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21. 发明申请

US20070196055A1 Optical connector and connection structure of optical fibers 有权
标题翻译：光纤连接器和光纤的连接结构
公开(公告)号：US20070196055A1
公开(公告)日：2007-08-23
申请号：US11637743
申请日：2006-12-13
申请人： Yoshihisa Kato , Kanako Suzuki , Noribumi Shiina , Tomoyuki Nisio , Kazumasa Ohsono , Yoshikazu Namekawa , Yoshihiro Nakatani
发明人： Yoshihisa Kato , Kanako Suzuki , Noribumi Shiina , Tomoyuki Nisio , Kazumasa Ohsono , Yoshikazu Namekawa , Yoshihiro Nakatani
IPC分类号： G02B6/36
CPC分类号： G02B6/3846 , G02B6/02333 , G02B6/382 , G02B6/3838
摘要： An optical connector having: a ferrule into which a first optical fiber is inserted; an optical fiber connector disposed at an back end of the ferrule; and a cross-linkable refractive index matching member attached onto an end face on a back end side of the first optical fiber. The end face on the back end side of the first optical fiber and an end face of a second optical fiber to be inserted into the optical fiber connector from a back end side thereof are to be connected by a butting connection. The cross-linkable refractive index matching member is formed such that a cross-linkable refractive index matching agent is coated on the end face on the back end side of the first optical fiber, and the coated agent is cross-linked and hardened.
摘要翻译：一种光连接器，具有：插入第一光纤的套圈; 设置在所述套圈的后端的光纤连接器; 以及附接到第一光纤的后端侧的端面上的可交联折射率匹配构件。第一光纤的后端侧的端面和从其后端侧插入到光纤连接器的第二光纤的端面通过对接连接来连接。可交联折射率匹配构件形成为使得可交联折射率匹配剂涂覆在第一光纤的后端侧的端面上，并且涂覆剂交联并硬化。

22. 发明授权

US5510901A Signal recording system using sound memory 失效
标题翻译：信号记录系统使用声音记忆
公开(公告)号：US5510901A
公开(公告)日：1996-04-23
申请号：US337317
申请日：1994-11-10
申请人： Koji Takahashi , Teruo Hieda , Kenji Kyuma , Yoshihiro Nakatani , Koichiro Suzuki , Takeshi Abe , Yoshifumi Ishikawa
发明人： Koji Takahashi , Teruo Hieda , Kenji Kyuma , Yoshihiro Nakatani , Koichiro Suzuki , Takeshi Abe , Yoshifumi Ishikawa
IPC分类号： G11B15/18 , G11B15/20 , G11B27/029 , H04N5/77 , H04N5/782 , H04N5/7826 , H04N5/92 , H04N5/76
CPC分类号： G11B27/029 , G11B15/1875 , H04N5/772 , G11B15/20 , H04N5/78213 , H04N5/78263 , H04N5/9202
摘要： In a system for reading out an information signal stored in a memory and recording it on a recording medium, renewal of the address of the memory is performed in synchronism with the recording operation, thereby making it possible to record the information signal on the recording medium continuously despite intermittent performance of recording. The address of the memory is returned by a predetermined amount in synchronism with renewal of the address of the memory or the recording operation. Thereby it is also possible to assure good continuity of the recorded information signals. Further, the above-described processing is made easier by making the address of the memory controllable in units of track on the recording medium.
摘要翻译：在用于读出存储在存储器中并将其记录在记录介质上的信息信号的系统中，与记录操作同步地执行存储器的地址的更新，从而使得可以将信息信号记录在记录介质上连续不断地进行录音。存储器的地址与存储器的地址的更新或记录操作同步地返回预定量。因此，也可以确保记录的信息信号的良好的连续性。此外，通过使存储器的地址以记录介质上的轨道为单位被控制，使得上述处理变得更容易。

