摘要： This invention relates to compounds that are selective inhibitors of Matrix Metalloprotease (also known as Matrix Metalloproteinase, MMP), to cosmetic and pharmaceutical compositions containing them, and to their use in the prevention and/or treatment of ailments associated with MMP, including inflammation, wound healing, skin aging, skin tone discoloration, body odor, oral cavity odor, rosacea, acne, and hair growth modulation.
摘要翻译：本发明涉及基质金属蛋白酶（也称为基质金属蛋白酶，MMP）的选择性抑制剂，含有它们的化妆品和药物组合物以及用于预防和/或治疗与MMP相关的疾病，包括炎症，伤口愈合，皮肤老化，肤色变色，身体异味，口腔气味，红斑痤疮，痤疮和头发生长调节。

22. 发明授权

US07993630B2 Protection of skin from UV and peroxide 失效
标题翻译：防紫外线和过氧化物保护皮肤
公开(公告)号：US07993630B2
公开(公告)日：2011-08-09
申请号：US12497662
申请日：2009-07-04
申请人： Shyam K Gupta
发明人： Shyam K Gupta
IPC分类号： A61K8/18 , A61K8/02 , A61K33/00 , A61K33/40 , A61K33/24 , A61K33/34 , A61K33/32 , A61K33/26 , A61K33/04 , A61Q17/04 , A01N59/00 , A01N39/00 , A01N59/16 , A01N59/20 , A01N59/02
CPC分类号： A61K8/19 , A61K8/4946 , A61K2800/58 , A61Q17/04 , A61Q19/004 , A61Q19/08
摘要： The present invention discloses certain heterocyclic complexes of metals of formula (I), especially those of manganese, which enhance the safety and efficacy of sunscreens via urocanate pathway modulation. The present invention also discloses a method for topical application of said complexes, which causes the reduction of topical peroxide including hydrogen peroxide, the reduction of topical inflammation including sunburn, increased sun protection of skin, comprehensive protection from UVA, UVB, and UVC, reduction of radiation-initiated inflammation, the reduction of skin wrinkles, acne, and overall treatment of skin damaged from natural aging and exposure to sun:
摘要翻译：本发明公开了一些式（I）金属的杂环络合物，特别是锰的杂环络合物，其通过尿素途径调节增强了防晒剂的安全性和有效性。本发明还公开了一种用于局部施用所述复合物的方法，其导致包括过氧化氢在内的局部过氧化物的还原，包括晒伤的局部炎症的减少，皮肤的增加的防晒，对UVA，UVB和UVC的综合保护，还原辐射引发的炎症，减少皮肤皱纹，痤疮，以及从自然老化和暴露于阳光下损坏的皮肤的整体治疗：

23. 发明授权

US07834210B2 Hair loss prevention by natural amino acid and peptide complexes 有权
标题翻译：由天然氨基酸和肽复合物脱发预防
公开(公告)号：US07834210B2
公开(公告)日：2010-11-16
申请号：US12485302
申请日：2009-06-16
申请人： Shyam K Gupta
发明人： Shyam K Gupta
IPC分类号： C07C229/36 , C07C229/34
CPC分类号： A61K8/27 , A61K8/347 , A61K8/35 , A61K8/355 , A61K8/498 , A61K8/55 , A61K8/602 , A61K2800/58 , A61Q5/006 , A61Q7/00 , A61Q19/02
摘要： This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related skin, hair and scalp problems, for example, hair aging including premature hair loss and hair graying; male pattern baldness; hair loss from dandruff; alopecia; split ends, acne, darkened skin, dark circles around eyes, stretch marks, wrinkles and fine lines, loss of collagen, loss of skin pliability and combinations thereof:
摘要翻译：本发明涉及衍生自天然氨基酸和肽的某些式（I）的皮肤和护发剂。这些药物提供酶相关皮肤，毛发和头皮问题的多功能治疗，例如包括过早脱发和头发变灰的头发老化; 男性型秃发; 头皮屑脱发; 脱发分娩，痤疮，黑皮肤，眼睛周围的黑眼圈，妊娠纹，皱纹和细纹，胶原损失，皮肤柔韧性丧失及其组合：

