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21. 发明授权

US07142354B2 Wavelength conversion method, wavelength conversion device, and laser beam machine 有权
标题翻译：波长转换方法，波长转换装置和激光束机
公开(公告)号：US07142354B2
公开(公告)日：2006-11-28
申请号：US10511170
申请日：2001-12-12
申请人： Tetsuo Kojima , Susumu Konno , Shuichi Fujikawa , Koji Yasui , Takatomo Sasaki , Yusuke Mori , Masashi Yoshimura
发明人： Tetsuo Kojima , Susumu Konno , Shuichi Fujikawa , Koji Yasui , Takatomo Sasaki , Yusuke Mori , Masashi Yoshimura
IPC分类号： G02F1/35 , H01S3/108
CPC分类号： G02F1/3501 , G02F2001/3505
摘要： In a wavelength converting method, an ambient that is in contact with a surface of a non-linear optical crystal from which wavelength-converted light is outputted is a gas that is lower in content of nitrogen than air. A wavelength converting device includes a device for controlling the ambient in contact with a surface of the non-linear optical crystal from which the wavelength-converted light is outputted so the ambient is lower in nitrogen than air. A laser machining device includes the wavelength converting device.
摘要翻译：在波长转换方法中，与输出波长转换光的非线性光学晶体的表面接触的环境是氮含量低于空气的气体。波长转换装置包括用于控制与非线性光学晶体的表面接触的环境的装置，从该波长转换光输出波长转换的光，使得氮气中的环境比空气低。激光加工装置包括波长转换装置。

22. 发明申请

US20060159673A1 Methods of screening light chain of antibody 有权
标题翻译：筛选抗体轻链的方法
公开(公告)号：US20060159673A1
公开(公告)日：2006-07-20
申请号：US10542839
申请日：2004-01-21
申请人： Tetsuo Kojima
发明人： Tetsuo Kojima
IPC分类号： C40B40/10 , A61K39/395 , C12N15/74 , C12N1/21
CPC分类号： C07K16/005 , C07K2317/31 , C07K2317/55
摘要： The present invention relates to methods of screening for commonly shared light chains, in which the method comprises the steps of (a) generating a host secreting the heavy chain of an antibody that binds to a desired antigen; (b) introducing an antibody light chain library into the host of step (a) to generate libraries presenting antibodies composed of the heavy chain and the light chains; (c) selecting a library presenting antibodies that bind specifically to the desired antigen of step (a); (d) introducing the library selected in step (c) into a host secreting the heavy chain of an antibody that binds to a desired antigen different from the antigen of step (a) to generate libraries that display antibodies composed of the heavy chains and light chains; and (e) selecting a library that displays antibodies that bind specifically to the desired antigen of step (d).
摘要翻译：本发明涉及筛选普遍共享的轻链的方法，其中该方法包括以下步骤：（a）产生分泌结合所需抗原的抗体重链的宿主; （b）将抗体轻链文库导入步骤（a）的宿主，以产生呈现由重链和轻链组成的抗体的文库; （c）选择呈递与步骤（a）的所需抗原特异性结合的抗体的文库; （d）将步骤（c）中选择的文库导入分泌与不同于步骤（a）的抗原的期望抗原结合的抗体的重链的宿主，以产生显示由重链和光组成的抗体的文库链条和（e）选择显示与步骤（d）的所需抗原特异性结合的抗体的文库。

23. 发明授权

US5723318A DNA coding for megakaryocyte potentiator 失效
标题翻译：编码巨核细胞增强子的DNA
公开(公告)号：US5723318A
公开(公告)日：1998-03-03
申请号：US426819
申请日：1995-04-21
申请人： Nozomi Yamaguchi , Tetsuo Kojima , Masayoshi Oh-eda , Kunihiro Hattori
发明人： Nozomi Yamaguchi , Tetsuo Kojima , Masayoshi Oh-eda , Kunihiro Hattori
IPC分类号： C07K14/475 , C07K14/52 , C12N15/19
CPC分类号： C07K14/475 , C07K14/52
摘要： Genes coding for a polypeptide having a human megakaryocyte potentiator activity, recombinant vectors containing said genes, host cells that have been transformed with said recombinant vectors, and a process for producing a polypeptide having a human megakaryocyte potentiator activity by first cultivating said transformed host cells and then isolating the desired polypeptide from the culture.
摘要翻译：编码具有人巨核细胞增强子活性的多肽的基因，含有所述基因的重组载体，已经用所述重组载体转化的宿主细胞，以及通过首先培养所述转化的宿主细胞产生具有人巨核细胞增强子活性的多肽的方法，以及然后从培养物中分离所需的多肽。

24. 外观设计

USD680916S1 Side cover for a motor scooter 有权
标题翻译：汽车摩托车侧盖
公开(公告)号：USD680916S1
公开(公告)日：2013-04-30
申请号：US29401280
申请日：2011-09-09
申请人： Tetsuo Kojima , Kouhei Suzuki
设计人： Tetsuo Kojima , Kouhei Suzuki