23. 发明授权

US5347318A Apparatus for processing video signals having different aspect ratios 失效
标题翻译：用于处理具有不同宽高比的视频信号的装置
公开(公告)号：US5347318A
公开(公告)日：1994-09-13
申请号：US74957
申请日：1993-06-10
申请人： Takashi Kobayashi , Hiroyuki Takimoto , Taizou Hori , Hiroyuki Fukuoka , Yoshihiro Nakatani , Jun Makino , Shinichi Koyama
发明人： Takashi Kobayashi , Hiroyuki Takimoto , Taizou Hori , Hiroyuki Fukuoka , Yoshihiro Nakatani , Jun Makino , Shinichi Koyama
IPC分类号： H04N5/44 , H04N7/01 , H04N7/087 , H04N7/088 , H04N9/79 , H04N9/82 , H04N5/48
CPC分类号： H04N7/0122 , H04N7/0135 , H04N7/087 , H04N7/088 , H04N9/7925 , H04N9/8205 , H04N9/8233
摘要： A video signal processing apparatus including an input unit for inputting a video signal, a detecting unit for detecting an aspect ratio of the video signal inputted to the input unit, a holding unit for holding aspect information representing the aspect ratio detected by the detecting unit, an abnormal state detecting unit for detecting an abnormal state of the video signal inputted to the input unit, and an output unit for selectively outputting aspect information outputted from the aspect ratio detecting unit and the aspect information held by the holding unit, in accordance with an output of the abnormal state detecting unit.
摘要翻译：一种视频信号处理装置，包括用于输入视频信号的输入单元，用于检测输入到输入单元的视频信号的宽高比的检测单元，用于保存表示由检测单元检测到的宽高比的纵横比信息的保持单元，用于检测输入到输入单元的视频信号的异常状态的异常状态检测单元，以及用于选择性地输出从宽高比检测单元输出的宽高比信息和由保持单元保存的方面信息的输出单元，异常状态检测单元的输出。

24. 发明授权

US10766937B2 Compositions and methods of treating cancer 有权
公开(公告)号：US10766937B2
公开(公告)日：2020-09-08
申请号：US14343022
申请日：2012-09-06
申请人： Yoshihiro Nakatani
发明人： Yoshihiro Nakatani
IPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides compositions and methods of treating various disorders associated with aberrant cell growth.

25. 发明申请

US20150045308A1 Compositions and Methods of Treating Cancer 审中-公开
标题翻译：治疗癌症的组合物和方法
公开(公告)号：US20150045308A1
公开(公告)日：2015-02-12
申请号：US14343022
申请日：2012-09-06
申请人： Yoshihiro Nakatani
发明人： Yoshihiro Nakatani
IPC分类号： C07K14/47
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/4702
摘要： The present invention provides compositions and methods of treating various disorders associated with aberrant cell growth.
摘要翻译：本发明提供了治疗与异常细胞生长相关的各种疾病的组合物和方法。

26. 发明授权

US08213791B2 Communication light detecting device 有权
标题翻译：通信光检测装置
公开(公告)号：US08213791B2
公开(公告)日：2012-07-03
申请号：US12465735
申请日：2009-05-14
申请人： Seiji Kojima , Kanako Suzuki , Yoshihiro Nakatani , Toshihiko Ishikawa , Takao Nishikawa , Kojiro Ito , Tetsuya Sueoka
发明人： Seiji Kojima , Kanako Suzuki , Yoshihiro Nakatani , Toshihiko Ishikawa , Takao Nishikawa , Kojiro Ito , Tetsuya Sueoka
IPC分类号： H04B10/08
CPC分类号： G02B6/4201 , G02B6/4219 , G02B6/424 , G02B6/4259 , G02B6/4286 , G02B6/429
摘要： A communication light detecting device interconnecting light transmission paths and collocated therebetween, comprises: an optical coupling body including a core portion for photo coupling with the light transmission paths, and a light extracting portion for extracting a part of the communication light as a leakage light; and a light detecting portion having a light receiving member for receiving the leakage light. The light extracting portion is preferable to possess a lower refractive index than that of the core portion. Besides, the light extracting portion is preferable to include a light detecting use groove with a groove width of 50 μm or more and 140 μm or less formed by cutting and separating the core portion. Besides, the light extracting portion is preferable to be the optical coupling body in which outer diameter of the core portion is different from the outer diameter of a core of the light transmission path.
摘要翻译：一种将光传输路径互连并配置在其间的通信光检测装置，包括：光耦合体，包括用于与所述光传输路径进行光耦合的芯部;以及光提取部，用于将所述通信光的一部分提取为泄漏光; 以及具有用于接收泄漏光的光接收部件的光检测部。光提取部优选具有比芯部更低的折射率。此外，光提取部优选包括通过切割和分离芯部而形成的沟宽度为50μm以上且140μm以下的光检测用槽。此外，光提取部优选为芯部的外径与光传输路径的芯的外径不同的光耦合体。