24. 发明申请

US20090253668A1 Hair Loss Prevention by Natural Amino Acid and Peptide Complexes 有权
标题翻译：天然氨基酸和肽配合物脱发预防
公开(公告)号：US20090253668A1
公开(公告)日：2009-10-08
申请号：US12485302
申请日：2009-06-16
申请人： SHYAM K GUPTA
发明人： SHYAM K GUPTA
IPC分类号： A61K31/555 , A61P17/00
CPC分类号： A61K8/27 , A61K8/347 , A61K8/35 , A61K8/355 , A61K8/498 , A61K8/55 , A61K8/602 , A61K2800/58 , A61Q5/006 , A61Q7/00 , A61Q19/02
摘要： This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related skin, hair and scalp problems, for example, hair aging including premature hair loss and hair graying; male pattern baldness; hair loss from dandruff; alopecia; split ends, acne, darkened skin, dark circles around eyes, stretch marks, wrinkles and fine lines, loss of collagen, loss of skin pliability and combinations thereof:
摘要翻译：本发明涉及衍生自天然氨基酸和肽的某些式（I）的皮肤和护发剂。这些药物提供酶相关皮肤，毛发和头皮问题的多功能治疗，例如包括过早脱发和头发变灰的头发老化; 男性型秃发; 头皮屑脱发; 脱发分娩，痤疮，黑皮肤，眼睛周围的黑眼圈，妊娠纹，皱纹和细纹，胶原损失，皮肤柔韧性丧失及其组合：

25. 发明申请

US20090130154A1 Topical Delivery of Biological and Cosmetic Agents by Zeolites 审中-公开
标题翻译：通过沸石局部递送生物和化妆品
公开(公告)号：US20090130154A1
公开(公告)日：2009-05-21
申请号：US12361615
申请日：2009-01-29
申请人： Shyam K. Gupta
发明人： Shyam K. Gupta
IPC分类号： A61K8/02 , A61Q19/02 , A61Q19/08 , A61Q19/00 , A61Q5/00 , A61Q15/00
CPC分类号： A61K8/19 , A61K8/0212 , A61K8/26 , A61K31/7135 , A61K31/715 , A61K38/063 , A61K45/06 , A61K48/00 , A61K2800/242 , A61Q5/02 , A61Q5/065 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q19/02 , A61Q19/08 , A61K2300/00
摘要： The present invention discloses certain di- and polyvalent metal zeolite compounds (formula I) for topical delivery of biological and skin and hair care agents. The method of treating skin and hair condition via topical application of said zeolite compounds is also disclosed. The said method provides a treatment for topical condition, which includes alleviation of skin conditions such as skin rash including diaper rash, dry skin, scalp dandruff, broken or chafed skin, sunburn, skin damage from UV, skin irritation, acne including excess facial oil and facial pore size; darkened skin including age spots, dark circles around the eyes, and discoloration of skin from stretch marks; skin aging including wrinkles and fine lines; loss of collagen including thinning skin and loss of skin pliability; body odor, including oral cavity odor, arm-pit odor, and incontinence odor; cellular inflammation including intracellular and extra cellular inflammation; premature hair aging including premature hair loss hair graying; malfunction of tyrosinase group of enzymes, malfunction of matrix metalloprotease group of enzymes; and combinations thereof. The said method also provides topical delivery of certain metals, including trace metals, and certain zirconium aluminum amino acids that provide antiperspirant benefits;
摘要翻译：本发明公开了用于局部递送生物和皮肤和护发剂的某些二价和多价金属沸石化合物（式I）。还公开了通过局部施用所述沸石化合物治疗皮肤和毛发状况的方法。所述方法提供了局部病症的治疗，其包括减轻皮肤病症如皮疹，例如皮疹，包括尿布疹，干性皮肤，头皮头皮屑，破裂或擦伤的皮肤，晒伤，紫外线皮肤损伤，皮肤刺激，痤疮，包括过量面部油和面孔孔径; 皮肤变黑，包括老年斑，眼睛周围的黑眼圈，以及妊娠纹皮肤变色; 皮肤老化包括皱纹和细纹; 胶原蛋白损失包括皮肤变薄和皮肤柔韧性丧失; 身体异味，包括口腔气味，手臂坑气味和失禁气味; 细胞炎症包括细胞内和细胞外炎症; 头发老化过早，包括头发脱发过早脱发; 酪氨酸酶组酶失活，酶基质金属蛋白酶组失常; 及其组合。所述方法还提供某些金属（包括痕量金属）和提供止汗益处的某些锆铝氨基酸的局部递送;