25. 发明授权

US08062635B2 Bispecific antibody substituting for functional proteins 有权
标题翻译：替代功能蛋白的双特异性抗体
公开(公告)号：US08062635B2
公开(公告)日：2011-11-22
申请号：US10575193
申请日：2004-10-08
申请人： Kunihiro Hattori , Tetsuo Kojima , Taro Miyazaki , Tetsuhiro Soeda
发明人： Kunihiro Hattori , Tetsuo Kojima , Taro Miyazaki , Tetsuhiro Soeda
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , C07K16/2866 , C07K2317/24 , C07K2317/31 , C07K2317/622
摘要： The present inventors succeeded in constructing bispecific antibodies, which bind to both the blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X, and functionally substitute for blood coagulation factor VIII/activated blood coagulation factor VIII which enhances the enzymatic reaction.
摘要翻译：本发明人成功构建了结合凝血因子IX /活化凝血因子IX和血液凝固因子X两者的双特异性抗体，并且功能性地代替增强酶促反应的凝血因子VIII /活化凝血因子VIII。

26. 发明申请

US20110245473A1 Anti-IL-6 Receptor Antibody 审中-公开
标题翻译：抗IL-6受体抗体
公开(公告)号：US20110245473A1
公开(公告)日：2011-10-06
申请号：US12680112
申请日：2008-09-26
申请人： Tomoyuki Igawa , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Atsuhiko Maeda
发明人： Tomoyuki Igawa , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Atsuhiko Maeda
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6854 , G01N33/6869 , G01N2333/7155 , G01N2500/04 , G01N2500/10
摘要： The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of TOCILIZUMAB, and this enables to reduce immunogenicity risk and the heterogeneity originated from disulfide bonds in the hinge region, as well as to improve antigen binding activity, pharmacokinetics, stability under acidic conditions, and stability in high concentration preparations.
摘要翻译：本发明人成功地发现了TOCILIZUMAB的可变区，框架区和恒定区中的特异性氨基酸突变，这使得能够降低源自铰链区的二硫键的免疫原性风险和异质性，并且改善抗原结合活性，药代动力学，酸性条件下的稳定性和高浓度制剂中的稳定性。

27. 发明申请

US20110098450A1 Antibody Molecules 有权
标题翻译：抗体分子
公开(公告)号：US20110098450A1
公开(公告)日：2011-04-28
申请号：US12680087
申请日：2009-09-25
申请人： Tomoyuki Igawa , Shinya Ishii , Atsuhiko Maeda , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Yoshinobu Higuchi
发明人： Tomoyuki Igawa , Shinya Ishii , Atsuhiko Maeda , Mika Sakurai , Tetsuo Kojima , Tatsuhiko Tachibana , Hirotake Shiraiwa , Hiroyuki Tsunoda , Yoshinobu Higuchi
IPC分类号： C07K16/28 , C07H21/00 , C12N15/63 , C12P21/02 , C12N5/10
CPC分类号： C07K16/2866 , A61K39/00 , A61K2039/505 , C07K16/461 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92
摘要： The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.
摘要翻译：本发明通过改变作为人源化抗IL-6受体IgG1抗体的TOCILIZUMAB的可变区和恒定区的氨基酸序列来提供优于TOCILIZUMAB的第二代分子的药物组合物，以增强抗原 - 中和能力增强，药代动力学改善，治疗效果较差，免疫原性，安全性和物理化学性质（稳定性和均一性）均有改善。本发明还提供了制备这些药物组合物的方法。通过适当地组合CDR结构域，可变区和恒定区中的氨基酸序列改变，本发明人成功地生产出优于TOCILIZUMAB的第二代分子。

28. 发明授权

US07796670B1 Diode laser pumped solid state laser amplifier and diode laser pumped solid state laser 失效
标题翻译：二极管激光泵浦固态激光放大器和二极管激光泵浦固态激光器
公开(公告)号：US07796670B1
公开(公告)日：2010-09-14
申请号：US08938700
申请日：1997-09-26
申请人： Shuichi Fujikawa , Tetsuo Kojima
发明人： Shuichi Fujikawa , Tetsuo Kojima
IPC分类号： H01S3/09 , H01S3/091
CPC分类号： H01S3/0941 , H01S3/025 , H01S3/0407 , H01S3/042 , H01S3/0602 , H01S3/061 , H01S3/08072 , H01S3/094057 , H01S3/094084 , H01S3/2308
摘要： A diode laser pumped solid-state laser amplifier capable of homogenizing the distribution of heat dissipation levels on a section of a solid-state laser rod and not causing a bifocal phenomenon, and a diode laser pumped solid-state laser using the diode laser pumped solid-state laser amplifier. A diode laser pumped solid-state laser amplifier includes a solid-state laser rod having an optical axis along which a laser beam propagates and includes an active medium therein and a plurality of pumping sources having optical axes that run on a plane orthogonal to the axial core of the solid-state laser rod and are separated by a given distance from the axial core of the solid-state laser rod. When pumping light rays are projected on a plane orthogonal to the axial core of the solid-state laser rod, the plurality of pumping sources are located at equiangular intervals with respect to the axial core of the solid-state laser rod.
摘要翻译：一种二极管激光泵浦固态激光放大器，其能够使固态激光棒的一部分上的散热水平分布均匀化并且不引起双焦现象，并且使用二极管激光泵浦固体的二极管激光泵浦固态激光器状态激光放大器。二极管激光泵浦固体激光放大器包括固态激光棒，其具有光轴，激光束沿着该光轴传播并且包括其中的有源介质，以及多个泵浦源，其具有在与轴向正交的平面上延伸的光轴并且与固态激光棒的轴芯分开给定的距离。当泵浦光线投射在与固态激光棒的轴向芯正交的平面上时，多个泵浦源相对于固态激光棒的轴向芯等角间隔设置。