27. 发明申请

US20060160984A1 Biodegradable material and process for producing the same 审中-公开
标题翻译：生物降解材料及其生产方法
公开(公告)号：US20060160984A1
公开(公告)日：2006-07-20
申请号：US10569966
申请日：2004-10-20
申请人： Naotsugu Nagasawa , Toshiaki Yagi , Fumio Yoshii , Shin-ichi Kanazawa , Kiyoshi Kawano , Yoshihiro Nakatani , Hiroshi Mitomo
发明人： Naotsugu Nagasawa , Toshiaki Yagi , Fumio Yoshii , Shin-ichi Kanazawa , Kiyoshi Kawano , Yoshihiro Nakatani , Hiroshi Mitomo
IPC分类号： C08G63/02
CPC分类号： C08F283/02 , C08F226/06
摘要： A biodegradable aliphatic polyester, such as polylactic acid, is mixed with a monomer having allyl and molded into a molding having the crosslinking degree of the biodegradable aliphatic polyester increased. Thereafter, the molding is exposed to ionizing radiation to thereby obtain a molding excelling in heat resistance. Triallyl isocyanurate or triallyl cyanurate is used as the monomer having allyl.
摘要翻译：将可生物降解的脂肪族聚酯如聚乳酸与具有烯丙基的单体混合并成型为具有可生物降解的脂肪族聚酯的交联度增加的成型体。此后，将模制品暴露于电离辐射，从而获得耐热性优异的模制品。三烯丙基异氰脲酸酯或三烯丙基氰脲酸酯用作具有烯丙基的单体。

28. 发明授权

US07067646B2 Methods and compositions for modulating tumor suppression 失效
公开(公告)号：US07067646B2
公开(公告)日：2006-06-27
申请号：US10107521
申请日：2002-03-25
申请人： Yoshihiro Nakatani
发明人： Yoshihiro Nakatani
IPC分类号： C07H19/00 , C07H21/04
CPC分类号： C07K14/4736 , A61K38/00 , C07K14/47
摘要： The purification of native RB (retinoblastoma) as a complex, including P107, P130, and a 600 kDa subunit, termed MTAF600 (microtubule associated factor 600) is described. MTAF600 binds to RB regardless of the phosphorylation status of RB, and binds to RB without disrupting the interaction between RB and E2F. It is further shown that E2F and DP proteins co-purified with MTAF600 and RB, such that hypophosphorylated RB may gain access to E2F as a complex with MTAF600. In addition, MTAF600 binds to microtubules and plays a role in active repression of E2F-responsive genes, cell cycle arrest, and genomic stability. The sequence of MTAF600 is described herein, along with its binding properties to proteins such as RB and microtubules, and its sequence homology. Further, methods and reagents for assaying the presence of MTAF600 or mutants thereof, pharmaceutical formulations, and methods for treating disease are also described.

29. 发明授权

US6014179A Apparatus and method for processing video signals with different aspect ratios 失效
标题翻译：用于处理不同宽高比的视频信号的装置和方法
公开(公告)号：US6014179A
公开(公告)日：2000-01-11
申请号：US822504
申请日：1997-03-24
申请人： Takashi Kobayashi , Hiroyuki Takimoto , Taizou Hori , Hiroyuki Fukuoka , Yoshihiro Nakatani , Jun Makino , Shinichi Koyama
发明人： Takashi Kobayashi , Hiroyuki Takimoto , Taizou Hori , Hiroyuki Fukuoka , Yoshihiro Nakatani , Jun Makino , Shinichi Koyama
IPC分类号： H04N5/44 , H04N7/01 , H04N7/087 , H04N7/088 , H04N9/79 , H04N9/82 , H04N5/46
CPC分类号： H04N7/0122 , H04N7/0135 , H04N7/087 , H04N7/088 , H04N9/7925 , H04N9/8205 , H04N9/8233
摘要： An apparatus and method for inputting one or more video signals, synthesizing the video signals and outputting the synthesized video signals with aspect information. The aspect information represents an aspect ratio of the synthesized video signal. The aspect information may be superposed within the vertical blanking period.
摘要翻译：一种用于输入一个或多个视频信号的装置和方法，合成视频信号并用方面信息输出合成的视频信号。方面信息表示合成视频信号的宽高比。方面信息可以叠加在垂直消隐期内。