26. 发明申请

US20080287536A1 Skin and Hair Restoration by Natural Amino Acid and Peptide Crown Complexes 失效
标题翻译：天然氨基酸和肽冠复合物的皮肤和头发恢复
公开(公告)号：US20080287536A1
公开(公告)日：2008-11-20
申请号：US12182864
申请日：2008-07-30
申请人： SHYAM K. GUPTA
发明人： SHYAM K. GUPTA
IPC分类号： A61K31/315 , C07C57/30 , A61K31/198 , C07C279/04 , A61K31/295 , A61P17/00 , A61K31/28 , C07F15/00 , A61K31/30
CPC分类号： A61K8/347 , A61K8/19 , A61K8/27 , A61K8/35 , A61K8/355 , A61K8/447 , A61K8/498 , A61K8/55 , A61K8/602 , A61K2800/31 , A61K2800/58 , A61Q19/02 , A61Q19/08
摘要： This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related topical problems, for example, darkened skin including age spots, circles around eyes and stretch marks; skin conditions related to acne including excess facial oil and facial pore size; premature hair aging including hair loss and graying; inflammation including intra-cellular and extra-cellular inflammation; skin aging including wrinkles and fine lines; loss of collagen including thinning skin and loss of skin pliability; malfunction of tyrosinase group of enzymes; malfunction of matrix metalloprotease group of enzymes; and combinations thereof: Wherein, R, R′, and R″=any substituent(s); and M=H, Li, Na, K, Ca, Mg, Zn, Mn, Cu, Fe, Co, Mo, V, Cr, Ammonium, Alkyl ammonium, and Nitrogen Heterocyclic ammonium.
摘要翻译：本发明涉及衍生自天然氨基酸和肽的某些式（I）的皮肤和护发剂。这些试剂提供了酶相关局部问题的多功能治疗，例如包括老年斑，眼睛周围的圈和妊娠纹的变黑的皮肤; 与痤疮有关的皮肤状况，包括多余的面部油脂和面孔孔径; 头发老化包括脱发和变灰; 炎症包括细胞内和细胞外炎症; 皮肤老化包括皱纹和细纹; 胶原蛋白损失包括皮肤变薄和皮肤柔韧性丧失; 酪氨酸酶组失效酶; 基质金属蛋白酶组酶失效; 及其组合：其中，R，R'和R“=任何取代基; 和M = H，Li，Na，K，Ca，Mg，Zn，Mn，Cu，Fe，Co，Mo，V，Cr，铵，烷基铵和氮杂环铵。

27. 发明申请

US20080287533A1 Ascorbic Acid - Natural Sugar Lactone Esters for Comprehensive Skin & Scalp Care 有权
标题翻译：抗坏血酸 - 天然糖内酯类综合皮肤和头皮护理
公开(公告)号：US20080287533A1
公开(公告)日：2008-11-20
申请号：US12184340
申请日：2008-08-01
申请人： SHYAM K. GUPTA
发明人： SHYAM K. GUPTA
IPC分类号： A61K31/375 , C07D307/62
CPC分类号： A61K8/0208 , A61K8/345 , A61K8/365 , A61K8/4973 , A61K8/498 , A61K8/60 , A61K31/375 , A61K2800/28 , A61K2800/57 , A61Q5/006 , A61Q9/04 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： This invention relates to esters of ascorbic acid with natural sugar lactones [formula (I)], which are useful for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof;
摘要翻译：本发明涉及抗坏血酸与天然糖内酯（式（I）]的酯，其可用于治疗皮肤病症，包括老年斑，痤疮，细胞抗氧化剂的丧失，胶原损失，皮肤柔韧性丧失，皮肤柔软度，皮肤皱纹，包括细纹，氧化，辐射损伤，基质金属蛋白酶的故障，酪氨酸酶的故障，自由基的损伤，紫外线，皮肤干燥，干癣病，鱼鳞病，头皮屑，褐斑，角化病，黑斑病，斑点斑，肝斑，色素斑点，眼睛下方的黑眼圈，皮肤色素沉着，包括皮肤变黑，瑕疵，油性皮肤，疣，湿疹，瘙痒皮肤，牛皮癣，炎性皮肤病，局部炎症，受干扰的角质化，与衰老相关的皮肤变化，指甲或需要清洁剂，调理或治疗的皮肤，以及需要洗发或调理的头发或头皮及其组合;