29. 发明申请

US20100074296A1 SOLID STATE LASER AND WAVELENGTH CONVERSION LASER 有权
标题翻译：固态激光和波长转换激光
公开(公告)号：US20100074296A1
公开(公告)日：2010-03-25
申请号：US12513176
申请日：2007-12-06
申请人： Kuniaki Iwashiro , Hiroyuki Suzuki , Tetsuo Kojima , Tomotaka Katsura
发明人： Kuniaki Iwashiro , Hiroyuki Suzuki , Tetsuo Kojima , Tomotaka Katsura
IPC分类号： H01S3/08
CPC分类号： H01S3/08045 , G02F1/353 , G02F1/37 , G02F2001/3503 , G02F2001/3507 , G02F2001/354 , H01S3/08 , H01S3/08072
摘要： Two convex lenses (61, 62), each of which has a focal length “f”, and a 90 degree polarization rotator (5) are interposed between solid-state laser elements (21, 22) of a symmetrical resonator having the two solid-state laser elements (21, 22); a space between the two lenses (61, 62) is made shorter than 2f; and distances between the respective lenses (61, 62) and centers of their adjacent solid-state laser elements (21, 22) are set substantially to “f”, to thus achieve a solid-state laser capable of stably performing high power transverse single mode oscillation desirably having power of 100 W or more. There is acquired a wavelength conversion laser that is further provided with a Q switch (3) and a polarization element (4) and that causes an output fundamental wave laser beam to enter nonlinear elements (91, 92) so as to undergo wavelength conversion, thereby producing a high power harmonic laser beam having a high frequency of; desirably, about 100 kHz.
摘要翻译：在具有两个固体的对称共振器的固体激光元件（21,22）之间插入两个具有焦距“f”的凸透镜（61,62）和90度偏振旋转器（5）状态激光元件（21,22）; 使两个透镜（61,62）之间的空间短于2f; 并且各透镜（61,62）与其相邻的固体激光元件（21,22）的中心之间的距离设定为大致为“f”，从而实现能够稳定地执行大功率横向单期望具有100W或更大的功率的模式振荡。获得进一步设置有Q开关（3）和偏振元件（4）的波长转换激光器，并且使得输出基波激光束进入非线性元件（91,92）以进行波长转换，从而产生具有高频率的高功率谐波激光束; 理想地，约100kHz。

30. 发明申请

US20070263677A1 Laser System 失效
标题翻译：激光系统
公开(公告)号：US20070263677A1
公开(公告)日：2007-11-15
申请号：US11632164
申请日：2005-04-08
申请人： Eiichi Tanaka , Tetsuo Kojima
发明人： Eiichi Tanaka , Tetsuo Kojima
IPC分类号： H01S3/127
CPC分类号： H01S3/2316 , H01S3/0057 , H01S3/0085 , H01S3/117 , H01S3/127 , H01S2301/02
摘要： In the case where, e.g., because of provision of a high-gain and high-energy Q-switched laser oscillator in a laser system in a MOPA configuration, the duration τz from the time point when oscillation-stage Q switches (13a and 13b) start the gate ON to the time point when a pulse laser beam (18) starts to grow is shorter than the fall time τf of amplification-stage Q switches (13c, 13d, and 13e), by implementing control in such a way that the gate-ON timing of the oscillation-stage Q switches (13a and 13b) lag behind the gate-ON timing of the amplification-stage Q switches (13c, 13d, and 13e) by a predetermined time, the loss in the pulse laser beam (18) at the amplification-stage Q switches (13c, 13d, and 13e) can be prevented, while the gain deterioration due to a spontaneously amplified ray (17) produced in the amplification stage is being suppressed. Therefore, a high-energy pulse laser beam can efficiently be obtained.
摘要翻译：在例如由于在MOPA配置中在激光系统中提供高增益和高能量Q开关激光振荡器的情况下，从振荡级Q切换的时间点（13 a和 13 b）通过实施控制，启动栅极ON到脉冲激光束（18）开始增长的时间点比放大级Q开关（13c，13d和13e）的下降时间τf短使得振荡级Q开关（13a和13b）的栅极导通定时滞后于放大级Q开关（13c，13d和13e）的栅极导通定时，由在预定时间内，可以防止在放大级Q开关（13c，13d和13e）处的脉冲激光束（18）中的损失，同时由于自发放大的光线（17）产生的增益劣化在放大阶段被抑制。因此，可以有效地获得高能脉冲激光束。

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