30. 发明授权

US5627047A Astrocyte-specific transcription of human genes 失效
标题翻译：人类基因的星形胶质细胞特异性转录
公开(公告)号：US5627047A
公开(公告)日：1997-05-06
申请号：US197463
申请日：1994-02-16
申请人： Michael Brenner , Francois Besnard , Yoshihiro Nakatani
发明人： Michael Brenner , Francois Besnard , Yoshihiro Nakatani
IPC分类号： C07K14/47 , C12N15/85 , C12N15/10 , C12N15/62
CPC分类号： C12N15/85 , C07K14/47 , C07K14/4711 , C12N15/8509 , A01K2217/05 , A01K2227/10 , A01K2267/03 , A01K2267/0318 , C12N2830/008 , C12N2830/85
摘要： Three unique control DNA sequences of the glial fibrillary acidic (gfa) protein gene have been identified upstream of its basal promoter that are capable of regulating astrocyte-specific transcription of the human gene for glial fibrillary acidic protein (GFAP). One or more of those three regions alone or together with the SV40 early promoter and SV40 enhancer control expression of endogenous or heterologous protein in astrocytes. Transgenic animals expressing amyloid protein can be prepared and used as a model for evaluating Alzheimer's disease. Many heterologous proteins can be expressed in the astrocytes so as to take advantage of the growing list of astrocyte functions. Such proteins include hormones, growth factors, and their receptors. Examples include basic fibroblast growth factor (bFGF), acidic FGF (aFGF), platelet derived growth factor (PDGF), insulin like growth factors 1 and 2 (IGF-1, IGF-2), epidermal growth factor (EGF), transforming growth factors .beta.-1 and .beta.-2 (TGF.beta.1, TGF.beta.2), and S100.beta.; other examples totalled proteins encoded by oncogenes like myc, fos, and erb-a, ion channels, like the calcium channel and the potassium channel, and metabolic enzymes, especially ones involved in processing drugs or neurotransmitters; e.g., glutamine synthetase. Additionally, in each case, a dominant dysfunctional protein, an antisense RNA, or a ribozyme, all of which can inhibit the function or production of the protein, can be expressed in astrocytes.
摘要翻译：已经在其基础启动子的上游鉴定了胶质纤维酸性（gfa）蛋白基因的三个独特的对照DNA序列，其能够调节神经胶质纤维酸性蛋白（GFAP）的人类基因的星形胶质细胞特异性转录。这三个区域中的一个或多个单独或与SV40早期启动子和SV40增强子一起控制内源或异源蛋白质在星形胶质细胞中的表达。可以制备表达淀粉样蛋白的转基因动物并用作评价阿尔茨海默病的模型。许多异源蛋白质可以在星形胶质细胞中表达，以便利用增长的星形胶质细胞功能列表。这些蛋白质包括激素，生长因子及其受体。实例包括碱性成纤维细胞生长因子（bFGF），酸性FGF（aFGF），血小板衍生生长因子（PDGF），胰岛素样生长因子1和2（IGF-1，IGF-2），表皮生长因子（EGF）因子β-1和β-2（TGFβ1，TGFβ2）和S100β; 其他实例总共由癌基因如myc，fos和erb-a编码的蛋白质，离子通道，如钙通道和钾通道，以及代谢酶，特别是涉及加工药物或神经递质的代谢酶; 例如谷氨酰胺合成酶。此外，在每种情况下，可以在星形胶质细胞中表达所有可以抑制蛋白质的功能或产生的显性功能障碍蛋白质，反义RNA或核酶。

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