28. 发明申请

US20080139507A1 Method of Treating Skin Condition Including Acne, Skin Aging, Body Odor & Diaper Rash by Zinc Zeolite Clathrates 审中-公开
标题翻译：治疗包括痤疮，皮肤老化，身体气味和尿布疹在内的锌沸石包合物皮肤病症的方法
公开(公告)号：US20080139507A1
公开(公告)日：2008-06-12
申请号：US12032751
申请日：2008-02-18
申请人： SHYAM K. GUPTA
发明人： SHYAM K. GUPTA
IPC分类号： A61K31/695
CPC分类号： A61K33/30 , A61K8/26 , A61K2800/56 , A61K2800/58 , A61K2800/75 , A61Q5/006 , A61Q15/00 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： The present invention discloses a method of treating skin conditions that include acne, skin wrinkles, age spots, pimples, scars, skin rash including diaper rash, dry skin, scalp dandruff, scalp dry skin, darkened skin, skin discoloration, broken skin, chafed skin, sunburn, skin damage from UV, skin irritation, body odor, or a combination thereof, via topical application of certain clathrates of zinc zeolite with non-antibiotic organic agents.
摘要翻译：本发明公开了一种治疗皮肤病症的方法，包括痤疮，皮肤皱纹，老年斑，丘疹，疤痕，皮疹，包括尿布疹，皮肤干燥，头皮头皮屑，头皮干燥皮肤，变黑的皮肤，皮肤变色，破裂的皮肤，擦伤皮肤，晒伤，UV的皮肤损伤，皮肤刺激，身体气味或其组合，通过局部施用锌沸石与非抗生素有机试剂的某些包合物。

29. 发明申请

US20070269537A1 Skin Condition Improvement Including Acne, Rosacea, and Topical Wounds by Artemisia Annua Extract via Iron Siderophore Trojan Horse Delivery System 审中-公开
标题翻译：皮肤状况改善包括艾蒿提取物中的痤疮，红斑痤疮和局部伤口通过铁铁载体特洛伊木马传递系统
公开(公告)号：US20070269537A1
公开(公告)日：2007-11-22
申请号：US11615561
申请日：2007-01-01
申请人： Shyam Gupta
发明人： Shyam Gupta
IPC分类号： A61K31/335 , A61K36/282 , A61P17/10
CPC分类号： A61K8/0212 , A61K8/35 , A61K8/63 , A61K8/64 , A61K8/673 , A61K8/675 , A61K8/676 , A61K8/736 , A61K8/97 , A61K31/205 , A61K31/60 , A61K31/7008 , A61K31/728 , A61K2800/28 , A61K2800/522 , A61K2800/75 , A61Q19/00 , A61K2300/00
摘要： This invention relates to certain extracts of Artemisia annua plant, both in their crude and refined forms, and certain refined forms of Artemisia annua plant extracts composed substantially of Artemisinin and its analogs, which are chemically classified as sesquiterpenes with an endo-peroxide group [FIG. 1]. These are suitable for compositions comprising topical application, and for the treatment or improvement of skin condition including acne, rosacea, topical wounds, age spots, wrinkles, excess facial oil, and darkened skin.
摘要翻译：本发明涉及青蒿植物的粗制和精制形式的某些提取物，以及基本上由青蒿素及其类似物组成的某些精制形式的青蒿植物提取物，其被化学分类为具有内切过氧化物基团的倍半萜[图。 1]。这些适用于包含局部应用的组合物，以及用于治疗或改善包括痤疮，红斑痤疮，局部创伤，老年斑，皱纹，多余面部油和变黑皮肤的皮肤病症的组合物。

30. 发明申请

US20070189992A1 Sunscreen Safety and Efficacy Enhancement with Manganese Complexes via Urocanate Pathway 失效
标题翻译：通过乌氨酸途径与锰配合物的防晒安全和功效增强
公开(公告)号：US20070189992A1
公开(公告)日：2007-08-16
申请号：US11676284
申请日：2007-02-17
申请人： Shyam Gupta
发明人： Shyam Gupta
IPC分类号： A61K8/49
CPC分类号： A61Q17/04 , A61K8/19 , A61K8/4946 , A61K2800/58 , A61Q19/004 , A61Q19/08
摘要： The present invention discloses safety and efficacy enhancement of sunscreens with certain heterocyclic base complexes of manganese via urocanate pathway modulation. The present invention also discloses a method for topical application of said complexes, which causes the reduction of topical peroxide including hydrogen peroxide, the reduction of topical inflammation including sunburn, increased sun protection of skin, the reduction of skin wrinkles, comprehensive protection from UVA, UVB, and UVC, and reduction of radiation-initiated inflammation.
摘要翻译：本发明公开了通过尿素途径调节的某些含锰杂环碱配合物的防晒剂的安全性和功效增强。本发明还公开了一种用于局部施用所述复合物的方法，其导致局部过氧化物包括过氧化氢的还原，包括晒伤的局部炎症的减少，皮肤的防晒增加，皮肤皱纹减少，UVA综合防护， UVB和UVC，以及减少辐射引发的炎症。

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